Expression of Transforming Growth Factor-β Receptors in Meningeal Fibroblasts of the Injured Mouse Brain View Full Text


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Article Info

DATE

2009-08-04

AUTHORS

Yukari Komuta, Xichuan Teng, Hiroko Yanagisawa, Kazunori Sango, Koki Kawamura, Hitoshi Kawano

ABSTRACT

The fibrotic scar which is formed after traumatic damage of the central nervous system (CNS) is considered as a major impediment for axonal regeneration. In the process of the fibrotic scar formation, meningeal fibroblasts invade and proliferate in the lesion site to secrete extracellular matrix proteins, such as collagen and laminin. Thereafter, end feet of reactive astrocytes elaborate a glia limitans surrounding the fibrotic scar. Transforming growth factor-β1 (TGF-β1), a potent scar-inducing factor, which is upregulated after CNS injury, has been implicated in the formation of the fibrotic scar and glia limitans. In the present study, expression of receptors to TGF-β1 was examined by in situ hybridization histochemistry in transcortical knife lesions of the striatum in the mouse brain in combination with immunofluorescent staining for fibroblasts and astrocytes. Type I and type II TGF-β receptor mRNAs were barely detected in the intact brain and first found in meningeal cells near the lesion 1 day postinjury. Many cells expressing TGF-β receptors were found around the lesion site 3 days postinjury, and some of them were immunoreactive for fibronectin. After 5 days postinjury, many fibroblasts migrated from the meninges to the lesion site formed the fibrotic scar, and most of them expressed TGF-β receptors. In contrast, few of reactive astrocytes expressed the receptors throughout the postinjury period examined. These results indicate that meningeal fibroblasts not reactive astrocytes are a major target of TGF-β1 that is upregulated after CNS injury. More... »

PAGES

101-111

References to SciGraph publications

  • 1983. Deposition of Scar Tissue in the Central Nervous System in TRAUMA AND REGENERATION
  • 2004-02. Regeneration beyond the glial scar in NATURE REVIEWS NEUROSCIENCE
  • 2001-05-09. The astrocyte/meningeal cell interface – a barrier to successful nerve regeneration? in CELL AND TISSUE RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10571-009-9435-x

    DOI

    http://dx.doi.org/10.1007/s10571-009-9435-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019563484

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19653094


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