One-pot synthesis of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines and their reactions View Full Text


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Article Info

DATE

2012-07

AUTHORS

A. H. Moustafa, A. S. Shestakov, Kh. S. Shikhaliev

ABSTRACT

A series of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines was obtained as a result of a multicomponent Biginelli reaction using 1,3-dicarbonyl compounds, aromatic aldehydes, and cyanamide. Alkylation of the obtained compounds with benzyl chloride takes place at the two nitrogen atoms of the tetrahydropyrimidine ring, while oxidation with manganese dioxide leads to the corresponding 1-(pyrimidin-2-yl)carbamides or pyrimidine-2-amines, depending on the conditions. More... »

PAGES

613-619

References to SciGraph publications

  • 2005-07. N-Cyanoimines in the Synthesis of Heterocyclic Compounds. (Review) in CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10593-012-1034-y

    DOI

    http://dx.doi.org/10.1007/s10593-012-1034-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004847000


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