Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03

AUTHORS

Madeleine J. Oudin, Shannon K. Hughes, Nazanin Rohani, Mira N. Moufarrej, Joan G. Jones, John S. Condeelis, Douglas A. Lauffenburger, Frank B. Gertler

ABSTRACT

Several functionally distinct isoforms of the actin regulatory Mena are produced by alternative splicing during tumor progression. Forced expression of the Mena(INV) isoform drives invasion, intravasation and metastasis. However, the abundance and distribution of endogenously expressed Mena(INV) within primary tumors during progression remain unknown, as most studies to date have only assessed relative mRNA levels from dissociated tumor samples. We have developed a Mena(INV) isoform-specific monoclonal antibody and used it to examine Mena(INV) expression patterns in mouse mammary and human breast tumors. Mena(INV) expression increases during tumor progression and to examine the relationship between Mena(INV) expression and markers for epithelial or mesenchymal status, stemness, stromal cell types and hypoxic regions. Further, while Mena(INV) robustly expressed in vascularized areas of the tumor, it is not confined to cells adjacent to blood vessels. Altogether, these data demonstrate the specificity and utility of the anti-Mena(INV)-isoform specific antibody, and provide the first description of endogenous Mena(INV) protein expression in mouse and human tumors. More... »

PAGES

249-261

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10585-015-9775-5

DOI

http://dx.doi.org/10.1007/s10585-015-9775-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037632115

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26680363


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10585-015-9775-5'


 

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