CircZNF609 promotes bladder cancer progression and inhibits cisplatin sensitivity via miR-1200/CDC25B pathway View Full Text


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Article Info

DATE

2022-05-14

AUTHORS

Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu

ABSTRACT

Circular RNAs (circRNAs) have been extensively studied in tumor development and treatment. CircZNF609 (hsa_circ_0000615) has been shown to serve as an oncogene in all kinds of solid tumors and may act as the novel biomarker in tumor diagnosis and therapy in tumor early diagnosis and therapy. However, the underlying character and mechanism of circZNF609 in cisplatin chemosensitivity and bladder cancer (BCa) development were unknown. The expression level of cell division cycle 25B (CDC25B), microRNA 1200 (miR-1200), and circZNF609 in BCa cells and tissues depended on quantitative real-time PCR (qRT-PCR). CDC25B protein level was assayed with Western blot. Functional assays in vitro and in vivo had been conducted to inspect the important role of circZNF609 on BCa progression and cisplatin chemosensitivity in BCa. RNA sequencing and online databases were used to predict the interactions among circZNF609, miR-1200, and CDC25B. Mechanistic exploration was confirmed by RNA pull-down assay, RNA fluorescence in situ hybridization (FISH) and Dual luciferase reporter assay. CircZNF609 expression was increased significantly in BCa cell lines and tissues. For BCa patients, increased expression of circZNF609 was correlated with a worse survival. In vitro and in vivo, enforced expression of circZNF609 enhanced BCa cells proliferation, migration, and cisplatin chemoresistance. Mechanistically, circZNF609 alleviated the inhibition effect on target CDC25B expression by sponging miR-1200. CircZNF609 promoted tumor growth through novel circZNF609/miR-1200/CDC25B axis, implying that circZNF609 has significant potential to act as a new diagnostic biomarker and therapeutic target in BCa.Graphical abstractEnhancing cisplatin sensitivity is an important direction for bladder cancer management.1. This research reveals that circZNF609 improves bladder cancer progression and inhibits cisplatin sensitivity by inducing G1/S cell cycle arrest via a novel miR-1200/CDC25B cascades.2. CircZNF609 was confirmed associated with worse survival of bladder cancer patients.3. CircZNF609 act as a prognostic biomarker for bladder cancer treatment. More... »

PAGES

1-18

References to SciGraph publications

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  • 2019-05-17. Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis in MOLECULAR CANCER
  • 2016-04-02. Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2020-05-12. CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions in CELL DEATH & DISEASE
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  • 2008-02-12. Small interfering RNA targeting CDC25B inhibits liver tumor growth in vitro and in vivo in MOLECULAR CANCER
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  • 2020-08-17. CircRNAs in anticancer drug resistance: recent advances and future potential in MOLECULAR CANCER
  • 2020-04-04. CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population in MOLECULAR BIOLOGY REPORTS
  • 2021-04-19. CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer in MOLECULAR CANCER
  • 2017-01-03. Circular RNAs in cancer: an emerging key player in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2014-12-23. Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity in NATURE REVIEWS CANCER
  • 2013-02-27. Circular RNAs are a large class of animal RNAs with regulatory potency in NATURE
  • 2007-07. CDC25 phosphatases in cancer cells: key players? Good targets? in NATURE REVIEWS CANCER
  • 2018-01-31. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression in MOLECULAR CANCER
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    http://scigraph.springernature.com/pub.10.1007/s10565-022-09715-3

    DOI

    http://dx.doi.org/10.1007/s10565-022-09715-3

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35567596


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    23 schema:description Circular RNAs (circRNAs) have been extensively studied in tumor development and treatment. CircZNF609 (hsa_circ_0000615) has been shown to serve as an oncogene in all kinds of solid tumors and may act as the novel biomarker in tumor diagnosis and therapy in tumor early diagnosis and therapy. However, the underlying character and mechanism of circZNF609 in cisplatin chemosensitivity and bladder cancer (BCa) development were unknown. The expression level of cell division cycle 25B (CDC25B), microRNA 1200 (miR-1200), and circZNF609 in BCa cells and tissues depended on quantitative real-time PCR (qRT-PCR). CDC25B protein level was assayed with Western blot. Functional assays in vitro and in vivo had been conducted to inspect the important role of circZNF609 on BCa progression and cisplatin chemosensitivity in BCa. RNA sequencing and online databases were used to predict the interactions among circZNF609, miR-1200, and CDC25B. Mechanistic exploration was confirmed by RNA pull-down assay, RNA fluorescence in situ hybridization (FISH) and Dual luciferase reporter assay. CircZNF609 expression was increased significantly in BCa cell lines and tissues. For BCa patients, increased expression of circZNF609 was correlated with a worse survival. In vitro and in vivo, enforced expression of circZNF609 enhanced BCa cells proliferation, migration, and cisplatin chemoresistance. Mechanistically, circZNF609 alleviated the inhibition effect on target CDC25B expression by sponging miR-1200. CircZNF609 promoted tumor growth through novel circZNF609/miR-1200/CDC25B axis, implying that circZNF609 has significant potential to act as a new diagnostic biomarker and therapeutic target in BCa.Graphical abstractEnhancing cisplatin sensitivity is an important direction for bladder cancer management.1. This research reveals that circZNF609 improves bladder cancer progression and inhibits cisplatin sensitivity by inducing G1/S cell cycle arrest via a novel miR-1200/CDC25B cascades.2. CircZNF609 was confirmed associated with worse survival of bladder cancer patients.3. CircZNF609 act as a prognostic biomarker for bladder cancer treatment.
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