T-DM1, a novel antibody-drug conjugate, is highly effective against uterine and ovarian carcinosarcomas overexpressing HER2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01

AUTHORS

Roberta Nicoletti, Salvatore Lopez, Stefania Bellone, Emiliano Cocco, Carlton L. Schwab, Jonathan D. Black, Floriana Centritto, Liancheng Zhu, Elena Bonazzoli, Natalia Buza, Pei Hui, Delia Mezzanzanica, Silvana Canevari, Peter E. Schwartz, Thomas J. Rutherford, Alessandro D. Santin

ABSTRACT

Ovarian and uterine carcinosarcoma (CS) are characterized by their aggressive clinical behavior and poor prognosis. We evaluated the efficacy of trastuzumab-emtansine (T-DM1), against primary HER2 positive and HER2 negative CS cell lines in vitro and in vivo. Eight primary CS cell lines were evaluated for HER2 amplification and protein expression by fluorescence in situ hybridization, immunohistochemistry, flow cytometry and qRT-PCR. Sensitivity to T-DM1-induced antibody-dependent-cell-mediated-cytotoxicity (ADCC) was evaluated in 4-h-chromium-release-assays. T-DM1 cytostatic and apoptotic activities were evaluated using flow cytometry based proliferation assays. In vivo activity of T-DM1 was also evaluated. HER2 protein overexpression and gene amplification were detected in 25 % (2/8) of the primary CS cell lines. T-DM1 and T were similarly effective in inducing strong ADCC against CS overexpressing HER2 at 3+ levels. In contrast, T-DM1 was dramatically more effective than T in inhibiting cell proliferation (P < 0.0001) and in inducing G2/M phase cell cycle arrest in the HER2 expressing cell lines (shift of G2/M: mean ± SEM from 14.87 ± 1.23 to 66.57 ± 4.56 %, P < 0.0001). Importantly, T-DM1 was highly active at reducing tumor formation in vivo in CS xenografts overexpressing HER2 (P = 0.0001 and P < 0.0001 compared to T and vehicle respectively) with a significantly longer survival when compared to T and vehicle mice (P = 0.008 and P = 0.0001 respectively). T-DM1 may represent a novel treatment option for the subset of HER2 positive CS patients with disease refractory to chemotherapy. More... »

PAGES

29-38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10585-014-9688-8

DOI

http://dx.doi.org/10.1007/s10585-014-9688-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026784798

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25398397


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody-Dependent Cell Cytotoxicity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoconjugates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "M Phase Cell Cycle Checkpoints", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maytansine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trastuzumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA", 
            "Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicoletti", 
        "givenName": "Roberta", 
        "id": "sg:person.01216002300.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216002300.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA", 
            "Division of Gynecologic Oncology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "Salvatore", 
        "id": "sg:person.01240404276.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240404276.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bellone", 
        "givenName": "Stefania", 
        "id": "sg:person.01244366775.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366775.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cocco", 
        "givenName": "Emiliano", 
        "id": "sg:person.01364015242.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364015242.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwab", 
        "givenName": "Carlton L.", 
        "id": "sg:person.01007727276.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007727276.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Black", 
        "givenName": "Jonathan D.", 
        "id": "sg:person.01136056104.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136056104.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA", 
            "Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Centritto", 
        "givenName": "Floriana", 
        "id": "sg:person.01011212010.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011212010.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA", 
            "Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medial University, 110004, Shenyang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Liancheng", 
        "id": "sg:person.01216407216.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216407216.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonazzoli", 
        "givenName": "Elena", 
        "id": "sg:person.0610700461.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610700461.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Pathology, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buza", 
        "givenName": "Natalia", 
        "id": "sg:person.01264655440.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264655440.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Pathology, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hui", 
        "givenName": "Pei", 
        "id": "sg:person.01057557510.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057557510.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mezzanzanica", 
        "givenName": "Delia", 
        "id": "sg:person.01026004417.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026004417.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Canevari", 
        "givenName": "Silvana", 
        "id": "sg:person.01200663565.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200663565.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "Peter E.", 
        "id": "sg:person.01207015645.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207015645.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rutherford", 
        "givenName": "Thomas J.", 
        "id": "sg:person.01017553075.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017553075.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA", 
            "333 Cedar Street, LSOG 305, PO Box 208063, 06520-8063, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santin", 
        "givenName": "Alessandro D.", 
        "id": "sg:person.01134001475.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134001475.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2006.07.0250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000199030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-1776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002574345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2006.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004336586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006812.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005458652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.2002.01151.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006181553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2004.07.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007641652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2003.12.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009557754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2013.775113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010107387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-1090-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010566071", 
          "https://doi.org/10.1007/s10549-010-1090-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011011108", 
          "https://doi.org/10.1038/sj.bjc.6605448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011011108", 
          "https://doi.org/10.1038/sj.bjc.6605448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-13-143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012956592", 
          "https://doi.org/10.1186/1476-4598-13-143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0091270011403742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014251586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2011.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016565509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026719751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027689264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027689264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2014.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028388296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.55.5.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030090076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0004-8666.2003.00003.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030397457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030590989", 
          "https://doi.org/10.1038/nrc3559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2004.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032209634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2008.n.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033182820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01389.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033893614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01389.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033893614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035458619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035458619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.07.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040471770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.07.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040471770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpobgyn.2011.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041983906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1209124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042743567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2010.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042894232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ogx.0b013e3181b8aff3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047758426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ogx.0b013e3181b8aff3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047758426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ogx.0b013e3181b8aff3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047758426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2006.00760.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049427157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2006.00760.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049427157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e31823bb24d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050698489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e31823bb24d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050698489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2011.12.418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051791606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181dc8292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061838288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181dc8292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061838288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181dc8292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061838288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181dc8292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061838288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.9.2639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549894"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01", 
    "datePublishedReg": "2015-01-01", 
    "description": "Ovarian and uterine carcinosarcoma (CS) are characterized by their aggressive clinical behavior and poor prognosis. We evaluated the efficacy of trastuzumab-emtansine (T-DM1), against primary HER2 positive and HER2 negative CS cell lines in vitro and in vivo. Eight primary CS cell lines were evaluated for HER2 amplification and protein expression by fluorescence in situ hybridization, immunohistochemistry, flow cytometry and qRT-PCR. Sensitivity to T-DM1-induced antibody-dependent-cell-mediated-cytotoxicity (ADCC) was evaluated in 4-h-chromium-release-assays. T-DM1 cytostatic and apoptotic activities were evaluated using flow cytometry based proliferation assays. In vivo activity of T-DM1 was also evaluated. HER2 protein overexpression and gene amplification were detected in 25 % (2/8) of the primary CS cell lines. T-DM1 and T were similarly effective in inducing strong ADCC against CS overexpressing HER2 at 3+ levels. In contrast, T-DM1 was dramatically more effective than T in inhibiting cell proliferation (P < 0.0001) and in inducing G2/M phase cell cycle arrest in the HER2 expressing cell lines (shift of G2/M: mean \u00b1 SEM from 14.87 \u00b1 1.23 to 66.57 \u00b1 4.56 %, P < 0.0001). Importantly, T-DM1 was highly active at reducing tumor formation in vivo in CS xenografts overexpressing HER2 (P = 0.0001 and P < 0.0001 compared to T and vehicle respectively) with a significantly longer survival when compared to T and vehicle mice (P = 0.008 and P = 0.0001 respectively). T-DM1 may represent a novel treatment option for the subset of HER2 positive CS patients with disease refractory to chemotherapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10585-014-9688-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705220", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2481110", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3624705", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438823", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094856", 
        "issn": [
          "0262-0898", 
          "1573-7276"
        ], 
        "name": "Clinical & Experimental Metastasis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "T-DM1, a novel antibody-drug conjugate, is highly effective against uterine and ovarian carcinosarcomas overexpressing HER2", 
    "pagination": "29-38", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7f999a13eb1b01411717ecce18eaef1ab6c448324524d86f3f5c9ed21724c817"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25398397"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8409970"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10585-014-9688-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026784798"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10585-014-9688-8", 
      "https://app.dimensions.ai/details/publication/pub.1026784798"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10585-014-9688-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9688-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9688-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9688-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9688-8'


 

This table displays all metadata directly associated to this object as RDF triples.

368 TRIPLES      21 PREDICATES      80 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10585-014-9688-8 schema:about N019f23d8e4c240ff8074bb019681b27a
2 N07484987618a4d4d91a44fb0d78907f8
3 N0ece445ddfe64435ac15f802fe421e7f
4 N2d52e7d9156449a7a9cff73a69ba2ffc
5 N371abb9a1b49445baee7875367aa6595
6 N3902d8a7547f4cdb874a30f09586a7d3
7 N3a8b06c37887484da6b03ae9221e469d
8 N5e4823e096e94e479eae3b23db01db0a
9 N687adf23fa0545d3b60505c885fac65b
10 N6f877333aafd49dbab8c4ccf2b69fc20
11 N993e8442d6294d2d87780a502d493e0d
12 N9c3a391ec194400d9f37b648a28babe0
13 Naf1a931215924812bf082dc5ca0390b0
14 Nbb3da30d1b334c468f385930ef1daa69
15 Nca6fdb2753f94335a31c5c42bf481667
16 Nda2f11f9de3441d89ca12ebaa0481d30
17 Ne579934167d44c90adc70dd9d01b92eb
18 Neabe319e7937409a83963badc0845828
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N8cb98164cfe446389a50b2127a8839b2
22 schema:citation sg:pub.10.1007/s10549-010-1090-x
23 sg:pub.10.1038/nrc3559
24 sg:pub.10.1038/sj.bjc.6605448
25 sg:pub.10.1186/1476-4598-13-143
26 https://doi.org/10.1002/14651858.cd006812.pub2
27 https://doi.org/10.1002/cncr.21308
28 https://doi.org/10.1016/j.bpobgyn.2011.05.010
29 https://doi.org/10.1016/j.canlet.2011.03.002
30 https://doi.org/10.1016/j.ctrv.2014.02.008
31 https://doi.org/10.1016/j.jconrel.2010.04.009
32 https://doi.org/10.1016/j.ygyno.2003.12.029
33 https://doi.org/10.1016/j.ygyno.2004.07.041
34 https://doi.org/10.1016/j.ygyno.2004.09.050
35 https://doi.org/10.1016/j.ygyno.2005.07.124
36 https://doi.org/10.1016/j.ygyno.2005.09.017
37 https://doi.org/10.1016/j.ygyno.2006.11.001
38 https://doi.org/10.1016/j.ygyno.2011.12.418
39 https://doi.org/10.1046/j.0004-8666.2003.00003.x
40 https://doi.org/10.1046/j.1525-1438.2002.01151.x
41 https://doi.org/10.1056/nejmoa1209124
42 https://doi.org/10.1097/ogx.0b013e3181b8aff3
43 https://doi.org/10.1097/pgp.0b013e31823bb24d
44 https://doi.org/10.1111/igc.0b013e3181dc8292
45 https://doi.org/10.1111/j.1349-7006.2003.tb01389.x
46 https://doi.org/10.1111/j.1525-1438.2006.00760.x
47 https://doi.org/10.1136/jcp.55.5.321
48 https://doi.org/10.1158/0008-5472.can-08-1776
49 https://doi.org/10.1177/0091270011403742
50 https://doi.org/10.1185/03007995.2013.775113
51 https://doi.org/10.1200/jco.1999.17.9.2639
52 https://doi.org/10.1200/jco.2006.07.0250
53 https://doi.org/10.1200/jco.2006.09.2775
54 https://doi.org/10.3816/cbc.2008.n.047
55 schema:datePublished 2015-01
56 schema:datePublishedReg 2015-01-01
57 schema:description Ovarian and uterine carcinosarcoma (CS) are characterized by their aggressive clinical behavior and poor prognosis. We evaluated the efficacy of trastuzumab-emtansine (T-DM1), against primary HER2 positive and HER2 negative CS cell lines in vitro and in vivo. Eight primary CS cell lines were evaluated for HER2 amplification and protein expression by fluorescence in situ hybridization, immunohistochemistry, flow cytometry and qRT-PCR. Sensitivity to T-DM1-induced antibody-dependent-cell-mediated-cytotoxicity (ADCC) was evaluated in 4-h-chromium-release-assays. T-DM1 cytostatic and apoptotic activities were evaluated using flow cytometry based proliferation assays. In vivo activity of T-DM1 was also evaluated. HER2 protein overexpression and gene amplification were detected in 25 % (2/8) of the primary CS cell lines. T-DM1 and T were similarly effective in inducing strong ADCC against CS overexpressing HER2 at 3+ levels. In contrast, T-DM1 was dramatically more effective than T in inhibiting cell proliferation (P < 0.0001) and in inducing G2/M phase cell cycle arrest in the HER2 expressing cell lines (shift of G2/M: mean ± SEM from 14.87 ± 1.23 to 66.57 ± 4.56 %, P < 0.0001). Importantly, T-DM1 was highly active at reducing tumor formation in vivo in CS xenografts overexpressing HER2 (P = 0.0001 and P < 0.0001 compared to T and vehicle respectively) with a significantly longer survival when compared to T and vehicle mice (P = 0.008 and P = 0.0001 respectively). T-DM1 may represent a novel treatment option for the subset of HER2 positive CS patients with disease refractory to chemotherapy.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N7d8743d307b343cd9dacd2e2de76863c
62 Na7394fef0901457e992ebe74f27d8570
63 sg:journal.1094856
64 schema:name T-DM1, a novel antibody-drug conjugate, is highly effective against uterine and ovarian carcinosarcomas overexpressing HER2
65 schema:pagination 29-38
66 schema:productId N5a7a2ca16c544111a9d239a3e2afdb02
67 N95e919062cdd445b8e84e08990d51e30
68 Nb9bb98b257084409968d726aeaee63d5
69 Nead8e66a34784177887fe655bf5d5e16
70 Nfd3e9478fef04c79aec12cc0bb8fe381
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026784798
72 https://doi.org/10.1007/s10585-014-9688-8
73 schema:sdDatePublished 2019-04-10T16:42
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Na195cc53d3cc4a0393b46be7f692732e
76 schema:url http://link.springer.com/10.1007%2Fs10585-014-9688-8
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N019f23d8e4c240ff8074bb019681b27a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Cell Line, Tumor
82 rdf:type schema:DefinedTerm
83 N07484987618a4d4d91a44fb0d78907f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Ovarian Neoplasms
85 rdf:type schema:DefinedTerm
86 N0ece445ddfe64435ac15f802fe421e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Receptor, ErbB-2
88 rdf:type schema:DefinedTerm
89 N1aeed5d3a5ad4e31b15fb6aedae02e2d rdf:first sg:person.01057557510.46
90 rdf:rest N8e2a553b5b854a419ef97281ac285fe8
91 N2d52e7d9156449a7a9cff73a69ba2ffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mice
93 rdf:type schema:DefinedTerm
94 N371abb9a1b49445baee7875367aa6595 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Female
96 rdf:type schema:DefinedTerm
97 N3902d8a7547f4cdb874a30f09586a7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Trastuzumab
99 rdf:type schema:DefinedTerm
100 N3a8b06c37887484da6b03ae9221e469d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name M Phase Cell Cycle Checkpoints
102 rdf:type schema:DefinedTerm
103 N4550c42b58424c10a979626576f96736 rdf:first sg:person.01364015242.73
104 rdf:rest N90de3ddf5a6d4d84b343d024e5c627fc
105 N4a144934fb7f4274b2b4457fe6f7a510 rdf:first sg:person.01240404276.58
106 rdf:rest N6550e2365bc14eb1a336baec3a9ee022
107 N5a7a2ca16c544111a9d239a3e2afdb02 schema:name nlm_unique_id
108 schema:value 8409970
109 rdf:type schema:PropertyValue
110 N5e4823e096e94e479eae3b23db01db0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antibody-Dependent Cell Cytotoxicity
112 rdf:type schema:DefinedTerm
113 N6550e2365bc14eb1a336baec3a9ee022 rdf:first sg:person.01244366775.56
114 rdf:rest N4550c42b58424c10a979626576f96736
115 N687adf23fa0545d3b60505c885fac65b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Maytansine
117 rdf:type schema:DefinedTerm
118 N6f877333aafd49dbab8c4ccf2b69fc20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Proliferation
120 rdf:type schema:DefinedTerm
121 N7d8743d307b343cd9dacd2e2de76863c schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N7ec1e955252841cb8139d99dbafabd17 rdf:first sg:person.01264655440.98
124 rdf:rest N1aeed5d3a5ad4e31b15fb6aedae02e2d
125 N836345426f9346f8bee7c21e1b52d7d5 rdf:first sg:person.01017553075.00
126 rdf:rest N956198b99b454a778d439e8a124da9a9
127 N8cb98164cfe446389a50b2127a8839b2 rdf:first sg:person.01216002300.82
128 rdf:rest N4a144934fb7f4274b2b4457fe6f7a510
129 N8e2a553b5b854a419ef97281ac285fe8 rdf:first sg:person.01026004417.38
130 rdf:rest Na97adc00cc294b15926872b3fbff3755
131 N90de3ddf5a6d4d84b343d024e5c627fc rdf:first sg:person.01007727276.32
132 rdf:rest Nbb1b76ef57484429985e3103b07409ee
133 N956198b99b454a778d439e8a124da9a9 rdf:first sg:person.01134001475.57
134 rdf:rest rdf:nil
135 N95e919062cdd445b8e84e08990d51e30 schema:name dimensions_id
136 schema:value pub.1026784798
137 rdf:type schema:PropertyValue
138 N96ef940016604b5f93f032b9e6bee89b rdf:first sg:person.01011212010.01
139 rdf:rest Nb2a3d2f7e6da48bba1f56cf9c32c3c9f
140 N993e8442d6294d2d87780a502d493e0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Carcinosarcoma
142 rdf:type schema:DefinedTerm
143 N9c3a391ec194400d9f37b648a28babe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 Na195cc53d3cc4a0393b46be7f692732e schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 Na7394fef0901457e992ebe74f27d8570 schema:volumeNumber 32
149 rdf:type schema:PublicationVolume
150 Na97adc00cc294b15926872b3fbff3755 rdf:first sg:person.01200663565.36
151 rdf:rest Ne3f945b7742d455d98758dd6f4e76eca
152 Naf1a931215924812bf082dc5ca0390b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Xenograft Model Antitumor Assays
154 rdf:type schema:DefinedTerm
155 Nb2a3d2f7e6da48bba1f56cf9c32c3c9f rdf:first sg:person.01216407216.20
156 rdf:rest Nc920ed5d481c478099bbb62eff851376
157 Nb9bb98b257084409968d726aeaee63d5 schema:name pubmed_id
158 schema:value 25398397
159 rdf:type schema:PropertyValue
160 Nbb1b76ef57484429985e3103b07409ee rdf:first sg:person.01136056104.31
161 rdf:rest N96ef940016604b5f93f032b9e6bee89b
162 Nbb3da30d1b334c468f385930ef1daa69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mice, SCID
164 rdf:type schema:DefinedTerm
165 Nc920ed5d481c478099bbb62eff851376 rdf:first sg:person.0610700461.25
166 rdf:rest N7ec1e955252841cb8139d99dbafabd17
167 Nca6fdb2753f94335a31c5c42bf481667 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Uterine Neoplasms
169 rdf:type schema:DefinedTerm
170 Nda2f11f9de3441d89ca12ebaa0481d30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Antibodies, Monoclonal, Humanized
172 rdf:type schema:DefinedTerm
173 Ne3f945b7742d455d98758dd6f4e76eca rdf:first sg:person.01207015645.37
174 rdf:rest N836345426f9346f8bee7c21e1b52d7d5
175 Ne579934167d44c90adc70dd9d01b92eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Antineoplastic Agents
177 rdf:type schema:DefinedTerm
178 Neabe319e7937409a83963badc0845828 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Immunoconjugates
180 rdf:type schema:DefinedTerm
181 Nead8e66a34784177887fe655bf5d5e16 schema:name doi
182 schema:value 10.1007/s10585-014-9688-8
183 rdf:type schema:PropertyValue
184 Nfd3e9478fef04c79aec12cc0bb8fe381 schema:name readcube_id
185 schema:value 7f999a13eb1b01411717ecce18eaef1ab6c448324524d86f3f5c9ed21724c817
186 rdf:type schema:PropertyValue
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
191 schema:name Oncology and Carcinogenesis
192 rdf:type schema:DefinedTerm
193 sg:grant.2438823 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9688-8
194 rdf:type schema:MonetaryGrant
195 sg:grant.2481110 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9688-8
196 rdf:type schema:MonetaryGrant
197 sg:grant.2705220 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9688-8
198 rdf:type schema:MonetaryGrant
199 sg:grant.3624705 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9688-8
200 rdf:type schema:MonetaryGrant
201 sg:journal.1094856 schema:issn 0262-0898
202 1573-7276
203 schema:name Clinical & Experimental Metastasis
204 rdf:type schema:Periodical
205 sg:person.01007727276.32 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
206 schema:familyName Schwab
207 schema:givenName Carlton L.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007727276.32
209 rdf:type schema:Person
210 sg:person.01011212010.01 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
211 schema:familyName Centritto
212 schema:givenName Floriana
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011212010.01
214 rdf:type schema:Person
215 sg:person.01017553075.00 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
216 schema:familyName Rutherford
217 schema:givenName Thomas J.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017553075.00
219 rdf:type schema:Person
220 sg:person.01026004417.38 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
221 schema:familyName Mezzanzanica
222 schema:givenName Delia
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026004417.38
224 rdf:type schema:Person
225 sg:person.01057557510.46 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
226 schema:familyName Hui
227 schema:givenName Pei
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057557510.46
229 rdf:type schema:Person
230 sg:person.01134001475.57 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
231 schema:familyName Santin
232 schema:givenName Alessandro D.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134001475.57
234 rdf:type schema:Person
235 sg:person.01136056104.31 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
236 schema:familyName Black
237 schema:givenName Jonathan D.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136056104.31
239 rdf:type schema:Person
240 sg:person.01200663565.36 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
241 schema:familyName Canevari
242 schema:givenName Silvana
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200663565.36
244 rdf:type schema:Person
245 sg:person.01207015645.37 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
246 schema:familyName Schwartz
247 schema:givenName Peter E.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207015645.37
249 rdf:type schema:Person
250 sg:person.01216002300.82 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
251 schema:familyName Nicoletti
252 schema:givenName Roberta
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216002300.82
254 rdf:type schema:Person
255 sg:person.01216407216.20 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
256 schema:familyName Zhu
257 schema:givenName Liancheng
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216407216.20
259 rdf:type schema:Person
260 sg:person.01240404276.58 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
261 schema:familyName Lopez
262 schema:givenName Salvatore
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240404276.58
264 rdf:type schema:Person
265 sg:person.01244366775.56 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
266 schema:familyName Bellone
267 schema:givenName Stefania
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366775.56
269 rdf:type schema:Person
270 sg:person.01264655440.98 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
271 schema:familyName Buza
272 schema:givenName Natalia
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264655440.98
274 rdf:type schema:Person
275 sg:person.01364015242.73 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
276 schema:familyName Cocco
277 schema:givenName Emiliano
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364015242.73
279 rdf:type schema:Person
280 sg:person.0610700461.25 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
281 schema:familyName Bonazzoli
282 schema:givenName Elena
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610700461.25
284 rdf:type schema:Person
285 sg:pub.10.1007/s10549-010-1090-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010566071
286 https://doi.org/10.1007/s10549-010-1090-x
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nrc3559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030590989
289 https://doi.org/10.1038/nrc3559
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.bjc.6605448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011011108
292 https://doi.org/10.1038/sj.bjc.6605448
293 rdf:type schema:CreativeWork
294 sg:pub.10.1186/1476-4598-13-143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012956592
295 https://doi.org/10.1186/1476-4598-13-143
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/14651858.cd006812.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458652
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/cncr.21308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027689264
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.bpobgyn.2011.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041983906
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.canlet.2011.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016565509
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.ctrv.2014.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028388296
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jconrel.2010.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042894232
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.ygyno.2003.12.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009557754
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.ygyno.2004.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007641652
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.ygyno.2004.09.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032209634
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.ygyno.2005.07.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040471770
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.ygyno.2005.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035458619
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.ygyno.2006.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004336586
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.ygyno.2011.12.418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051791606
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1046/j.0004-8666.2003.00003.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030397457
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1046/j.1525-1438.2002.01151.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006181553
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1056/nejmoa1209124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042743567
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1097/ogx.0b013e3181b8aff3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047758426
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1097/pgp.0b013e31823bb24d schema:sameAs https://app.dimensions.ai/details/publication/pub.1050698489
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/igc.0b013e3181dc8292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061838288
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1111/j.1349-7006.2003.tb01389.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033893614
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1525-1438.2006.00760.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049427157
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1136/jcp.55.5.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030090076
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1158/0008-5472.can-08-1776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002574345
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1177/0091270011403742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014251586
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1185/03007995.2013.775113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010107387
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1200/jco.1999.17.9.2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549894
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1200/jco.2006.07.0250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000199030
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1200/jco.2006.09.2775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026719751
352 rdf:type schema:CreativeWork
353 https://doi.org/10.3816/cbc.2008.n.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033182820
354 rdf:type schema:CreativeWork
355 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
356 schema:name Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133, Milan, Italy
357 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA
358 rdf:type schema:Organization
359 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
360 schema:name 333 Cedar Street, LSOG 305, PO Box 208063, 06520-8063, New Haven, CT, USA
361 Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medial University, 110004, Shenyang, China
362 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA
363 Department of Pathology, Yale University School of Medicine, 06520, New Haven, CT, USA
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.9657.d schema:alternateName Università Campus Bio-Medico
366 schema:name Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 06520, New Haven, CT, USA
367 Division of Gynecologic Oncology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128, Rome, Italy
368 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...