Conformational analysis of yvae peptide derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-11

AUTHORS

V. V. Pak, D. Y. Kwon, L. M. Yun, A. Yili, H. A. Aisa, Kh. M. Shakhidoyatov

ABSTRACT

Active conformations of YVAE peptide derivatives that were competitive inhibitors of 3-hydroxy3-methylglutaryl–coenzyme A reductase (HMG–CoA reductase) were determined. A type I β-turn in N-terminuses of the studied peptides was shown to be present. The steric positioning of active conformations of peptides and statins revealed the structure–function similarity between these compounds. The results agreed with the observed increase of inhibitor activity in the studied series of peptides. More... »

PAGES

848-852

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10600-012-0399-6

DOI

http://dx.doi.org/10.1007/s10600-012-0399-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045377688


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