The Anti-Cancer Effect of COX-2 Inhibitors on Gastric Cancer Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03-28

AUTHORS

Soo-Jeong Cho, Nayoung Kim, Joo Sung Kim, Hyun Chae Jung, In Sung Song

ABSTRACT

Epidemiologic studies have shown that nonsteroidal anti-inflammatory drugs could reduce the risk of cancer development including gastric cancer. This study was performed to identify the antineoplastic mechanism in gastric cancer cells affected by celecoxib, a selective COX-2 inhibitor. MTT assay, ELISA for prostaglandin E2 (PGE2), cell-cycle analyses, immunofluorescent staining, and flow cytometry were performed after treating human gastric cancer cell lines (AGS and MKN-45) with celecoxib or indomethacin. The viabilities of celecoxib-treated cells decreased in a dose- and time-dependent manner compared with indomethacin. Drop of PGE2 levels was more prominent in the presence of indomethacin than in that of celecoxib. Celecoxib arrested the cell cycle in the G0–G1 phase, which reduced cell numbers in the S phase. Moreover, celecoxib increased the apoptotic cell proportions, a 4-fold increase over control cells. The anticancer effects of celecoxib on gastric cancer cells appear to be mediated by cell-cycle arrest and apoptosis, and not by COX-2 or PGE2 suppression alone. More... »

PAGES

1713-1721

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-007-9787-3

DOI

http://dx.doi.org/10.1007/s10620-007-9787-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025425327

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17393325


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Celecoxib", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2 Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dinoprostone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfonamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrazolium Salts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Soo-Jeong", 
        "id": "sg:person.0641563624.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641563624.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Internal Medicine and, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
            "Departments of Internal Medicine and, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Nayoung", 
        "id": "sg:person.010433760625.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010433760625.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Joo Sung", 
        "id": "sg:person.07514633567.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07514633567.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Hyun Chae", 
        "id": "sg:person.01230372236.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230372236.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "In Sung", 
        "id": "sg:person.01001342362.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncpcardio0214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009634726", 
          "https://doi.org/10.1038/ncpcardio0214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.1702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027485077", 
          "https://doi.org/10.1054/bjoc.2001.1702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0028-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033257000", 
          "https://doi.org/10.1007/s00280-005-0028-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024581782", 
          "https://doi.org/10.1038/nrc780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-005-1028-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044054040", 
          "https://doi.org/10.1007/s10637-005-1028-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10753-004-6052-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032643080", 
          "https://doi.org/10.1007/s10753-004-6052-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-004-9179-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043553268", 
          "https://doi.org/10.1007/s11060-004-9179-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022281051", 
          "https://doi.org/10.1038/sj.onc.1203286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029472727", 
          "https://doi.org/10.1054/bjoc.2000.1607"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-03-28", 
    "datePublishedReg": "2007-03-28", 
    "description": "Epidemiologic studies have shown that nonsteroidal anti-inflammatory drugs could reduce the risk of cancer development including gastric cancer. This study was performed to identify the antineoplastic mechanism in gastric cancer cells affected by celecoxib, a selective COX-2 inhibitor. MTT assay, ELISA for prostaglandin E2 (PGE2), cell-cycle analyses, immunofluorescent staining, and flow cytometry were performed after treating human gastric cancer cell lines (AGS and MKN-45) with celecoxib or indomethacin. The viabilities of celecoxib-treated cells decreased in a dose- and time-dependent manner compared with indomethacin. Drop of PGE2 levels was more prominent in the presence of indomethacin than in that of celecoxib. Celecoxib arrested the cell cycle in the G0\u2013G1 phase, which reduced cell numbers in the S phase. Moreover, celecoxib increased the apoptotic cell proportions, a 4-fold increase over control cells. The anticancer effects of celecoxib on gastric cancer cells appear to be mediated by cell-cycle arrest and apoptosis, and not by COX-2 or PGE2 suppression alone.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10620-007-9787-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "52"
      }
    ], 
    "keywords": [
      "gastric cancer cells", 
      "prostaglandin E2", 
      "COX-2 inhibitors", 
      "cancer cells", 
      "nonsteroidal anti-inflammatory drugs", 
      "anti-inflammatory drugs", 
      "human gastric cancer cell lines", 
      "presence of indomethacin", 
      "apoptotic cell proportion", 
      "anti-cancer effects", 
      "gastric cancer cell lines", 
      "selective COX-2 inhibitors", 
      "time-dependent manner", 
      "cell-cycle analysis", 
      "celecoxib-treated cells", 
      "cancer cell lines", 
      "PGE2 levels", 
      "gastric cancer", 
      "epidemiologic studies", 
      "cell-cycle arrest", 
      "cell proportions", 
      "celecoxib", 
      "flow cytometry", 
      "G0-G1 phase", 
      "PGE2 suppression", 
      "anticancer effects", 
      "cancer development", 
      "antineoplastic mechanism", 
      "indomethacin", 
      "immunofluorescent staining", 
      "MTT assay", 
      "cell number", 
      "control cells", 
      "cell lines", 
      "cells", 
      "inhibitors", 
      "cell cycle", 
      "COX-2", 
      "cancer", 
      "dose", 
      "ELISA", 
      "cytometry", 
      "drugs", 
      "E2", 
      "staining", 
      "risk", 
      "study", 
      "arrest", 
      "apoptosis", 
      "effect", 
      "assays", 
      "suppression", 
      "proportion", 
      "levels", 
      "viability", 
      "increase", 
      "manner", 
      "presence", 
      "mechanism", 
      "development", 
      "lines", 
      "number", 
      "analysis", 
      "cycle", 
      "phase", 
      "drop"
    ], 
    "name": "The Anti-Cancer Effect of COX-2 Inhibitors on Gastric Cancer Cells", 
    "pagination": "1713-1721", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025425327"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10620-007-9787-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17393325"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10620-007-9787-3", 
      "https://app.dimensions.ai/details/publication/pub.1025425327"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_448.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10620-007-9787-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10620-007-9787-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10620-007-9787-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10620-007-9787-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10620-007-9787-3'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      22 PREDICATES      115 URIs      98 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10620-007-9787-3 schema:about N19ce7f93f0974fd4b8c527b5edd38d81
2 N232bfe895c8842fb9244e410429faff4
3 N2a0635776440457a8295965c0a86551f
4 N43ce504d68e441fca144d755194213e9
5 N4563fc8aa13040a8b4dc20f5e3ee6668
6 N56f18fd326a5488188c169d1c63914c8
7 N653171ebb794400db3361bfc8f41a555
8 N72e9f829def14e47851bc5fb4b6a7b40
9 N81181ecceb3f4429bbf21e442e5bcbb5
10 N87ab90e62ac54670b6177b0130cf24ff
11 Nae0bb10c839941b38154e2138175b5d5
12 Nc4b82fbeec0148e787524ad361843a3f
13 Nc9ed4e37c8a2465889484a64a735f571
14 Nca214db4b6b349789a29f882ad2ecc02
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N150d1496ebcf4fe596ca0eb0f6c48a4f
18 schema:citation sg:pub.10.1007/s00280-005-0028-1
19 sg:pub.10.1007/s10637-005-1028-z
20 sg:pub.10.1007/s10753-004-6052-1
21 sg:pub.10.1007/s11060-004-9179-x
22 sg:pub.10.1038/ncpcardio0214
23 sg:pub.10.1038/nrc780
24 sg:pub.10.1038/sj.onc.1203286
25 sg:pub.10.1054/bjoc.2000.1607
26 sg:pub.10.1054/bjoc.2001.1702
27 schema:datePublished 2007-03-28
28 schema:datePublishedReg 2007-03-28
29 schema:description Epidemiologic studies have shown that nonsteroidal anti-inflammatory drugs could reduce the risk of cancer development including gastric cancer. This study was performed to identify the antineoplastic mechanism in gastric cancer cells affected by celecoxib, a selective COX-2 inhibitor. MTT assay, ELISA for prostaglandin E2 (PGE2), cell-cycle analyses, immunofluorescent staining, and flow cytometry were performed after treating human gastric cancer cell lines (AGS and MKN-45) with celecoxib or indomethacin. The viabilities of celecoxib-treated cells decreased in a dose- and time-dependent manner compared with indomethacin. Drop of PGE2 levels was more prominent in the presence of indomethacin than in that of celecoxib. Celecoxib arrested the cell cycle in the G0–G1 phase, which reduced cell numbers in the S phase. Moreover, celecoxib increased the apoptotic cell proportions, a 4-fold increase over control cells. The anticancer effects of celecoxib on gastric cancer cells appear to be mediated by cell-cycle arrest and apoptosis, and not by COX-2 or PGE2 suppression alone.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N1a09eca5b9d04eefb58dcb0cebab1ecb
34 Na4e2f4559d4340f0ad6ac722656afe22
35 sg:journal.1018525
36 schema:keywords COX-2
37 COX-2 inhibitors
38 E2
39 ELISA
40 G0-G1 phase
41 MTT assay
42 PGE2 levels
43 PGE2 suppression
44 analysis
45 anti-cancer effects
46 anti-inflammatory drugs
47 anticancer effects
48 antineoplastic mechanism
49 apoptosis
50 apoptotic cell proportion
51 arrest
52 assays
53 cancer
54 cancer cell lines
55 cancer cells
56 cancer development
57 celecoxib
58 celecoxib-treated cells
59 cell cycle
60 cell lines
61 cell number
62 cell proportions
63 cell-cycle analysis
64 cell-cycle arrest
65 cells
66 control cells
67 cycle
68 cytometry
69 development
70 dose
71 drop
72 drugs
73 effect
74 epidemiologic studies
75 flow cytometry
76 gastric cancer
77 gastric cancer cell lines
78 gastric cancer cells
79 human gastric cancer cell lines
80 immunofluorescent staining
81 increase
82 indomethacin
83 inhibitors
84 levels
85 lines
86 manner
87 mechanism
88 nonsteroidal anti-inflammatory drugs
89 number
90 phase
91 presence
92 presence of indomethacin
93 proportion
94 prostaglandin E2
95 risk
96 selective COX-2 inhibitors
97 staining
98 study
99 suppression
100 time-dependent manner
101 viability
102 schema:name The Anti-Cancer Effect of COX-2 Inhibitors on Gastric Cancer Cells
103 schema:pagination 1713-1721
104 schema:productId N7503837508b7454589a11a3569f73041
105 Naa803f8da43f4444ac7f95defd178771
106 Ncd65d98bd3d24726b5464a55b034cf6c
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025425327
108 https://doi.org/10.1007/s10620-007-9787-3
109 schema:sdDatePublished 2021-12-01T19:19
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N5bdc9173c57949cea5b1d5d35c28f7f2
112 schema:url https://doi.org/10.1007/s10620-007-9787-3
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N150d1496ebcf4fe596ca0eb0f6c48a4f rdf:first sg:person.0641563624.14
117 rdf:rest Necf93bc14b7147dab3b3249b44180779
118 N19ce7f93f0974fd4b8c527b5edd38d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Microscopy, Fluorescence
120 rdf:type schema:DefinedTerm
121 N1a09eca5b9d04eefb58dcb0cebab1ecb schema:issueNumber 7
122 rdf:type schema:PublicationIssue
123 N232bfe895c8842fb9244e410429faff4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Stomach Neoplasms
125 rdf:type schema:DefinedTerm
126 N2a0635776440457a8295965c0a86551f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Tetrazolium Salts
128 rdf:type schema:DefinedTerm
129 N43ce504d68e441fca144d755194213e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Pyrazoles
131 rdf:type schema:DefinedTerm
132 N4563fc8aa13040a8b4dc20f5e3ee6668 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cyclooxygenase 2 Inhibitors
134 rdf:type schema:DefinedTerm
135 N56f18fd326a5488188c169d1c63914c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Line, Tumor
137 rdf:type schema:DefinedTerm
138 N5bdc9173c57949cea5b1d5d35c28f7f2 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N653171ebb794400db3361bfc8f41a555 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Celecoxib
142 rdf:type schema:DefinedTerm
143 N6ad4ef54386f4f45af4bc176c2002b4e rdf:first sg:person.01230372236.08
144 rdf:rest N7048678caabc476da2642906d4d16fb3
145 N7048678caabc476da2642906d4d16fb3 rdf:first sg:person.01001342362.12
146 rdf:rest rdf:nil
147 N72e9f829def14e47851bc5fb4b6a7b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Apoptosis
149 rdf:type schema:DefinedTerm
150 N7503837508b7454589a11a3569f73041 schema:name doi
151 schema:value 10.1007/s10620-007-9787-3
152 rdf:type schema:PropertyValue
153 N81181ecceb3f4429bbf21e442e5bcbb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Dinoprostone
155 rdf:type schema:DefinedTerm
156 N87ab90e62ac54670b6177b0130cf24ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Adenocarcinoma
158 rdf:type schema:DefinedTerm
159 N97ff1865b81d43a58c83dd04909df7cc rdf:first sg:person.07514633567.21
160 rdf:rest N6ad4ef54386f4f45af4bc176c2002b4e
161 Na4e2f4559d4340f0ad6ac722656afe22 schema:volumeNumber 52
162 rdf:type schema:PublicationVolume
163 Naa803f8da43f4444ac7f95defd178771 schema:name dimensions_id
164 schema:value pub.1025425327
165 rdf:type schema:PropertyValue
166 Nae0bb10c839941b38154e2138175b5d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Humans
168 rdf:type schema:DefinedTerm
169 Nc4b82fbeec0148e787524ad361843a3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Sulfonamides
171 rdf:type schema:DefinedTerm
172 Nc9ed4e37c8a2465889484a64a735f571 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Cell Cycle
174 rdf:type schema:DefinedTerm
175 Nca214db4b6b349789a29f882ad2ecc02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Thiazoles
177 rdf:type schema:DefinedTerm
178 Ncd65d98bd3d24726b5464a55b034cf6c schema:name pubmed_id
179 schema:value 17393325
180 rdf:type schema:PropertyValue
181 Necf93bc14b7147dab3b3249b44180779 rdf:first sg:person.010433760625.29
182 rdf:rest N97ff1865b81d43a58c83dd04909df7cc
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
187 schema:name Oncology and Carcinogenesis
188 rdf:type schema:DefinedTerm
189 sg:journal.1018525 schema:issn 0163-2116
190 1573-2568
191 schema:name Digestive Diseases and Sciences
192 schema:publisher Springer Nature
193 rdf:type schema:Periodical
194 sg:person.01001342362.12 schema:affiliation grid-institutes:grid.31501.36
195 schema:familyName Song
196 schema:givenName In Sung
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12
198 rdf:type schema:Person
199 sg:person.010433760625.29 schema:affiliation grid-institutes:grid.412480.b
200 schema:familyName Kim
201 schema:givenName Nayoung
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010433760625.29
203 rdf:type schema:Person
204 sg:person.01230372236.08 schema:affiliation grid-institutes:grid.31501.36
205 schema:familyName Jung
206 schema:givenName Hyun Chae
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230372236.08
208 rdf:type schema:Person
209 sg:person.0641563624.14 schema:affiliation grid-institutes:grid.31501.36
210 schema:familyName Cho
211 schema:givenName Soo-Jeong
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641563624.14
213 rdf:type schema:Person
214 sg:person.07514633567.21 schema:affiliation grid-institutes:grid.31501.36
215 schema:familyName Kim
216 schema:givenName Joo Sung
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07514633567.21
218 rdf:type schema:Person
219 sg:pub.10.1007/s00280-005-0028-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033257000
220 https://doi.org/10.1007/s00280-005-0028-1
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s10637-005-1028-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044054040
223 https://doi.org/10.1007/s10637-005-1028-z
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s10753-004-6052-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032643080
226 https://doi.org/10.1007/s10753-004-6052-1
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s11060-004-9179-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043553268
229 https://doi.org/10.1007/s11060-004-9179-x
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ncpcardio0214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009634726
232 https://doi.org/10.1038/ncpcardio0214
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nrc780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024581782
235 https://doi.org/10.1038/nrc780
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/sj.onc.1203286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022281051
238 https://doi.org/10.1038/sj.onc.1203286
239 rdf:type schema:CreativeWork
240 sg:pub.10.1054/bjoc.2000.1607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029472727
241 https://doi.org/10.1054/bjoc.2000.1607
242 rdf:type schema:CreativeWork
243 sg:pub.10.1054/bjoc.2001.1702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027485077
244 https://doi.org/10.1054/bjoc.2001.1702
245 rdf:type schema:CreativeWork
246 grid-institutes:grid.31501.36 schema:alternateName Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
247 Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea
248 schema:name Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
249 Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea
250 rdf:type schema:Organization
251 grid-institutes:grid.412480.b schema:alternateName Departments of Internal Medicine and, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, South Korea
252 schema:name Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
253 Departments of Internal Medicine and, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, South Korea
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...