The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05

AUTHORS

Jin Ha Lee, Jae Hee Cheon, Eun Soo Kim, Moon Jae Chung, Wonseok Kang, Duk Hwan Kim, You Jung Ha, Jae Jun Park, Tae Il Kim, Won Ho Kim

ABSTRACT

Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7%) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1%, with a female preponderance (male, 21.5%; female, 31.6%; P < 0.05). Proctitis was more common in pANCA-negative patients (pANCA-negative, 37.6%; pANCA-positive, 25.2%, P < 0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness. More... »

PAGES

1406-1412

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-009-0847-8

DOI

http://dx.doi.org/10.1007/s10620-009-0847-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052607014

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19507028


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Antineutrophil Cytoplasmic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chi-Square Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colitis, Ulcerative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique, Indirect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Korea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jin Ha", 
        "id": "sg:person.01005060513.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005060513.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheon", 
        "givenName": "Jae Hee", 
        "id": "sg:person.01361111112.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361111112.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Eun Soo", 
        "id": "sg:person.01032303111.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032303111.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Moon Jae", 
        "id": "sg:person.01001121133.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001121133.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Wonseok", 
        "id": "sg:person.0636646366.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636646366.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Duk Hwan", 
        "id": "sg:person.0647656265.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647656265.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "You Jung", 
        "id": "sg:person.0772213645.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772213645.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Jae Jun", 
        "id": "sg:person.01121307113.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121307113.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae Il", 
        "id": "sg:person.015302742440.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015302742440.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Won Ho", 
        "id": "sg:person.012071233174.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012071233174.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10350-006-0574-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000357101", 
          "https://doi.org/10.1007/s10350-006-0574-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-006-0574-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000357101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-006-0574-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000357101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70381-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000627345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70381-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000627345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1996.d01-724.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001060378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.12.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001257970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2006.00798.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004321314", 
          "https://doi.org/10.1111/j.1572-0241.2006.00798.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra020831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004344000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365527809182199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006200987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1746.2001.02546.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006797727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dld.2003.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008380956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1998.540_i.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008433440", 
          "https://doi.org/10.1111/j.1572-0241.1998.540_i.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000201453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013227415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013381013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013381013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2007.01756.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015643655", 
          "https://doi.org/10.1111/j.1572-0241.2007.01756.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2007.05079.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017320645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.082909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018299078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1026471303921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021419230", 
          "https://doi.org/10.1023/a:1026471303921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-6749(05)80067-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021558934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jaut.1996.0114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021812370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026358708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0171-2985(11)80509-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028546935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(95)90069-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030300148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69114-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035784127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1443-9573.2007.00296.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036329208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.34.1.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040562233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365528909091340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044988763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2007.01700.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045576830", 
          "https://doi.org/10.1111/j.1572-0241.2007.01700.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4065/71.5.431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046900246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.63.742.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049392965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.63.742.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049392965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e3280110fb9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052786264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e3280110fb9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052786264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1999.00905.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053268615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i21.3406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071364603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v8.i1.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071375192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077060499", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mog.0000167731.93425.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077060499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mog.0000167731.93425.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077060499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082834843", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083273529", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05", 
    "datePublishedReg": "2010-05-01", 
    "description": "Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7%) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1%, with a female preponderance (male, 21.5%; female, 31.6%; P < 0.05). Proctitis was more common in pANCA-negative patients (pANCA-negative, 37.6%; pANCA-positive, 25.2%, P < 0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10620-009-0847-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis", 
    "pagination": "1406-1412", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-009-0847-8"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fa95637ea607653bf956bc8564b16b802cba1a4d9bc564bc93d259e9fddecfc9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052607014"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19507028"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-009-0847-8", 
      "https://app.dimensions.ai/details/publication/pub.1052607014"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56191_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10620-009-0847-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-009-0847-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-009-0847-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-009-0847-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-009-0847-8'


 

This table displays all metadata directly associated to this object as RDF triples.

286 TRIPLES      21 PREDICATES      76 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-009-0847-8 schema:about N02dfd1c4b75f47bb91190d9bbe0d6b43
2 N0bb13936314e4df4bf6f876fbedfa2fb
3 N38a5e948aec847f0ae9aa19f4c34bd61
4 N44ed8a206fce4fedb88ad05f085b17dd
5 N4b1fe79b1a5a4f7f92ada0d80a0f8479
6 N8b25bfd67b33476796298f323a785e82
7 Na07c3b840fcf4ae09e2b9976b5960777
8 Nada3521158d54feabc00f4aa662532bc
9 Naeaf6fa80c1a4bc5aaf2e88cad2d9477
10 Nbe8dab0439ba4d7681320548348c268a
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author Nc2531b8b716f4f1e8957eb6f398f3863
14 schema:citation sg:pub.10.1007/s10350-006-0574-6
15 sg:pub.10.1023/a:1026471303921
16 sg:pub.10.1111/j.1572-0241.1998.540_i.x
17 sg:pub.10.1111/j.1572-0241.2006.00798.x
18 sg:pub.10.1111/j.1572-0241.2007.01700.x
19 sg:pub.10.1111/j.1572-0241.2007.01756.x
20 https://app.dimensions.ai/details/publication/pub.1077060499
21 https://app.dimensions.ai/details/publication/pub.1082834843
22 https://app.dimensions.ai/details/publication/pub.1083273529
23 https://doi.org/10.1002/ibd.20015
24 https://doi.org/10.1006/jaut.1996.0114
25 https://doi.org/10.1007/s10350-006-0574-6
26 https://doi.org/10.1016/0016-5085(95)90069-1
27 https://doi.org/10.1016/j.dld.2003.07.001
28 https://doi.org/10.1016/s0016-5085(98)70381-6
29 https://doi.org/10.1016/s0091-6749(05)80067-3
30 https://doi.org/10.1016/s0140-6736(06)69114-9
31 https://doi.org/10.1016/s0171-2985(11)80509-7
32 https://doi.org/10.1046/j.1365-2249.1996.d01-724.x
33 https://doi.org/10.1046/j.1365-2249.1999.00905.x
34 https://doi.org/10.1046/j.1440-1746.2001.02546.x
35 https://doi.org/10.1053/j.gastro.2006.12.038
36 https://doi.org/10.1056/nejmra020831
37 https://doi.org/10.1097/01.mog.0000167731.93425.49
38 https://doi.org/10.1097/meg.0b013e3280110fb9
39 https://doi.org/10.1111/j.1440-1746.2007.05079.x
40 https://doi.org/10.1111/j.1443-9573.2007.00296.x
41 https://doi.org/10.1136/gut.2005.082909
42 https://doi.org/10.1136/gut.34.1.46
43 https://doi.org/10.1136/pgmj.63.742.629
44 https://doi.org/10.1159/000201453
45 https://doi.org/10.1172/jci116613
46 https://doi.org/10.3109/00365527809182199
47 https://doi.org/10.3109/00365528909091340
48 https://doi.org/10.3748/wjg.v12.i21.3406
49 https://doi.org/10.3748/wjg.v8.i1.158
50 https://doi.org/10.4065/71.5.431
51 schema:datePublished 2010-05
52 schema:datePublishedReg 2010-05-01
53 schema:description Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7%) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1%, with a female preponderance (male, 21.5%; female, 31.6%; P < 0.05). Proctitis was more common in pANCA-negative patients (pANCA-negative, 37.6%; pANCA-positive, 25.2%, P < 0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf Nbdf8332caee949fca495c6d3507d1806
58 Nf783a1c8c14b4bee835e9e5207efb421
59 sg:journal.1018525
60 schema:name The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis
61 schema:pagination 1406-1412
62 schema:productId N188fe2d0d37c4fd7b7a0685f10a7afa8
63 N3bc08fadb2884d69952be65d6f18f3d8
64 N6c9e1dc01c2847d3a219d08da8a2a37d
65 N99d5b3405e3d4a15930d9495529e833c
66 Ncb1077dce3154c3ab1f5d5dc7a7dca32
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052607014
68 https://doi.org/10.1007/s10620-009-0847-8
69 schema:sdDatePublished 2019-04-15T09:25
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N14ddd95709db4ea59d930f3d08e3fb5c
72 schema:url http://link.springer.com/10.1007/s10620-009-0847-8
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N02dfd1c4b75f47bb91190d9bbe0d6b43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Korea
78 rdf:type schema:DefinedTerm
79 N06f0e0d5c4ee43d186f5a99f84b7db81 rdf:first sg:person.01361111112.51
80 rdf:rest N9d0139069a0546fe8733c8bd524e2a31
81 N0bb13936314e4df4bf6f876fbedfa2fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Colitis, Ulcerative
83 rdf:type schema:DefinedTerm
84 N14ddd95709db4ea59d930f3d08e3fb5c schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N188fe2d0d37c4fd7b7a0685f10a7afa8 schema:name pubmed_id
87 schema:value 19507028
88 rdf:type schema:PropertyValue
89 N194819e170f24dde8772de74536b8795 rdf:first sg:person.015302742440.35
90 rdf:rest N23f135e0f467495497fa0dfa904c885a
91 N20d3ed9b323b41068f9b4744df55dfac rdf:first sg:person.0772213645.45
92 rdf:rest N4f69dc51ae3a4cf0bf7bfc4de9961be6
93 N23f135e0f467495497fa0dfa904c885a rdf:first sg:person.012071233174.13
94 rdf:rest rdf:nil
95 N38a5e948aec847f0ae9aa19f4c34bd61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Prevalence
97 rdf:type schema:DefinedTerm
98 N3bc08fadb2884d69952be65d6f18f3d8 schema:name nlm_unique_id
99 schema:value 7902782
100 rdf:type schema:PropertyValue
101 N44ed8a206fce4fedb88ad05f085b17dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Female
103 rdf:type schema:DefinedTerm
104 N4b1fe79b1a5a4f7f92ada0d80a0f8479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Male
106 rdf:type schema:DefinedTerm
107 N4f69dc51ae3a4cf0bf7bfc4de9961be6 rdf:first sg:person.01121307113.63
108 rdf:rest N194819e170f24dde8772de74536b8795
109 N6c9e1dc01c2847d3a219d08da8a2a37d schema:name dimensions_id
110 schema:value pub.1052607014
111 rdf:type schema:PropertyValue
112 N867186467267424192ab93cb0005a7ad rdf:first sg:person.0636646366.49
113 rdf:rest N9557629935a84cd5a11a44d086e4a9e7
114 N8b25bfd67b33476796298f323a785e82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Chi-Square Distribution
116 rdf:type schema:DefinedTerm
117 N9557629935a84cd5a11a44d086e4a9e7 rdf:first sg:person.0647656265.35
118 rdf:rest N20d3ed9b323b41068f9b4744df55dfac
119 N99d5b3405e3d4a15930d9495529e833c schema:name doi
120 schema:value 10.1007/s10620-009-0847-8
121 rdf:type schema:PropertyValue
122 N9d0139069a0546fe8733c8bd524e2a31 rdf:first sg:person.01032303111.00
123 rdf:rest Nbb19836d0b31424ea468515b42805bab
124 Na07c3b840fcf4ae09e2b9976b5960777 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Antibodies, Antineutrophil Cytoplasmic
126 rdf:type schema:DefinedTerm
127 Nada3521158d54feabc00f4aa662532bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Adult
129 rdf:type schema:DefinedTerm
130 Naeaf6fa80c1a4bc5aaf2e88cad2d9477 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Fluorescent Antibody Technique, Indirect
132 rdf:type schema:DefinedTerm
133 Nbb19836d0b31424ea468515b42805bab rdf:first sg:person.01001121133.77
134 rdf:rest N867186467267424192ab93cb0005a7ad
135 Nbdf8332caee949fca495c6d3507d1806 schema:issueNumber 5
136 rdf:type schema:PublicationIssue
137 Nbe8dab0439ba4d7681320548348c268a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 Nc2531b8b716f4f1e8957eb6f398f3863 rdf:first sg:person.01005060513.63
141 rdf:rest N06f0e0d5c4ee43d186f5a99f84b7db81
142 Ncb1077dce3154c3ab1f5d5dc7a7dca32 schema:name readcube_id
143 schema:value fa95637ea607653bf956bc8564b16b802cba1a4d9bc564bc93d259e9fddecfc9
144 rdf:type schema:PropertyValue
145 Nf783a1c8c14b4bee835e9e5207efb421 schema:volumeNumber 55
146 rdf:type schema:PublicationVolume
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1018525 schema:issn 0163-2116
154 1573-2568
155 schema:name Digestive Diseases and Sciences
156 rdf:type schema:Periodical
157 sg:person.01001121133.77 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
158 schema:familyName Chung
159 schema:givenName Moon Jae
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001121133.77
161 rdf:type schema:Person
162 sg:person.01005060513.63 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
163 schema:familyName Lee
164 schema:givenName Jin Ha
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005060513.63
166 rdf:type schema:Person
167 sg:person.01032303111.00 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
168 schema:familyName Kim
169 schema:givenName Eun Soo
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032303111.00
171 rdf:type schema:Person
172 sg:person.01121307113.63 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
173 schema:familyName Park
174 schema:givenName Jae Jun
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121307113.63
176 rdf:type schema:Person
177 sg:person.012071233174.13 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
178 schema:familyName Kim
179 schema:givenName Won Ho
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012071233174.13
181 rdf:type schema:Person
182 sg:person.01361111112.51 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
183 schema:familyName Cheon
184 schema:givenName Jae Hee
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361111112.51
186 rdf:type schema:Person
187 sg:person.015302742440.35 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
188 schema:familyName Kim
189 schema:givenName Tae Il
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015302742440.35
191 rdf:type schema:Person
192 sg:person.0636646366.49 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
193 schema:familyName Kang
194 schema:givenName Wonseok
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636646366.49
196 rdf:type schema:Person
197 sg:person.0647656265.35 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
198 schema:familyName Kim
199 schema:givenName Duk Hwan
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647656265.35
201 rdf:type schema:Person
202 sg:person.0772213645.45 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
203 schema:familyName Ha
204 schema:givenName You Jung
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772213645.45
206 rdf:type schema:Person
207 sg:pub.10.1007/s10350-006-0574-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000357101
208 https://doi.org/10.1007/s10350-006-0574-6
209 rdf:type schema:CreativeWork
210 sg:pub.10.1023/a:1026471303921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021419230
211 https://doi.org/10.1023/a:1026471303921
212 rdf:type schema:CreativeWork
213 sg:pub.10.1111/j.1572-0241.1998.540_i.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008433440
214 https://doi.org/10.1111/j.1572-0241.1998.540_i.x
215 rdf:type schema:CreativeWork
216 sg:pub.10.1111/j.1572-0241.2006.00798.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004321314
217 https://doi.org/10.1111/j.1572-0241.2006.00798.x
218 rdf:type schema:CreativeWork
219 sg:pub.10.1111/j.1572-0241.2007.01700.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045576830
220 https://doi.org/10.1111/j.1572-0241.2007.01700.x
221 rdf:type schema:CreativeWork
222 sg:pub.10.1111/j.1572-0241.2007.01756.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015643655
223 https://doi.org/10.1111/j.1572-0241.2007.01756.x
224 rdf:type schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1077060499 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082834843 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1083273529 schema:CreativeWork
228 https://doi.org/10.1002/ibd.20015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013381013
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1006/jaut.1996.0114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812370
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1007/s10350-006-0574-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000357101
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0016-5085(95)90069-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030300148
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.dld.2003.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008380956
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0016-5085(98)70381-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000627345
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0091-6749(05)80067-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021558934
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0140-6736(06)69114-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035784127
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0171-2985(11)80509-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028546935
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1046/j.1365-2249.1996.d01-724.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001060378
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1046/j.1365-2249.1999.00905.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053268615
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1046/j.1440-1746.2001.02546.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006797727
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1053/j.gastro.2006.12.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001257970
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1056/nejmra020831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004344000
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/01.mog.0000167731.93425.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077060499
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/meg.0b013e3280110fb9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052786264
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1440-1746.2007.05079.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017320645
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1443-9573.2007.00296.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036329208
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1136/gut.2005.082909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018299078
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1136/gut.34.1.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040562233
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1136/pgmj.63.742.629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049392965
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1159/000201453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013227415
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1172/jci116613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026358708
273 rdf:type schema:CreativeWork
274 https://doi.org/10.3109/00365527809182199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006200987
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3109/00365528909091340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044988763
277 rdf:type schema:CreativeWork
278 https://doi.org/10.3748/wjg.v12.i21.3406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364603
279 rdf:type schema:CreativeWork
280 https://doi.org/10.3748/wjg.v8.i1.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071375192
281 rdf:type schema:CreativeWork
282 https://doi.org/10.4065/71.5.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046900246
283 rdf:type schema:CreativeWork
284 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
285 schema:name Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, 120-752, Seoul, Korea
286 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...