Dramatic Changes of the Gut Flora Immediately After Severe and Sudden Insults View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08

AUTHORS

Mineji Hayakawa, Takashi Asahara, Naomi Henzan, Hiromoto Murakami, Hiroshi Yamamoto, Nobutaka Mukai, Yousuke Minami, Masahiro Sugano, Nobuhiko Kubota, Shinji Uegaki, Hisako Kamoshida, Atsushi Sawamura, Koji Nomoto, Satoshi Gando

ABSTRACT

BACKGROUND: The gut flora is crucially involved in host homeostasis. However, the changes in the gut flora during the early phase of a critical illness are unknown. AIMS: We investigated the changes in the gut flora at an early phase of severe insult in critically ill patients. METHODS: Fifteen patients who experienced a sudden and severe insult were studied, along with 12 healthy volunteers as the control group. Fecal samples were acquired from the subjects by swabs of the rectum within 6 h after admission to the emergency room (day 0). Samples were serially collected from patients until day 14. Samples were also collected from control subjects. RESULTS: On day 0, total bacterial counts were decreased to one-thousandth the number of the control subjects, in particular, obligate anaerobes and Lactobacillus were significantly decreased. In addition, on day 0, the major short-chain fatty acids of the patients were significantly lower than those of the control subjects. The gut flora and the concentrations of major short-chain fatty acids did not recover to normal levels. In contrast, Enterococcus and Pseudomonas increased during the study period. CONCLUSIONS: The gut flora in critically ill patients changed immediately after a severe insult. The concentrations of the three major short-chain fatty acids were immediately decreased in tandem with the destruction of the gut flora. The gut flora and the concentration of major short-chain fatty acids did not improve during the first 2 weeks after hospital admission. At the same time, the number of harmful bacteria gradually increased. More... »

PAGES

2361-2365

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-011-1649-3

DOI

http://dx.doi.org/10.1007/s10620-011-1649-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032167806

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21384123


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Load", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterococcus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Volatile", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactobacillus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pseudomonas", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayakawa", 
        "givenName": "Mineji", 
        "id": "sg:person.01205637706.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205637706.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yakult Central Institute", 
          "id": "https://www.grid.ac/institutes/grid.433815.8", 
          "name": [
            "Yakult Central Institute for Microbiological Research, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asahara", 
        "givenName": "Takashi", 
        "id": "sg:person.01004213362.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004213362.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henzan", 
        "givenName": "Naomi", 
        "id": "sg:person.01173422762.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173422762.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murakami", 
        "givenName": "Hiromoto", 
        "id": "sg:person.0712270457.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712270457.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01004351705.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004351705.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukai", 
        "givenName": "Nobutaka", 
        "id": "sg:person.01120600305.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120600305.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minami", 
        "givenName": "Yousuke", 
        "id": "sg:person.0617212302.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617212302.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugano", 
        "givenName": "Masahiro", 
        "id": "sg:person.01235026705.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235026705.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubota", 
        "givenName": "Nobuhiko", 
        "id": "sg:person.01303142105.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303142105.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uegaki", 
        "givenName": "Shinji", 
        "id": "sg:person.01047667302.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047667302.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamoshida", 
        "givenName": "Hisako", 
        "id": "sg:person.01063035462.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063035462.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sawamura", 
        "givenName": "Atsushi", 
        "id": "sg:person.0752655570.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752655570.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yakult Central Institute", 
          "id": "https://www.grid.ac/institutes/grid.433815.8", 
          "name": [
            "Yakult Central Institute for Microbiological Research, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomoto", 
        "givenName": "Koji", 
        "id": "sg:person.01052326562.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052326562.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gando", 
        "givenName": "Satoshi", 
        "id": "sg:person.01244521463.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244521463.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2006.03174.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000249528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.35.4.483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007500948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2007.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011816220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.45.2.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011897257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000197374.99755.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014097603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000197374.99755.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014097603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000197374.99755.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014097603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000197374.99755.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014097603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12489-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023507262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000045576.55937.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024092814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000045576.55937.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024092814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000045576.55937.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024092814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024731363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024731363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000162680.52397.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027382158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000162680.52397.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027382158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000162680.52397.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027382158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2672.1991.tb02739.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027960315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1521-6918(03)00073-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031350933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1521-6918(03)00073-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031350933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.01843-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035114590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199802000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039709175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199802000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039709175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e31805569df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041836061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e31805569df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041836061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.01224-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047043711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-004-0536-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050224928", 
          "https://doi.org/10.1007/s00423-004-0536-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-004-0536-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050224928", 
          "https://doi.org/10.1007/s00423-004-0536-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-008-0460-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053540455", 
          "https://doi.org/10.1007/s10620-008-0460-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jsfa.2740600202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053741395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/73.6.1131s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074830868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/85.3.816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077382070"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-08", 
    "datePublishedReg": "2011-08-01", 
    "description": "BACKGROUND: The gut flora is crucially involved in host homeostasis. However, the changes in the gut flora during the early phase of a critical illness are unknown.\nAIMS: We investigated the changes in the gut flora at an early phase of severe insult in critically ill patients.\nMETHODS: Fifteen patients who experienced a sudden and severe insult were studied, along with 12 healthy volunteers as the control group. Fecal samples were acquired from the subjects by swabs of the rectum within 6\u00a0h after admission to the emergency room (day 0). Samples were serially collected from patients until day 14. Samples were also collected from control subjects.\nRESULTS: On day 0, total bacterial counts were decreased to one-thousandth the number of the control subjects, in particular, obligate anaerobes and Lactobacillus were significantly decreased. In addition, on day 0, the major short-chain fatty acids of the patients were significantly lower than those of the control subjects. The gut flora and the concentrations of major short-chain fatty acids did not recover to normal levels. In contrast, Enterococcus and Pseudomonas increased during the study period.\nCONCLUSIONS: The gut flora in critically ill patients changed immediately after a severe insult. The concentrations of the three major short-chain fatty acids were immediately decreased in tandem with the destruction of the gut flora. The gut flora and the concentration of major short-chain fatty acids did not improve during the first 2\u00a0weeks after hospital admission. At the same time, the number of harmful bacteria gradually increased.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-011-1649-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6082574", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "name": "Dramatic Changes of the Gut Flora Immediately After Severe and Sudden Insults", 
    "pagination": "2361-2365", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "993d466168ddf658ec9bbd35b2d69da42f136e802ca4a94fcb2591772caf9ec9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21384123"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-011-1649-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032167806"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-011-1649-3", 
      "https://app.dimensions.ai/details/publication/pub.1032167806"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000489.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10620-011-1649-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1649-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1649-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1649-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-011-1649-3'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      21 PREDICATES      62 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-011-1649-3 schema:about N069630469a6144f2b374ff74cd7bf50a
2 N19b246b9bb364ed191ce5ef76a8759b8
3 N22b60969f4d2444ca4000678a02d0056
4 N25869267851e4a59a31f4a7ca05535cd
5 N49511aeddca04628a44fbdbbe7cb2270
6 N8c56e7dcf2434720bc6991ff637a7f01
7 Na5fb312842ce4ca693a831f4a1dfcc80
8 Naa69e1922cbe4e2d880401c25080360d
9 Nd1c6e9d6d63e40938be20acd110646a9
10 Nd434d29e7a9b4bf4975554f21c294390
11 Nd5896a3d22dc4402ba3c0252599db241
12 Nf6cc84d16b9e4776b01387aa35ad2b3f
13 Nf97b643785144e12b6b2f86c023fef04
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Ndccbd49172cb4d8f8907681fdb387d57
17 schema:citation sg:pub.10.1007/s00423-004-0536-1
18 sg:pub.10.1007/s10620-008-0460-2
19 https://doi.org/10.1002/bjs.5184
20 https://doi.org/10.1002/jsfa.2740600202
21 https://doi.org/10.1016/j.surg.2007.01.021
22 https://doi.org/10.1016/s0140-6736(03)12489-0
23 https://doi.org/10.1016/s1521-6918(03)00073-8
24 https://doi.org/10.1093/ajcn/73.6.1131s
25 https://doi.org/10.1093/ajcn/85.3.816
26 https://doi.org/10.1097/00024382-199802000-00004
27 https://doi.org/10.1097/01.ccm.0000045576.55937.67
28 https://doi.org/10.1097/01.ccm.0000162680.52397.97
29 https://doi.org/10.1097/01.ta.0000197374.99755.fe
30 https://doi.org/10.1097/shk.0b013e31805569df
31 https://doi.org/10.1111/j.1365-2036.2006.03174.x
32 https://doi.org/10.1111/j.1365-2672.1991.tb02739.x
33 https://doi.org/10.1128/aem.01224-06
34 https://doi.org/10.1128/aem.01843-08
35 https://doi.org/10.1136/gut.35.4.483
36 https://doi.org/10.1136/gut.45.2.223
37 schema:datePublished 2011-08
38 schema:datePublishedReg 2011-08-01
39 schema:description BACKGROUND: The gut flora is crucially involved in host homeostasis. However, the changes in the gut flora during the early phase of a critical illness are unknown. AIMS: We investigated the changes in the gut flora at an early phase of severe insult in critically ill patients. METHODS: Fifteen patients who experienced a sudden and severe insult were studied, along with 12 healthy volunteers as the control group. Fecal samples were acquired from the subjects by swabs of the rectum within 6 h after admission to the emergency room (day 0). Samples were serially collected from patients until day 14. Samples were also collected from control subjects. RESULTS: On day 0, total bacterial counts were decreased to one-thousandth the number of the control subjects, in particular, obligate anaerobes and Lactobacillus were significantly decreased. In addition, on day 0, the major short-chain fatty acids of the patients were significantly lower than those of the control subjects. The gut flora and the concentrations of major short-chain fatty acids did not recover to normal levels. In contrast, Enterococcus and Pseudomonas increased during the study period. CONCLUSIONS: The gut flora in critically ill patients changed immediately after a severe insult. The concentrations of the three major short-chain fatty acids were immediately decreased in tandem with the destruction of the gut flora. The gut flora and the concentration of major short-chain fatty acids did not improve during the first 2 weeks after hospital admission. At the same time, the number of harmful bacteria gradually increased.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N16870b7da63e404dac6554764eabfd26
44 N5b6733d96cc948918d8e7ac41d6cbd3b
45 sg:journal.1018525
46 schema:name Dramatic Changes of the Gut Flora Immediately After Severe and Sudden Insults
47 schema:pagination 2361-2365
48 schema:productId N0962d1df699e4ac590af0b1b2570c408
49 N1e7e3fa1ac7f4af79fd9f689a79c6837
50 N2b796d3246d447a688f6c8f2544fce15
51 N51a555fb241c446f9ebba186ea017bc8
52 Nc63b9ac192c244399dc08e8719b7cde2
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032167806
54 https://doi.org/10.1007/s10620-011-1649-3
55 schema:sdDatePublished 2019-04-10T23:19
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Nbaac95a40ada416087d7b645520e5361
58 schema:url http://link.springer.com/10.1007/s10620-011-1649-3
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N069630469a6144f2b374ff74cd7bf50a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Enterococcus
64 rdf:type schema:DefinedTerm
65 N0962d1df699e4ac590af0b1b2570c408 schema:name doi
66 schema:value 10.1007/s10620-011-1649-3
67 rdf:type schema:PropertyValue
68 N0eace32b71c3450baa1a70a60945f0cd rdf:first sg:person.01303142105.83
69 rdf:rest N4cf84c4b455946eba1cfaec7c8430f8b
70 N152a5ea73cca46f096083aeecbcc6dde rdf:first sg:person.01004351705.35
71 rdf:rest N6e28cef1f69a46769c16e700cace1bfd
72 N16870b7da63e404dac6554764eabfd26 schema:issueNumber 8
73 rdf:type schema:PublicationIssue
74 N19b246b9bb364ed191ce5ef76a8759b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Middle Aged
76 rdf:type schema:DefinedTerm
77 N1e7e3fa1ac7f4af79fd9f689a79c6837 schema:name pubmed_id
78 schema:value 21384123
79 rdf:type schema:PropertyValue
80 N22b60969f4d2444ca4000678a02d0056 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Feces
82 rdf:type schema:DefinedTerm
83 N25869267851e4a59a31f4a7ca05535cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Adult
85 rdf:type schema:DefinedTerm
86 N2b796d3246d447a688f6c8f2544fce15 schema:name readcube_id
87 schema:value 993d466168ddf658ec9bbd35b2d69da42f136e802ca4a94fcb2591772caf9ec9
88 rdf:type schema:PropertyValue
89 N39c91b28590044b4942b2f029b49860d rdf:first sg:person.01063035462.43
90 rdf:rest N629dea297a894675957b0584bdf1a836
91 N3fa69d580caa4d43a356f794eb5e6542 rdf:first sg:person.0617212302.69
92 rdf:rest Na5b56d6ab4a749df8f4ec5d2085979c8
93 N49511aeddca04628a44fbdbbe7cb2270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Female
95 rdf:type schema:DefinedTerm
96 N4cf84c4b455946eba1cfaec7c8430f8b rdf:first sg:person.01047667302.46
97 rdf:rest N39c91b28590044b4942b2f029b49860d
98 N51a555fb241c446f9ebba186ea017bc8 schema:name dimensions_id
99 schema:value pub.1032167806
100 rdf:type schema:PropertyValue
101 N5b6733d96cc948918d8e7ac41d6cbd3b schema:volumeNumber 56
102 rdf:type schema:PublicationVolume
103 N629dea297a894675957b0584bdf1a836 rdf:first sg:person.0752655570.98
104 rdf:rest N82d5fb38403f4ab7afa32e5d12249a49
105 N6e28cef1f69a46769c16e700cace1bfd rdf:first sg:person.01120600305.07
106 rdf:rest N3fa69d580caa4d43a356f794eb5e6542
107 N736a827774464570bc2a19106552970c rdf:first sg:person.0712270457.01
108 rdf:rest N152a5ea73cca46f096083aeecbcc6dde
109 N82d5fb38403f4ab7afa32e5d12249a49 rdf:first sg:person.01052326562.75
110 rdf:rest Nc6beb0dfd90f440f892bcff65b25adc3
111 N8c56e7dcf2434720bc6991ff637a7f01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Critical Illness
113 rdf:type schema:DefinedTerm
114 N98054c501d324911be20f89bd59e2758 rdf:first sg:person.01173422762.29
115 rdf:rest N736a827774464570bc2a19106552970c
116 Na5b56d6ab4a749df8f4ec5d2085979c8 rdf:first sg:person.01235026705.56
117 rdf:rest N0eace32b71c3450baa1a70a60945f0cd
118 Na5fb312842ce4ca693a831f4a1dfcc80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Intestines
120 rdf:type schema:DefinedTerm
121 Naa69e1922cbe4e2d880401c25080360d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Bacterial Load
123 rdf:type schema:DefinedTerm
124 Nbaac95a40ada416087d7b645520e5361 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 Nc63b9ac192c244399dc08e8719b7cde2 schema:name nlm_unique_id
127 schema:value 7902782
128 rdf:type schema:PropertyValue
129 Nc6beb0dfd90f440f892bcff65b25adc3 rdf:first sg:person.01244521463.72
130 rdf:rest rdf:nil
131 Ncde8ae78f9674b6296e92ed38846fbd4 rdf:first sg:person.01004213362.14
132 rdf:rest N98054c501d324911be20f89bd59e2758
133 Nd1c6e9d6d63e40938be20acd110646a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 Nd434d29e7a9b4bf4975554f21c294390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Male
138 rdf:type schema:DefinedTerm
139 Nd5896a3d22dc4402ba3c0252599db241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Pseudomonas
141 rdf:type schema:DefinedTerm
142 Ndccbd49172cb4d8f8907681fdb387d57 rdf:first sg:person.01205637706.36
143 rdf:rest Ncde8ae78f9674b6296e92ed38846fbd4
144 Nf6cc84d16b9e4776b01387aa35ad2b3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Fatty Acids, Volatile
146 rdf:type schema:DefinedTerm
147 Nf97b643785144e12b6b2f86c023fef04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Lactobacillus
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
154 schema:name Clinical Sciences
155 rdf:type schema:DefinedTerm
156 sg:grant.6082574 http://pending.schema.org/fundedItem sg:pub.10.1007/s10620-011-1649-3
157 rdf:type schema:MonetaryGrant
158 sg:journal.1018525 schema:issn 0163-2116
159 1573-2568
160 schema:name Digestive Diseases and Sciences
161 rdf:type schema:Periodical
162 sg:person.01004213362.14 schema:affiliation https://www.grid.ac/institutes/grid.433815.8
163 schema:familyName Asahara
164 schema:givenName Takashi
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004213362.14
166 rdf:type schema:Person
167 sg:person.01004351705.35 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
168 schema:familyName Yamamoto
169 schema:givenName Hiroshi
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004351705.35
171 rdf:type schema:Person
172 sg:person.01047667302.46 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
173 schema:familyName Uegaki
174 schema:givenName Shinji
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047667302.46
176 rdf:type schema:Person
177 sg:person.01052326562.75 schema:affiliation https://www.grid.ac/institutes/grid.433815.8
178 schema:familyName Nomoto
179 schema:givenName Koji
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052326562.75
181 rdf:type schema:Person
182 sg:person.01063035462.43 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
183 schema:familyName Kamoshida
184 schema:givenName Hisako
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063035462.43
186 rdf:type schema:Person
187 sg:person.01120600305.07 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
188 schema:familyName Mukai
189 schema:givenName Nobutaka
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120600305.07
191 rdf:type schema:Person
192 sg:person.01173422762.29 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
193 schema:familyName Henzan
194 schema:givenName Naomi
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173422762.29
196 rdf:type schema:Person
197 sg:person.01205637706.36 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
198 schema:familyName Hayakawa
199 schema:givenName Mineji
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205637706.36
201 rdf:type schema:Person
202 sg:person.01235026705.56 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
203 schema:familyName Sugano
204 schema:givenName Masahiro
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235026705.56
206 rdf:type schema:Person
207 sg:person.01244521463.72 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
208 schema:familyName Gando
209 schema:givenName Satoshi
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244521463.72
211 rdf:type schema:Person
212 sg:person.01303142105.83 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
213 schema:familyName Kubota
214 schema:givenName Nobuhiko
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303142105.83
216 rdf:type schema:Person
217 sg:person.0617212302.69 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
218 schema:familyName Minami
219 schema:givenName Yousuke
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617212302.69
221 rdf:type schema:Person
222 sg:person.0712270457.01 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
223 schema:familyName Murakami
224 schema:givenName Hiromoto
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712270457.01
226 rdf:type schema:Person
227 sg:person.0752655570.98 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
228 schema:familyName Sawamura
229 schema:givenName Atsushi
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752655570.98
231 rdf:type schema:Person
232 sg:pub.10.1007/s00423-004-0536-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050224928
233 https://doi.org/10.1007/s00423-004-0536-1
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s10620-008-0460-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053540455
236 https://doi.org/10.1007/s10620-008-0460-2
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/bjs.5184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024731363
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/jsfa.2740600202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053741395
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.surg.2007.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011816220
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0140-6736(03)12489-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023507262
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s1521-6918(03)00073-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031350933
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/ajcn/73.6.1131s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074830868
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/ajcn/85.3.816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077382070
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/00024382-199802000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039709175
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1097/01.ccm.0000045576.55937.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024092814
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/01.ccm.0000162680.52397.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027382158
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/01.ta.0000197374.99755.fe schema:sameAs https://app.dimensions.ai/details/publication/pub.1014097603
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/shk.0b013e31805569df schema:sameAs https://app.dimensions.ai/details/publication/pub.1041836061
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1365-2036.2006.03174.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000249528
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1365-2672.1991.tb02739.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027960315
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1128/aem.01224-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047043711
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1128/aem.01843-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035114590
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1136/gut.35.4.483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007500948
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1136/gut.45.2.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011897257
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.412167.7 schema:alternateName Hokkaido University Hospital
275 schema:name Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, 060-8648, Sapporo, Japan
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.433815.8 schema:alternateName Yakult Central Institute
278 schema:name Yakult Central Institute for Microbiological Research, Tokyo, Japan
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...