A retrospective study on annual evaluation of radiation processing for frozen bone allografts complying to quality system requirements View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02-17

AUTHORS

Saravana Ramalingam, Suhaili Mohd, Sharifah Mazni Samsuddin, N. G. Wuey Min, Norimah Yusof, Azura Mansor

ABSTRACT

Bone allografts have been used widely to fill up essential void in orthopaedic surgeries. The benefit of using allografts to replace and reconstruct musculoskeletal injuries, fractures or disease has obtained overwhelming acceptance from orthopaedic surgeons worldwide. However, bacterial infection and disease transmission through bone allograft transplantation have always been a significant issue. Sterilization by radiation is an effective method to eliminate unwanted microorganisms thus assist in preventing life threatening allograft associated infections. Femoral heads procured from living donors and long bones (femur and tibia) procured from cadaveric donors were sterilized at 25 kGy in compliance with international standard ISO 11137. According to quality requirements, all records of bone banking were evaluated annually. This retrospective study was carried out on annual evaluation of radiation records from 1998 until 2012. The minimum doses absorbed by the bones were ranging from 25.3 to 38.2 kGy while the absorbed maximum doses were from 25.4 to 42.3 kGy. All the bones supplied by our UMMC Bone Bank were sterile at the required minimum dose of 25 kGy. Our analysis on dose variation showed that the dose uniformity ratios in 37 irradiated boxes of 31 radiation batches were in the range of 1.003–1.251, which indicated the doses were well distributed. More... »

PAGES

545-552

References to SciGraph publications

  • 2000-06. The Evolution of Quality Systems in Human Bone Banking: The U.S. Experience in CELL AND TISSUE BANKING
  • 2005-09. Irradiation as a Safety Procedure in Tissue Banking in CELL AND TISSUE BANKING
  • 2000-06. Bone Allografts: Past, Present and Future in CELL AND TISSUE BANKING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10561-015-9501-1

    DOI

    http://dx.doi.org/10.1007/s10561-015-9501-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047293743

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25687771


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