Alkylation of 1,3-benzothiazin-4-one 2-oxo-, 2-arylimino-, and 2-thioxo derivatives View Full Text


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Article Info

DATE

2015-04

AUTHORS

Alexandr S. Shestakov, Mikhail A. Prezent, Evgenia O. Zlatoustovskaya, Khidmet S. Shikhaliev, Alexandr V. Falaleev, Oleg E. Sidorenko

ABSTRACT

Sodium salt of 3Н-benzo[e][1,3]thiazine-2,4-dione is easily alkylated at position 3. In the case of 2-(arylimino)-2,3-dihydrobenzo[e][1,3]-thiazin-4-ones, the alkylation reaction at this position occurs regioselectively. Alkylation of 2-thioxo-2,3-dihydrobenzo[e][1,3]thiazin-4-one under the same conditions produced regioisomers, but S-alkylation at the exocyclic sulfur atom occurred in the presence of triethylamine. The reaction of 1-(4-oxo-3,4-dihydrobenzo[e][1,3]thiazin-2-ylidene)guanidine with methyl anthranilate led to the formation of tetracyclic quinazolinо[2,1-b]quinazolinedione. More... »

PAGES

370-376

References to SciGraph publications

  • 2015-01-06. Alkylation and Aminomethylation of 1,3-Dihydro-2Н-Benzimidazole-2-Thione in CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • 1982-02. Synthesis and pharmacological activity of benzothiazine derivatives in PHARMACEUTICAL CHEMISTRY JOURNAL
  • 1985. Ring-Chain Tautomerism in NONE
  • 1987-02. Synthesis of 2-alkylthioquinazol-4-ones in CHEMISTRY OF HETEROCYCLIC COMPOUNDS
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    http://scigraph.springernature.com/pub.10.1007/s10593-015-1709-2

    DOI

    http://dx.doi.org/10.1007/s10593-015-1709-2

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