Anti-Osteoporotic Components of Rubus chingii View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Wen-Qing Liang, Guo-Jian Xu, Dong Weng, Bo Gao, Xing-Feng Zheng, Yu Qian

ABSTRACT

Phytochemical studies of Rubus chingii Hu afforded a new chromone (1), identified as rubusin B, along with six known compounds, kaempferol (2), rubusin A (3), quercetin (4), β-sitosterol (5), oleanolic acid (6), and liballinol (7). All the chemical structures were identified using 1D and 2D NMR data and MS data. It was found that compounds 1–4 displayed anti-osteoporotic activities to different degrees, quercetin and kaempferol significantly increased alkaline phosphatase (ALP) activity and can stimulate osteoblastic activity, and rubusin A and B strongly inhibit osteoclastic cell and bone resorption even at a concentration of 0.01 ppm. More... »

PAGES

47-49

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10600-015-1200-4

DOI

http://dx.doi.org/10.1007/s10600-015-1200-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003730322


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