Effect of Calcium Polycarbophil on Bowel Function After Restorative Proctocolectomy for Ulcerative Colitis: A Randomized Controlled Trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03-30

AUTHORS

Chikashi Shibata, Yuji Funayama, Kouhei Fukushima, Ken-Ichi Takahashi, Hitoshi Ogawa, Sho Haneda, Kazuhiro Watanabe, Katsuyoshi Kudoh, Atsushi Kohyama, Kei-Ichi Hayashi, Iwao Sasaki

ABSTRACT

The aim of the present study was to determine if calcium polycarbophil ameliorates diarrhea after ileal J-pouch anal anastomosis for ulcerative colitis. Twenty-one randomized patients were given either bifidobacterium (3 g/day) plus calcium polycarbophil (3 g/day), in the polycarbophil group (11 patients), or bifidobacterium (3 g/day), in the control group (10 patients), p.o. for 6 months. Anal manometry was performed and bowel function (stool frequency, stool consistency, and nighttime soiling) was assessed via a questionnaire before and 1, 3, and 6 months after drug administration. Eight patients were deemed eligible in each group; five patients were excluded from the study, including two patients whose stool consistency was too firm and who experienced difficulty in defecating attributed to polycarbophil. Anal manometry and stool consistency did not change with time and did not differ between the polycarbophil and the control groups. Stool frequency decreased with time in both groups and did not differ between the groups. Nighttime soiling improved with time in the polycarbophil group but did not change in the control subjects. These results suggest that polycarbophil might be able to improve nighttime soiling without obviously affecting stool frequency and consistency after ileal J-pouch anal anastomosis for ulcerative colitis. More... »

PAGES

1423-1426

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10620-006-9270-6

DOI

http://dx.doi.org/10.1007/s10620-006-9270-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029557702

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17394081


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