Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02

AUTHORS

Raghunath Das, Dipankar Das, Paulomi Ghosh, Animesh Ghosh, Santanu Dhara, A. B. Panda, Sagar Pal

ABSTRACT

Herein, the microwave-assisted grafting method was employed for the development of a novel pH-responsive graft copolymer derived from polyacrylamide-modified hydroxypropyl methyl cellulose [g-HPMC (M)]. The synthesised copolymer has been used for in vitro sustained release of ornidazole. Various characterizations confirm the formation of graft copolymer. Swelling studies indicate the pH-dependent swelling behaviour, while deswelling studies suggest that g-HPMC (M) shows faster deswelling in response to change in pH and/temperature. The cell viability study signifies that g-HPMC (M) is cytocompatible. The in-vitro release study demonstrates that g-HPMC (M) delivers ornidazole specifically in the colon pH, without release of the drug in the acidic environment, ensuring g-HPMC (M) as an ideal candidate for orally administered colonic drug carriers. The kinetics and mechanism of drug release suggest that it follows a non-Fickian release mechanism. More... »

PAGES

313-327

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10570-014-0511-0

DOI

http://dx.doi.org/10.1007/s10570-014-0511-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011744846


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