JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Xiu Mei", 
        "id": "sg:person.010015543072.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010015543072.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Plastic and Burn Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.488387.8", 
          "name": [
            "Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Department of Plastic and Burn Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geng", 
        "givenName": "Kang", 
        "id": "sg:person.012310632325.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310632325.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.259384.1", 
          "name": [
            "Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Law", 
        "givenName": "Betty Yuen-Kwan", 
        "id": "sg:person.012460517772.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012460517772.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.259384.1", 
          "name": [
            "Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Peng", 
        "id": "sg:person.012206064472.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012206064472.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pu", 
        "givenName": "Yue Li", 
        "id": "sg:person.013203507533.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013203507533.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Qing", 
        "id": "sg:person.016123276333.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016123276333.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Hui Wen", 
        "id": "sg:person.014376406072.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376406072.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Xiao Zhen", 
        "id": "sg:person.013607161567.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013607161567.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Zong Zhe", 
        "id": "sg:person.014454472561.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014454472561.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Avenida Wai Long, Taipa, Macau, People\u2019s Republic of China", 
            "Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Metabolic Vascular Diseases Key Laboratory of Sichuan Province, 646000, Luzhou, Sichuan, People\u2019s Republic of China", 
            "Sichuan Clinical Research Center for Nephropathy, 646000, Luzhou, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Yong", 
        "id": "sg:person.0730471106.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730471106.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/s41392-020-0198-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1128421545", 
          "https://doi.org/10.1038/s41392-020-0198-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10741-013-9377-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021737655", 
          "https://doi.org/10.1007/s10741-013-9377-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-019-1000-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112582551", 
          "https://doi.org/10.1038/s41586-019-1000-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0287-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105301895", 
          "https://doi.org/10.1038/s41586-018-0287-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2017.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084767921", 
          "https://doi.org/10.1038/nri.2017.21"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/485179a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022508571", 
          "https://doi.org/10.1038/485179a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s42003-020-0986-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1127785564", 
          "https://doi.org/10.1038/s42003-020-0986-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004054083", 
          "https://doi.org/10.1038/nature08476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-020-2719-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1130502921", 
          "https://doi.org/10.1038/s41586-020-2719-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009348903", 
          "https://doi.org/10.1038/nature10992"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-03-02", 
    "datePublishedReg": "2022-03-02", 
    "description": "Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pathway in the adipose, liver, and kidney tissues. However, the role of cytosolic mtDNA in the progression of DCM is unclear. In this study, with an obesity-related DCM mouse model established by feeding db/db mice with a high-fat diet (HFD), we observed increased mtDNA in the cytosol and activated cGAS-STING signaling pathway during DCM, as well as the downstream targets, IRF3, NF-\u03baB, IL-18, and IL-1\u03b2. In a further study with a palmitic acid (PA)-induced lipotoxic cell model established in H9C2 cells, we revealed that the cytosolic mtDNA was the result of PA-induced overproduction of mitochondrial ROS, which also led to the activation of the cGAS/STING system and its downstream targets. Notably, treatment of extracted mtDNA alone was sufficient to activate the cGAS-STING signaling pathway in cultured H9C2 cells. Besides, both knockdown of STING in PA-induced H9C2 cells and inhibition of STING by C-176 injection in the DCM mouse model could remarkably block the inflammation and apoptosis of cardiomyocytes. In conclusion, our study elucidated the critical role of cytosolic mtDNA-induced cGAS-STING activation in the pathogenesis of obesity-related DCM and provided preclinical validation for using a STING inhibitor as a new potential therapeutic strategy for the treatment of DCM.Graphical abstract", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10565-021-09692-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8887268", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1095523", 
        "issn": [
          "0742-2091", 
          "1573-6822"
        ], 
        "name": "Cell Biology and Toxicology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "high-fat diet", 
      "DCM mouse model", 
      "cyclic GMP-AMP synthase", 
      "H9c2 cells", 
      "mouse model", 
      "cGAS-STING", 
      "db/db mice", 
      "progression of DCM", 
      "new potential therapeutic strategy", 
      "obesity-related diabetes", 
      "cultured H9c2 cells", 
      "treatment of DCM", 
      "inhibition of STING", 
      "potential therapeutic strategy", 
      "cytosolic mtDNA", 
      "apoptosis of cardiomyocytes", 
      "cGAS-STING pathway", 
      "interferon genes (STING) pathway", 
      "downstream targets", 
      "cGAS-STING activation", 
      "STING inhibitor", 
      "GMP-AMP synthase", 
      "IL-18", 
      "db mice", 
      "knockdown of STING", 
      "inflammatory activation", 
      "IL-1\u03b2", 
      "therapeutic strategies", 
      "NF-\u03baB", 
      "kidney tissue", 
      "preclinical validation", 
      "mtDNA release", 
      "lipid accumulation", 
      "cytosolic DNA", 
      "mitochondrial dysfunction", 
      "Further studies", 
      "inflammation", 
      "mitochondrial ROS", 
      "DCM", 
      "activation", 
      "treatment", 
      "stings", 
      "cell model", 
      "palmitic acid", 
      "cells", 
      "gene pathways", 
      "pathway", 
      "critical role", 
      "diabetes", 
      "dysfunction", 
      "pathogenesis", 
      "mice", 
      "liver", 
      "IRF3", 
      "progression", 
      "study", 
      "cardiomyocytes", 
      "stimulator", 
      "adipose", 
      "diet", 
      "target", 
      "results of PA", 
      "injection", 
      "apoptosis", 
      "knockdown", 
      "inhibitors", 
      "tissue", 
      "inhibition", 
      "role", 
      "conclusion", 
      "ROS", 
      "synthase", 
      "overproduction", 
      "release", 
      "cytosol", 
      "accumulation", 
      "mitochondria", 
      "mtDNA", 
      "PA", 
      "acid", 
      "DNA", 
      "strategies", 
      "model", 
      "validation", 
      "results", 
      "system"
    ], 
    "name": "Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes", 
    "pagination": "1-23", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1145980784"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10565-021-09692-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35235096"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10565-021-09692-z", 
      "https://app.dimensions.ai/details/publication/pub.1145980784"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_934.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10565-021-09692-z"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      22 PREDICATES      120 URIs      102 LITERALS      5 BLANK NODES