Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Enkhjargal Tsend-Ayush, R. Daniel Kortschak, Pascal Bernard, Shu Ly Lim, Janelle Ryan, Ruben Rosenkranz, Tatiana Borodina, Juliane C. Dohm, Heinz Himmelbauer, Vincent R. Harley, Frank Grützner

ABSTRACT

The basal lineage of monotremes features an extraordinarily complex sex chromosome system which has provided novel insights into the evolution of mammalian sex chromosomes. Recently, sequence information from autosomes, X chromosomes, and XY-shared pseudoautosomal regions has become available. However, no gene has so far been described on any of the Y chromosome-specific regions. We analyzed sequences derived from Y-specific BAC clones to identify genes with potentially male-specific function. Here, we report the identification and characterization of the mediator complex protein gametologs on platypus Y5 (Crspy). We also identified the X-chromosomal copy which unexpectedly maps to X1 (Crspx). Sequence comparison shows extensive divergence between the X and Y copy, but we found no significant positive selection on either gametolog. Expression analysis shows widespread expression of Crspx. Crspy is expressed exclusively in males with particularly strong expression in testis and kidney. Reporter gene assays to investigate whether Crspx/y can act on the recently discovered mouse Sox9 testis-specific enhancer element did reveal a modest effect together with mouse Sox9 + Sf1, but showed overall no significant upregulation of the reporter gene. This is the first report of a differentiated functional male-specific gene on platypus Y chromosomes, providing new insights into sex chromosome evolution and a candidate gene for male-specific function in monotremes. More... »

PAGES

127-138

References to SciGraph publications

  • 2008-06. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer in NATURE
  • 2007-07. Role of the epididymis in sperm competition in ASIAN JOURNAL OF ANDROLOGY
  • 2004-12. In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes in NATURE
  • 2009-03. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome in GENOME BIOLOGY
  • 2005-08. Steps in the evolution of heteromorphic sex chromosomes in HEREDITY
  • 2003-06. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes in NATURE
  • 2003-06. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes in NATURE
  • 2008-05-08. Genome analysis of the platypus reveals unique signatures of evolution in NATURE
  • 2007-11. The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z in GENOME BIOLOGY
  • 2006-01. Fast Accumulation of Nonsynonymous Mutations on the Female-Specific W Chromosome in Birds in JOURNAL OF MOLECULAR EVOLUTION
  • 1999-02. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 in NATURE
  • 2009-02. Higher-order genome organization in platypus and chicken sperm and repositioning of sex chromosomes during mammalian evolution in CHROMOSOMA
  • 2007-08. Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes in GENOME BIOLOGY
  • 2007-08. PyCogent: a toolkit for making sense from sequence in GENOME BIOLOGY
  • 2010-11. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation in NATURE REVIEWS GENETICS
  • 1977-03. A unique cytogenetic system in monotremes in CHROMOSOMA
  • 2005-07. Male-Driven Evolution in Closely Related Species of the Mouse Genus Mus in JOURNAL OF MOLECULAR EVOLUTION
  • 2011-03. Sex-chromosome evolution: recent progress and the influence of male and female heterogamety in NATURE REVIEWS GENETICS
  • 2011-12. Cross-species chromosome painting tracks the independent origin of multiple sex chromosomes in two cofamiliar Erythrinidae fishes in BMC EVOLUTIONARY BIOLOGY
  • 2007-12. Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes in CHROMOSOME RESEARCH
  • 2010-01. Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content in NATURE
  • 2007-12. Evolutionary dynamics of autosomal-heterosomal rearrangements in a multiple-X chromosome system of tiger beetles (Cicindelidae) in BMC EVOLUTIONARY BIOLOGY
  • 2006-04. How did the platypus get its sex chromosome chain? A comparison of meiotic multiples and sex chromosomes in plants and animals in CHROMOSOMA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10577-011-9270-z

    DOI

    http://dx.doi.org/10.1007/s10577-011-9270-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019421911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22215486


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