Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

David J. McConkey, Woonyoung Choi, Lauren Marquis, Frances Martin, Michael B. Williams, Jay Shah, Robert Svatek, Aditi Das, Liana Adam, Ashish Kamat, Arlene Siefker-Radtke, Colin Dinney

ABSTRACT

Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased invasion and migration. At the molecular level, EMT is characterized by loss of E-cadherin and increased expression of several transcriptional repressors of E-cadherin expression (Zeb-1, Zeb-2, Twist, Snail, and Slug). Early work established that loss of E-cadherin and increased expression of MMP-9 was associated with a poor clinical outcome in patients with urothelial tumors, suggesting that EMT might also be associated with bladder cancer progression and metastasis. More recently, we have used global gene expression profiling to characterize the molecular heterogeneity in human urothelial cancer cell lines (n = 20) and primary patient tumors, and unsupervised clustering analyses revealed that the cells naturally segregate into two discrete "epithelial" and "mesenchymal" subsets, the latter consisting entirely of muscle-invasive tumors. Importantly, sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) or type-3 fibroblast growth factor receptor (FGFR3) was confined to the "epithelial" subset, and sensitivity to EGFR inhibitors could be reestablished by micro-RNA-mediated molecular reversal of EMT. The results suggest that EMT coordinately regulates drug resistance and muscle invasion/metastasis in urothelial cancer and is a dominant feature of overall cancer biology. More... »

PAGES

335-344

References to SciGraph publications

  • 1994-06. Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis in BRITISH JOURNAL OF CANCER
  • 2001-07. Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours in ONCOGENE
  • 1992-11. Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix in CANCER AND METASTASIS REVIEWS
  • 2007-11. Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer in IMMUNOLOGIC RESEARCH
  • 2008-07-03. SMAD proteins control DROSHA-mediated microRNA maturation in NATURE
  • 2003-08. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray in VIRCHOWS ARCHIV
  • 2008-05. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 in NATURE CELL BIOLOGY
  • 2007-06. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? in NATURE REVIEWS CANCER
  • 2007-08. Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer in ONCOGENE
  • 2007-09-02. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL in NATURE MEDICINE
  • 2006-03. Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases in VIRCHOWS ARCHIV
  • 2007-07. p63: revving up epithelial stem-cell potential in NATURE CELL BIOLOGY
  • 2003-03. Impaired ΔNp63 expression associates with reduced β-catenin and aggressive phenotypes of urothelial neoplasms in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10555-009-9194-7

    DOI

    http://dx.doi.org/10.1007/s10555-009-9194-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015776432

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20012924


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cadherins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Transitional Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transdifferentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "ErbB Receptors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblast Growth Factor 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Developmental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mesoderm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TNF-Related Apoptosis-Inducing Ligand", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Urinary Bladder Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wound Healing", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA", 
                "Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McConkey", 
            "givenName": "David J.", 
            "id": "sg:person.0627351417.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627351417.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA", 
                "Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Woonyoung", 
            "id": "sg:person.01136134734.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136134734.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA", 
                "Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marquis", 
            "givenName": "Lauren", 
            "id": "sg:person.0772326727.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772326727.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin", 
            "givenName": "Frances", 
            "id": "sg:person.01033265532.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033265532.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Williams", 
            "givenName": "Michael B.", 
            "id": "sg:person.01267402642.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267402642.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shah", 
            "givenName": "Jay", 
            "id": "sg:person.011305552677.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011305552677.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Svatek", 
            "givenName": "Robert", 
            "id": "sg:person.0635344437.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635344437.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA", 
                "Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Das", 
            "givenName": "Aditi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA", 
                "Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adam", 
            "givenName": "Liana", 
            "id": "sg:person.01043217537.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043217537.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamat", 
            "givenName": "Ashish", 
            "id": "sg:person.016172066457.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016172066457.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Genitourinary Medical Oncology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siefker-Radtke", 
            "givenName": "Arlene", 
            "id": "sg:person.0617467327.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617467327.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box\u00a01373, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dinney", 
            "givenName": "Colin", 
            "id": "sg:person.012610632077.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012610632077.22"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19960717)67:2<275::aid-ijc20>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000386759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-03-1327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001228442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1640608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004123559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-0407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004898502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.18.8108-8125.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006589108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.22.3370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006674721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-2409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006822742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008946163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminoncol.2006.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009297891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12026-007-0084-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009450589", 
              "https://doi.org/10.1007/s12026-007-0084-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.06.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010114196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010511161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m804777200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011000378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-5002(03)00137-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012032996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-5002(03)00137-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012032996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0902042106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012154477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2004.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012235373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-1224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012584979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013751870", 
              "https://doi.org/10.1038/sj.onc.1210399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.21.6796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013944755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-005-0092-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014168007", 
              "https://doi.org/10.1007/s00428-005-0092-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-005-0092-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014168007", 
              "https://doi.org/10.1007/s00428-005-0092-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014868759", 
              "https://doi.org/10.1038/sj.bjc.6600764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014868759", 
              "https://doi.org/10.1038/sj.bjc.6600764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.neo.7900124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015250015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa051918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015724931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa051918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015724931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015827562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.9858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015875660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-0374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016195866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64814-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016219929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-2819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023349225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.00533.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023457044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.urolonc.2007.11.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024573892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024861161", 
              "https://doi.org/10.1038/nm1627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025092385", 
              "https://doi.org/10.1038/nrc2131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025904872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000108845.91485.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026945329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000108845.91485.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026945329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029477989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.03.2375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030127381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.14.7116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031599680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032756706", 
              "https://doi.org/10.1038/nature07086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.02.857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033277450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m709428200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033356364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033771185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.00938-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034283061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035206966", 
              "https://doi.org/10.1038/sj.onc.1204543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035206966", 
              "https://doi.org/10.1038/sj.onc.1204543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1044-579x(02)00057-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035748567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-0286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035886500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-003-0859-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037526590", 
              "https://doi.org/10.1007/s00428-003-0859-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1820209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038770877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4644(1998)72:30/31+<111::aid-jcb15>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039591027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0705158104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040257663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.03.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042567148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.13.0062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042910508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-2938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043226815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64016-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043312631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1994.220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044017172", 
              "https://doi.org/10.1038/bjc.1994.220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1994.220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044017172", 
              "https://doi.org/10.1038/bjc.1994.220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(97)10075-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044689306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044751385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0707-731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045082329", 
              "https://doi.org/10.1038/ncb0707-731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047429448", 
              "https://doi.org/10.1038/ncb1722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047482036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01307187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049961968", 
              "https://doi.org/10.1007/bf01307187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01307187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049961968", 
              "https://doi.org/10.1007/bf01307187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.10083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050164062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0500165102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050332338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-2330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051544472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-05-0474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051570730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64396-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052037734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-2245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052436680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.14.8924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052598954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/83.4.285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059817007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.09.985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.09.985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.20.1.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071512071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.8.1.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071536358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.6.6.4088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072294587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.5.2.2340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074255182", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074539501", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074613524", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074660235", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074673345", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074880629", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074997015", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075031502", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075087967", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076607143", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076607150", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076607168", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082635862", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082995554", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083084091", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083219806", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347358", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083379569", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-12", 
        "datePublishedReg": "2009-12-01", 
        "description": "Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased invasion and migration. At the molecular level, EMT is characterized by loss of E-cadherin and increased expression of several transcriptional repressors of E-cadherin expression (Zeb-1, Zeb-2, Twist, Snail, and Slug). Early work established that loss of E-cadherin and increased expression of MMP-9 was associated with a poor clinical outcome in patients with urothelial tumors, suggesting that EMT might also be associated with bladder cancer progression and metastasis. More recently, we have used global gene expression profiling to characterize the molecular heterogeneity in human urothelial cancer cell lines (n = 20) and primary patient tumors, and unsupervised clustering analyses revealed that the cells naturally segregate into two discrete \"epithelial\" and \"mesenchymal\" subsets, the latter consisting entirely of muscle-invasive tumors. Importantly, sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) or type-3 fibroblast growth factor receptor (FGFR3) was confined to the \"epithelial\" subset, and sensitivity to EGFR inhibitors could be reestablished by micro-RNA-mediated molecular reversal of EMT. The results suggest that EMT coordinately regulates drug resistance and muscle invasion/metastasis in urothelial cancer and is a dominant feature of overall cancer biology.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10555-009-9194-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438826", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1096239", 
            "issn": [
              "0167-7659", 
              "1573-7233"
            ], 
            "name": "Cancer and Metastasis Reviews", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3-4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "28"
          }
        ], 
        "name": "Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer", 
        "pagination": "335-344", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4b2b6c8b016f5f666c744aed4aa0f0f5c62dc32cd3555a573c9ed9925e0cc4ff"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20012924"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8605731"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10555-009-9194-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1015776432"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10555-009-9194-7", 
          "https://app.dimensions.ai/details/publication/pub.1015776432"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T14:33", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13104_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs10555-009-9194-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9194-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9194-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9194-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9194-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    501 TRIPLES      21 PREDICATES      141 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10555-009-9194-7 schema:about N00e3c6bacb4e427583dc6793471978b6
    2 N03d51d090f4042b9b348e577e99107c9
    3 N091d8a7bc6bb49c2914f0228c16bb9e3
    4 N1dd53130342341de88840d3703a19e34
    5 N2680c8c70cca499c932e25e27d636a32
    6 N3e5f4e629c3d49859e7395aead59b361
    7 N458da6e16a584d59b3ed02d0b1bf7855
    8 N4cbe3d26795f4f51b54867787f79f965
    9 N595a032d17924a5a958db8e2e16f1e4c
    10 N6a91976bd09c4d97897ad492ae38954e
    11 N6d2c4a0a0f094afd95e473ebc983d5cc
    12 N7f32f19c539b4cc78de304c25f14a968
    13 Na2ac1f1e97f94cb2a161164b865940ef
    14 Nb0183ba705434f0282b957ecbaf74e34
    15 Nb111cfba7ef941b1b50d2751b38f0ac2
    16 Nbaca5657b6144101beff6255fca2c43b
    17 Ncf39136e6e994690a6e63a07265670d6
    18 Ndc48c49407f441cc96c29c2b33b3d327
    19 Nea78cb1679904295b188d42e19c9538e
    20 Nf2ca417bd4de488e87af819ed4bc5874
    21 Nf7ea3e96ae6e4894a55555be73533fe7
    22 anzsrc-for:06
    23 anzsrc-for:0601
    24 schema:author N04e7f8dffa04461997437c1081225e00
    25 schema:citation sg:pub.10.1007/bf01307187
    26 sg:pub.10.1007/s00428-003-0859-2
    27 sg:pub.10.1007/s00428-005-0092-2
    28 sg:pub.10.1007/s12026-007-0084-1
    29 sg:pub.10.1038/bjc.1994.220
    30 sg:pub.10.1038/nature07086
    31 sg:pub.10.1038/ncb0707-731
    32 sg:pub.10.1038/ncb1722
    33 sg:pub.10.1038/nm1627
    34 sg:pub.10.1038/nrc2131
    35 sg:pub.10.1038/sj.bjc.6600764
    36 sg:pub.10.1038/sj.onc.1204543
    37 sg:pub.10.1038/sj.onc.1210399
    38 https://app.dimensions.ai/details/publication/pub.1074255182
    39 https://app.dimensions.ai/details/publication/pub.1074539501
    40 https://app.dimensions.ai/details/publication/pub.1074613524
    41 https://app.dimensions.ai/details/publication/pub.1074660235
    42 https://app.dimensions.ai/details/publication/pub.1074673345
    43 https://app.dimensions.ai/details/publication/pub.1074880629
    44 https://app.dimensions.ai/details/publication/pub.1074997015
    45 https://app.dimensions.ai/details/publication/pub.1075031502
    46 https://app.dimensions.ai/details/publication/pub.1075087967
    47 https://app.dimensions.ai/details/publication/pub.1076607143
    48 https://app.dimensions.ai/details/publication/pub.1076607150
    49 https://app.dimensions.ai/details/publication/pub.1076607168
    50 https://app.dimensions.ai/details/publication/pub.1082635862
    51 https://app.dimensions.ai/details/publication/pub.1082995554
    52 https://app.dimensions.ai/details/publication/pub.1083084091
    53 https://app.dimensions.ai/details/publication/pub.1083219806
    54 https://app.dimensions.ai/details/publication/pub.1083347358
    55 https://app.dimensions.ai/details/publication/pub.1083379569
    56 https://doi.org/10.1002/(sici)1097-0215(19960717)67:2<275::aid-ijc20>3.0.co;2-9
    57 https://doi.org/10.1002/(sici)1097-4644(1998)72:30/31+<111::aid-jcb15>3.0.co;2-5
    58 https://doi.org/10.1002/gcc.10083
    59 https://doi.org/10.1002/path.2207
    60 https://doi.org/10.1016/j.ccr.2004.08.002
    61 https://doi.org/10.1016/j.cell.2008.03.027
    62 https://doi.org/10.1016/j.cell.2009.06.034
    63 https://doi.org/10.1016/j.urolonc.2007.11.031
    64 https://doi.org/10.1016/s0002-9440(10)64016-3
    65 https://doi.org/10.1016/s0002-9440(10)64396-9
    66 https://doi.org/10.1016/s0002-9440(10)64814-6
    67 https://doi.org/10.1016/s0169-5002(03)00137-5
    68 https://doi.org/10.1016/s0959-8049(97)10075-2
    69 https://doi.org/10.1016/s1044-579x(02)00057-3
    70 https://doi.org/10.1038/sj.neo.7900124
    71 https://doi.org/10.1053/j.seminoncol.2006.04.003
    72 https://doi.org/10.1056/nejmoa051918
    73 https://doi.org/10.1073/pnas.0500165102
    74 https://doi.org/10.1073/pnas.0705158104
    75 https://doi.org/10.1073/pnas.0902042106
    76 https://doi.org/10.1074/jbc.m709428200
    77 https://doi.org/10.1074/jbc.m804777200
    78 https://doi.org/10.1093/jnci/83.4.285
    79 https://doi.org/10.1097/01.ju.0000108845.91485.20
    80 https://doi.org/10.1101/gad.1640608
    81 https://doi.org/10.1101/gad.1820209
    82 https://doi.org/10.1128/iai.00938-06
    83 https://doi.org/10.1128/mcb.25.18.8108-8125.2005
    84 https://doi.org/10.1152/ajprenal.00533.2007
    85 https://doi.org/10.1158/0008-5472.can-04-0374
    86 https://doi.org/10.1158/0008-5472.can-04-1909
    87 https://doi.org/10.1158/0008-5472.can-05-1536
    88 https://doi.org/10.1158/0008-5472.can-05-1988
    89 https://doi.org/10.1158/0008-5472.can-06-1224
    90 https://doi.org/10.1158/0008-5472.can-07-1058
    91 https://doi.org/10.1158/0008-5472.can-07-2938
    92 https://doi.org/10.1158/0008-5472.can-08-2819
    93 https://doi.org/10.1158/1078-0432.ccr-04-2409
    94 https://doi.org/10.1158/1078-0432.ccr-06-0286
    95 https://doi.org/10.1158/1078-0432.ccr-06-0407
    96 https://doi.org/10.1158/1078-0432.ccr-06-2330
    97 https://doi.org/10.1158/1078-0432.ccr-07-1593
    98 https://doi.org/10.1158/1078-0432.ccr-08-2245
    99 https://doi.org/10.1158/1535-7163.mct-05-0474
    100 https://doi.org/10.1158/1535-7163.mct-06-0513
    101 https://doi.org/10.1172/jci38017
    102 https://doi.org/10.1182/blood-2005-03-1327
    103 https://doi.org/10.1200/jco.2005.02.857
    104 https://doi.org/10.1200/jco.2005.03.2375
    105 https://doi.org/10.1200/jco.2005.09.985
    106 https://doi.org/10.1200/jco.2007.12.9858
    107 https://doi.org/10.1200/jco.2007.13.0062
    108 https://doi.org/10.1200/jco.2007.14.7116
    109 https://doi.org/10.1200/jco.2007.14.8924
    110 https://doi.org/10.1200/jco.2008.21.6796
    111 https://doi.org/10.1200/jco.2009.22.3370
    112 https://doi.org/10.3892/ijo.20.1.5
    113 https://doi.org/10.3892/or.8.1.9
    114 https://doi.org/10.4161/cbt.6.6.4088
    115 https://doi.org/10.4161/cc.5.2.2340
    116 schema:datePublished 2009-12
    117 schema:datePublishedReg 2009-12-01
    118 schema:description Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased invasion and migration. At the molecular level, EMT is characterized by loss of E-cadherin and increased expression of several transcriptional repressors of E-cadherin expression (Zeb-1, Zeb-2, Twist, Snail, and Slug). Early work established that loss of E-cadherin and increased expression of MMP-9 was associated with a poor clinical outcome in patients with urothelial tumors, suggesting that EMT might also be associated with bladder cancer progression and metastasis. More recently, we have used global gene expression profiling to characterize the molecular heterogeneity in human urothelial cancer cell lines (n = 20) and primary patient tumors, and unsupervised clustering analyses revealed that the cells naturally segregate into two discrete "epithelial" and "mesenchymal" subsets, the latter consisting entirely of muscle-invasive tumors. Importantly, sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) or type-3 fibroblast growth factor receptor (FGFR3) was confined to the "epithelial" subset, and sensitivity to EGFR inhibitors could be reestablished by micro-RNA-mediated molecular reversal of EMT. The results suggest that EMT coordinately regulates drug resistance and muscle invasion/metastasis in urothelial cancer and is a dominant feature of overall cancer biology.
    119 schema:genre research_article
    120 schema:inLanguage en
    121 schema:isAccessibleForFree true
    122 schema:isPartOf N08f43bafa6b54378afede90068e17940
    123 Na78f99df87d9426cac06aeb095914353
    124 sg:journal.1096239
    125 schema:name Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
    126 schema:pagination 335-344
    127 schema:productId N3d607386fad240f78b0d459a2689620b
    128 N6c48ac84383141afad589d8880e377d2
    129 N8b734b572d7443c4a047468c13203237
    130 N9f0109605e0c4d6c8cd7638d12ad064e
    131 Nec906b7d28194b4ba2bc29766b538a85
    132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015776432
    133 https://doi.org/10.1007/s10555-009-9194-7
    134 schema:sdDatePublished 2019-04-11T14:33
    135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    136 schema:sdPublisher N868a4a886bfa4392a9fc016cb4d87318
    137 schema:url http://link.springer.com/10.1007%2Fs10555-009-9194-7
    138 sgo:license sg:explorer/license/
    139 sgo:sdDataset articles
    140 rdf:type schema:ScholarlyArticle
    141 N00e3c6bacb4e427583dc6793471978b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Carcinoma, Transitional Cell
    143 rdf:type schema:DefinedTerm
    144 N03d51d090f4042b9b348e577e99107c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Disease Progression
    146 rdf:type schema:DefinedTerm
    147 N04e7f8dffa04461997437c1081225e00 rdf:first sg:person.0627351417.14
    148 rdf:rest N6aed37aaad0544a8867c3c3f3c1311e3
    149 N08f43bafa6b54378afede90068e17940 schema:volumeNumber 28
    150 rdf:type schema:PublicationVolume
    151 N091d8a7bc6bb49c2914f0228c16bb9e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Gene Expression Regulation, Neoplastic
    153 rdf:type schema:DefinedTerm
    154 N0fe0ef59d8594a55a03f2f90a90365a2 rdf:first sg:person.0635344437.47
    155 rdf:rest Nc20d0eff597a42f59088686acdd7cd3c
    156 N0ff143331803472d8633e3b931be72cb rdf:first sg:person.01267402642.45
    157 rdf:rest Ne31410e8a2934cc1b5865be85b08751f
    158 N1dd53130342341de88840d3703a19e34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Gene Expression Profiling
    160 rdf:type schema:DefinedTerm
    161 N22b8bcdbc6b046d0a3f3d32917dbfc7e rdf:first sg:person.01043217537.74
    162 rdf:rest N85c5a0f8c2604444a402d0d7466fff1f
    163 N2680c8c70cca499c932e25e27d636a32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Neoplasm Invasiveness
    165 rdf:type schema:DefinedTerm
    166 N33da5d58feeb49d2a0e2e97266b8d577 rdf:first sg:person.0772326727.20
    167 rdf:rest N661a0307154e4f74bd84a0010c3ac7ad
    168 N3d607386fad240f78b0d459a2689620b schema:name nlm_unique_id
    169 schema:value 8605731
    170 rdf:type schema:PropertyValue
    171 N3e5f4e629c3d49859e7395aead59b361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Cadherins
    173 rdf:type schema:DefinedTerm
    174 N458da6e16a584d59b3ed02d0b1bf7855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Urinary Bladder Neoplasms
    176 rdf:type schema:DefinedTerm
    177 N4cbe3d26795f4f51b54867787f79f965 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Neoplasm Proteins
    179 rdf:type schema:DefinedTerm
    180 N595a032d17924a5a958db8e2e16f1e4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name TNF-Related Apoptosis-Inducing Ligand
    182 rdf:type schema:DefinedTerm
    183 N5cb04fdf822746849575e2301bcfc585 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    184 schema:familyName Das
    185 schema:givenName Aditi
    186 rdf:type schema:Person
    187 N661a0307154e4f74bd84a0010c3ac7ad rdf:first sg:person.01033265532.03
    188 rdf:rest N0ff143331803472d8633e3b931be72cb
    189 N6a91976bd09c4d97897ad492ae38954e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Epithelium
    191 rdf:type schema:DefinedTerm
    192 N6aed37aaad0544a8867c3c3f3c1311e3 rdf:first sg:person.01136134734.23
    193 rdf:rest N33da5d58feeb49d2a0e2e97266b8d577
    194 N6c48ac84383141afad589d8880e377d2 schema:name pubmed_id
    195 schema:value 20012924
    196 rdf:type schema:PropertyValue
    197 N6d2c4a0a0f094afd95e473ebc983d5cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Drug Resistance, Neoplasm
    199 rdf:type schema:DefinedTerm
    200 N7f32f19c539b4cc78de304c25f14a968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name ErbB Receptors
    202 rdf:type schema:DefinedTerm
    203 N85c5a0f8c2604444a402d0d7466fff1f rdf:first sg:person.016172066457.96
    204 rdf:rest Nbd2b2ab3bd704744b9940e834c65f593
    205 N868a4a886bfa4392a9fc016cb4d87318 schema:name Springer Nature - SN SciGraph project
    206 rdf:type schema:Organization
    207 N8b734b572d7443c4a047468c13203237 schema:name readcube_id
    208 schema:value 4b2b6c8b016f5f666c744aed4aa0f0f5c62dc32cd3555a573c9ed9925e0cc4ff
    209 rdf:type schema:PropertyValue
    210 N9f0109605e0c4d6c8cd7638d12ad064e schema:name dimensions_id
    211 schema:value pub.1015776432
    212 rdf:type schema:PropertyValue
    213 Na2ac1f1e97f94cb2a161164b865940ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Models, Biological
    215 rdf:type schema:DefinedTerm
    216 Na78f99df87d9426cac06aeb095914353 schema:issueNumber 3-4
    217 rdf:type schema:PublicationIssue
    218 Naa7d4a8ff56b4b3fa5d095f0536518fe rdf:first sg:person.012610632077.22
    219 rdf:rest rdf:nil
    220 Nb0183ba705434f0282b957ecbaf74e34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Gene Expression Regulation, Developmental
    222 rdf:type schema:DefinedTerm
    223 Nb111cfba7ef941b1b50d2751b38f0ac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Wound Healing
    225 rdf:type schema:DefinedTerm
    226 Nbaca5657b6144101beff6255fca2c43b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Fibroblast Growth Factor 3
    228 rdf:type schema:DefinedTerm
    229 Nbd2b2ab3bd704744b9940e834c65f593 rdf:first sg:person.0617467327.15
    230 rdf:rest Naa7d4a8ff56b4b3fa5d095f0536518fe
    231 Nc20d0eff597a42f59088686acdd7cd3c rdf:first N5cb04fdf822746849575e2301bcfc585
    232 rdf:rest N22b8bcdbc6b046d0a3f3d32917dbfc7e
    233 Ncf39136e6e994690a6e63a07265670d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Cell Line, Tumor
    235 rdf:type schema:DefinedTerm
    236 Ndc48c49407f441cc96c29c2b33b3d327 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Cell Transdifferentiation
    238 rdf:type schema:DefinedTerm
    239 Ne31410e8a2934cc1b5865be85b08751f rdf:first sg:person.011305552677.69
    240 rdf:rest N0fe0ef59d8594a55a03f2f90a90365a2
    241 Nea78cb1679904295b188d42e19c9538e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name MicroRNAs
    243 rdf:type schema:DefinedTerm
    244 Nec906b7d28194b4ba2bc29766b538a85 schema:name doi
    245 schema:value 10.1007/s10555-009-9194-7
    246 rdf:type schema:PropertyValue
    247 Nf2ca417bd4de488e87af819ed4bc5874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    248 schema:name Mesoderm
    249 rdf:type schema:DefinedTerm
    250 Nf7ea3e96ae6e4894a55555be73533fe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Humans
    252 rdf:type schema:DefinedTerm
    253 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    254 schema:name Biological Sciences
    255 rdf:type schema:DefinedTerm
    256 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    257 schema:name Biochemistry and Cell Biology
    258 rdf:type schema:DefinedTerm
    259 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1007/s10555-009-9194-7
    260 rdf:type schema:MonetaryGrant
    261 sg:journal.1096239 schema:issn 0167-7659
    262 1573-7233
    263 schema:name Cancer and Metastasis Reviews
    264 rdf:type schema:Periodical
    265 sg:person.01033265532.03 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    266 schema:familyName Martin
    267 schema:givenName Frances
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033265532.03
    269 rdf:type schema:Person
    270 sg:person.01043217537.74 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    271 schema:familyName Adam
    272 schema:givenName Liana
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043217537.74
    274 rdf:type schema:Person
    275 sg:person.011305552677.69 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    276 schema:familyName Shah
    277 schema:givenName Jay
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011305552677.69
    279 rdf:type schema:Person
    280 sg:person.01136134734.23 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    281 schema:familyName Choi
    282 schema:givenName Woonyoung
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136134734.23
    284 rdf:type schema:Person
    285 sg:person.012610632077.22 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    286 schema:familyName Dinney
    287 schema:givenName Colin
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012610632077.22
    289 rdf:type schema:Person
    290 sg:person.01267402642.45 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    291 schema:familyName Williams
    292 schema:givenName Michael B.
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267402642.45
    294 rdf:type schema:Person
    295 sg:person.016172066457.96 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    296 schema:familyName Kamat
    297 schema:givenName Ashish
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016172066457.96
    299 rdf:type schema:Person
    300 sg:person.0617467327.15 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    301 schema:familyName Siefker-Radtke
    302 schema:givenName Arlene
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617467327.15
    304 rdf:type schema:Person
    305 sg:person.0627351417.14 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    306 schema:familyName McConkey
    307 schema:givenName David J.
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627351417.14
    309 rdf:type schema:Person
    310 sg:person.0635344437.47 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    311 schema:familyName Svatek
    312 schema:givenName Robert
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635344437.47
    314 rdf:type schema:Person
    315 sg:person.0772326727.20 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    316 schema:familyName Marquis
    317 schema:givenName Lauren
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772326727.20
    319 rdf:type schema:Person
    320 sg:pub.10.1007/bf01307187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049961968
    321 https://doi.org/10.1007/bf01307187
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1007/s00428-003-0859-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037526590
    324 https://doi.org/10.1007/s00428-003-0859-2
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1007/s00428-005-0092-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014168007
    327 https://doi.org/10.1007/s00428-005-0092-2
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1007/s12026-007-0084-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009450589
    330 https://doi.org/10.1007/s12026-007-0084-1
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/bjc.1994.220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044017172
    333 https://doi.org/10.1038/bjc.1994.220
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/nature07086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032756706
    336 https://doi.org/10.1038/nature07086
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/ncb0707-731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045082329
    339 https://doi.org/10.1038/ncb0707-731
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/ncb1722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047429448
    342 https://doi.org/10.1038/ncb1722
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/nm1627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024861161
    345 https://doi.org/10.1038/nm1627
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nrc2131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025092385
    348 https://doi.org/10.1038/nrc2131
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/sj.bjc.6600764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014868759
    351 https://doi.org/10.1038/sj.bjc.6600764
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/sj.onc.1204543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035206966
    354 https://doi.org/10.1038/sj.onc.1204543
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/sj.onc.1210399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013751870
    357 https://doi.org/10.1038/sj.onc.1210399
    358 rdf:type schema:CreativeWork
    359 https://app.dimensions.ai/details/publication/pub.1074255182 schema:CreativeWork
    360 https://app.dimensions.ai/details/publication/pub.1074539501 schema:CreativeWork
    361 https://app.dimensions.ai/details/publication/pub.1074613524 schema:CreativeWork
    362 https://app.dimensions.ai/details/publication/pub.1074660235 schema:CreativeWork
    363 https://app.dimensions.ai/details/publication/pub.1074673345 schema:CreativeWork
    364 https://app.dimensions.ai/details/publication/pub.1074880629 schema:CreativeWork
    365 https://app.dimensions.ai/details/publication/pub.1074997015 schema:CreativeWork
    366 https://app.dimensions.ai/details/publication/pub.1075031502 schema:CreativeWork
    367 https://app.dimensions.ai/details/publication/pub.1075087967 schema:CreativeWork
    368 https://app.dimensions.ai/details/publication/pub.1076607143 schema:CreativeWork
    369 https://app.dimensions.ai/details/publication/pub.1076607150 schema:CreativeWork
    370 https://app.dimensions.ai/details/publication/pub.1076607168 schema:CreativeWork
    371 https://app.dimensions.ai/details/publication/pub.1082635862 schema:CreativeWork
    372 https://app.dimensions.ai/details/publication/pub.1082995554 schema:CreativeWork
    373 https://app.dimensions.ai/details/publication/pub.1083084091 schema:CreativeWork
    374 https://app.dimensions.ai/details/publication/pub.1083219806 schema:CreativeWork
    375 https://app.dimensions.ai/details/publication/pub.1083347358 schema:CreativeWork
    376 https://app.dimensions.ai/details/publication/pub.1083379569 schema:CreativeWork
    377 https://doi.org/10.1002/(sici)1097-0215(19960717)67:2<275::aid-ijc20>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000386759
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1002/(sici)1097-4644(1998)72:30/31+<111::aid-jcb15>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039591027
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1002/gcc.10083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050164062
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1002/path.2207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025904872
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/j.ccr.2004.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012235373
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/j.cell.2008.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042567148
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/j.cell.2009.06.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010114196
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/j.urolonc.2007.11.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024573892
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/s0002-9440(10)64016-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043312631
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1016/s0002-9440(10)64396-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052037734
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1016/s0002-9440(10)64814-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016219929
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1016/s0169-5002(03)00137-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012032996
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/s0959-8049(97)10075-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044689306
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1016/s1044-579x(02)00057-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035748567
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1038/sj.neo.7900124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015250015
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1053/j.seminoncol.2006.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009297891
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1056/nejmoa051918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015724931
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1073/pnas.0500165102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050332338
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1073/pnas.0705158104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040257663
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1073/pnas.0902042106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012154477
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1074/jbc.m709428200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033356364
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1074/jbc.m804777200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011000378
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1093/jnci/83.4.285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059817007
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1097/01.ju.0000108845.91485.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026945329
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1101/gad.1640608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004123559
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1101/gad.1820209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038770877
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1128/iai.00938-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034283061
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1128/mcb.25.18.8108-8125.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006589108
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1152/ajprenal.00533.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023457044
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1158/0008-5472.can-04-0374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016195866
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1158/0008-5472.can-04-1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008946163
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1158/0008-5472.can-05-1536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010511161
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1158/0008-5472.can-05-1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047482036
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1158/0008-5472.can-06-1224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012584979
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1158/0008-5472.can-07-1058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033771185
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1158/0008-5472.can-07-2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043226815
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1158/0008-5472.can-08-2819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023349225
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1158/1078-0432.ccr-04-2409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006822742
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1158/1078-0432.ccr-06-0286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035886500
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1158/1078-0432.ccr-06-0407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004898502
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1158/1078-0432.ccr-06-2330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051544472
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1158/1078-0432.ccr-07-1593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029477989
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1158/1078-0432.ccr-08-2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052436680
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1158/1535-7163.mct-05-0474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051570730
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1158/1535-7163.mct-06-0513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015827562
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1172/jci38017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044751385
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1182/blood-2005-03-1327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001228442
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1200/jco.2005.02.857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033277450
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1200/jco.2005.03.2375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030127381
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1200/jco.2005.09.985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204294
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1200/jco.2007.12.9858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015875660
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1200/jco.2007.13.0062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042910508
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1200/jco.2007.14.7116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031599680
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1200/jco.2007.14.8924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052598954
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1200/jco.2008.21.6796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013944755
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1200/jco.2009.22.3370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006674721
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.3892/ijo.20.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071512071
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.3892/or.8.1.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071536358
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.4161/cbt.6.6.4088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072294587
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.4161/cc.5.2.2340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298650
    496 rdf:type schema:CreativeWork
    497 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    498 schema:name Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA
    499 Department of Genitourinary Medical Oncology, U.T. M.D. Anderson Cancer Center, 77030, Houston, TX, USA
    500 Department of Urology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, P.O. Box 1373, 77030, Houston, TX, USA
    501 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...