Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1α/VEGFA axis by delivering microRNA-26a-5p View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-05-13

AUTHORS

Dan Zhang, Jian Du, Min Yu, Linna Suo

ABSTRACT

Critical roles of stem cell-extracellular vesicles (EVs) in the management of osteoporosis have been documented. Here, this study was designed to enlarge the research of the specific effects and underlying mechanism of urine-derived stem cells-EVs (USCs-EVs) on osteoporosis in diabetes rats. Firstly, miR-26a-5p and histone deacetylase 4 (HDAC4) expression in USCs of rats after diabetic osteoporosis (DOP) modeling induced by streptozotocin injection was determined, followed by study of their interaction. Then, USCs-EVs were co-cultured with osteogenic precursor cells, the effects of miRNA-26a-5p (miR-26a-5p) on osteoblasts, osteoclasts, bone mineralization deposition rate were evaluated. Meanwhile, the effect of USCs-EVs carrying miR-26a-5p on DOP rats was assessed. Elevated miR-26a-5p was seen in USCs-EVs which limited HDAC4 expression. Moreover, USCs-EVs delivered miR-26a-5p to osteogenic precursor cells, thereby promoting their differentiation, enhancing the activity of osteoblasts, and inhibiting the activity of osteoclasts, thereby preventing DOP through the activation of hypoxia inducible factor 1 subunit alpha (HIF-1α)/vascular endothelial growth factor A (VEGFA) pathway by repressing HDAC4. In a word, USCs-EVs-miR-26a-5p is a promising therapy for DOP by activating HIF-1α/VEGFA pathway through HDAC4 inhibition.Graphical abstract 1. USCs-EVs-miR-26a-5p targeted HDAC4 and limited HDAC4 expression. 2. miR-26a-5p was delivered by USCs-EVs into osteoblast precursor cells. 3. USCs-EVs-miR-26a-5p promoted the differentiation of osteoblast precursor cells into osteoblasts. 4. miR-26a-5p delivered by USCs-EVs could inhibit HDAC4. 5. USCs-EVs-miR-26a-5p could prevent the pathogenesis of DOP via HIF-1α/VEGFA aix. More... »

PAGES

1-15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10565-022-09713-5

DOI

http://dx.doi.org/10.1007/s10565-022-09713-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1147859301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35554780


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.412644.1", 
          "name": [
            "Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Dan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.412644.1", 
          "name": [
            "Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Du", 
        "givenName": "Jian", 
        "id": "sg:person.015666321535.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015666321535.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, 110122, Shenyang, China", 
          "id": "http://www.grid.ac/institutes/grid.412449.e", 
          "name": [
            "Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, 110122, Shenyang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Min", 
        "id": "sg:person.01354223110.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354223110.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.412644.1", 
          "name": [
            "Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suo", 
        "givenName": "Linna", 
        "id": "sg:person.01062261032.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062261032.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2164-14-111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040112254", 
          "https://doi.org/10.1186/1471-2164-14-111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41413-019-0056-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1117497273", 
          "https://doi.org/10.1038/s41413-019-0056-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2017.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129939", 
          "https://doi.org/10.1038/onc.2017.51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s12276-020-0475-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1130014501", 
          "https://doi.org/10.1038/s12276-020-0475-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13287-021-02636-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1142565021", 
          "https://doi.org/10.1186/s13287-021-02636-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40618-018-0828-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100551601", 
          "https://doi.org/10.1007/s40618-018-0828-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41419-019-2159-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1123118884", 
          "https://doi.org/10.1038/s41419-019-2159-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-981-13-3681-2_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112861124", 
          "https://doi.org/10.1007/978-981-13-3681-2_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6823-14-33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049986759", 
          "https://doi.org/10.1186/1472-6823-14-33"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-05-13", 
    "datePublishedReg": "2022-05-13", 
    "description": "Critical roles of stem cell-extracellular vesicles (EVs) in the management of osteoporosis have been documented. Here, this study was designed to enlarge the research of the specific effects and underlying mechanism of urine-derived stem cells-EVs (USCs-EVs) on osteoporosis in diabetes rats. Firstly, miR-26a-5p and histone deacetylase 4 (HDAC4) expression in USCs of rats after diabetic osteoporosis (DOP) modeling induced by streptozotocin injection was determined, followed by study of their interaction. Then, USCs-EVs were co-cultured with osteogenic precursor cells, the effects of miRNA-26a-5p (miR-26a-5p) on osteoblasts, osteoclasts, bone mineralization deposition rate were evaluated. Meanwhile, the effect of USCs-EVs carrying miR-26a-5p on DOP rats was assessed. Elevated miR-26a-5p was seen in USCs-EVs which limited HDAC4 expression. Moreover, USCs-EVs delivered miR-26a-5p to osteogenic precursor cells, thereby promoting their differentiation, enhancing the activity of osteoblasts, and inhibiting the activity of osteoclasts, thereby preventing DOP through the activation of hypoxia inducible factor 1 subunit alpha (HIF-1\u03b1)/vascular endothelial growth factor A (VEGFA) pathway by repressing HDAC4. In a word, USCs-EVs-miR-26a-5p is a promising therapy for DOP by activating HIF-1\u03b1/VEGFA pathway through HDAC4 inhibition.Graphical abstract\n1. USCs-EVs-miR-26a-5p targeted HDAC4 and limited HDAC4 expression. 2. miR-26a-5p was delivered by USCs-EVs into osteoblast precursor cells. 3. USCs-EVs-miR-26a-5p promoted the differentiation of osteoblast precursor cells into osteoblasts. 4. miR-26a-5p delivered by USCs-EVs could inhibit HDAC4. 5. USCs-EVs-miR-26a-5p could prevent the pathogenesis of DOP via HIF-1\u03b1/VEGFA aix.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10565-022-09713-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095523", 
        "issn": [
          "0742-2091", 
          "1573-6822"
        ], 
        "name": "Cell Biology and Toxicology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "precursor cells", 
      "HDAC4 expression", 
      "management of osteoporosis", 
      "miR-26a-5p", 
      "activity of osteoclasts", 
      "hypoxia inducible factor 1 subunit alpha", 
      "endothelial growth factor", 
      "stem cell extracellular vesicles", 
      "DOP rats", 
      "streptozotocin injection", 
      "diabetic osteoporosis", 
      "diabetes rats", 
      "histone deacetylase 4 (HDAC4) expression", 
      "activity of osteoblasts", 
      "cell extracellular vesicles", 
      "promising therapy", 
      "osteoblast precursor cells", 
      "HIF-1\u03b1/VEGFA", 
      "VEGFA pathway", 
      "osteoporosis", 
      "HDAC4 inhibition", 
      "growth factor", 
      "osteogenic precursor cells", 
      "rats", 
      "osteoclasts", 
      "HDAC4", 
      "specific effects", 
      "subunit alpha", 
      "cells", 
      "osteoblasts", 
      "critical role", 
      "expression", 
      "pathogenesis", 
      "therapy", 
      "pathway", 
      "VEGFA", 
      "differentiation", 
      "injection", 
      "activity", 
      "inhibition", 
      "effect", 
      "alpha", 
      "study", 
      "activation", 
      "AIx", 
      "management", 
      "factors", 
      "role", 
      "rate", 
      "vesicles", 
      "mechanism", 
      "USC", 
      "USCS", 
      "stem", 
      "DOP", 
      "research", 
      "interaction", 
      "words", 
      "modeling", 
      "deposition rate"
    ], 
    "name": "Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1\u03b1/VEGFA axis by delivering microRNA-26a-5p", 
    "pagination": "1-15", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1147859301"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10565-022-09713-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35554780"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10565-022-09713-5", 
      "https://app.dimensions.ai/details/publication/pub.1147859301"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_932.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10565-022-09713-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10565-022-09713-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10565-022-09713-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10565-022-09713-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10565-022-09713-5'


 

This table displays all metadata directly associated to this object as RDF triples.

175 TRIPLES      22 PREDICATES      93 URIs      76 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10565-022-09713-5 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author Neabba5d3128041f59788a128efb2817a
4 schema:citation sg:pub.10.1007/978-981-13-3681-2_16
5 sg:pub.10.1007/s40618-018-0828-x
6 sg:pub.10.1038/onc.2017.51
7 sg:pub.10.1038/s12276-020-0475-0
8 sg:pub.10.1038/s41413-019-0056-9
9 sg:pub.10.1038/s41419-019-2159-z
10 sg:pub.10.1186/1471-2164-14-111
11 sg:pub.10.1186/1472-6823-14-33
12 sg:pub.10.1186/s13287-021-02636-8
13 schema:datePublished 2022-05-13
14 schema:datePublishedReg 2022-05-13
15 schema:description Critical roles of stem cell-extracellular vesicles (EVs) in the management of osteoporosis have been documented. Here, this study was designed to enlarge the research of the specific effects and underlying mechanism of urine-derived stem cells-EVs (USCs-EVs) on osteoporosis in diabetes rats. Firstly, miR-26a-5p and histone deacetylase 4 (HDAC4) expression in USCs of rats after diabetic osteoporosis (DOP) modeling induced by streptozotocin injection was determined, followed by study of their interaction. Then, USCs-EVs were co-cultured with osteogenic precursor cells, the effects of miRNA-26a-5p (miR-26a-5p) on osteoblasts, osteoclasts, bone mineralization deposition rate were evaluated. Meanwhile, the effect of USCs-EVs carrying miR-26a-5p on DOP rats was assessed. Elevated miR-26a-5p was seen in USCs-EVs which limited HDAC4 expression. Moreover, USCs-EVs delivered miR-26a-5p to osteogenic precursor cells, thereby promoting their differentiation, enhancing the activity of osteoblasts, and inhibiting the activity of osteoclasts, thereby preventing DOP through the activation of hypoxia inducible factor 1 subunit alpha (HIF-1α)/vascular endothelial growth factor A (VEGFA) pathway by repressing HDAC4. In a word, USCs-EVs-miR-26a-5p is a promising therapy for DOP by activating HIF-1α/VEGFA pathway through HDAC4 inhibition.Graphical abstract 1. USCs-EVs-miR-26a-5p targeted HDAC4 and limited HDAC4 expression. 2. miR-26a-5p was delivered by USCs-EVs into osteoblast precursor cells. 3. USCs-EVs-miR-26a-5p promoted the differentiation of osteoblast precursor cells into osteoblasts. 4. miR-26a-5p delivered by USCs-EVs could inhibit HDAC4. 5. USCs-EVs-miR-26a-5p could prevent the pathogenesis of DOP via HIF-1α/VEGFA aix.
16 schema:genre article
17 schema:inLanguage en
18 schema:isAccessibleForFree false
19 schema:isPartOf sg:journal.1095523
20 schema:keywords AIx
21 DOP
22 DOP rats
23 HDAC4
24 HDAC4 expression
25 HDAC4 inhibition
26 HIF-1α/VEGFA
27 USC
28 USCS
29 VEGFA
30 VEGFA pathway
31 activation
32 activity
33 activity of osteoblasts
34 activity of osteoclasts
35 alpha
36 cell extracellular vesicles
37 cells
38 critical role
39 deposition rate
40 diabetes rats
41 diabetic osteoporosis
42 differentiation
43 effect
44 endothelial growth factor
45 expression
46 factors
47 growth factor
48 histone deacetylase 4 (HDAC4) expression
49 hypoxia inducible factor 1 subunit alpha
50 inhibition
51 injection
52 interaction
53 management
54 management of osteoporosis
55 mechanism
56 miR-26a-5p
57 modeling
58 osteoblast precursor cells
59 osteoblasts
60 osteoclasts
61 osteogenic precursor cells
62 osteoporosis
63 pathogenesis
64 pathway
65 precursor cells
66 promising therapy
67 rate
68 rats
69 research
70 role
71 specific effects
72 stem
73 stem cell extracellular vesicles
74 streptozotocin injection
75 study
76 subunit alpha
77 therapy
78 vesicles
79 words
80 schema:name Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1α/VEGFA axis by delivering microRNA-26a-5p
81 schema:pagination 1-15
82 schema:productId N01da698273344710b7632b242b8e7c3a
83 N8ff4ec8c898b4b99a2875332ad65c49a
84 N95fcd179bb0549df89c01c80635ceb8d
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1147859301
86 https://doi.org/10.1007/s10565-022-09713-5
87 schema:sdDatePublished 2022-06-01T22:24
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Ne824b56fc24a44099644aae5c7284f3f
90 schema:url https://doi.org/10.1007/s10565-022-09713-5
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N01da698273344710b7632b242b8e7c3a schema:name pubmed_id
95 schema:value 35554780
96 rdf:type schema:PropertyValue
97 N8ff4ec8c898b4b99a2875332ad65c49a schema:name doi
98 schema:value 10.1007/s10565-022-09713-5
99 rdf:type schema:PropertyValue
100 N95fcd179bb0549df89c01c80635ceb8d schema:name dimensions_id
101 schema:value pub.1147859301
102 rdf:type schema:PropertyValue
103 Nc407a35011b3499a98c563931cc055d9 rdf:first sg:person.015666321535.70
104 rdf:rest Nf94e65cba4cf4201a5149f06fd65d050
105 Ne65e97ad2199452c93fb0c8aed0b0035 schema:affiliation grid-institutes:grid.412644.1
106 schema:familyName Zhang
107 schema:givenName Dan
108 rdf:type schema:Person
109 Ne824b56fc24a44099644aae5c7284f3f schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 Neabba5d3128041f59788a128efb2817a rdf:first Ne65e97ad2199452c93fb0c8aed0b0035
112 rdf:rest Nc407a35011b3499a98c563931cc055d9
113 Nf011d54a07be4fcca1e662a6685be5d9 rdf:first sg:person.01062261032.33
114 rdf:rest rdf:nil
115 Nf94e65cba4cf4201a5149f06fd65d050 rdf:first sg:person.01354223110.58
116 rdf:rest Nf011d54a07be4fcca1e662a6685be5d9
117 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
118 schema:name Biological Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
121 schema:name Biochemistry and Cell Biology
122 rdf:type schema:DefinedTerm
123 sg:journal.1095523 schema:issn 0742-2091
124 1573-6822
125 schema:name Cell Biology and Toxicology
126 schema:publisher Springer Nature
127 rdf:type schema:Periodical
128 sg:person.01062261032.33 schema:affiliation grid-institutes:grid.412644.1
129 schema:familyName Suo
130 schema:givenName Linna
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062261032.33
132 rdf:type schema:Person
133 sg:person.01354223110.58 schema:affiliation grid-institutes:grid.412449.e
134 schema:familyName Yu
135 schema:givenName Min
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354223110.58
137 rdf:type schema:Person
138 sg:person.015666321535.70 schema:affiliation grid-institutes:grid.412644.1
139 schema:familyName Du
140 schema:givenName Jian
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015666321535.70
142 rdf:type schema:Person
143 sg:pub.10.1007/978-981-13-3681-2_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112861124
144 https://doi.org/10.1007/978-981-13-3681-2_16
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s40618-018-0828-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1100551601
147 https://doi.org/10.1007/s40618-018-0828-x
148 rdf:type schema:CreativeWork
149 sg:pub.10.1038/onc.2017.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129939
150 https://doi.org/10.1038/onc.2017.51
151 rdf:type schema:CreativeWork
152 sg:pub.10.1038/s12276-020-0475-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130014501
153 https://doi.org/10.1038/s12276-020-0475-0
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/s41413-019-0056-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117497273
156 https://doi.org/10.1038/s41413-019-0056-9
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/s41419-019-2159-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1123118884
159 https://doi.org/10.1038/s41419-019-2159-z
160 rdf:type schema:CreativeWork
161 sg:pub.10.1186/1471-2164-14-111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040112254
162 https://doi.org/10.1186/1471-2164-14-111
163 rdf:type schema:CreativeWork
164 sg:pub.10.1186/1472-6823-14-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049986759
165 https://doi.org/10.1186/1472-6823-14-33
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/s13287-021-02636-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142565021
168 https://doi.org/10.1186/s13287-021-02636-8
169 rdf:type schema:CreativeWork
170 grid-institutes:grid.412449.e schema:alternateName Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, 110122, Shenyang, China
171 schema:name Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, 110122, Shenyang, China
172 rdf:type schema:Organization
173 grid-institutes:grid.412644.1 schema:alternateName Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People’s Republic of China
174 schema:name Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, 110032, Shenyang, People’s Republic of China
175 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...