Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-11

AUTHORS

Evgeny А. Kvetkin, Dmitry V. Osipov, Pavel E. Krasnikov, Vitaly А. Osyanin, Yuri N. Klimochkin

ABSTRACT

The three-component condensation of pyridinium acylmethylides generated in situ with aromatic aldehydes and 4-hydroxy-6-methylpyridones gave a series of 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones. The reaction proceeds diastereoselectively with the formation of trans-isomers and represents a cascade process involving the Knoevenagel condensation, the carbo-Michael reaction, and intramolecular nucleophilic substitution.

PAGES

1423-1428

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10593-020-02832-z

DOI

http://dx.doi.org/10.1007/s10593-020-02832-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1133108971


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