8-(Methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]- pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)- 2,3,4,7-dihydro-6H-pyrimido[1,6-a]pyrimidin-6-ones: synthesis and antiviral activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05-29

AUTHORS

Roman N. Solomyannyi, Olga V. Shablykina, Viktoriia S. Moskvina, Volodymir P. Khilya, Eduard B. Rusanov, Vladimir S. Brovarets

ABSTRACT

A convenient method for the synthesis of novel sulfonic cytosine derivatives, 8-(methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]-pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-ones, has been developed based on the reaction of 3-amino-2-(methyl(phenyl)sulfonyl)acrylonitriles with 2-chloroethyl isocyanate and 3-chloropropyl isocyanate. The resulting heteryl sulfones possess antiviral activity.

PAGES

401-407

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10593-019-02472-y

DOI

http://dx.doi.org/10.1007/s10593-019-02472-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1115971677


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