Ontology type: schema:ScholarlyArticle
2022-03-18
AUTHORSLiang-Jun Wang, Yuan-Chin Lee, Jing-Ting Chiou, Ying-Jung Chen, Long-Sen Chang
ABSTRACTOur previous studies indicated that the benzene metabolite hydroquinone (HQ) evokes the ROS/p38 MAPK/protein phosphatase 2A/tristetraprolin axis, leading to increased TNF-α expression in human acute myeloid leukemia cell lines U937 and HL-60. In this study, we aimed to identify the upstream pathway involved in ROS-mediated TNF-α expression. HQ treatment increased SIDT2 expression, which subsequently decreased miR-25 and SIRT3 expression in U937 cells. Notably, miR-25 downregulation promoted SIDT2 expression in HQ-treated U937 cells. SIDT2 induced lysosomal degradation of SIRT3 mRNA, but inhibited miR-25 expression through a lysosome-independent pathway. MiR-25 inhibition reduced NOX4 mRNA turnover, resulting in increased NOX4 protein levels. NOX4 induces mitochondrial ROS production and HuR downregulation. Restoration of HuR expression increased SIRT3 expression, suggesting that NOX4-mediated HuR downregulation promotes SIDT2-mediated degradation of SIRT3 mRNA. Inhibition of NOX4 or SIRT3 overexpression abolished HQ-induced ROS production, thereby abolishing TNF-α upregulation. Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-α upregulation in HQ-treated U937 cells. HQ-induced increase in TNF-α expression in HL-60 cells was also mediated through a similar pathway.Graphical abstract More... »
PAGES1-19
http://scigraph.springernature.com/pub.10.1007/s10565-022-09705-5
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/35302183
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169 | ″ | ″ | Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 807, Kaohsiung, Taiwan |
170 | ″ | ″ | Institute of Biomedical Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan |
171 | ″ | rdf:type | schema:Organization |
172 | grid-institutes:grid.412036.2 | schema:alternateName | Institute of Biomedical Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan |
173 | ″ | schema:name | Institute of Biomedical Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan |
174 | ″ | rdf:type | schema:Organization |