Synthesis of thieno[2,3-b]pyrrole-2(4)-carboxylic and 2,4-dicarboxylic acids View Full Text


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Article Info

DATE

2019-05-27

AUTHORS

Alina N. Grozav, Mariana Z. Fedoriv, Vitaliy A. Chornous, Alina A. Palamar, Mykhailo K. Bratenko, Mykhailo V. Vovk

ABSTRACT

1-Substituted 5-chloro-4-formylpyrrole-3-carboxylates reacted with thioglycolic acid or ethyl thioglycolate in EtOH containing EtONa at room temperature, forming 4-(ethoxycarbonyl)thieno[2,3-b]pyrrole-2-carboxylic acids or thieno[2,3-b]pyrrole-2,4-dicarboxylates. Cyclocondensation with thioglycolic acid upon refluxing in K2CO3–DMF system was accompanied by decarboxylation and led to the formation of thieno[2,3-b]pyrrole-4-carboxylates. Hydrolysis of the obtained carboxylates with LiOH provided thieno[2,3-b]pyrrole-2(4)-carboxylic and 2,4-dicarboxylic acids. More... »

PAGES

435-441

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10593-019-02476-8

DOI

http://dx.doi.org/10.1007/s10593-019-02476-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1115901150


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