Synthesis and structure of 6-bromo-4-hydroxy-2,3-tetramethylene-3,4-dihydroquinazoline and its mixed crystal with 4-hydroxy-2,3-tetramethylene-3,4-dihydroquinazoline View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-11

AUTHORS

N. I. Mukarramov, R. Ya. Okmanov, F. R. Utaeva, K. K. Turgunov, B. Tashkhodzhaev, Z. M. Khakimova, Kh. M. Shakhidoyatov

ABSTRACT

Bromination of the alkaloid 2,3-tetramethylene-3,4-dihydroquinazoline by N-bromosuccinimide was studied. It was shown that either 4-hydroxy-2,3-tetramethylene-3,4-dihydroquinazoline or 6-bromo-4-hydroxy-2,3tetramethylene-3,4-dihydroquinazoline was formed depending on the ratio of reagents. Oxidation of 2,3tetramethylene-3,4-dihydroquinazoline by KMnO4 produced 4-hydroxy-2,3-tetramethylene-3,4dihydroquinazoline. The crystal structures of 6-bromo-4-hydroxy-2,3-tetramethylene-3,4-dihydroquinazoline and its mixed crystal with 4-hydroxy-2,3-tetramethylene-3,4-dihydroquinazoline were studied by x-ray structure analysis. The enantiomeric molecules in all crystal structures formed associates owing to two opposing OH...N1 H-bonds. More... »

PAGES

854-858

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10600-010-9491-y

DOI

http://dx.doi.org/10.1007/s10600-010-9491-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042069597


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