Cardioprotection by Curcumin Post-Treatment in Rats with Established Chronic Kidney Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03-17

AUTHORS

Sauri Hernández-Reséndiz, Francisco Correa, Wylly R. García-Niño, Mabel Buelna-Chontal, Francisco J. Roldán, Ixchel Ramírez-Camacho, Carolina Delgado-Toral, Roxana Carbó, José Pedraza-Chaverrí, Edilia Tapia, Cecilia Zazueta

ABSTRACT

PurposeThe pathogenic mechanisms leading to cardiovascular disorders in patients with chronic kidney disease have not been clearly established, although increased oxidative stress has been pointed out as a potential cause. Therefore, as cardiovascular events are still the first cause of death in patients with chronic kidney disease and traditional drugs or therapies rarely have effects on cardiac complications, we sought to determine the effect of curcumin in treating cardiac dysfunction in rats with established chronic renal disease.Methods and ResultsTreatment consisted in daily administration of curcumin (120 mg/kg/day) dissolved in 0.05 % carboxymethylcellulose via oral gavages during 30 days, beginning from day 30 after 5/6 nephrectomy (5/6Nx). Cardiac function, markers of oxidative stress, activation of PI3K/Akt/GSK3β and MEK1/2-ERK1/2 pathway, metalloproteinase-II (MMP-2) content, overall gelatinolytic activity, ROS production and mitochondrial integrity were evaluated after 1-month treatment. Curcumin restored systolic blood pressure, diminished interventricular and rear wall thickening, decreased left ventricle dimension at end-systole (LVSd) and restored ejection fraction in nephrectomized rats. Also, it diminished metalloproteinase-II levels and overall gelatinase activity, decreased oxidative stress and inhibited the mitochondrial permeability transition pore opening.ConclusionOur findings suggest that curcumin might have therapeutic potential in treatment of heart disease in patients with established CKD by attenuating oxidative stress-related events as cardiac remodeling, mitochondrial dysfunction and cell death. More... »

PAGES

111-120

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10557-015-6581-x

DOI

http://dx.doi.org/10.1007/s10557-015-6581-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009548438

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25779825


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32 schema:description PurposeThe pathogenic mechanisms leading to cardiovascular disorders in patients with chronic kidney disease have not been clearly established, although increased oxidative stress has been pointed out as a potential cause. Therefore, as cardiovascular events are still the first cause of death in patients with chronic kidney disease and traditional drugs or therapies rarely have effects on cardiac complications, we sought to determine the effect of curcumin in treating cardiac dysfunction in rats with established chronic renal disease.Methods and ResultsTreatment consisted in daily administration of curcumin (120 mg/kg/day) dissolved in 0.05 % carboxymethylcellulose via oral gavages during 30 days, beginning from day 30 after 5/6 nephrectomy (5/6Nx). Cardiac function, markers of oxidative stress, activation of PI3K/Akt/GSK3β and MEK1/2-ERK1/2 pathway, metalloproteinase-II (MMP-2) content, overall gelatinolytic activity, ROS production and mitochondrial integrity were evaluated after 1-month treatment. Curcumin restored systolic blood pressure, diminished interventricular and rear wall thickening, decreased left ventricle dimension at end-systole (LVSd) and restored ejection fraction in nephrectomized rats. Also, it diminished metalloproteinase-II levels and overall gelatinase activity, decreased oxidative stress and inhibited the mitochondrial permeability transition pore opening.ConclusionOur findings suggest that curcumin might have therapeutic potential in treatment of heart disease in patients with established CKD by attenuating oxidative stress-related events as cardiac remodeling, mitochondrial dysfunction and cell death.
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40 CKD
41 ConclusionOur findings
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45 ROS production
46 ResultsTreatment
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48 activity
49 administration
50 blood pressure
51 carboxymethylcellulose
52 cardiac complications
53 cardiac dysfunction
54 cardiac function
55 cardiac remodeling
56 cardioprotection
57 cardiovascular disorders
58 cardiovascular events
59 cause
60 cell death
61 chronic kidney disease
62 chronic renal disease
63 complications
64 content
65 curcumin
66 daily administration
67 day 30
68 days
69 death
70 dimensions
71 disease
72 disorders
73 drugs
74 dysfunction
75 effect
76 effect of curcumin
77 ejection fraction
78 events
79 findings
80 first cause
81 fraction
82 function
83 gavage
84 gelatinase activity
85 gelatinolytic activity
86 heart disease
87 integrity
88 kidney disease
89 left ventricle dimensions
90 levels
91 markers
92 mechanism
93 method
94 mitochondrial dysfunction
95 mitochondrial integrity
96 mitochondrial permeability transition pore opening
97 nephrectomized rats
98 nephrectomy
99 opening
100 oral gavage
101 overall gelatinase activity
102 overall gelatinolytic activity
103 oxidative stress
104 oxidative stress-related events
105 pathogenic mechanisms
106 pathway
107 patients
108 permeability transition pore opening
109 pore opening
110 post treatment
111 potential
112 potential causes
113 pressure
114 production
115 rats
116 remodeling
117 renal disease
118 stress
119 stress-related events
120 systolic blood pressure
121 therapeutic potential
122 therapy
123 thickening
124 traditional drugs
125 transition pore opening
126 treatment
127 ventricle dimensions
128 wall thickening
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