Synthesis and tuberculostatic activity of new benzimidazole derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

H. Foks, D. Pancechowska-Ksepko, W. Kuzmierkiewicz, Z. Zwolska, E. Augustynowicz-Kopec, M. Janowiec

ABSTRACT

The reactions of o-phenylenediamine and 3,4-diaminotoluene with such acids as 3-cyclohexylpropionic, 4-phenylbutyric, 4-cyclohexylbutyric, 3,3-diphenylpropionic, and 3,4-dimethoxyphenylacetic resulted in the formation of the corresponding 2-substituted benzimidazoles. These compounds were transformed into methane-and benzenesulfonamide derivatives. The benzimidazole derivatives obtained were tested in vitro for their tuberculostatic activity. Compounds with good activity (MIC 6.2-25 µg/ml) have been found. More... »

PAGES

611-614

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10593-006-0135-x

DOI

http://dx.doi.org/10.1007/s10593-006-0135-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002283073


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