Ribosomal DNA instability and genome adaptability View Full Text


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Article Info

DATE

2019-03

AUTHORS

Devika Salim, Jennifer L. Gerton

ABSTRACT

Ribosomes are large, multi-subunit ribonucleoprotein complexes, essential for protein synthesis. To meet the high cellular demand for ribosomes, all eukaryotes have numerous copies of ribosomal DNA (rDNA) genes that encode ribosomal RNA (rRNA), usually far in excess of the requirement for ribosome biogenesis. In all eukaryotes studied, rDNA genes are arranged in one or more clusters of tandem repeats localized to nucleoli. The tandem arrangement of repeats, combined with the high rates of transcription at the rDNA loci, and the difficulty of replicating repetitive sequences make the rDNA inherently unstable and particularly susceptible to large variations in repeat copy number. Despite mounting evidence suggesting extra-ribosomal functions of the rDNA, its repetitive nature has excluded it from traditional sequencing-based studies. However, more recently, several studies have revealed the unique potential of the rDNA to act as a "canary in the coalmine," being particularly sensitive to genomic stresses and acting as a source of adaptive response. Here, we review evidence uncovering mechanisms of regulation of instability and copy number variation at the rDNA and their role in adaptation to the environment, which could serve to understand the basic principles governing the behavior of other tandem repeats and their role in shaping the genome. More... »

PAGES

73-87

References to SciGraph publications

  • 2016-07. The nature of mutations induced by replication–transcription collisions in NATURE
  • 2007-07. Methods and strategies for analyzing copy number variation using DNA microarrays in NATURE GENETICS
  • 2012-03. Transcription as a source of genome instability in NATURE REVIEWS GENETICS
  • 2012-07. Pericentric and centromeric transcription: a perfect balance required in CHROMOSOME RESEARCH
  • 2016-09. Transcription-replication conflicts: how they occur and how they are resolved in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-03. Accelerated gene evolution through replication–transcription conflicts in NATURE
  • 2018-09. Alpha satellite DNA biology: finding function in the recesses of the genome in CHROMOSOME RESEARCH
  • 2018-04. Genome evolution across 1,011 Saccharomyces cerevisiae isolates in NATURE
  • 2011-11. RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II in NATURE
  • 2010-06. DNA damage response and tumorigenesis in Mcm2-deficient mice in ONCOGENE
  • 2014-08. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells in NATURE
  • 2002-02. The genome sequence of Schizosaccharomyces pombe in NATURE
  • 2015-12. RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships in EPIGENETICS & CHROMATIN
  • 2014-12. Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans in NATURE COMMUNICATIONS
  • 2008-12. Analysis of the largest tandemly repeated DNA families in the human genome in BMC GENOMICS
  • 2006-11. Global variation in copy number in the human genome in NATURE
  • 2014-12. Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease in CELL & BIOSCIENCE
  • 2017. Human Chromosome Variation: Heteromorphism, Polymorphism and Pathogenesis in NONE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10577-018-9599-7

    DOI

    http://dx.doi.org/10.1007/s10577-018-9599-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111057769

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30604343


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