Synthesis of chitosan-graft-poly(sodium-l-glutamate) for preparation of protein nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Peter Perdih, David Pahovnik, Mateja Cegnar, Ana Miklavžin, Janez Kerč, Ema Žagar

ABSTRACT

In this manuscript we have designed a synthetic approach for the preparation of a series of chitosan-graft-poly(l-glutamate) copolymers with different lengths of poly(l-glutamate) grafts. First, organosulfonic chitosan salt, soluble in DMSO, was prepared in order to effectively initiate ring-opening polymerization of γ-benzyl-l-glutamate N-carboxyanhydride. The chitosan-graft-poly(γ-benzyl-l-glutamate) copolymers were fully deprotected by applying tetrabutylammonium hydroxide. The molar mass characteristics and chemical composition of graft copolymers with various lengths of polypeptide grafts were determined by SEC-MALS, FT-IR and various NMR spectroscopic techniques. The synthesized chitosan-graft-poly(sodium-l-glutamate) copolymers were used in combination with trimethyl chitosan for the preparation of nanoparticles (NPs) of a recombinant granulocyte colony-stimulating factor (GCSF). The suspensions of NPs with typical average diameter of 200–300 nm were obtained with polydispersity index values below 0.26. The achieved loading efficiency was up to 95 % and the final loading of GCSF protein in NPs was up to 45 %. The time, temperature and pH stability of NPs was also studied. More... »

PAGES

3469-3485

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10570-014-0362-8

DOI

http://dx.doi.org/10.1007/s10570-014-0362-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019653300


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