Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-09-30

AUTHORS

Yong Fang, Cailing E, Shixing Wu, Zudong Meng, Guifang Qin, Rongying Wang

ABSTRACT

Psoriasis is a skin disorder that is classed as an autoimmune disease. It is characterized by excessive proliferation, abnormal migration and differentiation of keratinocytes, as well as inflammatory cell infiltration. Circular RNAs (circRNAs/circ) have been reported to play an important role in several aspects of psoriasis. Thus in the present study, the role of circ-insulin-like growth factor 1 receptor (circ-IGF1R) in the development of psoriasis was assessed, and the involvement of microRNA (miR)-194-5p was also investigated as its expression was downregulated in psoriasis. StarBase analysis and dual luciferase reporter assays confirmed the interaction between circ-IGF1R with miR-194-5p. The increased expression of circ-IGF1R and decreased expression of miR-194-5p were further confirmed by reverse transcription-quantitative polymerase chain reaction in interleukin (IL-22)-stimulated HaCaT cells. The increased proliferation, migration and invasion, as well as decreased apoptosis, caspase 3 activity and cleaved-caspase 3/caspase 3 ratio were observed in IL-22-stimulated HaCaT cells. Conversely, transfection of circ-IGF1R-small interfering (si)RNA resulted in significantly increased expression of miR-194-5p with or without stimulation of IL-22 in HaCaT cells, and also overcame the effects of the miR-194-5p inhibitor. Additionally, transfection of circ-IGF1R-siRNA inhibited cell proliferation, migration and invasion, which were reversed by transfection of a miR-194-5p inhibitor. Similarly, circ-IGF1R-siRNA promoted apoptosis, caspase 3 activity and the cleaved-caspase 3/caspase 3 ratio, which were reversed by miR-194-5p inhibitor. These results showed that circ-IGF1R could affect the proliferation, apoptosis, migration and invasion of IL-22-stimulated HaCaT cells by regulating the expression of miR-194-5p. Based on TargetScan prediction and dual luciferase reporter assays, it was shown that cyclin-dependent kinase (CDK)1 was targeted by miR-194-5p. Additionally, the expression of CDK1 was upregulated following stimulation with IL-22 in HaCaT cells at the mRNA and protein levels. Transfection of miR-194-5p mimic or miR-194-5p inhibitor negatively regulated CDK1 expression in the IL-22 induced HaCaT cells. In conclusion, circ-IGF1R-siRNA could inhibit the cell proliferation, migration and invasion, and induce apoptosis by regulating the miR-194-5p/CDK1 axis. circ-IGF1R may thus serve as a potential treatment target for psoriasis. More... »

PAGES

775-785

References to SciGraph publications

  • 2007-07-31. Immunopathogenesis of Psoriasis in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2020-11-19. miR-617 Promotes the Growth of IL-22-Stimulated Keratinocytes Through Regulating FOXO4 Expression in BIOCHEMICAL GENETICS
  • 1983-05. Immunocompetent cells in psoriasis in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 2016-02. microRNAs in Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2016-03-30. The Inflammatory Response in Psoriasis: a Comprehensive Review in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2020-05-24. The new function of circRNA: translation in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2019-08-08. The biogenesis, biology and characterization of circular RNAs in NATURE REVIEWS GENETICS
  • 2019-01. Characterisation of the circular RNA landscape in mesenchymal stem cells from psoriatic skin lesions in EUROPEAN JOURNAL OF DERMATOLOGY
  • 2019-12-01. Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the pathogenesis of atopic dermatitis in children in EUROPEAN JOURNAL OF DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10616-021-00496-x

    DOI

    http://dx.doi.org/10.1007/s10616-021-00496-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141519445

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34776628


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China", 
              "id": "http://www.grid.ac/institutes/grid.443573.2", 
              "name": [
                "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fang", 
            "givenName": "Yong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China", 
              "id": "http://www.grid.ac/institutes/grid.443573.2", 
              "name": [
                "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "E", 
            "givenName": "Cailing", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China", 
              "id": "http://www.grid.ac/institutes/grid.443573.2", 
              "name": [
                "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Shixing", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China", 
              "id": "http://www.grid.ac/institutes/grid.443573.2", 
              "name": [
                "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meng", 
            "givenName": "Zudong", 
            "id": "sg:person.011765673264.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011765673264.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China", 
              "id": "http://www.grid.ac/institutes/grid.443573.2", 
              "name": [
                "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qin", 
            "givenName": "Guifang", 
            "id": "sg:person.010372732264.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010372732264.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China", 
              "id": "http://www.grid.ac/institutes/grid.443573.2", 
              "name": [
                "Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Rongying", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00510050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050465657", 
              "https://doi.org/10.1007/bf00510050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2015.409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079215712", 
              "https://doi.org/10.1038/jid.2015.409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12016-016-8535-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026939627", 
              "https://doi.org/10.1007/s12016-016-8535-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12094-020-02371-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1127867578", 
              "https://doi.org/10.1007/s12094-020-02371-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41576-019-0158-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120212416", 
              "https://doi.org/10.1038/s41576-019-0158-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1684/ejd.2019.3676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123830139", 
              "https://doi.org/10.1684/ejd.2019.3676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10528-020-09997-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1132748117", 
              "https://doi.org/10.1007/s10528-020-09997-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12016-007-0039-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010291692", 
              "https://doi.org/10.1007/s12016-007-0039-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1684/ejd.2018.3483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112513129", 
              "https://doi.org/10.1684/ejd.2018.3483"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-09-30", 
        "datePublishedReg": "2021-09-30", 
        "description": "Psoriasis is a skin disorder that is classed as an autoimmune disease. It is characterized by excessive proliferation, abnormal migration and differentiation of keratinocytes, as well as inflammatory cell infiltration. Circular RNAs (circRNAs/circ) have been reported to play an important role in several aspects of psoriasis. Thus in the present study, the role of circ-insulin-like growth factor 1 receptor (circ-IGF1R) in the development of psoriasis was assessed, and the involvement of microRNA (miR)-194-5p was also investigated as its expression was downregulated in psoriasis. StarBase analysis and dual luciferase reporter assays confirmed the interaction between circ-IGF1R with miR-194-5p. The increased expression of circ-IGF1R and decreased expression of miR-194-5p were further confirmed by reverse transcription-quantitative polymerase chain reaction in interleukin (IL-22)-stimulated HaCaT cells. The increased proliferation, migration and invasion, as well as decreased apoptosis, caspase 3 activity and cleaved-caspase 3/caspase 3 ratio were observed in IL-22-stimulated HaCaT cells. Conversely, transfection of circ-IGF1R-small interfering (si)RNA resulted in significantly increased expression of miR-194-5p with or without stimulation of IL-22 in HaCaT cells, and also overcame the effects of the miR-194-5p inhibitor. Additionally, transfection of circ-IGF1R-siRNA inhibited cell proliferation, migration and invasion, which were reversed by transfection of a miR-194-5p inhibitor. Similarly, circ-IGF1R-siRNA promoted apoptosis, caspase 3 activity and the cleaved-caspase 3/caspase 3 ratio, which were reversed by miR-194-5p inhibitor. These results showed that circ-IGF1R could affect the proliferation, apoptosis, migration and invasion of IL-22-stimulated HaCaT cells by regulating the expression of miR-194-5p. Based on TargetScan prediction and dual luciferase reporter assays, it was shown that cyclin-dependent kinase (CDK)1 was targeted by miR-194-5p. Additionally, the expression of CDK1 was upregulated following stimulation with IL-22 in HaCaT cells at the mRNA and protein levels. Transfection of miR-194-5p mimic or miR-194-5p inhibitor negatively regulated CDK1 expression in the IL-22 induced HaCaT cells. In conclusion, circ-IGF1R-siRNA could inhibit the cell proliferation, migration and invasion, and induce apoptosis by regulating the miR-194-5p/CDK1 axis. circ-IGF1R may thus serve as a potential treatment target for psoriasis.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10616-021-00496-x", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1086307", 
            "issn": [
              "1381-5741", 
              "1573-0603"
            ], 
            "name": "Cytotechnology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "73"
          }
        ], 
        "keywords": [
          "miR-194-5p inhibitor", 
          "IL-22-stimulated HaCaT cells", 
          "IL-22", 
          "caspase-3 ratio", 
          "HaCaT cells", 
          "aspects of psoriasis", 
          "reverse transcription-quantitative polymerase chain reaction", 
          "transcription-quantitative polymerase chain reaction", 
          "miR-194-5p mimic", 
          "inflammatory cell infiltration", 
          "development of psoriasis", 
          "cell proliferation", 
          "growth factor 1 receptor", 
          "dual-luciferase reporter assay", 
          "potential treatment target", 
          "dual-luciferase reporter", 
          "factor 1 receptor", 
          "luciferase reporter assays", 
          "autoimmune diseases", 
          "expression of CDK1", 
          "differentiation of keratinocytes", 
          "cell infiltration", 
          "polymerase chain reaction", 
          "psoriasis", 
          "skin disorders", 
          "treatment targets", 
          "involvement of microRNAs", 
          "increased expression", 
          "excessive proliferation", 
          "abnormal migration", 
          "CDK1 expression", 
          "luciferase reporter", 
          "protein levels", 
          "TargetScan prediction", 
          "chain reaction", 
          "reporter assays", 
          "proliferation", 
          "apoptosis", 
          "invasion", 
          "inhibitors", 
          "siRNA", 
          "present study", 
          "stimulation", 
          "cyclin-dependent kinases", 
          "cells", 
          "transfection", 
          "expression", 
          "circular RNAs", 
          "interleukin", 
          "disease", 
          "important role", 
          "receptors", 
          "disorders", 
          "role", 
          "infiltration", 
          "keratinocytes", 
          "activity", 
          "migration", 
          "involvement", 
          "IL", 
          "interfering", 
          "conclusion", 
          "mRNA", 
          "assays", 
          "significant role", 
          "microRNAs", 
          "differentiation", 
          "kinase", 
          "RNA", 
          "mimics", 
          "reporter", 
          "target", 
          "levels", 
          "CDK1", 
          "study", 
          "axis", 
          "ratio", 
          "regulation", 
          "effect", 
          "development", 
          "analysis", 
          "results", 
          "aspects", 
          "reaction", 
          "interaction", 
          "prediction", 
          "circ-insulin-like growth factor 1 receptor", 
          "StarBase analysis", 
          "circ-IGF1R", 
          "circ-IGF1R-small interfering", 
          "miR-194-5p/CDK1 axis", 
          "CDK1 axis"
        ], 
        "name": "Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis", 
        "pagination": "775-785", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1141519445"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10616-021-00496-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34776628"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10616-021-00496-x", 
          "https://app.dimensions.ai/details/publication/pub.1141519445"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_900.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10616-021-00496-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10616-021-00496-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10616-021-00496-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10616-021-00496-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10616-021-00496-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    221 TRIPLES      22 PREDICATES      127 URIs      110 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10616-021-00496-x schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author Ne1889823f2de48a8b6fecff4aeaad241
    4 schema:citation sg:pub.10.1007/bf00510050
    5 sg:pub.10.1007/s10528-020-09997-4
    6 sg:pub.10.1007/s12016-007-0039-2
    7 sg:pub.10.1007/s12016-016-8535-x
    8 sg:pub.10.1007/s12094-020-02371-1
    9 sg:pub.10.1038/jid.2015.409
    10 sg:pub.10.1038/s41576-019-0158-7
    11 sg:pub.10.1684/ejd.2018.3483
    12 sg:pub.10.1684/ejd.2019.3676
    13 schema:datePublished 2021-09-30
    14 schema:datePublishedReg 2021-09-30
    15 schema:description Psoriasis is a skin disorder that is classed as an autoimmune disease. It is characterized by excessive proliferation, abnormal migration and differentiation of keratinocytes, as well as inflammatory cell infiltration. Circular RNAs (circRNAs/circ) have been reported to play an important role in several aspects of psoriasis. Thus in the present study, the role of circ-insulin-like growth factor 1 receptor (circ-IGF1R) in the development of psoriasis was assessed, and the involvement of microRNA (miR)-194-5p was also investigated as its expression was downregulated in psoriasis. StarBase analysis and dual luciferase reporter assays confirmed the interaction between circ-IGF1R with miR-194-5p. The increased expression of circ-IGF1R and decreased expression of miR-194-5p were further confirmed by reverse transcription-quantitative polymerase chain reaction in interleukin (IL-22)-stimulated HaCaT cells. The increased proliferation, migration and invasion, as well as decreased apoptosis, caspase 3 activity and cleaved-caspase 3/caspase 3 ratio were observed in IL-22-stimulated HaCaT cells. Conversely, transfection of circ-IGF1R-small interfering (si)RNA resulted in significantly increased expression of miR-194-5p with or without stimulation of IL-22 in HaCaT cells, and also overcame the effects of the miR-194-5p inhibitor. Additionally, transfection of circ-IGF1R-siRNA inhibited cell proliferation, migration and invasion, which were reversed by transfection of a miR-194-5p inhibitor. Similarly, circ-IGF1R-siRNA promoted apoptosis, caspase 3 activity and the cleaved-caspase 3/caspase 3 ratio, which were reversed by miR-194-5p inhibitor. These results showed that circ-IGF1R could affect the proliferation, apoptosis, migration and invasion of IL-22-stimulated HaCaT cells by regulating the expression of miR-194-5p. Based on TargetScan prediction and dual luciferase reporter assays, it was shown that cyclin-dependent kinase (CDK)1 was targeted by miR-194-5p. Additionally, the expression of CDK1 was upregulated following stimulation with IL-22 in HaCaT cells at the mRNA and protein levels. Transfection of miR-194-5p mimic or miR-194-5p inhibitor negatively regulated CDK1 expression in the IL-22 induced HaCaT cells. In conclusion, circ-IGF1R-siRNA could inhibit the cell proliferation, migration and invasion, and induce apoptosis by regulating the miR-194-5p/CDK1 axis. circ-IGF1R may thus serve as a potential treatment target for psoriasis.
    16 schema:genre article
    17 schema:inLanguage en
    18 schema:isAccessibleForFree false
    19 schema:isPartOf N2b7ac6892be4444d8eee5aa788ec9635
    20 Ne1b4b0d9859a4248a53dbf523002e341
    21 sg:journal.1086307
    22 schema:keywords CDK1
    23 CDK1 axis
    24 CDK1 expression
    25 HaCaT cells
    26 IL
    27 IL-22
    28 IL-22-stimulated HaCaT cells
    29 RNA
    30 StarBase analysis
    31 TargetScan prediction
    32 abnormal migration
    33 activity
    34 analysis
    35 apoptosis
    36 aspects
    37 aspects of psoriasis
    38 assays
    39 autoimmune diseases
    40 axis
    41 caspase-3 ratio
    42 cell infiltration
    43 cell proliferation
    44 cells
    45 chain reaction
    46 circ-IGF1R
    47 circ-IGF1R-small interfering
    48 circ-insulin-like growth factor 1 receptor
    49 circular RNAs
    50 conclusion
    51 cyclin-dependent kinases
    52 development
    53 development of psoriasis
    54 differentiation
    55 differentiation of keratinocytes
    56 disease
    57 disorders
    58 dual-luciferase reporter
    59 dual-luciferase reporter assay
    60 effect
    61 excessive proliferation
    62 expression
    63 expression of CDK1
    64 factor 1 receptor
    65 growth factor 1 receptor
    66 important role
    67 increased expression
    68 infiltration
    69 inflammatory cell infiltration
    70 inhibitors
    71 interaction
    72 interfering
    73 interleukin
    74 invasion
    75 involvement
    76 involvement of microRNAs
    77 keratinocytes
    78 kinase
    79 levels
    80 luciferase reporter
    81 luciferase reporter assays
    82 mRNA
    83 miR-194-5p inhibitor
    84 miR-194-5p mimic
    85 miR-194-5p/CDK1 axis
    86 microRNAs
    87 migration
    88 mimics
    89 polymerase chain reaction
    90 potential treatment target
    91 prediction
    92 present study
    93 proliferation
    94 protein levels
    95 psoriasis
    96 ratio
    97 reaction
    98 receptors
    99 regulation
    100 reporter
    101 reporter assays
    102 results
    103 reverse transcription-quantitative polymerase chain reaction
    104 role
    105 siRNA
    106 significant role
    107 skin disorders
    108 stimulation
    109 study
    110 target
    111 transcription-quantitative polymerase chain reaction
    112 transfection
    113 treatment targets
    114 schema:name Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis
    115 schema:pagination 775-785
    116 schema:productId N2e78ee02413740b1b403e280bf77a2f6
    117 N51b5d214a1e8459199140fad96ab2b56
    118 N89979386487c4656b8fb7cb43f3bcd93
    119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141519445
    120 https://doi.org/10.1007/s10616-021-00496-x
    121 schema:sdDatePublished 2022-01-01T18:58
    122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    123 schema:sdPublisher Nb7ccfa3022fb4ca8957c04bee362c94b
    124 schema:url https://doi.org/10.1007/s10616-021-00496-x
    125 sgo:license sg:explorer/license/
    126 sgo:sdDataset articles
    127 rdf:type schema:ScholarlyArticle
    128 N0b540b20768a4a66a5d9b4c6786baa84 schema:affiliation grid-institutes:grid.443573.2
    129 schema:familyName Wu
    130 schema:givenName Shixing
    131 rdf:type schema:Person
    132 N25d7510117b64a42a1974c5ae44300fa rdf:first Na7a084c050474a67bfa7de9d52309cfc
    133 rdf:rest rdf:nil
    134 N2b7ac6892be4444d8eee5aa788ec9635 schema:issueNumber 6
    135 rdf:type schema:PublicationIssue
    136 N2e78ee02413740b1b403e280bf77a2f6 schema:name doi
    137 schema:value 10.1007/s10616-021-00496-x
    138 rdf:type schema:PropertyValue
    139 N3fda34ffc7c64320847cfd9c85a125bb rdf:first Nd2085a41ca9f4f97a8dd1d7474100286
    140 rdf:rest N790a548d7ee948eabb55b0adcd3ea6fd
    141 N51b5d214a1e8459199140fad96ab2b56 schema:name pubmed_id
    142 schema:value 34776628
    143 rdf:type schema:PropertyValue
    144 N6bd35859318c4320918cadc836e65491 rdf:first sg:person.011765673264.06
    145 rdf:rest Nb4ea1b3b1bc746f3a98b6706a6f89f57
    146 N790a548d7ee948eabb55b0adcd3ea6fd rdf:first N0b540b20768a4a66a5d9b4c6786baa84
    147 rdf:rest N6bd35859318c4320918cadc836e65491
    148 N89979386487c4656b8fb7cb43f3bcd93 schema:name dimensions_id
    149 schema:value pub.1141519445
    150 rdf:type schema:PropertyValue
    151 Na7a084c050474a67bfa7de9d52309cfc schema:affiliation grid-institutes:grid.443573.2
    152 schema:familyName Wang
    153 schema:givenName Rongying
    154 rdf:type schema:Person
    155 Nb4ea1b3b1bc746f3a98b6706a6f89f57 rdf:first sg:person.010372732264.02
    156 rdf:rest N25d7510117b64a42a1974c5ae44300fa
    157 Nb7ccfa3022fb4ca8957c04bee362c94b schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 Nd2085a41ca9f4f97a8dd1d7474100286 schema:affiliation grid-institutes:grid.443573.2
    160 schema:familyName E
    161 schema:givenName Cailing
    162 rdf:type schema:Person
    163 Ne1889823f2de48a8b6fecff4aeaad241 rdf:first Ne84e2b6f253648b2851747531cb4909a
    164 rdf:rest N3fda34ffc7c64320847cfd9c85a125bb
    165 Ne1b4b0d9859a4248a53dbf523002e341 schema:volumeNumber 73
    166 rdf:type schema:PublicationVolume
    167 Ne84e2b6f253648b2851747531cb4909a schema:affiliation grid-institutes:grid.443573.2
    168 schema:familyName Fang
    169 schema:givenName Yong
    170 rdf:type schema:Person
    171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Medical and Health Sciences
    173 rdf:type schema:DefinedTerm
    174 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    175 schema:name Clinical Sciences
    176 rdf:type schema:DefinedTerm
    177 sg:journal.1086307 schema:issn 1381-5741
    178 1573-0603
    179 schema:name Cytotechnology
    180 schema:publisher Springer Nature
    181 rdf:type schema:Periodical
    182 sg:person.010372732264.02 schema:affiliation grid-institutes:grid.443573.2
    183 schema:familyName Qin
    184 schema:givenName Guifang
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010372732264.02
    186 rdf:type schema:Person
    187 sg:person.011765673264.06 schema:affiliation grid-institutes:grid.443573.2
    188 schema:familyName Meng
    189 schema:givenName Zudong
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011765673264.06
    191 rdf:type schema:Person
    192 sg:pub.10.1007/bf00510050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050465657
    193 https://doi.org/10.1007/bf00510050
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/s10528-020-09997-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132748117
    196 https://doi.org/10.1007/s10528-020-09997-4
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/s12016-007-0039-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010291692
    199 https://doi.org/10.1007/s12016-007-0039-2
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s12016-016-8535-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026939627
    202 https://doi.org/10.1007/s12016-016-8535-x
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s12094-020-02371-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127867578
    205 https://doi.org/10.1007/s12094-020-02371-1
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/jid.2015.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079215712
    208 https://doi.org/10.1038/jid.2015.409
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/s41576-019-0158-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120212416
    211 https://doi.org/10.1038/s41576-019-0158-7
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1684/ejd.2018.3483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112513129
    214 https://doi.org/10.1684/ejd.2018.3483
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1684/ejd.2019.3676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123830139
    217 https://doi.org/10.1684/ejd.2019.3676
    218 rdf:type schema:CreativeWork
    219 grid-institutes:grid.443573.2 schema:alternateName Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China
    220 schema:name Department of Dermatology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, 442100, Shiyan City, Hubei Province, China
    221 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...