CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Hideyo Hirai, Teruaki Fujishita, Kazuki Kurimoto, Hitoshi Miyachi, Satsuki Kitano, Susumu Inamoto, Yoshiro Itatani, Mitinori Saitou, Taira Maekawa, M. Mark Taketo

ABSTRACT

To understand colon cancer metastasis, we earlier analyzed a mouse model that developed liver metastasis of cancer cells disseminated from the spleen. We suggested that CCR1(+) bone marrow (BM)-derived cells are recruited to the microenvironment of disseminated colon cancer cells, and produce metalloproteinases MMP9 and MMP2, helping metastatic colonization. In the present study, we have examined these myeloid cells expressing CCR1 and/or MMPs in detail. To this end, we have established bacterial artificial chromosome (BAC)-based transgenic mouse lines in which membrane-targeted Venus fluorescent protein (mVenus) was expressed under the control of Ccr1 gene promoter. Then, myeloid cells obtained from the BM and liver metastatic foci were analyzed by the combination of flow cytometry and cytology/immunohistochemistry, in situ RNA hybridization, or quantitative RT-PCR. We have found four distinct types of myeloid cells recruited to the metastatic foci; neutrophils, eosinophils, monocytes and fibrocytes. These cell types exhibited distinct expression patterns for CCR1, MMP2 and MMP9. Namely, neutrophils found in the early phase of cancer cell dissemination expressed CCR1 exclusively and MMP9 preferentially, whereas fibrocytes accumulated in later phase expressed MMP2 exclusively. Either genetic inactivation of Ccr1 or antibody-mediated neutrophil depletion reduced subsequent recruitment of fibrocytes. The recruitment of CCR1(+) neutrophils in early phase of colon cancer dissemination appears to cause that of fibrocytes in late phase. These results implicate the key role of CCR1 in colon cancer metastasis in this mouse model, and explain why both MMP9 and MMP2 are essential as genetically demonstrated previously. The results also suggest relevant mechanisms in humans. More... »

PAGES

977-989

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10585-014-9684-z

DOI

http://dx.doi.org/10.1007/s10585-014-9684-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053496886

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25326065


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Microenvironment", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Transfusion Medicine and Cell Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirai", 
        "givenName": "Hideyo", 
        "id": "sg:person.01313332642.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313332642.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Pharmacology, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan", 
            "Division of Molecular Pathology, Aichi Cancer Center Research Institute, 464-8681, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujishita", 
        "givenName": "Teruaki", 
        "id": "sg:person.01213344111.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213344111.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurimoto", 
        "givenName": "Kazuki", 
        "id": "sg:person.0704366301.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704366301.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Reproductive Engineering Team, Institute for Virus Research, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyachi", 
        "givenName": "Hitoshi", 
        "id": "sg:person.01264460712.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264460712.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Reproductive Engineering Team, Institute for Virus Research, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitano", 
        "givenName": "Satsuki", 
        "id": "sg:person.0734605336.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734605336.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inamoto", 
        "givenName": "Susumu", 
        "id": "sg:person.01354055055.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354055055.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Pharmacology, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan", 
            "Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
            "Moores Cancer Center, UCSD, 3855 Health Sciences Drive, 92093, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itatani", 
        "givenName": "Yoshiro", 
        "id": "sg:person.01120436234.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120436234.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
            "JST, ERATO, Yoshida-Kono\u00e9-Cho, Kyoto, Japan", 
            "Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan", 
            "Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saitou", 
        "givenName": "Mitinori", 
        "id": "sg:person.01265450666.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265450666.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Transfusion Medicine and Cell Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maekawa", 
        "givenName": "Taira", 
        "id": "sg:person.010705023452.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010705023452.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Pharmacology, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan", 
            "Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taketo", 
        "givenName": "M. Mark", 
        "id": "sg:person.011203742777.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011203742777.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2010.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003056135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-013-1021-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003763726", 
          "https://doi.org/10.1007/s00109-013-1021-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879172", 
          "https://doi.org/10.1038/ni1354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879172", 
          "https://doi.org/10.1038/ni1354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005000105", 
          "https://doi.org/10.1038/bjc.2013.167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006371738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008826828", 
          "https://doi.org/10.1038/nri2990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2013.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014058329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016512406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1103007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017100256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018392228", 
          "https://doi.org/10.1038/ng1997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.11.1959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018717566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-04-016600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020209636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0905680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027313693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/879897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028392348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-08-449413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030962063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.9498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031171791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jb/mvs035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033147450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0712365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034315684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034686698", 
          "https://doi.org/10.1038/nrc2444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2009.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035384579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036672274", 
          "https://doi.org/10.1038/nrc1877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036672274", 
          "https://doi.org/10.1038/nrc1877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2012.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038976575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2013.07.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040162273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042664529", 
          "https://doi.org/10.1038/nrc1098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042664529", 
          "https://doi.org/10.1038/nrc1098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045192849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2010.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049335248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-3049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050766457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-011-9340-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052919379", 
          "https://doi.org/10.1007/s10555-011-9340-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1002372107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053011411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.15.3112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.2.1178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074747132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075034107", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078642504", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1202857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078709816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082956383", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03403533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082956383", 
          "https://doi.org/10.1007/bf03403533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03403533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082956383", 
          "https://doi.org/10.1007/bf03403533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083373750", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "To understand colon cancer metastasis, we earlier analyzed a mouse model that developed liver metastasis of cancer cells disseminated from the spleen. We suggested that CCR1(+) bone marrow (BM)-derived cells are recruited to the microenvironment of disseminated colon cancer cells, and produce metalloproteinases MMP9 and MMP2, helping metastatic colonization. In the present study, we have examined these myeloid cells expressing CCR1 and/or MMPs in detail. To this end, we have established bacterial artificial chromosome (BAC)-based transgenic mouse lines in which membrane-targeted Venus fluorescent protein (mVenus) was expressed under the control of Ccr1 gene promoter. Then, myeloid cells obtained from the BM and liver metastatic foci were analyzed by the combination of flow cytometry and cytology/immunohistochemistry, in situ RNA hybridization, or quantitative RT-PCR. We have found four distinct types of myeloid cells recruited to the metastatic foci; neutrophils, eosinophils, monocytes and fibrocytes. These cell types exhibited distinct expression patterns for CCR1, MMP2 and MMP9. Namely, neutrophils found in the early phase of cancer cell dissemination expressed CCR1 exclusively and MMP9 preferentially, whereas fibrocytes accumulated in later phase expressed MMP2 exclusively. Either genetic inactivation of Ccr1 or antibody-mediated neutrophil depletion reduced subsequent recruitment of fibrocytes. The recruitment of CCR1(+) neutrophils in early phase of colon cancer dissemination appears to cause that of fibrocytes in late phase. These results implicate the key role of CCR1 in colon cancer metastasis in this mouse model, and explain why both MMP9 and MMP2 are essential as genetically demonstrated previously. The results also suggest relevant mechanisms in humans. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10585-014-9684-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6115001", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6112987", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6120127", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6149555", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6125388", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6078089", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6102047", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094856", 
        "issn": [
          "0262-0898", 
          "1573-7276"
        ], 
        "name": "Clinical & Experimental Metastasis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis", 
    "pagination": "977-989", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fecfb3efb76e64a0627515781493d63369185b2771d41fa9f2e382aac896f989"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25326065"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8409970"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10585-014-9684-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053496886"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10585-014-9684-z", 
      "https://app.dimensions.ai/details/publication/pub.1053496886"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88218_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10585-014-9684-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9684-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9684-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9684-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10585-014-9684-z'


 

This table displays all metadata directly associated to this object as RDF triples.

382 TRIPLES      21 PREDICATES      92 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10585-014-9684-z schema:about N020a873ec89a41bb83b05505d39de354
2 N0defe1364d11449c9b8d6e4ad3a28455
3 N108c287c27054c359ad2565b3e9be8c2
4 N10a8f0f126a04282924b4457ca5e8a0a
5 N1247ec1b7b664e00adcc0e712f37c2be
6 N1838b43170d247299c865c5e856434eb
7 N2e809cef8bb84a5eb4ed67565485d6fd
8 N307783f9ae6a431fb8db4e3a0e04271e
9 N51de669b8dfc4416a75e68febd2dd3b3
10 N65b28ef11467453a998a9e58ac133130
11 N690b20b4f51c4f29920d0bd40dd249a8
12 N6912eb9f4ff94c229d65c5ce4d47ee1e
13 N835e2c500488470b8548cbe2307c4fff
14 N8a27034a862c4810bca0887c871112cf
15 N912b2836eae14da39c46c409acd46433
16 N9fde91eecfa74799834be87dfaf3e349
17 Na138db968e51480484c524ef2866dcd0
18 Na6634c65c79a42ae9c3cba1486758835
19 Na80739a9daf248ddafc9c1b6d1f5a1b0
20 Nb4a3f93f9c604cf1a03a2ae1081b4952
21 Nd2d09e4ffbcd45d18d8412d9e97cafc8
22 Ne6155c26646844a685e1f2d4b20c4316
23 Ne689380c714142669ce9a4130fce6603
24 Nee5d5d6b96cf496895aa42a41be184b8
25 Nf9b0a7de7495426e8f86814f0f2b2e15
26 anzsrc-for:06
27 anzsrc-for:0601
28 schema:author N3954505f0541494f938e06604fe0e995
29 schema:citation sg:pub.10.1007/bf03403533
30 sg:pub.10.1007/s00109-013-1021-5
31 sg:pub.10.1007/s10555-011-9340-x
32 sg:pub.10.1038/bjc.2013.167
33 sg:pub.10.1038/ng1997
34 sg:pub.10.1038/ni1354
35 sg:pub.10.1038/nrc1098
36 sg:pub.10.1038/nrc1877
37 sg:pub.10.1038/nrc2444
38 sg:pub.10.1038/nri2990
39 https://app.dimensions.ai/details/publication/pub.1075034107
40 https://app.dimensions.ai/details/publication/pub.1078642504
41 https://app.dimensions.ai/details/publication/pub.1082956383
42 https://app.dimensions.ai/details/publication/pub.1083373750
43 https://doi.org/10.1016/j.cell.2010.03.014
44 https://doi.org/10.1016/j.cell.2014.03.004
45 https://doi.org/10.1016/j.molmed.2010.01.003
46 https://doi.org/10.1016/j.semcancer.2013.02.005
47 https://doi.org/10.1016/j.semcdb.2009.10.010
48 https://doi.org/10.1016/j.stem.2012.12.012
49 https://doi.org/10.1053/j.gastro.2013.07.033
50 https://doi.org/10.1056/nejmoa0905680
51 https://doi.org/10.1073/pnas.1002372107
52 https://doi.org/10.1084/jem.185.11.1959
53 https://doi.org/10.1093/jb/mvs035
54 https://doi.org/10.1155/2014/879897
55 https://doi.org/10.1158/0008-5472.can-07-6229
56 https://doi.org/10.1158/0008-5472.can-10-2583
57 https://doi.org/10.1158/1078-0432.ccr-13-3049
58 https://doi.org/10.1182/blood-2006-04-016600
59 https://doi.org/10.1182/blood-2012-08-449413
60 https://doi.org/10.1189/jlb.0712365
61 https://doi.org/10.1200/jco.2008.18.9498
62 https://doi.org/10.2741/3613
63 https://doi.org/10.4049/jimmunol.1103007
64 https://doi.org/10.4049/jimmunol.1202857
65 https://doi.org/10.4049/jimmunol.166.2.1178
66 https://doi.org/10.4161/cc.5.15.3112
67 schema:datePublished 2014-12
68 schema:datePublishedReg 2014-12-01
69 schema:description To understand colon cancer metastasis, we earlier analyzed a mouse model that developed liver metastasis of cancer cells disseminated from the spleen. We suggested that CCR1(+) bone marrow (BM)-derived cells are recruited to the microenvironment of disseminated colon cancer cells, and produce metalloproteinases MMP9 and MMP2, helping metastatic colonization. In the present study, we have examined these myeloid cells expressing CCR1 and/or MMPs in detail. To this end, we have established bacterial artificial chromosome (BAC)-based transgenic mouse lines in which membrane-targeted Venus fluorescent protein (mVenus) was expressed under the control of Ccr1 gene promoter. Then, myeloid cells obtained from the BM and liver metastatic foci were analyzed by the combination of flow cytometry and cytology/immunohistochemistry, in situ RNA hybridization, or quantitative RT-PCR. We have found four distinct types of myeloid cells recruited to the metastatic foci; neutrophils, eosinophils, monocytes and fibrocytes. These cell types exhibited distinct expression patterns for CCR1, MMP2 and MMP9. Namely, neutrophils found in the early phase of cancer cell dissemination expressed CCR1 exclusively and MMP9 preferentially, whereas fibrocytes accumulated in later phase expressed MMP2 exclusively. Either genetic inactivation of Ccr1 or antibody-mediated neutrophil depletion reduced subsequent recruitment of fibrocytes. The recruitment of CCR1(+) neutrophils in early phase of colon cancer dissemination appears to cause that of fibrocytes in late phase. These results implicate the key role of CCR1 in colon cancer metastasis in this mouse model, and explain why both MMP9 and MMP2 are essential as genetically demonstrated previously. The results also suggest relevant mechanisms in humans.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N1051a93ddde44e2caf1823681848c362
74 Nf27a8601c3f14ee2a0e9c68778e0f042
75 sg:journal.1094856
76 schema:name CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis
77 schema:pagination 977-989
78 schema:productId N3d5ac0c2ec374b219ac4f7432950b687
79 N71b3493d445d412dafdf1b7aa79923e8
80 Nb7d92e4f462f4841b0e145b2114429cf
81 Nba230e90c3f04b68b88e52276507bf84
82 Ne6c3dcecd4164ffa9eba6d13cd9abdc9
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053496886
84 https://doi.org/10.1007/s10585-014-9684-z
85 schema:sdDatePublished 2019-04-11T13:07
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N941ac6eeb8814a8da685d351bf387f70
88 schema:url http://link.springer.com/10.1007/s10585-014-9684-z
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N020a873ec89a41bb83b05505d39de354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Tumor Cells, Cultured
94 rdf:type schema:DefinedTerm
95 N0defe1364d11449c9b8d6e4ad3a28455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Matrix Metalloproteinase 9
97 rdf:type schema:DefinedTerm
98 N1051a93ddde44e2caf1823681848c362 schema:volumeNumber 31
99 rdf:type schema:PublicationVolume
100 N108c287c27054c359ad2565b3e9be8c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Mice, Inbred C57BL
102 rdf:type schema:DefinedTerm
103 N10a8f0f126a04282924b4457ca5e8a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Animals
105 rdf:type schema:DefinedTerm
106 N1247ec1b7b664e00adcc0e712f37c2be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Liver Neoplasms
108 rdf:type schema:DefinedTerm
109 N1838b43170d247299c865c5e856434eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Colonic Neoplasms
111 rdf:type schema:DefinedTerm
112 N2e809cef8bb84a5eb4ed67565485d6fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Immunoenzyme Techniques
114 rdf:type schema:DefinedTerm
115 N307783f9ae6a431fb8db4e3a0e04271e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Movement
117 rdf:type schema:DefinedTerm
118 N343f896d260242c5b1d6721509fdada4 rdf:first sg:person.011203742777.08
119 rdf:rest rdf:nil
120 N383d65e5db504a09886916db5d683f69 rdf:first sg:person.01120436234.56
121 rdf:rest Nd6a2fc795cbd4121ac31c8ab61f21a2a
122 N3954505f0541494f938e06604fe0e995 rdf:first sg:person.01313332642.02
123 rdf:rest Na6ae5f0e7fe74a3d84aa50e7977f8a1b
124 N3d5ac0c2ec374b219ac4f7432950b687 schema:name pubmed_id
125 schema:value 25326065
126 rdf:type schema:PropertyValue
127 N44eb6fce0a9945f9a510e7398d2e61d5 rdf:first sg:person.010705023452.11
128 rdf:rest N343f896d260242c5b1d6721509fdada4
129 N51de669b8dfc4416a75e68febd2dd3b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease Models, Animal
131 rdf:type schema:DefinedTerm
132 N570622edcaf94697b10013b5866cdf63 rdf:first sg:person.0704366301.03
133 rdf:rest Nf8f445248b78467091eca70f8fc0f49e
134 N65b28ef11467453a998a9e58ac133130 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mice, Transgenic
136 rdf:type schema:DefinedTerm
137 N690b20b4f51c4f29920d0bd40dd249a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Real-Time Polymerase Chain Reaction
139 rdf:type schema:DefinedTerm
140 N6912eb9f4ff94c229d65c5ce4d47ee1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mice, Knockout
142 rdf:type schema:DefinedTerm
143 N71b3493d445d412dafdf1b7aa79923e8 schema:name nlm_unique_id
144 schema:value 8409970
145 rdf:type schema:PropertyValue
146 N7f8fd633cc03479ba9a84f89efdd08dd rdf:first sg:person.01354055055.18
147 rdf:rest N383d65e5db504a09886916db5d683f69
148 N835e2c500488470b8548cbe2307c4fff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Bone Marrow Cells
150 rdf:type schema:DefinedTerm
151 N8a27034a862c4810bca0887c871112cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Matrix Metalloproteinase 2
153 rdf:type schema:DefinedTerm
154 N912b2836eae14da39c46c409acd46433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Reverse Transcriptase Polymerase Chain Reaction
156 rdf:type schema:DefinedTerm
157 N941ac6eeb8814a8da685d351bf387f70 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N9fde91eecfa74799834be87dfaf3e349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name RNA, Messenger
161 rdf:type schema:DefinedTerm
162 Na138db968e51480484c524ef2866dcd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 Na6634c65c79a42ae9c3cba1486758835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Blotting, Western
167 rdf:type schema:DefinedTerm
168 Na6ae5f0e7fe74a3d84aa50e7977f8a1b rdf:first sg:person.01213344111.01
169 rdf:rest N570622edcaf94697b10013b5866cdf63
170 Na80739a9daf248ddafc9c1b6d1f5a1b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Flow Cytometry
172 rdf:type schema:DefinedTerm
173 Na9b9296b31ae43bdb33dfed949358361 rdf:first sg:person.0734605336.12
174 rdf:rest N7f8fd633cc03479ba9a84f89efdd08dd
175 Nb4a3f93f9c604cf1a03a2ae1081b4952 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cell Cycle
177 rdf:type schema:DefinedTerm
178 Nb7d92e4f462f4841b0e145b2114429cf schema:name readcube_id
179 schema:value fecfb3efb76e64a0627515781493d63369185b2771d41fa9f2e382aac896f989
180 rdf:type schema:PropertyValue
181 Nba230e90c3f04b68b88e52276507bf84 schema:name doi
182 schema:value 10.1007/s10585-014-9684-z
183 rdf:type schema:PropertyValue
184 Nd2d09e4ffbcd45d18d8412d9e97cafc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Myeloid Cells
186 rdf:type schema:DefinedTerm
187 Nd6a2fc795cbd4121ac31c8ab61f21a2a rdf:first sg:person.01265450666.34
188 rdf:rest N44eb6fce0a9945f9a510e7398d2e61d5
189 Ne6155c26646844a685e1f2d4b20c4316 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Receptors, CCR1
191 rdf:type schema:DefinedTerm
192 Ne689380c714142669ce9a4130fce6603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Tumor Microenvironment
194 rdf:type schema:DefinedTerm
195 Ne6c3dcecd4164ffa9eba6d13cd9abdc9 schema:name dimensions_id
196 schema:value pub.1053496886
197 rdf:type schema:PropertyValue
198 Nee5d5d6b96cf496895aa42a41be184b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Mice
200 rdf:type schema:DefinedTerm
201 Nf27a8601c3f14ee2a0e9c68778e0f042 schema:issueNumber 8
202 rdf:type schema:PublicationIssue
203 Nf8f445248b78467091eca70f8fc0f49e rdf:first sg:person.01264460712.01
204 rdf:rest Na9b9296b31ae43bdb33dfed949358361
205 Nf9b0a7de7495426e8f86814f0f2b2e15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name In Situ Hybridization
207 rdf:type schema:DefinedTerm
208 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biological Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biochemistry and Cell Biology
213 rdf:type schema:DefinedTerm
214 sg:grant.6078089 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
215 rdf:type schema:MonetaryGrant
216 sg:grant.6102047 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
217 rdf:type schema:MonetaryGrant
218 sg:grant.6112987 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
219 rdf:type schema:MonetaryGrant
220 sg:grant.6115001 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
221 rdf:type schema:MonetaryGrant
222 sg:grant.6120127 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
223 rdf:type schema:MonetaryGrant
224 sg:grant.6125388 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
225 rdf:type schema:MonetaryGrant
226 sg:grant.6149555 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-014-9684-z
227 rdf:type schema:MonetaryGrant
228 sg:journal.1094856 schema:issn 0262-0898
229 1573-7276
230 schema:name Clinical & Experimental Metastasis
231 rdf:type schema:Periodical
232 sg:person.010705023452.11 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
233 schema:familyName Maekawa
234 schema:givenName Taira
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010705023452.11
236 rdf:type schema:Person
237 sg:person.011203742777.08 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
238 schema:familyName Taketo
239 schema:givenName M. Mark
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011203742777.08
241 rdf:type schema:Person
242 sg:person.01120436234.56 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
243 schema:familyName Itatani
244 schema:givenName Yoshiro
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120436234.56
246 rdf:type schema:Person
247 sg:person.01213344111.01 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
248 schema:familyName Fujishita
249 schema:givenName Teruaki
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213344111.01
251 rdf:type schema:Person
252 sg:person.01264460712.01 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
253 schema:familyName Miyachi
254 schema:givenName Hitoshi
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264460712.01
256 rdf:type schema:Person
257 sg:person.01265450666.34 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
258 schema:familyName Saitou
259 schema:givenName Mitinori
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265450666.34
261 rdf:type schema:Person
262 sg:person.01313332642.02 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
263 schema:familyName Hirai
264 schema:givenName Hideyo
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313332642.02
266 rdf:type schema:Person
267 sg:person.01354055055.18 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
268 schema:familyName Inamoto
269 schema:givenName Susumu
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354055055.18
271 rdf:type schema:Person
272 sg:person.0704366301.03 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
273 schema:familyName Kurimoto
274 schema:givenName Kazuki
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704366301.03
276 rdf:type schema:Person
277 sg:person.0734605336.12 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
278 schema:familyName Kitano
279 schema:givenName Satsuki
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734605336.12
281 rdf:type schema:Person
282 sg:pub.10.1007/bf03403533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082956383
283 https://doi.org/10.1007/bf03403533
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00109-013-1021-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003763726
286 https://doi.org/10.1007/s00109-013-1021-5
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s10555-011-9340-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052919379
289 https://doi.org/10.1007/s10555-011-9340-x
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/bjc.2013.167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005000105
292 https://doi.org/10.1038/bjc.2013.167
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/ng1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018392228
295 https://doi.org/10.1038/ng1997
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/ni1354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003879172
298 https://doi.org/10.1038/ni1354
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nrc1098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042664529
301 https://doi.org/10.1038/nrc1098
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nrc1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036672274
304 https://doi.org/10.1038/nrc1877
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nrc2444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034686698
307 https://doi.org/10.1038/nrc2444
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/nri2990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008826828
310 https://doi.org/10.1038/nri2990
311 rdf:type schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1075034107 schema:CreativeWork
313 https://app.dimensions.ai/details/publication/pub.1078642504 schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1082956383 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1083373750 schema:CreativeWork
316 https://doi.org/10.1016/j.cell.2010.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003056135
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.cell.2014.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045192849
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.molmed.2010.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049335248
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.semcancer.2013.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014058329
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.semcdb.2009.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035384579
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.stem.2012.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038976575
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1053/j.gastro.2013.07.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040162273
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1056/nejmoa0905680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027313693
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.1002372107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053011411
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1084/jem.185.11.1959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018717566
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/jb/mvs035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033147450
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1155/2014/879897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028392348
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1158/0008-5472.can-07-6229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006371738
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1158/0008-5472.can-10-2583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016512406
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1158/1078-0432.ccr-13-3049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050766457
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1182/blood-2006-04-016600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020209636
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1182/blood-2012-08-449413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030962063
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1189/jlb.0712365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034315684
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1200/jco.2008.18.9498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031171791
353 rdf:type schema:CreativeWork
354 https://doi.org/10.2741/3613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915815
355 rdf:type schema:CreativeWork
356 https://doi.org/10.4049/jimmunol.1103007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017100256
357 rdf:type schema:CreativeWork
358 https://doi.org/10.4049/jimmunol.1202857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078709816
359 rdf:type schema:CreativeWork
360 https://doi.org/10.4049/jimmunol.166.2.1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074747132
361 rdf:type schema:CreativeWork
362 https://doi.org/10.4161/cc.5.15.3112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298542
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.258799.8 schema:alternateName Kyoto University
365 schema:name Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
366 Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
367 Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
368 Department of Transfusion Medicine and Cell Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan
369 Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan
370 JST, ERATO, Yoshida-Konoé-Cho, Kyoto, Japan
371 Pharmacology, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan
372 Reproductive Engineering Team, Institute for Virus Research, Kyoto University, Kyoto, Japan
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
375 schema:name Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
376 Moores Cancer Center, UCSD, 3855 Health Sciences Drive, 92093, San Diego, CA, USA
377 Pharmacology, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.410800.d schema:alternateName Aichi Cancer Center
380 schema:name Division of Molecular Pathology, Aichi Cancer Center Research Institute, 464-8681, Nagoya, Japan
381 Pharmacology, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan
382 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...