Fructose Malabsorption May Be Gender Dependent and Fails to Show Compensation by Colonic Adaptation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-11

AUTHORS

Andrew Szilagyi, Paula Malolepszy, Samara Yesovitch, Christina Vinokuroff, Usha Nathwani, Albert Cohen, Xiaoqing Xue

ABSTRACT

Fructose malabsorption is linked to gastrointestinal and other unusual symptoms. Polymers of fructose are also recognized prebiotics. While some prebiotics can self-adapt when consumed regularly (resulting in decreased breath hydrogen and symptoms), we wondered whether self-adaptation occurs with basic fructose. We evaluated 90 subjects (61 females). Each completed a diet questionnaire and underwent a fructose challenge. Breath hydrogen and quantified symptom scores were recorded. Group comparisons for sum of breath hydrogen and total symptom scores were evaluated with the Mann-Whitney U test. Spearman's correlation coefficient and chi(2) or Fisher's exact test were used as appropriate. Malabsorption occurred in 29 patients (32.2%) and low-grade symptoms without malabsorption in 30 (33%). Women complained of symptoms more frequently (p = 0.04) and exhibited more fructose malabsorption (p = 0.0527). Breath hydrogen correlated with symptoms (r = 0.516, p = 0.0037). Adaptation with increasing pretest fructose intake was absent. We conclude that gender may influence fructose malabsorption and there is no adaptation to regular consumption. More... »

PAGES

2999-3004

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-006-9652-9

DOI

http://dx.doi.org/10.1007/s10620-006-9652-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000561234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17357833


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