Chemical transformations of mackinazolinone and its derivatives View Full Text


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Article Info

DATE

2012-09

AUTHORS

A. O. Nasrullaev, Zh. E. Turdibaev, B. Zh. Elmuradov, A. Yili, H. A. Aisa, Kh. M. Shakhidoyatov

ABSTRACT

The thioanalog of mackinazolinone (2,3,4,10-tetrahydro-1 H-pyrido[2,1-b]quinazolin-10-one) was synthesized for the first time by reacting it with P2S5. The thioanalog was reacted with aromatic aldehydes and Vilsmeier- Haack reagent (DMF + POCl3) to produce 4-arylidene- and -hydroxymethylidenemackinazolinthiones, respectively. The reactions of 4-hydroxymethylidenemackinazolinone with isomeric aminophenols and aminobenzoic acids and of hydroxymethylidenemackinazolinthione with thionylchloride were studied. Subsequent reaction of the obtained 4-chloromethylidene derivative with sodium hydroselenide was synthesized a new Se-containing derivative of mackinazolinone. It was shown that 4-formylmackinazolinthione existed in the enol form whereas 4-formylmackinazolinone existed as the enaminoaldehyde tautomer. More... »

PAGES

638-642

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10600-012-0331-0

DOI

http://dx.doi.org/10.1007/s10600-012-0331-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015551054


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