Serum Interleukin-33 Levels in Patients with Gastric Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Pinghu Sun, Qiwen Ben, Shuiping Tu, Wenjie Dong, Xiaoguang Qi, Yunlin Wu

ABSTRACT

BACKGROUND: Interleukin-33 (IL-33) is a novel member of the IL-1 family of cytokines, and it is closely related to IL-18, one of the best characterized members of the IL-1 family. It's been demonstrated that elevated levels of IL-18 are involved in a wide variety of tumors, especially in gastric cancer. AIMS: The purpose of this study was to determine the correlations between serum IL-33 levels and the clinicopathologic features in gastric cancer patients. METHODS: Serum samples were collected from 68 patients with gastric cancer and 57 controls. Serum IL-33 levels were measured by ELISA. Classical tumor markers of CEA and CA19-9 levels were routinely detected by chemiluminescence immunoassay. Western blot analysis was used to detect IL-33 expression in gastric cancer tissue samples and cell lines. The relationship between serum levels of IL-33 and clinical characteristics in patients was analyzed. RESULTS: IL-33 levels in the serum of gastric cancer patients were significantly elevated in comparison with that of healthy volunteers. Furthermore, higher serum levels of IL-33 in gastric cancer patients were found to correlate with several poor prognostic factors like depth of invasion, distant metastasis and advanced stage (stage III/IV). On the other hand, serum IL-33 levels did not correlate with CEA and CA19-9. The expression of IL-33 protein was upregulated in carcinoma tissues in comparison with matched normal tissues, and no statistically significant difference was found between the four gastric cancer cell lines and human gastric epithelial cell line GES-1. CONCLUSIONS: Serum IL-33 may be a useful biomarker for predicting the prognosis of gastric cancer. More... »

PAGES

3596-3601

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-011-1760-5

DOI

http://dx.doi.org/10.1007/s10620-011-1760-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003324859

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21643739


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "China", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-33", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ruijin Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Pinghu", 
        "id": "sg:person.0641413202.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641413202.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhai Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411525.6", 
          "name": [
            "Department of Gastroenterology, Changhai Hospital of Second Military Medical University, 168 Changhai Road, 200433, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ben", 
        "givenName": "Qiwen", 
        "id": "sg:person.01012125437.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012125437.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruijin Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tu", 
        "givenName": "Shuiping", 
        "id": "sg:person.014037312712.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014037312712.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruijin Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Wenjie", 
        "id": "sg:person.0622770642.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622770642.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruijin Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Xiaoguang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruijin Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Yunlin", 
        "id": "sg:person.01352236042.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352236042.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0606854104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000473814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003267822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003526811", 
          "https://doi.org/10.1038/nrd2660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003526811", 
          "https://doi.org/10.1038/nrd2660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2009.05791.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004678108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2009.05791.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004678108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/srao.30814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007832844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00178.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008108036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-007-0081-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015582846", 
          "https://doi.org/10.1007/s00281-007-0081-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-007-0081-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015582846", 
          "https://doi.org/10.1007/s00281-007-0081-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.4.2551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015677458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2007.00883.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017007205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08830189809043005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022938228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024433947", 
          "https://doi.org/10.1038/labinvest.3700663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024479780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199911000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033448363", 
          "https://doi.org/10.1097/00004647-199911000-00013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199911000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033448363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199911000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033448363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910550604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036320584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-009-0509-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939810", 
          "https://doi.org/10.1007/s10120-009-0509-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-009-0509-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939810", 
          "https://doi.org/10.1007/s10120-009-0509-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-009-0509-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038939810", 
          "https://doi.org/10.1007/s10120-009-0509-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-02-203372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042608970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-2478(01)00278-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043939176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.10.5784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044075036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19991115)86:10<1936::aid-cncr9>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045146764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.46.27905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047939232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3835(96)04213-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048473854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048876168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048876168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0705939104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049063460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20011015)92:8<2050::aid-cncr1544>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050020935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2004.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050913114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.22119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051602040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.22119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051602040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i28.4473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071364795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460080101600207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074854866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460080101600207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074854866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)36721-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076835045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077161238", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077823298", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "BACKGROUND: Interleukin-33 (IL-33) is a novel member of the IL-1 family of cytokines, and it is closely related to IL-18, one of the best characterized members of the IL-1 family. It's been demonstrated that elevated levels of IL-18 are involved in a wide variety of tumors, especially in gastric cancer.\nAIMS: The purpose of this study was to determine the correlations between serum IL-33 levels and the clinicopathologic features in gastric cancer patients.\nMETHODS: Serum samples were collected from 68 patients with gastric cancer and 57 controls. Serum IL-33 levels were measured by ELISA. Classical tumor markers of CEA and CA19-9 levels were routinely detected by chemiluminescence immunoassay. Western blot analysis was used to detect IL-33 expression in gastric cancer tissue samples and cell lines. The relationship between serum levels of IL-33 and clinical characteristics in patients was analyzed.\nRESULTS: IL-33 levels in the serum of gastric cancer patients were significantly elevated in comparison with that of healthy volunteers. Furthermore, higher serum levels of IL-33 in gastric cancer patients were found to correlate with several poor prognostic factors like depth of invasion, distant metastasis and advanced stage (stage III/IV). On the other hand, serum IL-33 levels did not correlate with CEA and CA19-9. The expression of IL-33 protein was upregulated in carcinoma tissues in comparison with matched normal tissues, and no statistically significant difference was found between the four gastric cancer cell lines and human gastric epithelial cell line GES-1.\nCONCLUSIONS: Serum IL-33 may be a useful biomarker for predicting the prognosis of gastric cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-011-1760-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "name": "Serum Interleukin-33 Levels in Patients with Gastric Cancer", 
    "pagination": "3596-3601", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0fd659e7f7322a856bf9aa53442f172eddbbb6fea99ac41b8d95082bde909363"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21643739"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-011-1760-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003324859"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-011-1760-5", 
      "https://app.dimensions.ai/details/publication/pub.1003324859"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000485.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10620-011-1760-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1760-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1760-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1760-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1760-5'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      21 PREDICATES      86 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-011-1760-5 schema:about N01d2c7e5ad6e456a8172a0e469ba3216
2 N07b9e728ff2c414ab3f5c6f8c471b22f
3 N1681620d573d43b6beb1f83c24f57c2d
4 N1ec5bb8bcb37498ea36a7f1d50d18f60
5 N2024800ce9654fb4b56af713e91ec391
6 N331177f956224b708964876c81e79580
7 N35f44ba668604839b2bcf0351cf7e405
8 N377dbf35c2eb45c68840bed53c8e9f93
9 N3d360f4675104a99b34798aa8d69963b
10 N3dda0d784fe8408380864ff4e6c690e1
11 N5188269803a64842bb67cbb1a3cdfaab
12 N5c031599fc8b42e8b36d58e144561fcb
13 N5c71479d947046ed97e4ad7e2aaedd5e
14 N6ac0dccada7f49fc95e5326a6afa0ee1
15 N9201fe8b8d7c4905bc05eab464eb909b
16 Na183e2bcc3d24999a553e1e763fb3f58
17 Nb99f62aed5d346698d377cdd3ea79251
18 Nc681a5f2a3c34548908a2da7c9e659eb
19 Nc8f1b86c3f044fc2a1e5d94fc961f1e3
20 Nccd54a3eab43448dad9778016da1993a
21 Ncf5d692d413c471382897b664f8e4de4
22 Ndf9031eb8c874092b5121b54b1324658
23 Nec5167b54fff4b3e85b46eb9f23a713e
24 Nfe1ca5051aca47c7aa8a668221b86b91
25 anzsrc-for:11
26 anzsrc-for:1112
27 schema:author Ncb4324feb4bf432289b050d922a1758f
28 schema:citation sg:pub.10.1007/s00281-007-0081-4
29 sg:pub.10.1007/s10120-009-0509-8
30 sg:pub.10.1038/labinvest.3700663
31 sg:pub.10.1038/nrd2660
32 sg:pub.10.1097/00004647-199911000-00013
33 https://app.dimensions.ai/details/publication/pub.1077161238
34 https://app.dimensions.ai/details/publication/pub.1077823298
35 https://doi.org/10.1002/(sici)1097-0142(19991115)86:10<1936::aid-cncr9>3.0.co;2-9
36 https://doi.org/10.1002/1097-0142(20011015)92:8<2050::aid-cncr1544>3.0.co;2-5
37 https://doi.org/10.1002/ijc.2910550604
38 https://doi.org/10.1002/jcp.22119
39 https://doi.org/10.1016/0304-3835(96)04213-9
40 https://doi.org/10.1016/j.cytogfr.2004.02.004
41 https://doi.org/10.1016/j.immuni.2005.09.015
42 https://doi.org/10.1016/s0022-5347(17)36721-6
43 https://doi.org/10.1016/s0165-2478(01)00278-4
44 https://doi.org/10.1053/srao.30814
45 https://doi.org/10.1073/pnas.0606854104
46 https://doi.org/10.1073/pnas.0705939104
47 https://doi.org/10.1074/jbc.270.46.27905
48 https://doi.org/10.1074/jbc.271.10.5784
49 https://doi.org/10.1093/carcin/bgp158
50 https://doi.org/10.1097/00004647-199911000-00013
51 https://doi.org/10.1111/j.1440-1746.2009.05791.x
52 https://doi.org/10.1111/j.1525-1438.2007.00883.x
53 https://doi.org/10.1152/ajpgi.00178.2010
54 https://doi.org/10.1158/1078-0432.ccr-09-1015
55 https://doi.org/10.1177/172460080101600207
56 https://doi.org/10.1182/blood-2009-02-203372
57 https://doi.org/10.1371/journal.pone.0003331
58 https://doi.org/10.3109/08830189809043005
59 https://doi.org/10.3748/wjg.v12.i28.4473
60 https://doi.org/10.4049/jimmunol.179.4.2551
61 schema:datePublished 2011-12
62 schema:datePublishedReg 2011-12-01
63 schema:description BACKGROUND: Interleukin-33 (IL-33) is a novel member of the IL-1 family of cytokines, and it is closely related to IL-18, one of the best characterized members of the IL-1 family. It's been demonstrated that elevated levels of IL-18 are involved in a wide variety of tumors, especially in gastric cancer. AIMS: The purpose of this study was to determine the correlations between serum IL-33 levels and the clinicopathologic features in gastric cancer patients. METHODS: Serum samples were collected from 68 patients with gastric cancer and 57 controls. Serum IL-33 levels were measured by ELISA. Classical tumor markers of CEA and CA19-9 levels were routinely detected by chemiluminescence immunoassay. Western blot analysis was used to detect IL-33 expression in gastric cancer tissue samples and cell lines. The relationship between serum levels of IL-33 and clinical characteristics in patients was analyzed. RESULTS: IL-33 levels in the serum of gastric cancer patients were significantly elevated in comparison with that of healthy volunteers. Furthermore, higher serum levels of IL-33 in gastric cancer patients were found to correlate with several poor prognostic factors like depth of invasion, distant metastasis and advanced stage (stage III/IV). On the other hand, serum IL-33 levels did not correlate with CEA and CA19-9. The expression of IL-33 protein was upregulated in carcinoma tissues in comparison with matched normal tissues, and no statistically significant difference was found between the four gastric cancer cell lines and human gastric epithelial cell line GES-1. CONCLUSIONS: Serum IL-33 may be a useful biomarker for predicting the prognosis of gastric cancer.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf Na3f19b8eb60e4d62920a5081e27dede2
68 Na421beed1bd0422d92b0546c4966c64b
69 sg:journal.1018525
70 schema:name Serum Interleukin-33 Levels in Patients with Gastric Cancer
71 schema:pagination 3596-3601
72 schema:productId N054f94205984465ebce7e0e2aad5f88b
73 N3605d101f5e74d64831d4389b303236c
74 N883081c6549a4d36b615d126ff015973
75 N8b509add0f994738941dd7f3793ca025
76 Nd128a9418e7447d68171dd27e711814c
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003324859
78 https://doi.org/10.1007/s10620-011-1760-5
79 schema:sdDatePublished 2019-04-11T01:53
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher Ne07fe3b0df8440748b9adb8754a74c6d
82 schema:url http://link.springer.com/10.1007/s10620-011-1760-5
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N01d2c7e5ad6e456a8172a0e469ba3216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Tumor Cells, Cultured
88 rdf:type schema:DefinedTerm
89 N054f94205984465ebce7e0e2aad5f88b schema:name readcube_id
90 schema:value 0fd659e7f7322a856bf9aa53442f172eddbbb6fea99ac41b8d95082bde909363
91 rdf:type schema:PropertyValue
92 N07b9e728ff2c414ab3f5c6f8c471b22f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Aged, 80 and over
94 rdf:type schema:DefinedTerm
95 N1681620d573d43b6beb1f83c24f57c2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N176f73a798d94eb79566ab87b9f3dfa1 rdf:first sg:person.0622770642.43
99 rdf:rest Na580fbc849104aef9b0da4a9dea352bc
100 N1949190f3c43471480bf3cd2f98084c8 rdf:first sg:person.01352236042.58
101 rdf:rest rdf:nil
102 N1ec5bb8bcb37498ea36a7f1d50d18f60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Male
104 rdf:type schema:DefinedTerm
105 N2024800ce9654fb4b56af713e91ec391 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name China
107 rdf:type schema:DefinedTerm
108 N331177f956224b708964876c81e79580 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Survival Rate
110 rdf:type schema:DefinedTerm
111 N35f44ba668604839b2bcf0351cf7e405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Retrospective Studies
113 rdf:type schema:DefinedTerm
114 N3605d101f5e74d64831d4389b303236c schema:name nlm_unique_id
115 schema:value 7902782
116 rdf:type schema:PropertyValue
117 N377dbf35c2eb45c68840bed53c8e9f93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Young Adult
119 rdf:type schema:DefinedTerm
120 N3d360f4675104a99b34798aa8d69963b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Stomach Neoplasms
122 rdf:type schema:DefinedTerm
123 N3dda0d784fe8408380864ff4e6c690e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Female
125 rdf:type schema:DefinedTerm
126 N5188269803a64842bb67cbb1a3cdfaab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Prognosis
128 rdf:type schema:DefinedTerm
129 N5c031599fc8b42e8b36d58e144561fcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease Progression
131 rdf:type schema:DefinedTerm
132 N5c71479d947046ed97e4ad7e2aaedd5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Biomarkers, Tumor
134 rdf:type schema:DefinedTerm
135 N6ac0dccada7f49fc95e5326a6afa0ee1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Interleukins
137 rdf:type schema:DefinedTerm
138 N883081c6549a4d36b615d126ff015973 schema:name doi
139 schema:value 10.1007/s10620-011-1760-5
140 rdf:type schema:PropertyValue
141 N8b509add0f994738941dd7f3793ca025 schema:name pubmed_id
142 schema:value 21643739
143 rdf:type schema:PropertyValue
144 N9201fe8b8d7c4905bc05eab464eb909b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Severity of Illness Index
146 rdf:type schema:DefinedTerm
147 N9e11fe7b58e24e0dbd85b76e01443980 rdf:first sg:person.014037312712.85
148 rdf:rest N176f73a798d94eb79566ab87b9f3dfa1
149 Na183e2bcc3d24999a553e1e763fb3f58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Middle Aged
151 rdf:type schema:DefinedTerm
152 Na3f19b8eb60e4d62920a5081e27dede2 schema:volumeNumber 56
153 rdf:type schema:PublicationVolume
154 Na421beed1bd0422d92b0546c4966c64b schema:issueNumber 12
155 rdf:type schema:PublicationIssue
156 Na580fbc849104aef9b0da4a9dea352bc rdf:first Nf7a31a73a88b43218e53d5f478ab3520
157 rdf:rest N1949190f3c43471480bf3cd2f98084c8
158 Nb99f62aed5d346698d377cdd3ea79251 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Biopsy
160 rdf:type schema:DefinedTerm
161 Nc681a5f2a3c34548908a2da7c9e659eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Aged
163 rdf:type schema:DefinedTerm
164 Nc8f1b86c3f044fc2a1e5d94fc961f1e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Enzyme-Linked Immunosorbent Assay
166 rdf:type schema:DefinedTerm
167 Ncab056f471764ad59d8c5546b40638f2 rdf:first sg:person.01012125437.28
168 rdf:rest N9e11fe7b58e24e0dbd85b76e01443980
169 Ncb4324feb4bf432289b050d922a1758f rdf:first sg:person.0641413202.40
170 rdf:rest Ncab056f471764ad59d8c5546b40638f2
171 Nccd54a3eab43448dad9778016da1993a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Follow-Up Studies
173 rdf:type schema:DefinedTerm
174 Ncf5d692d413c471382897b664f8e4de4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Adult
176 rdf:type schema:DefinedTerm
177 Nd128a9418e7447d68171dd27e711814c schema:name dimensions_id
178 schema:value pub.1003324859
179 rdf:type schema:PropertyValue
180 Ndf9031eb8c874092b5121b54b1324658 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Interleukin-33
182 rdf:type schema:DefinedTerm
183 Ne07fe3b0df8440748b9adb8754a74c6d schema:name Springer Nature - SN SciGraph project
184 rdf:type schema:Organization
185 Nec5167b54fff4b3e85b46eb9f23a713e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Blotting, Western
187 rdf:type schema:DefinedTerm
188 Nf7a31a73a88b43218e53d5f478ab3520 schema:affiliation https://www.grid.ac/institutes/grid.412277.5
189 schema:familyName Qi
190 schema:givenName Xiaoguang
191 rdf:type schema:Person
192 Nfe1ca5051aca47c7aa8a668221b86b91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Neoplasm Staging
194 rdf:type schema:DefinedTerm
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
199 schema:name Oncology and Carcinogenesis
200 rdf:type schema:DefinedTerm
201 sg:journal.1018525 schema:issn 0163-2116
202 1573-2568
203 schema:name Digestive Diseases and Sciences
204 rdf:type schema:Periodical
205 sg:person.01012125437.28 schema:affiliation https://www.grid.ac/institutes/grid.411525.6
206 schema:familyName Ben
207 schema:givenName Qiwen
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012125437.28
209 rdf:type schema:Person
210 sg:person.01352236042.58 schema:affiliation https://www.grid.ac/institutes/grid.412277.5
211 schema:familyName Wu
212 schema:givenName Yunlin
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352236042.58
214 rdf:type schema:Person
215 sg:person.014037312712.85 schema:affiliation https://www.grid.ac/institutes/grid.412277.5
216 schema:familyName Tu
217 schema:givenName Shuiping
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014037312712.85
219 rdf:type schema:Person
220 sg:person.0622770642.43 schema:affiliation https://www.grid.ac/institutes/grid.412277.5
221 schema:familyName Dong
222 schema:givenName Wenjie
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622770642.43
224 rdf:type schema:Person
225 sg:person.0641413202.40 schema:affiliation https://www.grid.ac/institutes/grid.412277.5
226 schema:familyName Sun
227 schema:givenName Pinghu
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641413202.40
229 rdf:type schema:Person
230 sg:pub.10.1007/s00281-007-0081-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015582846
231 https://doi.org/10.1007/s00281-007-0081-4
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s10120-009-0509-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038939810
234 https://doi.org/10.1007/s10120-009-0509-8
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/labinvest.3700663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024433947
237 https://doi.org/10.1038/labinvest.3700663
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nrd2660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003526811
240 https://doi.org/10.1038/nrd2660
241 rdf:type schema:CreativeWork
242 sg:pub.10.1097/00004647-199911000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033448363
243 https://doi.org/10.1097/00004647-199911000-00013
244 rdf:type schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1077161238 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1077823298 schema:CreativeWork
247 https://doi.org/10.1002/(sici)1097-0142(19991115)86:10<1936::aid-cncr9>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045146764
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/1097-0142(20011015)92:8<2050::aid-cncr1544>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050020935
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/ijc.2910550604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036320584
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/jcp.22119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051602040
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0304-3835(96)04213-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048473854
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.cytogfr.2004.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050913114
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.immuni.2005.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001616606
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0022-5347(17)36721-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076835045
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0165-2478(01)00278-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043939176
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1053/srao.30814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007832844
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1073/pnas.0606854104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000473814
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.0705939104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049063460
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1074/jbc.270.46.27905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047939232
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1074/jbc.271.10.5784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044075036
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1093/carcin/bgp158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048876168
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/00004647-199911000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033448363
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1440-1746.2009.05791.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004678108
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1525-1438.2007.00883.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017007205
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1152/ajpgi.00178.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008108036
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1158/1078-0432.ccr-09-1015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024479780
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1177/172460080101600207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074854866
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1182/blood-2009-02-203372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042608970
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1371/journal.pone.0003331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003267822
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3109/08830189809043005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022938228
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3748/wjg.v12.i28.4473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364795
296 rdf:type schema:CreativeWork
297 https://doi.org/10.4049/jimmunol.179.4.2551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015677458
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.411525.6 schema:alternateName Changhai Hospital
300 schema:name Department of Gastroenterology, Changhai Hospital of Second Military Medical University, 168 Changhai Road, 200433, Shanghai, People’s Republic of China
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.412277.5 schema:alternateName Ruijin Hospital
303 schema:name Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People’s Republic of China
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...