Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

E. O. Terent′eva, A. Sh. Saidov, Z. S. Khashimova, N. E. Tseomashko, S. A. Sasmakov, D. M. Abdurakhmanov, V. I. Vinogradova, Sh. S. Azimova

ABSTRACT

Two bis(tetrahydroisoquinoline) derivatives of undecane were synthesized from brassylic acid and 3,4-dimethoxy-(or methylenedioxy-)phenylethylamine. It was shown that 4a and 4b were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans. The antifungal activity of 4a exceeded that of the reference drug nystatin. More... »

PAGES

328-332

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10600-017-1981-8

DOI

http://dx.doi.org/10.1007/s10600-017-1981-8

DIMENSIONS

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