Keeping ribosomal DNA intact: a repeating challenge View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Daniël O. Warmerdam, Rob M. F. Wolthuis

ABSTRACT

More than half of the human genome consists of repetitive sequences, with the ribosomal DNA (rDNA) representing two of the largest repeats. Repetitive rDNA sequences may form a threat to genomic integrity and cellular homeostasis due to the challenging aspects of their transcription, replication, and repair. Predisposition to cancer, premature aging, and neurological impairment in ataxia-telangiectasia and Bloom syndrome, for instance, coincide with increased cellular rDNA repeat instability. However, the mechanisms by which rDNA instability contributes to these hereditary syndromes and tumorigenesis remain unknown. Here, we review how cells govern rDNA stability and how rDNA break repair influences expansion and contraction of repeat length, a process likely associated with human disease. Recent advancements in CRISPR-based genome engineering may help to explain how cells keep their rDNA intact in the near future. More... »

PAGES

57-72

References to SciGraph publications

  • 2016-12. Phase separation in biology; functional organization of a higher order in CELL COMMUNICATION AND SIGNALING
  • 2017-03-23. PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription in NATURE COMMUNICATIONS
  • 2014-12. Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease in CELL & BIOSCIENCE
  • 2014-12. Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans in NATURE COMMUNICATIONS
  • 2014-08. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells in NATURE
  • 2017-11-02. Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients in ONCOGENE
  • 2015-10. R loops: new modulators of genome dynamics and function in NATURE REVIEWS GENETICS
  • 2018-02-05. Tandem repeats mediating genetic plasticity in health and disease in NATURE REVIEWS GENETICS
  • 2016-04. Mechanisms underlying structural variant formation in genomic disorders in NATURE REVIEWS GENETICS
  • 2009-10. The DNA-damage response in human biology and disease in NATURE
  • 2014-06. Mechanisms and principles of homology search during recombination in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-08. The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus in NATURE CELL BIOLOGY
  • 2012-04. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation in NATURE CELL BIOLOGY
  • 2008-03. Genome instability: a mechanistic view of its causes and consequences in NATURE REVIEWS GENETICS
  • 2002-12. Mutations in PHF6 are associated with Börjeson–Forssman–Lehmann syndrome in NATURE GENETICS
  • 2014-03-05. C9orf72 nucleotide repeat structures initiate molecular cascades of disease in NATURE
  • 2017-04. Visualization of aging-associated chromatin alterations with an engineered TALE system in CELL RESEARCH
  • 2017-02-17. CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours in NATURE COMMUNICATIONS
  • 2009-02. DNA repair deficiency and neurological disease in NATURE REVIEWS NEUROSCIENCE
  • 2018-02. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders in NATURE
  • 2002-04. WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex in ONCOGENE
  • 2016-11-09. Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase in NATURE COMMUNICATIONS
  • 2016-10. The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2007-07. The multifunctional nucleolus in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-08. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion in NATURE CELL BIOLOGY
  • 2010-04. PHF6 mutations in T-cell acute lymphoblastic leukemia in NATURE GENETICS
  • 2015. Genome Engineering Using CRISPR-Cas9 System in CHROMOSOMAL MUTAGENESIS
  • 2017-06. Smc5/6 complex regulates Sgs1 recombination functions in CURRENT GENETICS
  • 2015-01. Targeting RNA polymerase I to treat MYC-driven cancer in ONCOGENE
  • 2008-01. Regulation of DNA double-strand break repair pathway choice in CELL RESEARCH
  • 2017-04. A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress in NATURE MEDICINE
  • 2011-03. Aberrant chromosome morphology in human cells defective for Holliday junction resolution in NATURE
  • 2018-05. Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis in ONCOGENE
  • 2018-09. C9orf72-mediated ALS and FTD: multiple pathways to disease in NATURE REVIEWS NEUROLOGY
  • Journal

    TITLE

    Chromosome Research

    ISSUE

    1-2

    VOLUME

    27

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10577-018-9594-z

    DOI

    http://dx.doi.org/10.1007/s10577-018-9594-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110684838

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30556094


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "CRISPR Platform, University of Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warmerdam", 
            "givenName": "Dani\u00ebl O.", 
            "id": "sg:person.0737741245.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737741245.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.12380.38", 
              "name": [
                "Section of Oncogenetics, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, de Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolthuis", 
            "givenName": "Rob M. F.", 
            "id": "sg:person.0660076121.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660076121.62"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.molmed.2013.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000085352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(02)02592-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000179704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2014.03.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000322631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2007.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477639", 
              "https://doi.org/10.1038/cr.2007.111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0804615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000521354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002207466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002318019", 
              "https://doi.org/10.1038/onc.2014.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/genesandcancer.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003498371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.02.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003642100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.02.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003642100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.24.9178-9188.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003879106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m115.682161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004167207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddp282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005205447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.283838.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005907574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.20723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006314895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1416878112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007049863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.24.3821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007539428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008470674", 
              "https://doi.org/10.1038/ncb1909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0906811106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008649415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1724308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009643202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1567-1364.12133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009977846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcancer.2015.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010536276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.544509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010898430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms13272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010907289", 
              "https://doi.org/10.1038/ncomms13272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-060713-035428", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011040017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-1862-1_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011080229", 
              "https://doi.org/10.1007/978-1-4939-1862-1_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0027-5107(02)00224-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011125357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0027-5107(02)00224-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011125357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012357188", 
              "https://doi.org/10.1038/nature09790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.6858507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012638078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.16.6899-6911.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013548596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2009.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013869115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12964-015-0125-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015503895", 
              "https://doi.org/10.1186/s12964-015-0125-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00414-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015859511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.082230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016194603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a011130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016291082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016766471", 
              "https://doi.org/10.1038/nature13619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016950723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrrev.2009.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017262076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2005.033084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017338247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2013.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017773258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/genes6020325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020158867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(01)00650-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020694115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.100448097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020922624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020923218", 
              "https://doi.org/10.1038/ng.542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020923218", 
              "https://doi.org/10.1038/ng.542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0012175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021172112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.260844.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021345808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2045-3701-4-43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022000628", 
              "https://doi.org/10.1186/2045-3701-4-43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022335019", 
              "https://doi.org/10.1038/ncb1619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.2015.80.027649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022684102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7400940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022849766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7400940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022849766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1179044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023162111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2183/pjab.90.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023230201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023891364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023910701", 
              "https://doi.org/10.1038/nrm2184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.221648.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023939368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2009.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024715220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01521-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025785675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026371501", 
              "https://doi.org/10.1038/nrg2268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026771555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2008.57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026980803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/embr.201337974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028003115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14728222.2013.818658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028046544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.111948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028147632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2013.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029364736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddr545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029583107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029770852", 
              "https://doi.org/10.1038/nrg3961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2015.25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029815690", 
              "https://doi.org/10.1038/nrg.2015.25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/rdis.27743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029989056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2008.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030221990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031446853", 
              "https://doi.org/10.1038/ncb2466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2013.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032007304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032849534", 
              "https://doi.org/10.1038/nrm3805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.24.110707.175259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034155807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.09.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034178752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034809007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2014.11.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035325932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200906075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035624304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.20533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035627248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036381124", 
              "https://doi.org/10.1038/nrn2559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e05-11-1006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037144397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-10-178129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037385191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037648002", 
              "https://doi.org/10.1038/nature13124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2016.40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038676358", 
              "https://doi.org/10.1038/ejhg.2016.40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2009.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039143782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.414839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039152394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040280875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq1326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041001597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-14-0673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041974121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagrm.2012.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042286380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.280545.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042360400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042937965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043125346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1140321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043601744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1422488112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044412007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044755469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2010.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044812347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-1728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045180438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.101006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045750705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.08.085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046528264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.178723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047116188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047284236", 
              "https://doi.org/10.1038/sj.onc.1205334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047284236", 
              "https://doi.org/10.1038/sj.onc.1205334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047284773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/genes7090069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047506432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047653219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-7992(94)90031-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048352191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048481025", 
              "https://doi.org/10.1038/ncomms5850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00294-016-0648-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048625005", 
              "https://doi.org/10.1007/s00294-016-0648-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00294-016-0648-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048625005", 
              "https://doi.org/10.1007/s00294-016-0648-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trecan.2015.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049413016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.2020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050574322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0360619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050972723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0360619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050972723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051337704", 
              "https://doi.org/10.1038/ng1040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051337704", 
              "https://doi.org/10.1038/ng1040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.3970105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052185670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.260703.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052319602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2004.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052780384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.04.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053688201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr3004369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056293068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3336775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062607892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2003477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062682818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1389450114666140106100909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069181241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.28627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072297620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1615395114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074211498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2017.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083396243", 
              "https://doi.org/10.1038/cr.2017.18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms14432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083846215", 
              "https://doi.org/10.1038/ncomms14432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/19491034.2017.1292193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083928193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms14771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128983", 
              "https://doi.org/10.1038/ncomms14771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129239", 
              "https://doi.org/10.1038/nm.4291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/genes8030098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084435552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2017.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084929342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086112961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms18071411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090318052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2017.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090575706", 
              "https://doi.org/10.1038/onc.2017.86"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkx655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090756091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkx741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091273993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091500999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1007006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091786226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/genes8100279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092273631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.schres.2018.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100319379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100587793", 
              "https://doi.org/10.1038/nature25449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100587793", 
              "https://doi.org/10.1038/nature25449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dmm.031930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100713244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2017.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100820187", 
              "https://doi.org/10.1038/nrg.2017.115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41388-017-0121-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100925147", 
              "https://doi.org/10.1038/s41388-017-0121-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41388-017-0121-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100925147", 
              "https://doi.org/10.1038/s41388-017-0121-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddy049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101024279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2018.00075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101220378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.201700229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101849001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1720391115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103477389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1720391115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103477389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2018.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104038318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2018.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104038318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.315192.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105813146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41582-018-0047-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106156386", 
              "https://doi.org/10.1038/s41582-018-0047-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41582-018-0047-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106156386", 
              "https://doi.org/10.1038/s41582-018-0047-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41582-018-0047-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106156386", 
              "https://doi.org/10.1038/s41582-018-0047-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jnc.14576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106334132"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "More than half of the human genome consists of repetitive sequences, with the ribosomal DNA (rDNA) representing two of the largest repeats. Repetitive rDNA sequences may form a threat to genomic integrity and cellular homeostasis due to the challenging aspects of their transcription, replication, and repair. Predisposition to cancer, premature aging, and neurological impairment in ataxia-telangiectasia and Bloom syndrome, for instance, coincide with increased cellular rDNA repeat instability. However, the mechanisms by which rDNA instability contributes to these hereditary syndromes and tumorigenesis remain unknown. Here, we review how cells govern rDNA stability and how rDNA break repair influences expansion and contraction of repeat length, a process likely associated with human disease. Recent advancements in CRISPR-based genome engineering may help to explain how cells keep their rDNA intact in the near future.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10577-018-9594-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1104385", 
            "issn": [
              "0967-3849", 
              "1573-6849"
            ], 
            "name": "Chromosome Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1-2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "27"
          }
        ], 
        "name": "Keeping ribosomal DNA intact: a repeating challenge", 
        "pagination": "57-72", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "dbc48383a70b875459335a6ce19a710c7229288c34d441c5fe9e63b734263a6c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30556094"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9313452"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10577-018-9594-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110684838"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10577-018-9594-z", 
          "https://app.dimensions.ai/details/publication/pub.1110684838"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130792_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs10577-018-9594-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10577-018-9594-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10577-018-9594-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10577-018-9594-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10577-018-9594-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    563 TRIPLES      21 PREDICATES      179 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10577-018-9594-z schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N92cf966f4a6849f5b618b3d1c0ca4561
    4 schema:citation sg:pub.10.1007/978-1-4939-1862-1_10
    5 sg:pub.10.1007/s00294-016-0648-5
    6 sg:pub.10.1038/cr.2007.111
    7 sg:pub.10.1038/cr.2017.18
    8 sg:pub.10.1038/ejhg.2016.40
    9 sg:pub.10.1038/nature08467
    10 sg:pub.10.1038/nature09790
    11 sg:pub.10.1038/nature13124
    12 sg:pub.10.1038/nature13619
    13 sg:pub.10.1038/nature25449
    14 sg:pub.10.1038/ncb1619
    15 sg:pub.10.1038/ncb1909
    16 sg:pub.10.1038/ncb2466
    17 sg:pub.10.1038/ncomms13272
    18 sg:pub.10.1038/ncomms14432
    19 sg:pub.10.1038/ncomms14771
    20 sg:pub.10.1038/ncomms5850
    21 sg:pub.10.1038/ng.542
    22 sg:pub.10.1038/ng1040
    23 sg:pub.10.1038/nm.4291
    24 sg:pub.10.1038/nrg.2015.25
    25 sg:pub.10.1038/nrg.2017.115
    26 sg:pub.10.1038/nrg2268
    27 sg:pub.10.1038/nrg3961
    28 sg:pub.10.1038/nrm2184
    29 sg:pub.10.1038/nrm3805
    30 sg:pub.10.1038/nrn2559
    31 sg:pub.10.1038/onc.2014.13
    32 sg:pub.10.1038/onc.2017.86
    33 sg:pub.10.1038/s41388-017-0121-z
    34 sg:pub.10.1038/s41582-018-0047-2
    35 sg:pub.10.1038/sj.onc.1205334
    36 sg:pub.10.1186/2045-3701-4-43
    37 sg:pub.10.1186/s12964-015-0125-7
    38 https://doi.org/10.1002/bies.201700229
    39 https://doi.org/10.1002/bies.20723
    40 https://doi.org/10.1002/embr.201337974
    41 https://doi.org/10.1016/0165-7992(94)90031-0
    42 https://doi.org/10.1016/j.bbadis.2013.09.016
    43 https://doi.org/10.1016/j.bbadis.2013.12.009
    44 https://doi.org/10.1016/j.bbadis.2013.12.012
    45 https://doi.org/10.1016/j.bbagrm.2012.10.014
    46 https://doi.org/10.1016/j.ccr.2012.05.019
    47 https://doi.org/10.1016/j.ccr.2013.12.009
    48 https://doi.org/10.1016/j.ceb.2017.03.004
    49 https://doi.org/10.1016/j.cell.2012.03.003
    50 https://doi.org/10.1016/j.cell.2014.09.031
    51 https://doi.org/10.1016/j.cell.2016.04.047
    52 https://doi.org/10.1016/j.celrep.2015.08.085
    53 https://doi.org/10.1016/j.celrep.2016.02.048
    54 https://doi.org/10.1016/j.dnarep.2009.01.009
    55 https://doi.org/10.1016/j.dnarep.2009.01.015
    56 https://doi.org/10.1016/j.dnarep.2014.03.023
    57 https://doi.org/10.1016/j.gene.2014.11.010
    58 https://doi.org/10.1016/j.molcel.2009.06.020
    59 https://doi.org/10.1016/j.molcel.2010.09.019
    60 https://doi.org/10.1016/j.molcel.2010.09.024
    61 https://doi.org/10.1016/j.molcel.2016.08.004
    62 https://doi.org/10.1016/j.molmed.2013.07.005
    63 https://doi.org/10.1016/j.mrrev.2009.12.001
    64 https://doi.org/10.1016/j.schres.2018.01.001
    65 https://doi.org/10.1016/j.semcancer.2015.12.004
    66 https://doi.org/10.1016/j.tcb.2018.03.007
    67 https://doi.org/10.1016/j.tibs.2004.12.008
    68 https://doi.org/10.1016/j.trecan.2015.07.007
    69 https://doi.org/10.1016/s0027-5107(02)00224-5
    70 https://doi.org/10.1016/s0092-8674(04)00414-3
    71 https://doi.org/10.1016/s0168-9525(02)02592-1
    72 https://doi.org/10.1016/s0960-9822(01)00650-9
    73 https://doi.org/10.1021/pr3004369
    74 https://doi.org/10.1038/emboj.2008.11
    75 https://doi.org/10.1038/emboj.2008.57
    76 https://doi.org/10.1038/emboj.2010.17
    77 https://doi.org/10.1038/sj.embor.7400940
    78 https://doi.org/10.1042/bst0360619
    79 https://doi.org/10.1056/nejmra0804615
    80 https://doi.org/10.1073/pnas.0906811106
    81 https://doi.org/10.1073/pnas.100448097
    82 https://doi.org/10.1073/pnas.1416878112
    83 https://doi.org/10.1073/pnas.1422488112
    84 https://doi.org/10.1073/pnas.1615395114
    85 https://doi.org/10.1073/pnas.1720391115
    86 https://doi.org/10.1074/jbc.m112.414839
    87 https://doi.org/10.1074/jbc.m115.682161
    88 https://doi.org/10.1080/19491034.2017.1292193
    89 https://doi.org/10.1083/jcb.200906075
    90 https://doi.org/10.1091/mbc.e05-11-1006
    91 https://doi.org/10.1093/hmg/ddp282
    92 https://doi.org/10.1093/hmg/ddr545
    93 https://doi.org/10.1093/hmg/ddy049
    94 https://doi.org/10.1093/nar/gki712
    95 https://doi.org/10.1093/nar/gkq1326
    96 https://doi.org/10.1093/nar/gkr589
    97 https://doi.org/10.1093/nar/gkv1312
    98 https://doi.org/10.1093/nar/gkx655
    99 https://doi.org/10.1093/nar/gkx741
    100 https://doi.org/10.1101/cshperspect.a011130
    101 https://doi.org/10.1101/gad.12.24.3821
    102 https://doi.org/10.1101/gad.1724308
    103 https://doi.org/10.1101/gad.221648.113
    104 https://doi.org/10.1101/gad.260703.115
    105 https://doi.org/10.1101/gad.260844.115
    106 https://doi.org/10.1101/gad.280545.116
    107 https://doi.org/10.1101/gad.283838.116
    108 https://doi.org/10.1101/gad.315192.118
    109 https://doi.org/10.1101/gad.544509
    110 https://doi.org/10.1101/gr.3970105
    111 https://doi.org/10.1101/gr.6858507
    112 https://doi.org/10.1101/sqb.2015.80.027649
    113 https://doi.org/10.1111/1567-1364.12133
    114 https://doi.org/10.1111/jnc.14576
    115 https://doi.org/10.1126/science.1140321
    116 https://doi.org/10.1126/science.1179044
    117 https://doi.org/10.1126/science.3336775
    118 https://doi.org/10.1126/scisignal.2003477
    119 https://doi.org/10.1128/mcb.01521-14
    120 https://doi.org/10.1128/mcb.23.24.9178-9188.2003
    121 https://doi.org/10.1128/mcb.25.16.6899-6911.2005
    122 https://doi.org/10.1136/jmg.2005.033084
    123 https://doi.org/10.1146/annurev-biochem-060713-035428
    124 https://doi.org/10.1146/annurev.cellbio.24.110707.175259
    125 https://doi.org/10.1158/0008-5472.can-09-2680
    126 https://doi.org/10.1158/0008-5472.can-10-1728
    127 https://doi.org/10.1158/1535-7163.mct-14-0256
    128 https://doi.org/10.1158/2159-8290.cd-14-0673
    129 https://doi.org/10.1182/blood-2009-10-178129
    130 https://doi.org/10.1242/dmm.031930
    131 https://doi.org/10.1242/jcs.082230
    132 https://doi.org/10.1242/jcs.101006
    133 https://doi.org/10.1242/jcs.111948
    134 https://doi.org/10.1242/jcs.178723
    135 https://doi.org/10.1371/journal.pgen.1002749
    136 https://doi.org/10.1371/journal.pgen.1006771
    137 https://doi.org/10.1371/journal.pgen.1006994
    138 https://doi.org/10.1371/journal.pgen.1007006
    139 https://doi.org/10.1371/journal.pone.0012175
    140 https://doi.org/10.1517/14728222.2013.818658
    141 https://doi.org/10.18632/genesandcancer.14
    142 https://doi.org/10.18632/oncotarget.2020
    143 https://doi.org/10.2174/1389450114666140106100909
    144 https://doi.org/10.2183/pjab.90.119
    145 https://doi.org/10.3389/fnins.2018.00075
    146 https://doi.org/10.3390/genes6020325
    147 https://doi.org/10.3390/genes7090069
    148 https://doi.org/10.3390/genes8030098
    149 https://doi.org/10.3390/genes8100279
    150 https://doi.org/10.3390/ijms18071411
    151 https://doi.org/10.4161/cc.28627
    152 https://doi.org/10.4161/rdis.27743
    153 https://doi.org/10.7554/elife.20533
    154 schema:datePublished 2019-03
    155 schema:datePublishedReg 2019-03-01
    156 schema:description More than half of the human genome consists of repetitive sequences, with the ribosomal DNA (rDNA) representing two of the largest repeats. Repetitive rDNA sequences may form a threat to genomic integrity and cellular homeostasis due to the challenging aspects of their transcription, replication, and repair. Predisposition to cancer, premature aging, and neurological impairment in ataxia-telangiectasia and Bloom syndrome, for instance, coincide with increased cellular rDNA repeat instability. However, the mechanisms by which rDNA instability contributes to these hereditary syndromes and tumorigenesis remain unknown. Here, we review how cells govern rDNA stability and how rDNA break repair influences expansion and contraction of repeat length, a process likely associated with human disease. Recent advancements in CRISPR-based genome engineering may help to explain how cells keep their rDNA intact in the near future.
    157 schema:genre research_article
    158 schema:inLanguage en
    159 schema:isAccessibleForFree false
    160 schema:isPartOf N73006982c5dc49f9974d9f045b49f807
    161 Nfd1cc99e6eb5487c83613e553c42f255
    162 sg:journal.1104385
    163 schema:name Keeping ribosomal DNA intact: a repeating challenge
    164 schema:pagination 57-72
    165 schema:productId N0566fed99296410298a88e67f71f3724
    166 N2dfc3756c08045348527eac6da09ab7b
    167 N81dbc029eb074b1cad85ee3fe4a50d8c
    168 N88a4c6dc582d4bc1b2752fb584431eeb
    169 Naf1c3a8e4dfd439d918874a365c7fe3d
    170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110684838
    171 https://doi.org/10.1007/s10577-018-9594-z
    172 schema:sdDatePublished 2019-04-11T13:48
    173 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    174 schema:sdPublisher Nff8adbbdbea8434ca3d8deac1b01b629
    175 schema:url https://link.springer.com/10.1007%2Fs10577-018-9594-z
    176 sgo:license sg:explorer/license/
    177 sgo:sdDataset articles
    178 rdf:type schema:ScholarlyArticle
    179 N0566fed99296410298a88e67f71f3724 schema:name doi
    180 schema:value 10.1007/s10577-018-9594-z
    181 rdf:type schema:PropertyValue
    182 N2dfc3756c08045348527eac6da09ab7b schema:name nlm_unique_id
    183 schema:value 9313452
    184 rdf:type schema:PropertyValue
    185 N73006982c5dc49f9974d9f045b49f807 schema:volumeNumber 27
    186 rdf:type schema:PublicationVolume
    187 N7b501e77f8204838ad2a7e9375197c73 rdf:first sg:person.0660076121.62
    188 rdf:rest rdf:nil
    189 N81dbc029eb074b1cad85ee3fe4a50d8c schema:name dimensions_id
    190 schema:value pub.1110684838
    191 rdf:type schema:PropertyValue
    192 N88a4c6dc582d4bc1b2752fb584431eeb schema:name readcube_id
    193 schema:value dbc48383a70b875459335a6ce19a710c7229288c34d441c5fe9e63b734263a6c
    194 rdf:type schema:PropertyValue
    195 N92cf966f4a6849f5b618b3d1c0ca4561 rdf:first sg:person.0737741245.50
    196 rdf:rest N7b501e77f8204838ad2a7e9375197c73
    197 Naf1c3a8e4dfd439d918874a365c7fe3d schema:name pubmed_id
    198 schema:value 30556094
    199 rdf:type schema:PropertyValue
    200 Nfd1cc99e6eb5487c83613e553c42f255 schema:issueNumber 1-2
    201 rdf:type schema:PublicationIssue
    202 Nff8adbbdbea8434ca3d8deac1b01b629 schema:name Springer Nature - SN SciGraph project
    203 rdf:type schema:Organization
    204 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Biological Sciences
    206 rdf:type schema:DefinedTerm
    207 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Genetics
    209 rdf:type schema:DefinedTerm
    210 sg:journal.1104385 schema:issn 0967-3849
    211 1573-6849
    212 schema:name Chromosome Research
    213 rdf:type schema:Periodical
    214 sg:person.0660076121.62 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
    215 schema:familyName Wolthuis
    216 schema:givenName Rob M. F.
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660076121.62
    218 rdf:type schema:Person
    219 sg:person.0737741245.50 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
    220 schema:familyName Warmerdam
    221 schema:givenName Daniël O.
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737741245.50
    223 rdf:type schema:Person
    224 sg:pub.10.1007/978-1-4939-1862-1_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011080229
    225 https://doi.org/10.1007/978-1-4939-1862-1_10
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00294-016-0648-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048625005
    228 https://doi.org/10.1007/s00294-016-0648-5
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/cr.2007.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477639
    231 https://doi.org/10.1038/cr.2007.111
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/cr.2017.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083396243
    234 https://doi.org/10.1038/cr.2017.18
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/ejhg.2016.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038676358
    237 https://doi.org/10.1038/ejhg.2016.40
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature08467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581766
    240 https://doi.org/10.1038/nature08467
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature09790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012357188
    243 https://doi.org/10.1038/nature09790
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature13124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037648002
    246 https://doi.org/10.1038/nature13124
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nature13619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016766471
    249 https://doi.org/10.1038/nature13619
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nature25449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100587793
    252 https://doi.org/10.1038/nature25449
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ncb1619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022335019
    255 https://doi.org/10.1038/ncb1619
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/ncb1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008470674
    258 https://doi.org/10.1038/ncb1909
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/ncb2466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031446853
    261 https://doi.org/10.1038/ncb2466
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/ncomms13272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010907289
    264 https://doi.org/10.1038/ncomms13272
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ncomms14432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083846215
    267 https://doi.org/10.1038/ncomms14432
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ncomms14771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128983
    270 https://doi.org/10.1038/ncomms14771
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/ncomms5850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048481025
    273 https://doi.org/10.1038/ncomms5850
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/ng.542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020923218
    276 https://doi.org/10.1038/ng.542
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/ng1040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051337704
    279 https://doi.org/10.1038/ng1040
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nm.4291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129239
    282 https://doi.org/10.1038/nm.4291
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nrg.2015.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029815690
    285 https://doi.org/10.1038/nrg.2015.25
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nrg.2017.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100820187
    288 https://doi.org/10.1038/nrg.2017.115
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nrg2268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026371501
    291 https://doi.org/10.1038/nrg2268
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nrg3961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029770852
    294 https://doi.org/10.1038/nrg3961
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nrm2184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023910701
    297 https://doi.org/10.1038/nrm2184
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nrm3805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032849534
    300 https://doi.org/10.1038/nrm3805
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nrn2559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036381124
    303 https://doi.org/10.1038/nrn2559
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/onc.2014.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002318019
    306 https://doi.org/10.1038/onc.2014.13
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/onc.2017.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090575706
    309 https://doi.org/10.1038/onc.2017.86
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/s41388-017-0121-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100925147
    312 https://doi.org/10.1038/s41388-017-0121-z
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/s41582-018-0047-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106156386
    315 https://doi.org/10.1038/s41582-018-0047-2
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/sj.onc.1205334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047284236
    318 https://doi.org/10.1038/sj.onc.1205334
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1186/2045-3701-4-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022000628
    321 https://doi.org/10.1186/2045-3701-4-43
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1186/s12964-015-0125-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015503895
    324 https://doi.org/10.1186/s12964-015-0125-7
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1002/bies.201700229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101849001
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1002/bies.20723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006314895
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1002/embr.201337974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028003115
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/0165-7992(94)90031-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048352191
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.bbadis.2013.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032007304
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/j.bbadis.2013.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029364736
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/j.bbadis.2013.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017773258
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/j.bbagrm.2012.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042286380
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/j.ccr.2012.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040280875
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1016/j.ccr.2013.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016950723
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/j.ceb.2017.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084929342
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/j.cell.2012.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047284773
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.cell.2014.09.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034178752
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.cell.2016.04.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053688201
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.celrep.2015.08.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046528264
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.celrep.2016.02.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003642100
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/j.dnarep.2009.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039143782
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/j.dnarep.2009.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013869115
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/j.dnarep.2014.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000322631
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/j.gene.2014.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035325932
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/j.molcel.2009.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024715220
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/j.molcel.2010.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198160
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/j.molcel.2010.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044755469
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/j.molcel.2016.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042937965
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/j.molmed.2013.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000085352
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/j.mrrev.2009.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017262076
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/j.schres.2018.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100319379
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/j.semcancer.2015.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010536276
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/j.tcb.2018.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104038318
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.tibs.2004.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052780384
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/j.trecan.2015.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049413016
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/s0027-5107(02)00224-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011125357
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/s0092-8674(04)00414-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015859511
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/s0168-9525(02)02592-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000179704
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/s0960-9822(01)00650-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020694115
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1021/pr3004369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293068
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1038/emboj.2008.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030221990
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1038/emboj.2008.57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026980803
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1038/emboj.2010.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044812347
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1038/sj.embor.7400940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022849766
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1042/bst0360619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050972723
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1056/nejmra0804615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000521354
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1073/pnas.0906811106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008649415
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1073/pnas.100448097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020922624
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1073/pnas.1416878112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007049863
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1073/pnas.1422488112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044412007
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1073/pnas.1615395114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074211498
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1073/pnas.1720391115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103477389
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1074/jbc.m112.414839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039152394
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1074/jbc.m115.682161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004167207
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1080/19491034.2017.1292193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083928193
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1083/jcb.200906075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035624304
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1091/mbc.e05-11-1006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037144397
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1093/hmg/ddp282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005205447
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1093/hmg/ddr545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029583107
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1093/hmg/ddy049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101024279
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1093/nar/gki712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023891364
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1093/nar/gkq1326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041001597
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1093/nar/gkr589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043125346
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1093/nar/gkv1312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034809007
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1093/nar/gkx655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090756091
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1093/nar/gkx741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091273993
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1101/cshperspect.a011130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016291082
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1101/gad.12.24.3821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007539428
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1101/gad.1724308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009643202
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1101/gad.221648.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023939368
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1101/gad.260703.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319602
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1101/gad.260844.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021345808
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1101/gad.280545.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042360400
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1101/gad.283838.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907574
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1101/gad.315192.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105813146
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1101/gad.544509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898430
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1101/gr.3970105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052185670
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1101/gr.6858507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012638078
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1101/sqb.2015.80.027649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022684102
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1111/1567-1364.12133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009977846
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1111/jnc.14576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106334132
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1126/science.1140321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043601744
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1126/science.1179044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023162111
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1126/science.3336775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062607892
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1126/scisignal.2003477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682818
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1128/mcb.01521-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025785675
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1128/mcb.23.24.9178-9188.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003879106
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1128/mcb.25.16.6899-6911.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013548596
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1136/jmg.2005.033084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017338247
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1146/annurev-biochem-060713-035428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011040017
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1146/annurev.cellbio.24.110707.175259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034155807
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1158/0008-5472.can-09-2680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002207466
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1158/0008-5472.can-10-1728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045180438
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1158/1535-7163.mct-14-0256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026771555
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1158/2159-8290.cd-14-0673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041974121
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1182/blood-2009-10-178129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037385191
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1242/dmm.031930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100713244
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1242/jcs.082230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016194603
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1242/jcs.101006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045750705
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1242/jcs.111948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028147632
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1242/jcs.178723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047116188
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1371/journal.pgen.1002749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047653219
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1371/journal.pgen.1006771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086112961
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1371/journal.pgen.1006994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091500999
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1371/journal.pgen.1007006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091786226
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1371/journal.pone.0012175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021172112
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1517/14728222.2013.818658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028046544
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.18632/genesandcancer.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003498371
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.18632/oncotarget.2020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050574322
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.2174/1389450114666140106100909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069181241
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.2183/pjab.90.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023230201
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.3389/fnins.2018.00075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101220378
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.3390/genes6020325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020158867
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.3390/genes7090069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047506432
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.3390/genes8030098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084435552
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.3390/genes8100279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092273631
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.3390/ijms18071411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090318052
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.4161/cc.28627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297620
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.4161/rdis.27743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029989056
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.7554/elife.20533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035627248
    557 rdf:type schema:CreativeWork
    558 https://www.grid.ac/institutes/grid.12380.38 schema:alternateName VU University Amsterdam
    559 schema:name Section of Oncogenetics, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, de Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands
    560 rdf:type schema:Organization
    561 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
    562 schema:name CRISPR Platform, University of Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands
    563 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...