Investigation of the neuroprotective and neuritogenic effects of halotolerant Penicillium flavigenum-derived sorbicillin-like compounds on PC-12 Adh cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-10-04

AUTHORS

Elif Kaya Tilki, Selin Engür Öztürk, Mustafa Güçlü Özarda, Zerrin Cantürk, Miriş Dikmen

ABSTRACT

Parkinson's disease (PD) is an adult-onset neurodegenerative condition caused by oxidative stress and mitochondrial malfunction. In this study, the neuroprotective and neuritogenic activity of water fraction (Sw-fr) containing sorbicillin-like active metabolites of halotolerant P. flavigenum isolated from Salt Lake in Konya, Turkey were investigated on a 6-hydroxydopamine (6-OHDA)-induced PD in vitro PC-12 Adh cell model. Firstly, Sw-fr containing sorbicillin-like active metabolites were extracted from P. flavigenum and was compared with a sorbicillin standard by liquid chromatography-mass spectrometry (LC–MS). Then, the effects of non-cytotoxic concentrations of Sw-fr on the 6-OHDA-induced PD cell model were investigated via real-time cell proliferation analysis using the RTCA DP instrument. The effects of these concentrations on mitochondrial membrane integrity, caspase-3 were investigated by flow cytometry. Neurite outgrowth analysis and immunofluorescence staining were used to explore the neuritogenic effects of neuroprotective doses. By improving PC-12 Adh cell viability, decreasing reactive oxygen species production, and reducing apoptotic cell death, 1 and 10 μg/mL Sw-fr and sorbicillin standard proved neuroprotective against 6-OHDA-induced neurotoxicity. Furthermore, 1 and 10 µg/mL Sw-fr significantly induced neurite outgrowth. As a result, sorbicillin-like active metabolites containing Sw-fr were found to have neuroprotective and neuritogenic effects. Sorbicillin-like metabolites obtained from fungi may be novel natural medicines for neurodegenerative diseases. More... »

PAGES

801-813

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10616-021-00498-9

DOI

http://dx.doi.org/10.1007/s10616-021-00498-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141601071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34776630


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203 grid-institutes:grid.41206.31 schema:alternateName Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26210, Eskisehir, Turkey
204 Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26210, Eskisehir, Turkey
205 schema:name Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26210, Eskisehir, Turkey
206 Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26210, Eskisehir, Turkey
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