The Anti-Cancer Effect of COX-2 Inhibitors on Gastric Cancer Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

Soo-Jeong Cho, Nayoung Kim, Joo Sung Kim, Hyun Chae Jung, In Sung Song

ABSTRACT

Epidemiologic studies have shown that nonsteroidal anti-inflammatory drugs could reduce the risk of cancer development including gastric cancer. This study was performed to identify the antineoplastic mechanism in gastric cancer cells affected by celecoxib, a selective COX-2 inhibitor. MTT assay, ELISA for prostaglandin E(2) (PGE(2)), cell-cycle analyses, immunofluorescent staining, and flow cytometry were performed after treating human gastric cancer cell lines (AGS and MKN-45) with celecoxib or indomethacin. The viabilities of celecoxib-treated cells decreased in a dose- and time-dependent manner compared with indomethacin. Drop of PGE(2) levels was more prominent in the presence of indomethacin than in that of celecoxib. Celecoxib arrested the cell cycle in the G(0)-G(1) phase, which reduced cell numbers in the S phase. Moreover, celecoxib increased the apoptotic cell proportions, a 4-fold increase over control cells. The anticancer effects of celecoxib on gastric cancer cells appear to be mediated by cell-cycle arrest and apoptosis, and not by COX-2 or PGE(2) suppression alone. More... »

PAGES

1713-1721

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-007-9787-3

DOI

http://dx.doi.org/10.1007/s10620-007-9787-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025425327

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17393325


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