Riboflavin Depletion Impairs Cell Proliferation in Adult Human Duodenum: Identification of Potential Effectors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09-17

AUTHORS

Emi Nakano, Sohail Mushtaq, Paul R. Heath, Eun-Sook Lee, Jonathan P. Bury, Stuart A. Riley, Hilary J. Powers, Bernard M. Corfe

ABSTRACT

Background and AimsRiboflavin (vitamin B2) is an essential dietary component with a known function in oxidative metabolism. Our previous data using a rat model of riboflavin deficiency suggested that riboflavin also functions as a luminal signaling molecule regulating crypt development and cell turnover. Riboflavin deficiency is prevalent in both high- and low-income countries across the globe. This study aims to establish whether riboflavin deficiency has consequences for gastrointestinal (GI) morphology in adults and what the effects and effectors of any such alteration may be.MethodsDuodenal biopsies and blood samples were collected from a cross-section of gastroscopy patients. Crypt morphology and cell division were studied by immunohistochemistry, and biochemical riboflavin status was determined. Additionally a cell culture model of riboflavin deficiency was developed and analyzed using a combination of flow cytometry, and microarray and clonogenic assays.ResultDuodenal crypts from subjects in the lowest quartile of riboflavin status were significantly shorter (P = 0.023), less cellular (P = 0.007), and had fewer cell divisions (P = 0.034) than the crypts of subjects in the top quartile of riboflavin status. Following riboflavin depletion of colon cells in culture, cell cycle slowed. Microscopy revealed impaired mitosis and accumulation of aneuploid cells. Alterations in gene expression profiles reflected this alteration, with several mitosis-related genes altered, including AspM, cyclin B1, and Birc5 downregulated and Kif23 upregulated. Riboflavin depletion in vitro caused irreversible loss of proliferative potential of cells.ConclusionsRiboflavin depletion in adult humans impairs proliferation and proliferative potential of intestinal cells, which may have implications for gastrointestinal function. More... »

PAGES

1007-1019

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-010-1374-3

DOI

http://dx.doi.org/10.1007/s10620-010-1374-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026754124

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20848206


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