Synthesis of methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates and their conversion to tert-butyl 4,5,6,7-tetrahydropyrazolo-[4,3-b]pyridine-6-carboxylates View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11

AUTHORS

Georgiy G. Yakovenko, Lesya N. Saliyeva, Eduard B. Rusanov, Il’ya S. Donchak, Mykhailo V. Vovk

ABSTRACT

N-Boc-4-aminopyrazole-5-carbaldehydes react with methyl 3,3-dimethoxypropanoate or β-keto esters in acetic acid under reflux to form methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates, which were converted to the corresponding tert-butyl carboxylates via intermediate carboxylic acids. Their subsequent hydrogenation on a 10% Pd/C catalyst at 100°C and 25 atm afforded tert-butyl 4,5,6,7-tetrahydropyrazolo[4,3-b]pyridine-6-carboxylates.

PAGES

1137-1145

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10593-021-03032-z

DOI

http://dx.doi.org/10.1007/s10593-021-03032-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1144440255


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