Helicobacter pylori Isolated from a Patient with Ménétrier’s Disease Increases Hepatocyte Growth Factor mRNA Expression in Gastric Fibroblasts: Comparison with ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-11-08

AUTHORS

Takeshi Ishikawa, Takashi Ando, Hiroshi Obayashi, Nami Nakabe, Mika Okita, Yutaka Isozaki, Yasuyuki Nagao, Hirokazu Oyamada, Yoshihiro Nakajima, Haruki Kato, Satoshi Kokura, Yuji Naito, Norimasa Yoshida, Toshikazu Yoshikawa

ABSTRACT

Ménétrier’s disease has been reported to be associated with Helicobacter pylori infection. The aim of this study was to investigate the genetic characteristics of various virulence factors and cytokine expression profiles in Helicobacter pylori isolated from patients with Ménétrier’s disease. The genotyping of virulence factors was accomplished by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). Induction of various cytokines in MKN45 cells or gastric fibroblasts by Helicobacter pylori stimulus was measured by real-time reverse transcription-PCR. We found that the Helicobacter pylori strain isolated from a patient with Ménétrier’s disease was different from other strains in the MseI-RFLP pattern of the ureC gene. Helicobacter pylori isolated from a patient with Ménétrier’s disease showed the highest hepatocyte growth factor (HGF) and TNF-α mRNA expressions from gastric fibroblasts, and the highest TNF-α expression from MKN45 cells. The results in this study suggest that the difference in cytokine production, depending on the difference in bacteria components, plays an important role in the development of Ménétrier’s disease. More... »

PAGES

1785-1791

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-007-0070-4

DOI

http://dx.doi.org/10.1007/s10620-007-0070-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004622071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17990109


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