H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of Mitochondria in Dogs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06

AUTHORS

Akemi Yoshida, Hiroshi Asanuma, Hideyuki Sasaki, Shoji Sanada, Satoru Yamazaki, Yoshihiro Asano, Yoshiro Shinozaki, Hidezo Mori, Akito Shimouchi, Motoaki Sano, Masanori Asakura, Tetsuo Minamino, Seiji Takashima, Masaru Sugimachi, Naoki Mochizuki, Masafumi Kitakaze

ABSTRACT

PURPOSE: Inhalation of hydrogen (H(2)) gas has been shown to limit infarct size following ischemia-reperfusion injury in rat hearts. However, H(2) gas-induced cardioprotection has not been tested in large animals and the precise cellular mechanism of protection has not been elucidated. We investigated whether opening of mitochondrial ATP-sensitive K+ channels (mK(ATP)) and subsequent inhibition of mitochondrial permeability transition pores (mPTP) mediates the infarct size-limiting effect of H(2) gas in canine hearts. METHODS: The left anterior descending coronary artery of beagle dogs was occluded for 90 min followed by reperfusion for 6 h. Either 1.3% H(2) or control gas was inhaled from 10 min prior to start of reperfusion until 1 h of reperfusion, in the presence or absence of either 5-hydroxydecanoate (5-HD; a selective mK(ATP) blocker), or atractyloside (Atr; a mPTP opener). RESULTS: Systemic hemodynamic parameters did not differ among the groups. Nevertheless, H(2) gas inhalation reduced infarct size normalized by risk area (20.6±2.8% vs. control gas 44.0±2.0%; p<0.001), and administration of either 5-HD or Atr abolished the infarct size-limiting effect of H(2) gas (42.0±2.2% with 5-HD and 45.1±2.7% with Atr; both p<0.001 vs. H(2) group). Neither Atr nor 5-HD affected infarct size per se. Among all groups, NAD content and the number of apoptotic and 8-OHdG positive cells was not significantly different, indicating that the cardioprotection afforded by H(2) was not due to anti-oxidative actions or effects on the NADH dehydrogenase pathway. CONCLUSIONS: Inhalation of H(2) gas reduces infarct size in canine hearts via opening of mitochondrial K(ATP) channels followed by inhibition of mPTP. H(2) gas may provide an effective adjunct strategy in patients with acute myocardial infarction receiving reperfusion therapy. More... »

PAGES

217-226

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10557-012-6381-5

DOI

http://dx.doi.org/10.1007/s10557-012-6381-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027416163

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22527618


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiotonic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Decanoic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxy Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "KATP Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Reperfusion Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channel Blockers", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Osaka, Japan", 
            "Department of Structural Analysis, National Cerebral and Cardiovascular Research Center, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Akemi", 
        "id": "sg:person.0640141175.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640141175.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto Prefectural University of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Cardiovascular Science and Technology, Kyoto Prefectural University of Medicine, Suita 565-8565, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asanuma", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01062533460.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062533460.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasaki", 
        "givenName": "Hideyuki", 
        "id": "sg:person.01306316622.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306316622.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanada", 
        "givenName": "Shoji", 
        "id": "sg:person.01032340260.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032340260.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamazaki", 
        "givenName": "Satoru", 
        "id": "sg:person.01205347767.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205347767.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asano", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0605102236.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605102236.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Physiological Science, Tokai University Graduate School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinozaki", 
        "givenName": "Yoshiro", 
        "id": "sg:person.01137573062.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137573062.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Physiological Science, Tokai University Graduate School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Hidezo", 
        "id": "sg:person.01157222312.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157222312.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiac Physiology, National Cerebral and Cardiovascular Research Center, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimouchi", 
        "givenName": "Akito", 
        "id": "sg:person.012414171571.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012414171571.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Cardiology, Keio University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sano", 
        "givenName": "Motoaki", 
        "id": "sg:person.01030207644.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030207644.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asakura", 
        "givenName": "Masanori", 
        "id": "sg:person.0721752760.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721752760.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minamino", 
        "givenName": "Tetsuo", 
        "id": "sg:person.015653244242.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015653244242.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takashima", 
        "givenName": "Seiji", 
        "id": "sg:person.01203142451.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203142451.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cardiovascular Dynamics, Research Institute, National Cerebral and Cardiovascular Center, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugimachi", 
        "givenName": "Masaru", 
        "id": "sg:person.01216244324.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216244324.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Structural Analysis, National Cerebral and Cardiovascular Research Center, Suita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochizuki", 
        "givenName": "Naoki", 
        "id": "sg:person.0715762471.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715762471.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitakaze", 
        "givenName": "Masafumi", 
        "id": "sg:person.01134507760.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134507760.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11064-010-0162-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001870957", 
          "https://doi.org/10.1007/s11064-010-0162-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-010-0162-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001870957", 
          "https://doi.org/10.1007/s11064-010-0162-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa071142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002994851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvq129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003847186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvq129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003847186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2010.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0100-879x1999001100001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007276041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2009.07.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010870800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.07.088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013666264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/0812-rm-349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014428002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/0812-rm-349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014428002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00678.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015957346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.05.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016500314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(96)00064-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017981122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2010.02.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019280309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.108.805242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021000950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.225730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022312896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.225730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022312896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.34.6.818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023094018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m600959200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025161346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2008.11.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028399961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.24.9265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029531947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2007.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030847723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.2001.1435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030919034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031138180", 
          "https://doi.org/10.1038/nm1577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.02.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031336302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-009-0080-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034453311", 
          "https://doi.org/10.1007/s00395-009-0080-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-009-0080-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034453311", 
          "https://doi.org/10.1007/s00395-009-0080-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10715760902870603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034851613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2010.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036664526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hh2201.100205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037477391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2005.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043156444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2008.02359.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043708509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61634-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045514991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.87.10.845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046706587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2010.02254.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047152852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2010.02254.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047152852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci19906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048278072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-010-0121-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050848579", 
          "https://doi.org/10.1007/s00395-010-0121-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-010-0121-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050848579", 
          "https://doi.org/10.1007/s00395-010-0121-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.10.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051703286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.10.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051703286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-009-0010-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051841494", 
          "https://doi.org/10.1007/s00395-009-0010-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-009-0010-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051841494", 
          "https://doi.org/10.1007/s00395-009-0010-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(02)00455-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054578170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2010.3375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059231305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7839143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.93.4.781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063336993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1992.263.6.h1946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076678255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1996.270.5.h1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083003111"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-06", 
    "datePublishedReg": "2012-06-01", 
    "description": "PURPOSE: Inhalation of hydrogen (H(2)) gas has been shown to limit infarct size following ischemia-reperfusion injury in rat hearts. However, H(2) gas-induced cardioprotection has not been tested in large animals and the precise cellular mechanism of protection has not been elucidated. We investigated whether opening of mitochondrial ATP-sensitive K+ channels (mK(ATP)) and subsequent inhibition of mitochondrial permeability transition pores (mPTP) mediates the infarct size-limiting effect of H(2) gas in canine hearts.\nMETHODS: The left anterior descending coronary artery of beagle dogs was occluded for 90 min followed by reperfusion for 6 h. Either 1.3% H(2) or control gas was inhaled from 10 min prior to start of reperfusion until 1 h of reperfusion, in the presence or absence of either 5-hydroxydecanoate (5-HD; a selective mK(ATP) blocker), or atractyloside (Atr; a mPTP opener).\nRESULTS: Systemic hemodynamic parameters did not differ among the groups. Nevertheless, H(2) gas inhalation reduced infarct size normalized by risk area (20.6\u00b12.8% vs. control gas 44.0\u00b12.0%; p<0.001), and administration of either 5-HD or Atr abolished the infarct size-limiting effect of H(2) gas (42.0\u00b12.2% with 5-HD and 45.1\u00b12.7% with Atr; both p<0.001 vs. H(2) group). Neither Atr nor 5-HD affected infarct size per se. Among all groups, NAD content and the number of apoptotic and 8-OHdG positive cells was not significantly different, indicating that the cardioprotection afforded by H(2) was not due to anti-oxidative actions or effects on the NADH dehydrogenase pathway.\nCONCLUSIONS: Inhalation of H(2) gas reduces infarct size in canine hearts via opening of mitochondrial K(ATP) channels followed by inhibition of mPTP. H(2) gas may provide an effective adjunct strategy in patients with acute myocardial infarction receiving reperfusion therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10557-012-6381-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6085555", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6040577", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6013436", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6066581", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6058860", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6066678", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097576", 
        "issn": [
          "0920-3206", 
          "1573-7241"
        ], 
        "name": "Cardiovascular Drugs and Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of Mitochondria in Dogs", 
    "pagination": "217-226", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "829a1540f04c958a8cd348070e430c60b2ec9d9bb3959c5cd0f9f89c2aac926f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22527618"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8712220"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10557-012-6381-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027416163"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10557-012-6381-5", 
      "https://app.dimensions.ai/details/publication/pub.1027416163"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54297_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10557-012-6381-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10557-012-6381-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10557-012-6381-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10557-012-6381-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10557-012-6381-5'


 

This table displays all metadata directly associated to this object as RDF triples.

384 TRIPLES      21 PREDICATES      83 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10557-012-6381-5 schema:about N152989ea582e44869251e24e00fb6280
2 N3d0b0423945240648181145b558f9a97
3 N43b67690c47044f180148a4741d45d0e
4 N6a6057de7e90497c95fb030f7f8a0ba4
5 N738ed19adf044b849d310341485ee085
6 N7c3f3bad899145148d443e985fadd7e7
7 N7dcd0aa09e8d43ecad3fca89eff801aa
8 N80230d77ea564806a6816f5698ee9963
9 N9282f2995b6a4cfda02e7d8d75ff8ae3
10 N9cda0001894a4176b1ad97db7ab3fedd
11 Nc4be7e1f21864d1c8f5e3988192f9c1e
12 Ne1f1584f84bb42008f6856e4d57d95b6
13 Nf7dc9aeb723c4591a95bdc31de08eac5
14 anzsrc-for:11
15 anzsrc-for:1102
16 schema:author N8cbc28a206eb4fdda1a7f415328c3856
17 schema:citation sg:pub.10.1007/s00395-009-0010-x
18 sg:pub.10.1007/s00395-009-0080-9
19 sg:pub.10.1007/s00395-010-0121-4
20 sg:pub.10.1007/s11064-010-0162-y
21 sg:pub.10.1038/nm1577
22 https://doi.org/10.1006/jmcc.2001.1435
23 https://doi.org/10.1016/0735-1097(96)00064-2
24 https://doi.org/10.1016/j.bbrc.2005.10.109
25 https://doi.org/10.1016/j.bbrc.2007.07.088
26 https://doi.org/10.1016/j.bbrc.2008.05.165
27 https://doi.org/10.1016/j.bbrc.2009.02.105
28 https://doi.org/10.1016/j.brainres.2008.11.048
29 https://doi.org/10.1016/j.brainres.2010.02.046
30 https://doi.org/10.1016/j.cardiores.2007.04.022
31 https://doi.org/10.1016/j.jss.2009.07.045
32 https://doi.org/10.1016/j.jss.2010.11.005
33 https://doi.org/10.1016/j.yjmcc.2005.04.002
34 https://doi.org/10.1016/j.yjmcc.2010.08.001
35 https://doi.org/10.1016/s0008-6363(02)00455-8
36 https://doi.org/10.1016/s0140-6736(07)61634-1
37 https://doi.org/10.1056/nejmoa071142
38 https://doi.org/10.1073/pnas.84.24.9265
39 https://doi.org/10.1074/jbc.m600959200
40 https://doi.org/10.1080/10715760902870603
41 https://doi.org/10.1089/ars.2010.3375
42 https://doi.org/10.1093/cvr/cvq129
43 https://doi.org/10.1111/j.1478-3231.2010.02254.x
44 https://doi.org/10.1111/j.1600-6143.2008.02359.x
45 https://doi.org/10.1126/science.7839143
46 https://doi.org/10.1136/gut.34.6.818
47 https://doi.org/10.1152/ajpheart.00678.2003
48 https://doi.org/10.1152/ajpheart.1992.263.6.h1946
49 https://doi.org/10.1152/ajpheart.1996.270.5.h1744
50 https://doi.org/10.1161/01.cir.93.4.781
51 https://doi.org/10.1161/01.res.87.10.845
52 https://doi.org/10.1161/circresaha.110.225730
53 https://doi.org/10.1161/circulationaha.108.805242
54 https://doi.org/10.1161/hh2201.100205
55 https://doi.org/10.1172/jci19906
56 https://doi.org/10.1590/s0100-879x1999001100001
57 https://doi.org/10.3181/0812-rm-349
58 schema:datePublished 2012-06
59 schema:datePublishedReg 2012-06-01
60 schema:description PURPOSE: Inhalation of hydrogen (H(2)) gas has been shown to limit infarct size following ischemia-reperfusion injury in rat hearts. However, H(2) gas-induced cardioprotection has not been tested in large animals and the precise cellular mechanism of protection has not been elucidated. We investigated whether opening of mitochondrial ATP-sensitive K+ channels (mK(ATP)) and subsequent inhibition of mitochondrial permeability transition pores (mPTP) mediates the infarct size-limiting effect of H(2) gas in canine hearts. METHODS: The left anterior descending coronary artery of beagle dogs was occluded for 90 min followed by reperfusion for 6 h. Either 1.3% H(2) or control gas was inhaled from 10 min prior to start of reperfusion until 1 h of reperfusion, in the presence or absence of either 5-hydroxydecanoate (5-HD; a selective mK(ATP) blocker), or atractyloside (Atr; a mPTP opener). RESULTS: Systemic hemodynamic parameters did not differ among the groups. Nevertheless, H(2) gas inhalation reduced infarct size normalized by risk area (20.6±2.8% vs. control gas 44.0±2.0%; p<0.001), and administration of either 5-HD or Atr abolished the infarct size-limiting effect of H(2) gas (42.0±2.2% with 5-HD and 45.1±2.7% with Atr; both p<0.001 vs. H(2) group). Neither Atr nor 5-HD affected infarct size per se. Among all groups, NAD content and the number of apoptotic and 8-OHdG positive cells was not significantly different, indicating that the cardioprotection afforded by H(2) was not due to anti-oxidative actions or effects on the NADH dehydrogenase pathway. CONCLUSIONS: Inhalation of H(2) gas reduces infarct size in canine hearts via opening of mitochondrial K(ATP) channels followed by inhibition of mPTP. H(2) gas may provide an effective adjunct strategy in patients with acute myocardial infarction receiving reperfusion therapy.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N476c199c8ecf49c99e6240b2db849cb3
65 Nbc634b17e2654d1f912b12ad1804a20c
66 sg:journal.1097576
67 schema:name H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of Mitochondria in Dogs
68 schema:pagination 217-226
69 schema:productId N5770415d8ac349368054696dbf19e5cb
70 N971a6c7407f8451f881c30f9b667943b
71 Na30b1a95ae42455b840a616f4c74d181
72 Nb3cf392e0f3344eab7dbd2adc5e900f9
73 Nf1263ab86a7b46538ab0ab38f54cee66
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027416163
75 https://doi.org/10.1007/s10557-012-6381-5
76 schema:sdDatePublished 2019-04-11T10:15
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N33426ea0e72749e785fb4c0a5eb3a694
79 schema:url https://link.springer.com/10.1007%2Fs10557-012-6381-5
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0488d6a141b0494cba8980c4f630a071 schema:name Department of Structural Analysis, National Cerebral and Cardiovascular Research Center, Suita, Japan
84 rdf:type schema:Organization
85 N049ec5d5123b45f08e6cb788ede7962b rdf:first sg:person.01134507760.94
86 rdf:rest rdf:nil
87 N0aa622db67ba4f8c93d1b3d92568937e rdf:first sg:person.012414171571.93
88 rdf:rest N48a786304528443d97d28bccf3bbbf60
89 N152989ea582e44869251e24e00fb6280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Myocardial Infarction
91 rdf:type schema:DefinedTerm
92 N22800b8b23bc4d4ca95dce7d771e183d rdf:first sg:person.0721752760.71
93 rdf:rest Nef21d921284a44479878a31561d11404
94 N2a0d3b749f1f406e8b84ee116e58b84e schema:name Department of Cardiac Physiology, National Cerebral and Cardiovascular Research Center, Suita, Japan
95 rdf:type schema:Organization
96 N2c1aa35036d84af3a5cf3a26349320d0 rdf:first sg:person.01062533460.24
97 rdf:rest N62a24a258c2a4e1dbb06d74101e366fd
98 N30ad71ce1ca14867a12095c39a0c0baa rdf:first sg:person.01205347767.91
99 rdf:rest Nb40660092b3949ea9d76822e87716b0e
100 N33426ea0e72749e785fb4c0a5eb3a694 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N3d0b0423945240648181145b558f9a97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name In Situ Nick-End Labeling
104 rdf:type schema:DefinedTerm
105 N3fa63131f54f4004a68e1b49ca8f62bc rdf:first sg:person.01032340260.07
106 rdf:rest N30ad71ce1ca14867a12095c39a0c0baa
107 N43b67690c47044f180148a4741d45d0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Mitochondrial Membrane Transport Proteins
109 rdf:type schema:DefinedTerm
110 N476c199c8ecf49c99e6240b2db849cb3 schema:volumeNumber 26
111 rdf:type schema:PublicationVolume
112 N48a786304528443d97d28bccf3bbbf60 rdf:first sg:person.01030207644.91
113 rdf:rest N22800b8b23bc4d4ca95dce7d771e183d
114 N5770415d8ac349368054696dbf19e5cb schema:name dimensions_id
115 schema:value pub.1027416163
116 rdf:type schema:PropertyValue
117 N62a24a258c2a4e1dbb06d74101e366fd rdf:first sg:person.01306316622.03
118 rdf:rest N3fa63131f54f4004a68e1b49ca8f62bc
119 N6a6057de7e90497c95fb030f7f8a0ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Decanoic Acids
121 rdf:type schema:DefinedTerm
122 N738ed19adf044b849d310341485ee085 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Dogs
124 rdf:type schema:DefinedTerm
125 N7c3f3bad899145148d443e985fadd7e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Apoptosis
127 rdf:type schema:DefinedTerm
128 N7dcd0aa09e8d43ecad3fca89eff801aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Hydroxy Acids
130 rdf:type schema:DefinedTerm
131 N80230d77ea564806a6816f5698ee9963 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name KATP Channels
133 rdf:type schema:DefinedTerm
134 N8cbc28a206eb4fdda1a7f415328c3856 rdf:first sg:person.0640141175.20
135 rdf:rest N2c1aa35036d84af3a5cf3a26349320d0
136 N9282f2995b6a4cfda02e7d8d75ff8ae3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Myocardial Reperfusion Injury
138 rdf:type schema:DefinedTerm
139 N971a6c7407f8451f881c30f9b667943b schema:name pubmed_id
140 schema:value 22527618
141 rdf:type schema:PropertyValue
142 N9cda0001894a4176b1ad97db7ab3fedd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Potassium Channel Blockers
144 rdf:type schema:DefinedTerm
145 N9d9d1e5fba314944ba77f5093bc18e83 rdf:first sg:person.01203142451.33
146 rdf:rest Ncba1dec21ef9439787da558b77d01073
147 Na29e9535698c4592a9e5c4bb31609a6f rdf:first sg:person.01157222312.10
148 rdf:rest N0aa622db67ba4f8c93d1b3d92568937e
149 Na30b1a95ae42455b840a616f4c74d181 schema:name doi
150 schema:value 10.1007/s10557-012-6381-5
151 rdf:type schema:PropertyValue
152 Nb3cf392e0f3344eab7dbd2adc5e900f9 schema:name readcube_id
153 schema:value 829a1540f04c958a8cd348070e430c60b2ec9d9bb3959c5cd0f9f89c2aac926f
154 rdf:type schema:PropertyValue
155 Nb40660092b3949ea9d76822e87716b0e rdf:first sg:person.0605102236.53
156 rdf:rest Nd5e7e7eab2fc41d78ee31a51c1db800d
157 Nbc634b17e2654d1f912b12ad1804a20c schema:issueNumber 3
158 rdf:type schema:PublicationIssue
159 Nbe3947d2d289430d9a9cbe088e1a0bf3 rdf:first sg:person.0715762471.09
160 rdf:rest N049ec5d5123b45f08e6cb788ede7962b
161 Nc4be7e1f21864d1c8f5e3988192f9c1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Hydrogen
163 rdf:type schema:DefinedTerm
164 Ncba1dec21ef9439787da558b77d01073 rdf:first sg:person.01216244324.21
165 rdf:rest Nbe3947d2d289430d9a9cbe088e1a0bf3
166 Nd5e7e7eab2fc41d78ee31a51c1db800d rdf:first sg:person.01137573062.13
167 rdf:rest Na29e9535698c4592a9e5c4bb31609a6f
168 Ne1f1584f84bb42008f6856e4d57d95b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cardiotonic Agents
170 rdf:type schema:DefinedTerm
171 Nef21d921284a44479878a31561d11404 rdf:first sg:person.015653244242.17
172 rdf:rest N9d9d1e5fba314944ba77f5093bc18e83
173 Nf1263ab86a7b46538ab0ab38f54cee66 schema:name nlm_unique_id
174 schema:value 8712220
175 rdf:type schema:PropertyValue
176 Nf7dc9aeb723c4591a95bdc31de08eac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Animals
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
183 schema:name Cardiorespiratory Medicine and Haematology
184 rdf:type schema:DefinedTerm
185 sg:grant.6013436 http://pending.schema.org/fundedItem sg:pub.10.1007/s10557-012-6381-5
186 rdf:type schema:MonetaryGrant
187 sg:grant.6040577 http://pending.schema.org/fundedItem sg:pub.10.1007/s10557-012-6381-5
188 rdf:type schema:MonetaryGrant
189 sg:grant.6058860 http://pending.schema.org/fundedItem sg:pub.10.1007/s10557-012-6381-5
190 rdf:type schema:MonetaryGrant
191 sg:grant.6066581 http://pending.schema.org/fundedItem sg:pub.10.1007/s10557-012-6381-5
192 rdf:type schema:MonetaryGrant
193 sg:grant.6066678 http://pending.schema.org/fundedItem sg:pub.10.1007/s10557-012-6381-5
194 rdf:type schema:MonetaryGrant
195 sg:grant.6085555 http://pending.schema.org/fundedItem sg:pub.10.1007/s10557-012-6381-5
196 rdf:type schema:MonetaryGrant
197 sg:journal.1097576 schema:issn 0920-3206
198 1573-7241
199 schema:name Cardiovascular Drugs and Therapy
200 rdf:type schema:Periodical
201 sg:person.01030207644.91 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
202 schema:familyName Sano
203 schema:givenName Motoaki
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030207644.91
205 rdf:type schema:Person
206 sg:person.01032340260.07 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
207 schema:familyName Sanada
208 schema:givenName Shoji
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032340260.07
210 rdf:type schema:Person
211 sg:person.01062533460.24 schema:affiliation https://www.grid.ac/institutes/grid.272458.e
212 schema:familyName Asanuma
213 schema:givenName Hiroshi
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062533460.24
215 rdf:type schema:Person
216 sg:person.01134507760.94 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
217 schema:familyName Kitakaze
218 schema:givenName Masafumi
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134507760.94
220 rdf:type schema:Person
221 sg:person.01137573062.13 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
222 schema:familyName Shinozaki
223 schema:givenName Yoshiro
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137573062.13
225 rdf:type schema:Person
226 sg:person.01157222312.10 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
227 schema:familyName Mori
228 schema:givenName Hidezo
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157222312.10
230 rdf:type schema:Person
231 sg:person.01203142451.33 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
232 schema:familyName Takashima
233 schema:givenName Seiji
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203142451.33
235 rdf:type schema:Person
236 sg:person.01205347767.91 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
237 schema:familyName Yamazaki
238 schema:givenName Satoru
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205347767.91
240 rdf:type schema:Person
241 sg:person.01216244324.21 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
242 schema:familyName Sugimachi
243 schema:givenName Masaru
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216244324.21
245 rdf:type schema:Person
246 sg:person.012414171571.93 schema:affiliation N2a0d3b749f1f406e8b84ee116e58b84e
247 schema:familyName Shimouchi
248 schema:givenName Akito
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012414171571.93
250 rdf:type schema:Person
251 sg:person.01306316622.03 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
252 schema:familyName Sasaki
253 schema:givenName Hideyuki
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306316622.03
255 rdf:type schema:Person
256 sg:person.015653244242.17 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
257 schema:familyName Minamino
258 schema:givenName Tetsuo
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015653244242.17
260 rdf:type schema:Person
261 sg:person.0605102236.53 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
262 schema:familyName Asano
263 schema:givenName Yoshihiro
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605102236.53
265 rdf:type schema:Person
266 sg:person.0640141175.20 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
267 schema:familyName Yoshida
268 schema:givenName Akemi
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640141175.20
270 rdf:type schema:Person
271 sg:person.0715762471.09 schema:affiliation N0488d6a141b0494cba8980c4f630a071
272 schema:familyName Mochizuki
273 schema:givenName Naoki
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715762471.09
275 rdf:type schema:Person
276 sg:person.0721752760.71 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
277 schema:familyName Asakura
278 schema:givenName Masanori
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721752760.71
280 rdf:type schema:Person
281 sg:pub.10.1007/s00395-009-0010-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051841494
282 https://doi.org/10.1007/s00395-009-0010-x
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s00395-009-0080-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034453311
285 https://doi.org/10.1007/s00395-009-0080-9
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s00395-010-0121-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050848579
288 https://doi.org/10.1007/s00395-010-0121-4
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s11064-010-0162-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001870957
291 https://doi.org/10.1007/s11064-010-0162-y
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nm1577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138180
294 https://doi.org/10.1038/nm1577
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1006/jmcc.2001.1435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030919034
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/0735-1097(96)00064-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017981122
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.bbrc.2005.10.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051703286
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.bbrc.2007.07.088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013666264
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.bbrc.2008.05.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016500314
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.bbrc.2009.02.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031336302
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.brainres.2008.11.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028399961
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.brainres.2010.02.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019280309
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.cardiores.2007.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030847723
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.jss.2009.07.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010870800
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.jss.2010.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006916932
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.yjmcc.2005.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043156444
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.yjmcc.2010.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036664526
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0008-6363(02)00455-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578170
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0140-6736(07)61634-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045514991
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1056/nejmoa071142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002994851
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.84.24.9265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029531947
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.m600959200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025161346
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1080/10715760902870603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034851613
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1089/ars.2010.3375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231305
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/cvr/cvq129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003847186
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1111/j.1478-3231.2010.02254.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047152852
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1111/j.1600-6143.2008.02359.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043708509
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1126/science.7839143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649872
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1136/gut.34.6.818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023094018
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1152/ajpheart.00678.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015957346
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1152/ajpheart.1992.263.6.h1946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076678255
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1152/ajpheart.1996.270.5.h1744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083003111
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1161/01.cir.93.4.781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336993
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1161/01.res.87.10.845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046706587
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1161/circresaha.110.225730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022312896
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1161/circulationaha.108.805242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021000950
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1161/hh2201.100205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037477391
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1172/jci19906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048278072
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1590/s0100-879x1999001100001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007276041
365 rdf:type schema:CreativeWork
366 https://doi.org/10.3181/0812-rm-349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014428002
367 rdf:type schema:CreativeWork
368 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
369 schema:name Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
372 schema:name Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
375 schema:name Department of Physiological Science, Tokai University Graduate School of Medicine, Isehara, Japan
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.272458.e schema:alternateName Kyoto Prefectural University of Medicine
378 schema:name Department of Cardiovascular Science and Technology, Kyoto Prefectural University of Medicine, Suita 565-8565, Osaka, Japan
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.410796.d schema:alternateName National Cerebral and Cardiovascular Center
381 schema:name Department of Cardiovascular Dynamics, Research Institute, National Cerebral and Cardiovascular Center, Suita, Japan
382 Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Osaka, Japan
383 Department of Structural Analysis, National Cerebral and Cardiovascular Research Center, Suita, Japan
384 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...