Synthesis and structure of dihydroberberine nitroaryl derivatives – potential ligands for G-quadruplexes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Oleg N. Burov, Sergey V. Kurbatov, Mikhail E. Kletskii, Alexander D. Zagrebaev, Igor E. Mikhailov

ABSTRACT

A method was developed for the synthesis of dihydroberberine nitroaryl derivatives on the basis of dihydroberberine reactions with aromatic electrophiles (picryl chloride, 4-chloro-7-nitrobenzofurazan, 4-chloro-5,7-dinitrobenzofurazan, and 7-chloro-4,6-dinitrobenzofuroxan). The obtained 13-substituted dihydroberberine derivatives represent structures with significant intramolecular charge transfer and, according to the results of molecular docking analysis, can effectively bind with G-quadruplexes of telomeric DNA fragments. More... »

PAGES

335-340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10593-017-2055-3

DOI

http://dx.doi.org/10.1007/s10593-017-2055-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085200787


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