JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Central Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, Guangdong, China", 
          "id": "http://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "Central Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeng", 
        "givenName": "Xiaokang", 
        "id": "sg:person.016227553465.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016227553465.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, Guangdong, China", 
          "id": "http://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "Central Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Xinhuai", 
        "id": "sg:person.010027232165.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027232165.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), 528300, Foshan, Guangdong, China", 
          "id": "http://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "Clinical Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), 528300, Foshan, Guangdong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Yanning", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Center, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, China", 
          "id": "http://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "Central Laboratory, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, Guangdong, China", 
            "Department of Laboratory Medicine, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde, Foshan), 528300, Foshan, Guangdong, China", 
            "Medical Research Center, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde Foshan), No.1, Jiazi Road, Lunjiao Street, Shunde District, 528300, Foshan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Jie", 
        "id": "sg:person.016201505257.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016201505257.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ni.3838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091828878", 
          "https://doi.org/10.1038/ni.3838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-07277-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109934304", 
          "https://doi.org/10.1038/s41467-018-07277-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41418-018-0263-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111268997", 
          "https://doi.org/10.1038/s41418-018-0263-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41419-018-0876-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106386672", 
          "https://doi.org/10.1038/s41419-018-0876-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41568-020-0272-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1128716901", 
          "https://doi.org/10.1038/s41568-020-0272-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/82_2014_376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011587333", 
          "https://doi.org/10.1007/82_2014_376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41577-018-0061-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106943646", 
          "https://doi.org/10.1038/s41577-018-0061-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017863023", 
          "https://doi.org/10.1038/nature13988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002722764", 
          "https://doi.org/10.1038/ni.3518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029785917", 
          "https://doi.org/10.1038/nri2381"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-03-19", 
    "datePublishedReg": "2022-03-19", 
    "description": "Chemokine (C-X-C motif) ligand 1 (CXCL1) is mainly expressed on neutrophils and macrophages and has neutrophil chemoattractant activity. However, natural killer (NK) cells also express CXCL1. We were curious about the role played by CXCL1 in NK cells. Knocking out CXCL1 in hematopoietic cells does not affect the occurrence of NK cells; however, it does hinder NK cell maturity. CXCL1 deletion enhances the expression of immature markers and decreases the expression of functional markers in NK cells, which may explain why it hinders the maturation of NK cells. Specific knockout of CXCL1 in NK cells (CXCL1flox/flox Ncr1-cre) leads to impaired IFN-\u03b3 production and degranulation of NK cells. The lack of CXCL1 may prevent IFN-\u03b3 production and degranulation of NK cells by inhibiting the phosphorylation of AKTS473 and S6. Therefore, we have discovered a new role for CXCL1 in regulating NK cell development and immune surveillance, providing a novel theoretical basis for immunotherapy based on NK cells and potential therapeutic targets for the clinical use of NK cells.Graphical abstract1. Knockout of CXCL1 in hematopoietic cells inhibits the maturation of NK cells.2. Knockout of CXCL1 in NK cells inhibits the clearance of lymphoma by NK cells and reduces IFN-\u03b3 production and CD107 expression in NK cells.3. CXCL1 activates the PKD2/mTOR signaling pathway, and promotes the production of IFN-\u03b3 and the expression of CD107a in NK cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10565-022-09708-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095523", 
        "issn": [
          "0742-2091", 
          "1573-6822"
        ], 
        "name": "Cell Biology and Toxicology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "chemokine ligand 1", 
      "IFN-\u03b3 production", 
      "NK cells", 
      "natural killer cells", 
      "killer cells", 
      "expression of CD107a", 
      "NK cell development", 
      "production of IFN", 
      "immune surveillance function", 
      "potential therapeutic target", 
      "ligand 1", 
      "hematopoietic cells", 
      "CD107 expression", 
      "immune surveillance", 
      "chemoattractant activity", 
      "immature markers", 
      "therapeutic target", 
      "novel theoretical basis", 
      "clinical use", 
      "specific knockout", 
      "cell maturity", 
      "degranulation", 
      "cell development", 
      "functional markers", 
      "mTOR", 
      "knockout", 
      "cells", 
      "surveillance function", 
      "markers", 
      "expression", 
      "maturation", 
      "CD107a", 
      "immunotherapy", 
      "lymphoma", 
      "IFN", 
      "neutrophils", 
      "pathway", 
      "macrophages", 
      "clearance", 
      "new role", 
      "surveillance", 
      "role", 
      "phosphorylation", 
      "target", 
      "deletion", 
      "activity", 
      "production", 
      "occurrence", 
      "lack", 
      "S6", 
      "use", 
      "function", 
      "development", 
      "basis", 
      "maturity", 
      "theoretical basis"
    ], 
    "name": "Chemokine (C-X-C motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway", 
    "pagination": "1-15", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1146380143"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10565-022-09708-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35304656"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10565-022-09708-2", 
      "https://app.dimensions.ai/details/publication/pub.1146380143"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_934.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10565-022-09708-2"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

177 TRIPLES      22 PREDICATES      90 URIs      72 LITERALS      5 BLANK NODES