Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes View Full Text


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Article Info

DATE

2007-11-09

AUTHORS

Jun-ichi Yamashiro, Sumihiro Shiraishi, Toru Fuwa, Toshiharu Horie

ABSTRACT

Dimerumic acid (DMA) is contained in Monascus anka and Monascus pilosus fermented products. The purpose of this study was to evaluate the effect of DMA against salicylic acid (SA)- and tert-butylhydroperoxide (t-BHP)-induced oxidative stress and cytotoxicity in the liver, using rat liver microsomes and isolated rat hepatocytes. DMA was extracted from monascus-garlic-fermented extract using M. pilosus. In rat liver microsomes, 1 μM DMA decreased SA-induced lipid peroxidation but did not affect the production of the oxidative metabolite of SA via CYP. In isolated rat hepatocytes, 1 μM DMA decreased SA-induced lipid peroxidation and chemiluminescence (CL) generation and the intracellular glutathione-reduced form/oxidized form (GSH/GSSG) ratio in the presence of 1 μM DMA was higher than that without DMA; however, 100 μM DMA suppressed the leakage of lactate dehydrogenase (LDH). On the other hand, t-BHP-induced lipid peroxidation, CL generation, and LDH leakage were prevented by 100 μM DMA. Thus, DMA showed an antioxidative effect in hepatocytes and protected against hepatotoxicity by suppressing oxidative stress without affecting CYP enzymes. More... »

PAGES

283-290

References to SciGraph publications

  • 1995-07. Antioxidant activity of allicin, an active principle in garlic in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10565-007-9037-7

    DOI

    http://dx.doi.org/10.1007/s10565-007-9037-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024079473

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17992573


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