Tauroursodeoxycholic Acid Attenuates Progression of Steatohepatitis in Mice Fed a Methionine–Choline-Deficient Diet View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07

AUTHORS

Eun-Ju Cho, Jung-Hwan Yoon, Min-Sun Kwak, Eun Sun Jang, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Chung Yong Kim, Hyo-Suk Lee

ABSTRACT

BACKGROUND AND AIM: Endoplasmic reticulum (ER) stress has been implicated in the development of nonalcoholic steatohepatitis. A methionine-choline-deficient (MCD) diet induces robust ER stress response and steatohepatitis, but the effects of ER stress modulation on the course of steatohepatitis remain uncertain. The present study evaluated whether reducing ER stress using the chemical chaperone tauroursodeoxycholic acid (TUDCA) could limit hepatocyte lipoapoptosis and progression of MCD diet-induced steatohepatitis. METHODS: HuH7 cells stably transfected with sodium taurocholate cotransporting polypeptide (HuH-Ntcp cells) and palmitate (PA) were used. Experimental steatohepatitis was induced in male C57BL/6 mice using an MCD diet, and three different doses of TUDCA (500, or 1,000 mg/kg, once daily; or 500 mg/kg twice daily) were administered by gavage from the start of the MCD diet regimen or after 4 weeks. RESULTS: TUDCA reduced PA-induced ER stress as manifested by decreased eIF2α phosphorylation, XBP1 splicing and expression of BiP, ATF4, and CHOP in HuH-Ntcp cells. TUDCA also decreased PA-induced JNK phosphorylation, Puma up-regulation and Bax activation, which in turn suppressed caspase-dependent hepatocyte lipoapoptosis. Mice given TUDCA did not show a significant decrease in the intrahepatic triglyceride contents and steatosis. However, TUDCA treatment significantly reduced hepatic damage compared to controls for both early and late treatment groups. TUDCA treatment reduced the expression of ER stress markers and pro-apoptotic proteins, leading to decreased apoptosis and oxidative stress. Finally, TUDCA reduced histological fibrosis along with the down-regulation of pro-fibrotic gene expression in both early and late treatment groups. CONCLUSIONS: These results show that TUDCA attenuates the progression of MCD diet-induced steatohepatitis by reducing ER stress. More... »

PAGES

1461-1474

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-014-3217-0

DOI

http://dx.doi.org/10.1007/s10620-014-3217-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037284906

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24865256


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animal Feed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choline Deficiency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endoplasmic Reticulum Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoblotting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methionine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Non-alcoholic Fatty Liver Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taurochenodeoxycholic Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Eun-Ju", 
        "id": "sg:person.01071723517.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071723517.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Jung-Hwan", 
        "id": "sg:person.0666661531.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666661531.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwak", 
        "givenName": "Min-Sun", 
        "id": "sg:person.01267515711.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267515711.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Bundang Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Eun Sun", 
        "id": "sg:person.01016263324.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016263324.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jeong-Hoon", 
        "id": "sg:person.016451652620.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451652620.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Su Jong", 
        "id": "sg:person.01141310262.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141310262.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yoon Jun", 
        "id": "sg:person.0716302167.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716302167.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Chung Yong", 
        "id": "sg:person.0714777622.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714777622.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyo-Suk", 
        "id": "sg:person.014357233714.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/hep.23719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001984086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2009.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006146622", 
          "https://doi.org/10.1038/labinvest.2009.112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(02)00102-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0809677105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006751809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2012.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007336481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m105300200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009387863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m510660200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009663644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2010.10.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011870974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00091.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014067878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1128294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017031795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017659113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0352-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025668384", 
          "https://doi.org/10.1007/s10495-009-0352-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0352-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025668384", 
          "https://doi.org/10.1007/s10495-009-0352-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0352-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025668384", 
          "https://doi.org/10.1007/s10495-009-0352-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2004.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027922510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00052.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030389996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0013858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030546201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2010.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033903231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200311055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033955669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2011.05.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033984805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00557.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034946805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2002.35441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037709789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.25630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038333538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039651506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m800042-jlr200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040925743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2011.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041709882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045721178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045721178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0959-9673.2006.00465.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049501032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0959-9673.2006.00465.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049501032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2362.2002.01030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050868938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-9574lsf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052334407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2010.3790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059231499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v18.i19.2300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071368283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077372136", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-07", 
    "datePublishedReg": "2014-07-01", 
    "description": "BACKGROUND AND AIM: Endoplasmic reticulum (ER) stress has been implicated in the development of nonalcoholic steatohepatitis. A methionine-choline-deficient (MCD) diet induces robust ER stress response and steatohepatitis, but the effects of ER stress modulation on the course of steatohepatitis remain uncertain. The present study evaluated whether reducing ER stress using the chemical chaperone tauroursodeoxycholic acid (TUDCA) could limit hepatocyte lipoapoptosis and progression of MCD diet-induced steatohepatitis.\nMETHODS: HuH7 cells stably transfected with sodium taurocholate cotransporting polypeptide (HuH-Ntcp cells) and palmitate (PA) were used. Experimental steatohepatitis was induced in male C57BL/6 mice using an MCD diet, and three different doses of TUDCA (500, or 1,000 mg/kg, once daily; or 500 mg/kg twice daily) were administered by gavage from the start of the MCD diet regimen or after 4 weeks.\nRESULTS: TUDCA reduced PA-induced ER stress as manifested by decreased eIF2\u03b1 phosphorylation, XBP1 splicing and expression of BiP, ATF4, and CHOP in HuH-Ntcp cells. TUDCA also decreased PA-induced JNK phosphorylation, Puma up-regulation and Bax activation, which in turn suppressed caspase-dependent hepatocyte lipoapoptosis. Mice given TUDCA did not show a significant decrease in the intrahepatic triglyceride contents and steatosis. However, TUDCA treatment significantly reduced hepatic damage compared to controls for both early and late treatment groups. TUDCA treatment reduced the expression of ER stress markers and pro-apoptotic proteins, leading to decreased apoptosis and oxidative stress. Finally, TUDCA reduced histological fibrosis along with the down-regulation of pro-fibrotic gene expression in both early and late treatment groups.\nCONCLUSIONS: These results show that TUDCA attenuates the progression of MCD diet-induced steatohepatitis by reducing ER stress.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-014-3217-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "59"
      }
    ], 
    "name": "Tauroursodeoxycholic Acid Attenuates Progression of Steatohepatitis in Mice Fed a Methionine\u2013Choline-Deficient Diet", 
    "pagination": "1461-1474", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b19d0469691d17959647dfd40362298246f444ae9e8abdf8e766d9472d1185ae"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24865256"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-014-3217-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037284906"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-014-3217-0", 
      "https://app.dimensions.ai/details/publication/pub.1037284906"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000490.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10620-014-3217-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-014-3217-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-014-3217-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-014-3217-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-014-3217-0'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      21 PREDICATES      79 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-014-3217-0 schema:about N1bd10ba4e2354226a48571d8a6f13cc6
2 N1d760c15514b409fb8dff8224aed47e5
3 N2a54f746605440709f8a6def09bc91fb
4 N346328c89cba440583ea044b9c1ea42c
5 N4aa98c5d664e4ac785bafee173f7a956
6 N4aff7e7391d44177b8597d41dbb4afd8
7 N51818d00b1ad45cf9b34a1032876df03
8 N6235fcd7eb5747aab99e5646f1b382ef
9 N756fb3d2ff0f4ec78ad5594bb98a6509
10 N7a1b3c8138114e3e801a94bf6717925b
11 N7cb9313132da4131bce6e4685517e563
12 N803c1d2a92dd4f058c1e3eaf86c1e5ef
13 N94ad89fbd7a14139abc0f763cc98d2e5
14 Na247364b11ee439e934287da08bf4491
15 Na9dadf6d237e409abd56188c1cc154b3
16 Nc3a2752edb414368ad0d773f969204ed
17 Ncdd6f7db9c5840aa92c79505d5b085e5
18 Nd2ecf815d3ad4bcbbd7faa3de7c14bbd
19 Nf5eba8fe63094270bb8efef57e49eea5
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author N12cf24b54a274b37b2461380a1b1e3f6
23 schema:citation sg:pub.10.1007/s10495-009-0352-8
24 sg:pub.10.1038/labinvest.2009.112
25 https://app.dimensions.ai/details/publication/pub.1077372136
26 https://doi.org/10.1002/hep.20701
27 https://doi.org/10.1002/hep.23280
28 https://doi.org/10.1002/hep.23719
29 https://doi.org/10.1002/hep.24376
30 https://doi.org/10.1002/hep.25630
31 https://doi.org/10.1016/j.bbrc.2011.05.043
32 https://doi.org/10.1016/j.freeradbiomed.2011.10.003
33 https://doi.org/10.1016/j.jhep.2004.04.034
34 https://doi.org/10.1016/j.jhep.2010.11.005
35 https://doi.org/10.1016/j.molmed.2012.06.010
36 https://doi.org/10.1016/j.yjmcc.2010.10.023
37 https://doi.org/10.1016/s0168-8278(02)00102-2
38 https://doi.org/10.1046/j.1365-2362.2002.01030.x
39 https://doi.org/10.1053/jhep.2002.35441
40 https://doi.org/10.1073/pnas.0809677105
41 https://doi.org/10.1074/jbc.m105300200
42 https://doi.org/10.1074/jbc.m510660200
43 https://doi.org/10.1083/jcb.200311055
44 https://doi.org/10.1089/ars.2010.3790
45 https://doi.org/10.1096/fj.07-9574lsf
46 https://doi.org/10.1111/j.0959-9673.2006.00465.x
47 https://doi.org/10.1126/science.1128294
48 https://doi.org/10.1152/ajpgi.00052.2012
49 https://doi.org/10.1152/ajpgi.00091.2010
50 https://doi.org/10.1152/ajpgi.00557.2005
51 https://doi.org/10.1194/jlr.m800042-jlr200
52 https://doi.org/10.1371/journal.pone.0013858
53 https://doi.org/10.3748/wjg.v18.i19.2300
54 schema:datePublished 2014-07
55 schema:datePublishedReg 2014-07-01
56 schema:description BACKGROUND AND AIM: Endoplasmic reticulum (ER) stress has been implicated in the development of nonalcoholic steatohepatitis. A methionine-choline-deficient (MCD) diet induces robust ER stress response and steatohepatitis, but the effects of ER stress modulation on the course of steatohepatitis remain uncertain. The present study evaluated whether reducing ER stress using the chemical chaperone tauroursodeoxycholic acid (TUDCA) could limit hepatocyte lipoapoptosis and progression of MCD diet-induced steatohepatitis. METHODS: HuH7 cells stably transfected with sodium taurocholate cotransporting polypeptide (HuH-Ntcp cells) and palmitate (PA) were used. Experimental steatohepatitis was induced in male C57BL/6 mice using an MCD diet, and three different doses of TUDCA (500, or 1,000 mg/kg, once daily; or 500 mg/kg twice daily) were administered by gavage from the start of the MCD diet regimen or after 4 weeks. RESULTS: TUDCA reduced PA-induced ER stress as manifested by decreased eIF2α phosphorylation, XBP1 splicing and expression of BiP, ATF4, and CHOP in HuH-Ntcp cells. TUDCA also decreased PA-induced JNK phosphorylation, Puma up-regulation and Bax activation, which in turn suppressed caspase-dependent hepatocyte lipoapoptosis. Mice given TUDCA did not show a significant decrease in the intrahepatic triglyceride contents and steatosis. However, TUDCA treatment significantly reduced hepatic damage compared to controls for both early and late treatment groups. TUDCA treatment reduced the expression of ER stress markers and pro-apoptotic proteins, leading to decreased apoptosis and oxidative stress. Finally, TUDCA reduced histological fibrosis along with the down-regulation of pro-fibrotic gene expression in both early and late treatment groups. CONCLUSIONS: These results show that TUDCA attenuates the progression of MCD diet-induced steatohepatitis by reducing ER stress.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N2690f55a30b7471ca30ce46722d78037
61 Nb2aaca7d56aa4e7285077120286fe7e9
62 sg:journal.1018525
63 schema:name Tauroursodeoxycholic Acid Attenuates Progression of Steatohepatitis in Mice Fed a Methionine–Choline-Deficient Diet
64 schema:pagination 1461-1474
65 schema:productId N5b2ef5f876d04c74ae1292abbd427a67
66 N70f59c53e1e74d239387f56ad26a5e17
67 N9ebf14db2a334af1a4b300444f99b0f9
68 Nb4281947bd0348ec998d1cc46f0019e1
69 Ndb7840179882434d977b88887f335f0a
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037284906
71 https://doi.org/10.1007/s10620-014-3217-0
72 schema:sdDatePublished 2019-04-10T13:09
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nf33b8cb1a33248d894669d4c18ce685f
75 schema:url http://link.springer.com/10.1007/s10620-014-3217-0
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N12cf24b54a274b37b2461380a1b1e3f6 rdf:first sg:person.01071723517.04
80 rdf:rest N45cb819469af46fbb226eb147688ba54
81 N1bd10ba4e2354226a48571d8a6f13cc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Drug Administration Schedule
83 rdf:type schema:DefinedTerm
84 N1d760c15514b409fb8dff8224aed47e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Mice
86 rdf:type schema:DefinedTerm
87 N2690f55a30b7471ca30ce46722d78037 schema:issueNumber 7
88 rdf:type schema:PublicationIssue
89 N2a54f746605440709f8a6def09bc91fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Taurochenodeoxycholic Acid
91 rdf:type schema:DefinedTerm
92 N346328c89cba440583ea044b9c1ea42c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Gastrointestinal Agents
94 rdf:type schema:DefinedTerm
95 N3de60a6be9cb49289d5ab50322ec4edb rdf:first sg:person.0714777622.22
96 rdf:rest Na1569d2d8a0446f18c91f0da07363d76
97 N45cb819469af46fbb226eb147688ba54 rdf:first sg:person.0666661531.30
98 rdf:rest Ne817079ccc204a4da93308473316a015
99 N4aa98c5d664e4ac785bafee173f7a956 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Non-alcoholic Fatty Liver Disease
101 rdf:type schema:DefinedTerm
102 N4aff7e7391d44177b8597d41dbb4afd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Real-Time Polymerase Chain Reaction
104 rdf:type schema:DefinedTerm
105 N4f05dfcc0b02453d9f3c0d55bb5a2d5c rdf:first sg:person.0716302167.71
106 rdf:rest N3de60a6be9cb49289d5ab50322ec4edb
107 N50ed0205ba34486fb64b66456d716e41 rdf:first sg:person.016451652620.09
108 rdf:rest N6212c3f6c3784da2af0e83185405d623
109 N51818d00b1ad45cf9b34a1032876df03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Endoplasmic Reticulum Stress
111 rdf:type schema:DefinedTerm
112 N5b2ef5f876d04c74ae1292abbd427a67 schema:name dimensions_id
113 schema:value pub.1037284906
114 rdf:type schema:PropertyValue
115 N6212c3f6c3784da2af0e83185405d623 rdf:first sg:person.01141310262.41
116 rdf:rest N4f05dfcc0b02453d9f3c0d55bb5a2d5c
117 N6235fcd7eb5747aab99e5646f1b382ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Animal Feed
119 rdf:type schema:DefinedTerm
120 N70f59c53e1e74d239387f56ad26a5e17 schema:name pubmed_id
121 schema:value 24865256
122 rdf:type schema:PropertyValue
123 N756fb3d2ff0f4ec78ad5594bb98a6509 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Choline Deficiency
125 rdf:type schema:DefinedTerm
126 N7a1b3c8138114e3e801a94bf6717925b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mice, Inbred C57BL
128 rdf:type schema:DefinedTerm
129 N7cb9313132da4131bce6e4685517e563 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Immunoblotting
131 rdf:type schema:DefinedTerm
132 N803c1d2a92dd4f058c1e3eaf86c1e5ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Animals
134 rdf:type schema:DefinedTerm
135 N94ad89fbd7a14139abc0f763cc98d2e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Disease Progression
137 rdf:type schema:DefinedTerm
138 N9ebf14db2a334af1a4b300444f99b0f9 schema:name readcube_id
139 schema:value b19d0469691d17959647dfd40362298246f444ae9e8abdf8e766d9472d1185ae
140 rdf:type schema:PropertyValue
141 Na1569d2d8a0446f18c91f0da07363d76 rdf:first sg:person.014357233714.08
142 rdf:rest rdf:nil
143 Na247364b11ee439e934287da08bf4491 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Na9dadf6d237e409abd56188c1cc154b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Fatty Liver
148 rdf:type schema:DefinedTerm
149 Nb2aaca7d56aa4e7285077120286fe7e9 schema:volumeNumber 59
150 rdf:type schema:PublicationVolume
151 Nb4281947bd0348ec998d1cc46f0019e1 schema:name nlm_unique_id
152 schema:value 7902782
153 rdf:type schema:PropertyValue
154 Nc3a2752edb414368ad0d773f969204ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Biomarkers
156 rdf:type schema:DefinedTerm
157 Ncdd6f7db9c5840aa92c79505d5b085e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Reverse Transcriptase Polymerase Chain Reaction
159 rdf:type schema:DefinedTerm
160 Nd2ecf815d3ad4bcbbd7faa3de7c14bbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Apoptosis
162 rdf:type schema:DefinedTerm
163 Ndb7840179882434d977b88887f335f0a schema:name doi
164 schema:value 10.1007/s10620-014-3217-0
165 rdf:type schema:PropertyValue
166 Ne817079ccc204a4da93308473316a015 rdf:first sg:person.01267515711.37
167 rdf:rest Nf5c3e78c224e4247b967ecc86be67268
168 Nf33b8cb1a33248d894669d4c18ce685f schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 Nf5c3e78c224e4247b967ecc86be67268 rdf:first sg:person.01016263324.78
171 rdf:rest N50ed0205ba34486fb64b66456d716e41
172 Nf5eba8fe63094270bb8efef57e49eea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Methionine
174 rdf:type schema:DefinedTerm
175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biological Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biochemistry and Cell Biology
180 rdf:type schema:DefinedTerm
181 sg:journal.1018525 schema:issn 0163-2116
182 1573-2568
183 schema:name Digestive Diseases and Sciences
184 rdf:type schema:Periodical
185 sg:person.01016263324.78 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
186 schema:familyName Jang
187 schema:givenName Eun Sun
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016263324.78
189 rdf:type schema:Person
190 sg:person.01071723517.04 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
191 schema:familyName Cho
192 schema:givenName Eun-Ju
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071723517.04
194 rdf:type schema:Person
195 sg:person.01141310262.41 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
196 schema:familyName Yu
197 schema:givenName Su Jong
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141310262.41
199 rdf:type schema:Person
200 sg:person.01267515711.37 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
201 schema:familyName Kwak
202 schema:givenName Min-Sun
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267515711.37
204 rdf:type schema:Person
205 sg:person.014357233714.08 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
206 schema:familyName Lee
207 schema:givenName Hyo-Suk
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08
209 rdf:type schema:Person
210 sg:person.016451652620.09 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
211 schema:familyName Lee
212 schema:givenName Jeong-Hoon
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451652620.09
214 rdf:type schema:Person
215 sg:person.0666661531.30 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
216 schema:familyName Yoon
217 schema:givenName Jung-Hwan
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666661531.30
219 rdf:type schema:Person
220 sg:person.0714777622.22 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
221 schema:familyName Kim
222 schema:givenName Chung Yong
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714777622.22
224 rdf:type schema:Person
225 sg:person.0716302167.71 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
226 schema:familyName Kim
227 schema:givenName Yoon Jun
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716302167.71
229 rdf:type schema:Person
230 sg:pub.10.1007/s10495-009-0352-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025668384
231 https://doi.org/10.1007/s10495-009-0352-8
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/labinvest.2009.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006146622
234 https://doi.org/10.1038/labinvest.2009.112
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1077372136 schema:CreativeWork
237 https://doi.org/10.1002/hep.20701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045721178
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/hep.23280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017659113
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/hep.23719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001984086
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/hep.24376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039651506
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/hep.25630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038333538
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.bbrc.2011.05.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033984805
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.freeradbiomed.2011.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041709882
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.jhep.2004.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027922510
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.jhep.2010.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033903231
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.molmed.2012.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007336481
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.yjmcc.2010.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011870974
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0168-8278(02)00102-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006390968
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1046/j.1365-2362.2002.01030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050868938
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1053/jhep.2002.35441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037709789
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1073/pnas.0809677105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006751809
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1074/jbc.m105300200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009387863
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1074/jbc.m510660200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009663644
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1083/jcb.200311055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033955669
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1089/ars.2010.3790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231499
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1096/fj.07-9574lsf schema:sameAs https://app.dimensions.ai/details/publication/pub.1052334407
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.0959-9673.2006.00465.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049501032
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.1128294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017031795
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1152/ajpgi.00052.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030389996
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1152/ajpgi.00091.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014067878
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1152/ajpgi.00557.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034946805
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1194/jlr.m800042-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040925743
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1371/journal.pone.0013858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030546201
290 rdf:type schema:CreativeWork
291 https://doi.org/10.3748/wjg.v18.i19.2300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071368283
292 rdf:type schema:CreativeWork
293 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
294 schema:name Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
297 schema:name Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
300 schema:name Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...