Single-Cell Analysis for Glycogen Localization and Metabolism in Cultured Astrocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12-20

AUTHORS

Yuanyuan Zhu, Ze Fan, Rui Wang, Rougang Xie, Haiyun Guo, Ming Zhang, Baolin Guo, Tangna Sun, Haifeng Zhang, Lixia Zhuo, Yan Li, Shengxi Wu

ABSTRACT

Cerebral glycogen is principally localized in astrocytes rather than in neurons. Glycogen metabolism has been implicated in higher brain functions, including learning and memory, yet the distribution patterns of glycogen in different types of astrocytes have not been fully described. Here, we applied a method based on the incorporation of 2-NBDG, a d-glucose fluorescent derivative that can trace glycogen, to investigate glycogen’s distribution in the brain. We identified two types of astrocytes, namely, 2-NBDGI (glycogen-deficient) and 2-NBDGII (glycogen-rich) cells. Whole-cell patch-clamp and fluorescence-activated cell sorting (FACS) were used to separate 2-NBDGII astrocytes from 2-NBDGI astrocytes. The expression levels of glycogen metabolic enzymes were analyzed in 2-NBDGI and 2-NBDGII astrocytes. We found unique glycogen metabolic patterns between 2-NBDGI and 2-NBDGII astrocytes. We also observed that 2-NBDGII astrocytes were mainly identified as fibrous astrocytes but not protoplasmic astrocytes. Our data reveal cell type-dependent glycogen distribution and metabolism patterns, suggesting diverse functions of these different astrocytes. More... »

PAGES

801-812

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10571-019-00775-4

DOI

http://dx.doi.org/10.1007/s10571-019-00775-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123563862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31863221


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