Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08

AUTHORS

Evanthia T. Roussos, Sumanta Goswami, Michele Balsamo, Yarong Wang, Robert Stobezki, Esther Adler, Brian D. Robinson, Joan G. Jones, Frank B. Gertler, John S. Condeelis, Maja H. Oktay

ABSTRACT

Mena, an actin regulatory protein, functions at the convergence of motility pathways that drive breast cancer cell invasion and migration in vivo. The tumor microenvironment spontaneously induces both increased expression of the Mena invasive (Mena(INV)) and decreased expression of Mena11a isoforms in invasive and migratory tumor cells. Tumor cells with this Mena expression pattern participate with macrophages in migration and intravasation in mouse mammary tumors in vivo. Consistent with these findings, anatomical sites containing tumor cells with high levels of Mena expression associated with perivascular macrophages were identified in human invasive ductal breast carcinomas and called TMEM. The number of TMEM sites positively correlated with the development of distant metastasis in humans. Here we demonstrate that mouse mammary tumors generated from EGFP-Mena(INV) expressing tumor cells are significantly less cohesive and have discontinuous cell-cell contacts compared to Mena11a xenografts. Using the mouse PyMT model we show that metastatic mammary tumors express 8.7 fold more total Mena and 7.5 fold more Mena(INV) mRNA than early non-metastatic ones. Furthermore, Mena(INV) expression in fine needle aspiration biopsy (FNA) samples of human invasive ductal carcinomas correlate with TMEM score while Mena11a does not. These results suggest that Mena(INV) is the isoform associated with breast cancer cell discohesion, invasion and intravasation in mice and in humans. They also imply that Mena(INV) expression and TMEM score measure related aspects of a common tumor cell dissemination mechanism and provide new insight into metastatic risk. More... »

PAGES

515-527

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10585-011-9388-6

DOI

http://dx.doi.org/10.1007/s10585-011-9388-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016283469

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21484349


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Isoforms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Microenvironment", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roussos", 
        "givenName": "Evanthia T.", 
        "id": "sg:person.01015342157.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015342157.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yeshiva University", 
          "id": "https://www.grid.ac/institutes/grid.268433.8", 
          "name": [
            "Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA", 
            "Department of Biology, Yeshiva University, 10033, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goswami", 
        "givenName": "Sumanta", 
        "id": "sg:person.01341514256.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341514256.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balsamo", 
        "givenName": "Michele", 
        "id": "sg:person.01065574377.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065574377.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yarong", 
        "id": "sg:person.015345256674.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015345256674.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yeshiva University", 
          "id": "https://www.grid.ac/institutes/grid.268433.8", 
          "name": [
            "Department of Biology, Yeshiva University, 10033, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stobezki", 
        "givenName": "Robert", 
        "id": "sg:person.01061372562.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061372562.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Pathology, Montefiore Medical Center, 10467, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adler", 
        "givenName": "Esther", 
        "id": "sg:person.0646775670.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646775670.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411935.b", 
          "name": [
            "Department of Pathology, Johns Hopkins Hospital, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robinson", 
        "givenName": "Brian D.", 
        "id": "sg:person.0667001430.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667001430.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Joan G.", 
        "id": "sg:person.01264617725.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264617725.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gertler", 
        "givenName": "Frank B.", 
        "id": "sg:person.0755724733.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755724733.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA", 
            "Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 10461, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Condeelis", 
        "givenName": "John S.", 
        "id": "sg:person.01054601762.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054601762.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Pathology, Montefiore Medical Center, 10467, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oktay", 
        "givenName": "Maja H.", 
        "id": "sg:person.0762041422.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762041422.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.devcel.2008.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003143948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003849052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006243400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2005.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006817700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008231171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010193396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.039057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012360574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81341-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018539855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200405156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020139451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.6.727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021607618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022580273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e01-10-0102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028573916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.conb.2008.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028764206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029719280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-5-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031905675", 
          "https://doi.org/10.1186/1472-6750-5-14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-008-9225-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032751094", 
          "https://doi.org/10.1007/s10585-008-9225-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699583", 
          "https://doi.org/10.1038/nrc1670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699583", 
          "https://doi.org/10.1038/nrc1670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.21.122303.120306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034103612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034655204", 
          "https://doi.org/10.1038/nbt899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034655204", 
          "https://doi.org/10.1038/nbt899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.3.954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034836584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63568-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039352615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040245389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040386073", 
          "https://doi.org/10.1038/ncb1973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040386073", 
          "https://doi.org/10.1038/ncb1973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.086231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040814049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(04)00108-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044366917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045768997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046642683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mc.20237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047140017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbaexp.2006.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047333508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048450081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2010.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050667548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80884-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052756606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074588329", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074640253", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075185050", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075200725", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077719637", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077897672", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081899739", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/68.3.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082060700"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-08", 
    "datePublishedReg": "2011-08-01", 
    "description": "Mena, an actin regulatory protein, functions at the convergence of motility pathways that drive breast cancer cell invasion and migration in vivo. The tumor microenvironment spontaneously induces both increased expression of the Mena invasive (Mena(INV)) and decreased expression of Mena11a isoforms in invasive and migratory tumor cells. Tumor cells with this Mena expression pattern participate with macrophages in migration and intravasation in mouse mammary tumors in vivo. Consistent with these findings, anatomical sites containing tumor cells with high levels of Mena expression associated with perivascular macrophages were identified in human invasive ductal breast carcinomas and called TMEM. The number of TMEM sites positively correlated with the development of distant metastasis in humans. Here we demonstrate that mouse mammary tumors generated from EGFP-Mena(INV) expressing tumor cells are significantly less cohesive and have discontinuous cell-cell contacts compared to Mena11a xenografts. Using the mouse PyMT model we show that metastatic mammary tumors express 8.7 fold more total Mena and 7.5 fold more Mena(INV) mRNA than early non-metastatic ones. Furthermore, Mena(INV) expression in fine needle aspiration biopsy (FNA) samples of human invasive ductal carcinomas correlate with TMEM score while Mena11a does not. These results suggest that Mena(INV) is the isoform associated with breast cancer cell discohesion, invasion and intravasation in mice and in humans. They also imply that Mena(INV) expression and TMEM score measure related aspects of a common tumor cell dissemination mechanism and provide new insight into metastatic risk.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10585-011-9388-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2699045", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2477976", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2480918", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2699024", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435795", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2516012", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094856", 
        "issn": [
          "0262-0898", 
          "1573-7276"
        ], 
        "name": "Clinical & Experimental Metastasis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM", 
    "pagination": "515-527", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d96670ebeb910404e55fc41b72668f820edab502165efb829d9e6ce83b2ad95"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21484349"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8409970"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10585-011-9388-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016283469"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10585-011-9388-6", 
      "https://app.dimensions.ai/details/publication/pub.1016283469"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10585-011-9388-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10585-011-9388-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10585-011-9388-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10585-011-9388-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10585-011-9388-6'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      83 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10585-011-9388-6 schema:about N00519bef1ae64a7496c2018e322d3fe0
2 N0878e8358bc24804b575e1b253f8cf1f
3 N11931b41db6a4fe28e41d0181b9f4f82
4 N1653eb30ef7744b8986c48d010f6b24c
5 N205ac168e4a343a88aae28388a7ae5c1
6 N42294e79eba44c83803ea83caa8430b7
7 N5357fa32e8c84163b8063c1451d99f99
8 N66229fffb6594d389ad740be3d03a645
9 N698cd8bb563f4bdc967c6f60c63af51b
10 N7be4213f1a064b39a6cf080055e1a09e
11 N80934ac57e894086b0cee6f5c446347c
12 Nc241adf44ab945a29a5402bd46ea9119
13 Ncf918ef5f02c4459b8a351af1b8ac648
14 Nfe69ff80aa694e8e96e7edf106a8801a
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Na23c8469f68e4321a3755a207e75a164
18 schema:citation sg:pub.10.1007/s10585-008-9225-8
19 sg:pub.10.1038/nbt899
20 sg:pub.10.1038/ncb1973
21 sg:pub.10.1038/nrc1670
22 sg:pub.10.1186/1472-6750-5-14
23 https://app.dimensions.ai/details/publication/pub.1074588329
24 https://app.dimensions.ai/details/publication/pub.1074640253
25 https://app.dimensions.ai/details/publication/pub.1075185050
26 https://app.dimensions.ai/details/publication/pub.1075200725
27 https://app.dimensions.ai/details/publication/pub.1077719637
28 https://app.dimensions.ai/details/publication/pub.1077897672
29 https://app.dimensions.ai/details/publication/pub.1081899739
30 https://doi.org/10.1002/cncr.11435
31 https://doi.org/10.1002/ijc.20094
32 https://doi.org/10.1002/mc.20237
33 https://doi.org/10.1016/j.bbaexp.2006.01.001
34 https://doi.org/10.1016/j.conb.2008.05.007
35 https://doi.org/10.1016/j.devcel.2008.09.003
36 https://doi.org/10.1016/j.tcb.2005.01.003
37 https://doi.org/10.1016/j.tcb.2010.10.001
38 https://doi.org/10.1016/s0002-9440(10)63568-7
39 https://doi.org/10.1016/s0092-8674(00)80884-3
40 https://doi.org/10.1016/s0092-8674(00)81341-0
41 https://doi.org/10.1016/s0896-6273(04)00108-4
42 https://doi.org/10.1083/jcb.200405156
43 https://doi.org/10.1084/jem.193.6.727
44 https://doi.org/10.1091/mbc.e01-10-0102
45 https://doi.org/10.1093/jnci/68.3.507
46 https://doi.org/10.1128/mcb.12.3.954
47 https://doi.org/10.1146/annurev.cellbio.21.122303.120306
48 https://doi.org/10.1158/0008-5472.can-04-1136
49 https://doi.org/10.1158/0008-5472.can-04-1449
50 https://doi.org/10.1158/0008-5472.can-06-1823
51 https://doi.org/10.1158/0008-5472.can-06-1997
52 https://doi.org/10.1158/0008-5472.can-06-3714
53 https://doi.org/10.1158/1078-0432.ccr-05-2027
54 https://doi.org/10.1158/1078-0432.ccr-08-0436
55 https://doi.org/10.1158/1078-0432.ccr-08-2179
56 https://doi.org/10.1242/jcs.039057
57 https://doi.org/10.1242/jcs.086231
58 schema:datePublished 2011-08
59 schema:datePublishedReg 2011-08-01
60 schema:description Mena, an actin regulatory protein, functions at the convergence of motility pathways that drive breast cancer cell invasion and migration in vivo. The tumor microenvironment spontaneously induces both increased expression of the Mena invasive (Mena(INV)) and decreased expression of Mena11a isoforms in invasive and migratory tumor cells. Tumor cells with this Mena expression pattern participate with macrophages in migration and intravasation in mouse mammary tumors in vivo. Consistent with these findings, anatomical sites containing tumor cells with high levels of Mena expression associated with perivascular macrophages were identified in human invasive ductal breast carcinomas and called TMEM. The number of TMEM sites positively correlated with the development of distant metastasis in humans. Here we demonstrate that mouse mammary tumors generated from EGFP-Mena(INV) expressing tumor cells are significantly less cohesive and have discontinuous cell-cell contacts compared to Mena11a xenografts. Using the mouse PyMT model we show that metastatic mammary tumors express 8.7 fold more total Mena and 7.5 fold more Mena(INV) mRNA than early non-metastatic ones. Furthermore, Mena(INV) expression in fine needle aspiration biopsy (FNA) samples of human invasive ductal carcinomas correlate with TMEM score while Mena11a does not. These results suggest that Mena(INV) is the isoform associated with breast cancer cell discohesion, invasion and intravasation in mice and in humans. They also imply that Mena(INV) expression and TMEM score measure related aspects of a common tumor cell dissemination mechanism and provide new insight into metastatic risk.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N5595c9d9b2ba4b11a2d1a8bb63d099e1
65 Nc77c3a33676449e3b6123515436a8d28
66 sg:journal.1094856
67 schema:name Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM
68 schema:pagination 515-527
69 schema:productId N1e6cd09c00b24d1b99a5da66b7262e97
70 N3b2e6ea4f9484cdcbb9119adbbdc003d
71 N5f0fdebf6eef4dde89fab7c74e67c956
72 N9a76838f73aa4955bad3b12814c154f8
73 Na5335cddba414cdf984fa9119a24a9cd
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016283469
75 https://doi.org/10.1007/s10585-011-9388-6
76 schema:sdDatePublished 2019-04-10T15:00
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nd20d496851314512a27b71dcf942792f
79 schema:url http://link.springer.com/10.1007%2Fs10585-011-9388-6
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N003184765d9641849179596f44da514d rdf:first sg:person.0762041422.33
84 rdf:rest rdf:nil
85 N00519bef1ae64a7496c2018e322d3fe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Cell Adhesion
87 rdf:type schema:DefinedTerm
88 N0878e8358bc24804b575e1b253f8cf1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Tumor Microenvironment
90 rdf:type schema:DefinedTerm
91 N11931b41db6a4fe28e41d0181b9f4f82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mice, SCID
93 rdf:type schema:DefinedTerm
94 N1653eb30ef7744b8986c48d010f6b24c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Neoplasm Metastasis
96 rdf:type schema:DefinedTerm
97 N1df30bcf26a94b38bd851afe7417e5c6 rdf:first sg:person.0755724733.10
98 rdf:rest N33f01c9d0acf4a4081bef52982cd3e09
99 N1e6cd09c00b24d1b99a5da66b7262e97 schema:name doi
100 schema:value 10.1007/s10585-011-9388-6
101 rdf:type schema:PropertyValue
102 N205ac168e4a343a88aae28388a7ae5c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mammary Neoplasms, Experimental
104 rdf:type schema:DefinedTerm
105 N30431e5eb4eb41d88310c7e0cc091d4a rdf:first sg:person.01341514256.07
106 rdf:rest N3dc5a0ceb0a7433db76047edc73b110a
107 N33f01c9d0acf4a4081bef52982cd3e09 rdf:first sg:person.01054601762.73
108 rdf:rest N003184765d9641849179596f44da514d
109 N3b2e6ea4f9484cdcbb9119adbbdc003d schema:name dimensions_id
110 schema:value pub.1016283469
111 rdf:type schema:PropertyValue
112 N3dc5a0ceb0a7433db76047edc73b110a rdf:first sg:person.01065574377.64
113 rdf:rest N3e2860c3733941fba7edc47ddb8de233
114 N3e2860c3733941fba7edc47ddb8de233 rdf:first sg:person.015345256674.42
115 rdf:rest N482cb60908b34b8c978ddc7ae1c6d9b4
116 N42294e79eba44c83803ea83caa8430b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 N482cb60908b34b8c978ddc7ae1c6d9b4 rdf:first sg:person.01061372562.06
120 rdf:rest N83f1dfd63ccb4ed1ad82d24f94f8caff
121 N5357fa32e8c84163b8063c1451d99f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mice
123 rdf:type schema:DefinedTerm
124 N5595c9d9b2ba4b11a2d1a8bb63d099e1 schema:issueNumber 6
125 rdf:type schema:PublicationIssue
126 N5f0fdebf6eef4dde89fab7c74e67c956 schema:name readcube_id
127 schema:value 4d96670ebeb910404e55fc41b72668f820edab502165efb829d9e6ce83b2ad95
128 rdf:type schema:PropertyValue
129 N66229fffb6594d389ad740be3d03a645 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 N698cd8bb563f4bdc967c6f60c63af51b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Tumor Cells, Cultured
134 rdf:type schema:DefinedTerm
135 N738ffa1b5c5b4fa0ae3acd90b89e96aa rdf:first sg:person.01264617725.95
136 rdf:rest N1df30bcf26a94b38bd851afe7417e5c6
137 N7be4213f1a064b39a6cf080055e1a09e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Gene Expression Regulation, Neoplastic
139 rdf:type schema:DefinedTerm
140 N80934ac57e894086b0cee6f5c446347c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Breast Neoplasms
142 rdf:type schema:DefinedTerm
143 N83f1dfd63ccb4ed1ad82d24f94f8caff rdf:first sg:person.0646775670.44
144 rdf:rest Ne69673160a67473898958254a12c0306
145 N9a76838f73aa4955bad3b12814c154f8 schema:name pubmed_id
146 schema:value 21484349
147 rdf:type schema:PropertyValue
148 Na23c8469f68e4321a3755a207e75a164 rdf:first sg:person.01015342157.14
149 rdf:rest N30431e5eb4eb41d88310c7e0cc091d4a
150 Na5335cddba414cdf984fa9119a24a9cd schema:name nlm_unique_id
151 schema:value 8409970
152 rdf:type schema:PropertyValue
153 Nc241adf44ab945a29a5402bd46ea9119 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cytoskeletal Proteins
155 rdf:type schema:DefinedTerm
156 Nc77c3a33676449e3b6123515436a8d28 schema:volumeNumber 28
157 rdf:type schema:PublicationVolume
158 Ncf918ef5f02c4459b8a351af1b8ac648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Female
160 rdf:type schema:DefinedTerm
161 Nd20d496851314512a27b71dcf942792f schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 Ne69673160a67473898958254a12c0306 rdf:first sg:person.0667001430.42
164 rdf:rest N738ffa1b5c5b4fa0ae3acd90b89e96aa
165 Nfe69ff80aa694e8e96e7edf106a8801a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Protein Isoforms
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
172 schema:name Oncology and Carcinogenesis
173 rdf:type schema:DefinedTerm
174 sg:grant.2435795 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-011-9388-6
175 rdf:type schema:MonetaryGrant
176 sg:grant.2477976 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-011-9388-6
177 rdf:type schema:MonetaryGrant
178 sg:grant.2480918 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-011-9388-6
179 rdf:type schema:MonetaryGrant
180 sg:grant.2516012 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-011-9388-6
181 rdf:type schema:MonetaryGrant
182 sg:grant.2699024 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-011-9388-6
183 rdf:type schema:MonetaryGrant
184 sg:grant.2699045 http://pending.schema.org/fundedItem sg:pub.10.1007/s10585-011-9388-6
185 rdf:type schema:MonetaryGrant
186 sg:journal.1094856 schema:issn 0262-0898
187 1573-7276
188 schema:name Clinical & Experimental Metastasis
189 rdf:type schema:Periodical
190 sg:person.01015342157.14 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
191 schema:familyName Roussos
192 schema:givenName Evanthia T.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015342157.14
194 rdf:type schema:Person
195 sg:person.01054601762.73 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
196 schema:familyName Condeelis
197 schema:givenName John S.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054601762.73
199 rdf:type schema:Person
200 sg:person.01061372562.06 schema:affiliation https://www.grid.ac/institutes/grid.268433.8
201 schema:familyName Stobezki
202 schema:givenName Robert
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061372562.06
204 rdf:type schema:Person
205 sg:person.01065574377.64 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
206 schema:familyName Balsamo
207 schema:givenName Michele
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065574377.64
209 rdf:type schema:Person
210 sg:person.01264617725.95 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
211 schema:familyName Jones
212 schema:givenName Joan G.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264617725.95
214 rdf:type schema:Person
215 sg:person.01341514256.07 schema:affiliation https://www.grid.ac/institutes/grid.268433.8
216 schema:familyName Goswami
217 schema:givenName Sumanta
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341514256.07
219 rdf:type schema:Person
220 sg:person.015345256674.42 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
221 schema:familyName Wang
222 schema:givenName Yarong
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015345256674.42
224 rdf:type schema:Person
225 sg:person.0646775670.44 schema:affiliation https://www.grid.ac/institutes/grid.240283.f
226 schema:familyName Adler
227 schema:givenName Esther
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646775670.44
229 rdf:type schema:Person
230 sg:person.0667001430.42 schema:affiliation https://www.grid.ac/institutes/grid.411935.b
231 schema:familyName Robinson
232 schema:givenName Brian D.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667001430.42
234 rdf:type schema:Person
235 sg:person.0755724733.10 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
236 schema:familyName Gertler
237 schema:givenName Frank B.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755724733.10
239 rdf:type schema:Person
240 sg:person.0762041422.33 schema:affiliation https://www.grid.ac/institutes/grid.240283.f
241 schema:familyName Oktay
242 schema:givenName Maja H.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762041422.33
244 rdf:type schema:Person
245 sg:pub.10.1007/s10585-008-9225-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032751094
246 https://doi.org/10.1007/s10585-008-9225-8
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nbt899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034655204
249 https://doi.org/10.1038/nbt899
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/ncb1973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040386073
252 https://doi.org/10.1038/ncb1973
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nrc1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033699583
255 https://doi.org/10.1038/nrc1670
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1472-6750-5-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031905675
258 https://doi.org/10.1186/1472-6750-5-14
259 rdf:type schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1074588329 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1074640253 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1075185050 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1075200725 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1077719637 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1077897672 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1081899739 schema:CreativeWork
267 https://doi.org/10.1002/cncr.11435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048450081
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/ijc.20094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040245389
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/mc.20237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047140017
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.bbaexp.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047333508
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.conb.2008.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028764206
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.devcel.2008.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003143948
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.tcb.2005.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006817700
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.tcb.2010.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050667548
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0002-9440(10)63568-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039352615
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0092-8674(00)80884-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052756606
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0092-8674(00)81341-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018539855
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0896-6273(04)00108-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044366917
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1083/jcb.200405156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020139451
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1084/jem.193.6.727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021607618
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1091/mbc.e01-10-0102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028573916
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/jnci/68.3.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082060700
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1128/mcb.12.3.954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836584
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1146/annurev.cellbio.21.122303.120306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034103612
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1158/0008-5472.can-04-1136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003849052
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1158/0008-5472.can-04-1449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029719280
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1158/0008-5472.can-06-1823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046642683
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1158/0008-5472.can-06-1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008231171
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1158/0008-5472.can-06-3714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022580273
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1158/1078-0432.ccr-05-2027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010193396
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1158/1078-0432.ccr-08-0436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045768997
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1158/1078-0432.ccr-08-2179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006243400
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1242/jcs.039057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012360574
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1242/jcs.086231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040814049
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
324 schema:name David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.240283.f schema:alternateName Montefiore Medical Center
327 schema:name Department of Pathology, Montefiore Medical Center, 10467, Bronx, NY, USA
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.251993.5 schema:alternateName Albert Einstein College of Medicine
330 schema:name Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA
331 Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 10461, Bronx, NY, USA
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.268433.8 schema:alternateName Yeshiva University
334 schema:name Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA
335 Department of Biology, Yeshiva University, 10033, New York, NY, USA
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.411935.b schema:alternateName Johns Hopkins Hospital
338 schema:name Department of Pathology, Johns Hopkins Hospital, 21287, Baltimore, MD, USA
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
341 schema:name Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, NY, USA
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...