Synthesis, hydrolysis, and reductive cyclization of ethyl 5-chloro-4-(4-nitropyrrolidin-3-yl)pyrrole-3-carboxylates View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-01

AUTHORS

Alina N. Grozav, Sergiy V. Kemskiy, Mariana Z. Fedoriv, Vitaliy А. Chornous, Alina А. Palamar, Viktor I. Dorokhov, Eduard B. Rusanov, Mikhailo V. Vovk

ABSTRACT

Ethyl 5-chloro-4-(2-nitroethenyl)pyrrole-3-carboxylates, obtained by the condensation of ethyl 5-chloro-4-formylpyrrole-3-carboxylates with nitromethane, react with N-methylazomethine ylide with the formation of ethyl 5-chloro-4-(4-nitropyrrolidin-3-yl)pyrrole-3-carboxylates. Their hydrolysis yielded the corresponding acids, while reductive cyclization led to the synthesis of hexahydrodipyrrolo[3,4-b:3',4'-d]pyridin-5(1Н)-one via intermediate ethyl 4-(4-aminopyrrolidin-3-yl)-5-chloropyrrole-3-carboxylate derivatives.

PAGES

24-31

References to SciGraph publications

  • 2019-05-27. Synthesis of thieno[2,3-b]pyrrole-2(4)-carboxylic and 2,4-dicarboxylic acids in CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s10593-022-03052-3

    DOI

    http://dx.doi.org/10.1007/s10593-022-03052-3

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