Cellulose ether derivatives: a new platform for prodrug formation of fluoroquinolone antibiotics View Full Text


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Article Info

DATE

2015-04-05

AUTHORS

Muhammad Amin, Nazia Shahana Abbas, Muhammad Ajaz Hussain, Kevin J. Edgar, Muhammad Nawaz Tahir, Wolfgang Tremel, Muhammad Sher

ABSTRACT

Novel macromolecular prodrugs of the second-generation fluoroquinolone antibiotic ofloxacin were fabricated based on the hydrophilic biopolymers hydroxypropylcellulose (HPC) and hydroxyethylcellulose (HEC). HPC- and HEC-ofloxacin conjugates were synthesized by activation of ofloxacin with p-toluenesulfonyl chloride under homogeneous reaction conditions at 70 °C in a one-pot synthesis. Structures of HPC- and HEC-ofloxacin conjugates were confirmed by spectroscopic and chromatographic techniques. Covalent drug loading was determined by UV/Vis spectrophotometry after hydrolysis of the conjugates. The results indicated significant covalent ofloxacin-loading (degree of substitution, 0.53–0.71 and 0.38–0.47) on HPC and HEC, respectively. All prodrugs were soluble in organic and aqueous solvents. Transmission electron microscopic analysis indicated formation of nanoparticles in the size range 100–250 nm and 150–210 nm for HPC- and HEC-ofloxacin conjugates, respectively. Ofloxacin, HPC-ofloxacin conjugate, and HEC-ofloxacin conjugate were orally administered to healthy male albino rabbits to determine pharmacokinetic parameters. Both HPC- and HEC-ofloxacin conjugates showed sustained release, with an increase in ofloxacin (control 1–3) half-life from 2.59, 4.56 and 4.63 h to 18.07 and 20.71 h, respectively. The relative AUC values clearly indicate ofloxacin oral bioavailability from conjugates that is enhanced, 1.6–1.8 and 2.1–2.3 times that of control. More... »

PAGES

2011-2022

References to SciGraph publications

  • 2000-12. Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin in COLLOID AND POLYMER SCIENCE
  • 2006-08-07. Synthesis and Characterization of Cellulose α-Lipoates: A Novel Material for Adsorption onto Gold in POLYMER BULLETIN
  • 2012-04-29. Water soluble photoactive cellulose derivatives: synthesis and characterization of mixed 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetic acid–(3-carboxypropyl)trimethylammonium chloride esters of cellulose in CELLULOSE
  • 2002-05. Self-Assembled Hydrogel Nanoparticles Responsive to Tumor Extracellular pH from Pullulan Derivative/Sulfonamide Conjugate: Characterization, Aggregation, and Adriamycin Release in Vitro in PHARMACEUTICAL RESEARCH
  • 2011-07-13. Synthesis of regioselectively brominated cellulose esters and 6-cyano-6-deoxycellulose esters in CELLULOSE
  • 2003-09. Unconventional Cellulose Esters: Synthesis, Characterization and Structure–Property Relations in CELLULOSE
  • 2011-11-03. Macromolecular prodrugs of aspirin with HPMC: A nano particulate drug design, characterization, and pharmacokinetic studies in MACROMOLECULAR RESEARCH
  • 2007-05-20. Oxygen and water vapor permeability of fully substituted long chain cellulose esters (LCCE) in CELLULOSE
  • 2011-03-19. Surface only modification of bacterial cellulose nanofibres with organic acids in CELLULOSE
  • 2013-01-05. Hydroxypropylcellulose-aceclofenac conjugates: high covalent loading design, structure characterization, nano-assemblies and thermal kinetics in CELLULOSE
  • 2012-05-22. Direct synthesis of cellulose adipate derivatives using adipic anhydride in CELLULOSE
  • 2014-10-10. Novel high-loaded, nanoparticulate and thermally stable macromolecular prodrug design of NSAIDs based on hydroxypropylcellulose in CELLULOSE
  • 2011-11-26. First report on the kinetics of the uncatalyzed esterification of cellulose under homogeneous reaction conditions: a rationale for the effect of carboxylic acid anhydride chain-length on the degree of biopolymer substitution in CELLULOSE
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    http://scigraph.springernature.com/pub.10.1007/s10570-015-0625-z

    DOI

    http://dx.doi.org/10.1007/s10570-015-0625-z

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