Osteosarcoma treatment: state of the art View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-02-12

AUTHORS

Hang T. Ta, Crispin R. Dass, Peter F. M. Choong, Dave E. Dunstan

ABSTRACT

Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed. More... »

PAGES

247-263

References to SciGraph publications

  • 2001-09-01. Growth suppression of established human osteosarcoma lung metastases in mice by aerosol gene therapy with PEI– p53 complexes in CANCER GENE THERAPY
  • 2007-10-27. A review of clinical and molecular prognostic factors in osteosarcoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2002. AJCC Cancer Staging Manual in NONE
  • 1982. Adjuvant Interferon Treatment of Human Osteosarcoma in ADJUVANT THERAPIES OF CANCER
  • 1983-01. Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2007-03-13. Prophylactic IL-12 treatment reduces postoperative metastasis: mediation by increased numbers but not cytotoxicity of NK cells in BREAST CANCER RESEARCH AND TREATMENT
  • 2002-04. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium–derived factor in NATURE MEDICINE
  • 2004-02. Primary Osteosarcoma of the Lung: Report of a Case in SURGERY TODAY
  • 2007-06-23. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome in JOURNAL OF MOLECULAR MEDICINE
  • 2007-03-13. Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis in BRITISH JOURNAL OF CANCER
  • 2006-12-23. A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma in CLINICAL & EXPERIMENTAL METASTASIS
  • 2007-01-23. Combined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma in BRITISH JOURNAL OF CANCER
  • 1993. Adjuvant interferon treatment in human osteosarcoma in OSTEOSARCOMA IN ADOLESCENTS AND YOUNG ADULTS: NEW DEVELOPMENTS AND CONTROVERSIES
  • 2004-01-04. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis in NATURE MEDICINE
  • 2007-05-04. Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis in CANCER GENE THERAPY
  • 2005-12. Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma in CLINICAL & EXPERIMENTAL METASTASIS
  • 2007-10-26. Interferon‐α enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53‐dependent apoptosis1 in ACTA PHARMACOLOGICA SINICA
  • 2006-08. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design in NATURE REVIEWS IMMUNOLOGY
  • 2006-02-03. Endostatin therapy reveals a U-shaped curve for antitumor activity in CANCER GENE THERAPY
  • 1996-09. Alterations of thep53, Rb andMDM2 genes in osteosarcoms in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2006-12-12. Anti-angiogenic therapy for osteosarcoma in CANCER AND METASTASIS REVIEWS
  • 1998-10-12. Integration of SV40 in human osteosarcoma DNA in ONCOGENE
  • 2007-01-23. Osteosarcoma (Osteogenic sarcoma) in ORPHANET JOURNAL OF RARE DISEASES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10555-009-9186-7

    DOI

    http://dx.doi.org/10.1007/s10555-009-9186-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010722520

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19214708


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone and Bones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Medical Oncology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteosarcoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Chemical and Biomolecular Engineering, University of Melbourne, 3010, Melbourne, VIC, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Department of Chemical and Biomolecular Engineering, University of Melbourne, 3010, Melbourne, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ta", 
            "givenName": "Hang T.", 
            "id": "sg:person.01241037500.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241037500.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Orthopaedics and Surgery, St Vincent\u2019s Hospital Melbourne, 3065, Melbourne, VIC, Australia", 
              "id": "http://www.grid.ac/institutes/grid.413105.2", 
              "name": [
                "Departments of Orthopaedics and Surgery, St Vincent\u2019s Hospital Melbourne, 3065, Melbourne, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dass", 
            "givenName": "Crispin R.", 
            "id": "sg:person.01151257616.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151257616.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sarcoma Service, Peter MacCallum Cancer Centre, 3002, Melbourne, VIC, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1055.1", 
              "name": [
                "Departments of Orthopaedics and Surgery, St Vincent\u2019s Hospital Melbourne, 3065, Melbourne, VIC, Australia", 
                "Sarcoma Service, Peter MacCallum Cancer Centre, 3002, Melbourne, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choong", 
            "givenName": "Peter F. M.", 
            "id": "sg:person.010622362137.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010622362137.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Chemical and Biomolecular Engineering, University of Melbourne, 3010, Melbourne, VIC, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Department of Chemical and Biomolecular Engineering, University of Melbourne, 3010, Melbourne, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dunstan", 
            "givenName": "Dave E.", 
            "id": "sg:person.0776147135.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776147135.60"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048361695", 
              "https://doi.org/10.1038/nm982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028419592", 
              "https://doi.org/10.1038/sj.bjc.6603678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019691444", 
              "https://doi.org/10.1038/sj.cgt.7700938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1750-1172-2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011926705", 
              "https://doi.org/10.1186/1750-1172-2-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-006-9004-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024569548", 
              "https://doi.org/10.1007/s10585-006-9004-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013076847", 
              "https://doi.org/10.1038/nri1901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-007-9540-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041684678", 
              "https://doi.org/10.1007/s10549-007-9540-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-81685-7_17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051473855", 
              "https://doi.org/10.1007/978-3-642-81685-7_17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-006-9031-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039592876", 
              "https://doi.org/10.1007/s10555-006-9031-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032794013", 
              "https://doi.org/10.1038/sj.cgt.7700343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01213553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039009422", 
              "https://doi.org/10.1007/bf01213553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0402-349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004091227", 
              "https://doi.org/10.1038/nm0402-349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-007-0330-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044293767", 
              "https://doi.org/10.1007/s00432-007-0330-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7701044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008252706", 
              "https://doi.org/10.1038/sj.cgt.7701044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-006-9046-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004001482", 
              "https://doi.org/10.1007/s10585-006-9046-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1745-7254.2007.00662.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039947503", 
              "https://doi.org/10.1111/j.1745-7254.2007.00662.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-3518-8_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033394010", 
              "https://doi.org/10.1007/978-1-4615-3518-8_5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013496985", 
              "https://doi.org/10.1038/sj.onc.1202179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4757-3656-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032089040", 
              "https://doi.org/10.1007/978-1-4757-3656-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00625042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027901111", 
              "https://doi.org/10.1007/bf00625042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-007-0221-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042163119", 
              "https://doi.org/10.1007/s00109-007-0221-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00595-003-2651-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313319", 
              "https://doi.org/10.1007/s00595-003-2651-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019463625", 
              "https://doi.org/10.1038/sj.bjc.6603548"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-02-12", 
        "datePublishedReg": "2009-02-12", 
        "description": "Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10555-009-9186-7", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096239", 
            "issn": [
              "0167-7659", 
              "1573-7233"
            ], 
            "name": "Cancer and Metastasis Reviews", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1-2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "28"
          }
        ], 
        "keywords": [
          "cancer-related death", 
          "new experimental drugs", 
          "second highest cause", 
          "form of therapy", 
          "new effective drugs", 
          "fatal metastases", 
          "potential therapy", 
          "effective drugs", 
          "classes of cancer", 
          "age groups", 
          "osteosarcoma", 
          "highest cause", 
          "experimental drugs", 
          "aggressive use", 
          "young adults", 
          "molecular pathways", 
          "therapy", 
          "drugs", 
          "art management", 
          "chemotherapy", 
          "patients", 
          "surgery", 
          "metastasis", 
          "radiotherapy", 
          "lung", 
          "cancer", 
          "death", 
          "survival", 
          "adults", 
          "bone", 
          "children", 
          "cause", 
          "group", 
          "pathway", 
          "management", 
          "use", 
          "development", 
          "biology", 
          "state", 
          "form", 
          "article", 
          "class", 
          "art"
        ], 
        "name": "Osteosarcoma treatment: state of the art", 
        "pagination": "247-263", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010722520"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10555-009-9186-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19214708"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10555-009-9186-7", 
          "https://app.dimensions.ai/details/publication/pub.1010722520"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T16:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_491.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10555-009-9186-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9186-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9186-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9186-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10555-009-9186-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    284 TRIPLES      21 PREDICATES      105 URIs      74 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10555-009-9186-7 schema:about N26c0f9ccfa494803bd42ec74572aae53
    2 N3b68fdc80b7d441cbd2972d85ffd8ef8
    3 N7a599d538232472da0a12dcd96ac58cf
    4 N803c4fe7e3b54c54843fb4d156b9de84
    5 N9265f8a969034524b10704b62878c959
    6 N9e625af476094cb098b0de2bcc2b6d5f
    7 Nc17bfcba7d204a2e8dacd177be676fbf
    8 Nc638ac5422674c68933ae1e63a9ad2e5
    9 Nc6eb8565b6ef45318e25ee4558d0d5ee
    10 Ncb0f9adb4bea4352b2d730d155592582
    11 Ncbfcfc741eeb4e7b8a497f69361f0d04
    12 Ne173cefaebbd4a18928b382f534bf79c
    13 Ne8576b423acd4192ab2587062f60438c
    14 Nf0f7529d15a24b279e849a2448dfe220
    15 Nf99e7d528b074875a02eea1b133d6e86
    16 anzsrc-for:11
    17 anzsrc-for:1112
    18 schema:author Nf5718cbad4fb4e56b9bbb69475b7afe5
    19 schema:citation sg:pub.10.1007/978-1-4615-3518-8_5
    20 sg:pub.10.1007/978-1-4757-3656-4
    21 sg:pub.10.1007/978-3-642-81685-7_17
    22 sg:pub.10.1007/bf00625042
    23 sg:pub.10.1007/bf01213553
    24 sg:pub.10.1007/s00109-007-0221-2
    25 sg:pub.10.1007/s00432-007-0330-x
    26 sg:pub.10.1007/s00595-003-2651-y
    27 sg:pub.10.1007/s10549-007-9540-9
    28 sg:pub.10.1007/s10555-006-9031-1
    29 sg:pub.10.1007/s10585-006-9004-3
    30 sg:pub.10.1007/s10585-006-9046-6
    31 sg:pub.10.1038/nm0402-349
    32 sg:pub.10.1038/nm982
    33 sg:pub.10.1038/nri1901
    34 sg:pub.10.1038/sj.bjc.6603548
    35 sg:pub.10.1038/sj.bjc.6603678
    36 sg:pub.10.1038/sj.cgt.7700343
    37 sg:pub.10.1038/sj.cgt.7700938
    38 sg:pub.10.1038/sj.cgt.7701044
    39 sg:pub.10.1038/sj.onc.1202179
    40 sg:pub.10.1111/j.1745-7254.2007.00662.x
    41 sg:pub.10.1186/1750-1172-2-6
    42 schema:datePublished 2009-02-12
    43 schema:datePublishedReg 2009-02-12
    44 schema:description Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.
    45 schema:genre article
    46 schema:isAccessibleForFree false
    47 schema:isPartOf N004f1c8e3603420f98a274d138d9fb6f
    48 N81a87ec2f7c9462aa96487f3d558d322
    49 sg:journal.1096239
    50 schema:keywords adults
    51 age groups
    52 aggressive use
    53 art
    54 art management
    55 article
    56 biology
    57 bone
    58 cancer
    59 cancer-related death
    60 cause
    61 chemotherapy
    62 children
    63 class
    64 classes of cancer
    65 death
    66 development
    67 drugs
    68 effective drugs
    69 experimental drugs
    70 fatal metastases
    71 form
    72 form of therapy
    73 group
    74 highest cause
    75 lung
    76 management
    77 metastasis
    78 molecular pathways
    79 new effective drugs
    80 new experimental drugs
    81 osteosarcoma
    82 pathway
    83 patients
    84 potential therapy
    85 radiotherapy
    86 second highest cause
    87 state
    88 surgery
    89 survival
    90 therapy
    91 use
    92 young adults
    93 schema:name Osteosarcoma treatment: state of the art
    94 schema:pagination 247-263
    95 schema:productId N616dc3d8f00f496b8791c813fac45cfe
    96 N634ced91393a4518b80fb533ef72479f
    97 Nec733dd0c9084dddbe006929abe471bd
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010722520
    99 https://doi.org/10.1007/s10555-009-9186-7
    100 schema:sdDatePublished 2022-08-04T16:58
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N4072abe1dc1f4d429d462a9965f32bc3
    103 schema:url https://doi.org/10.1007/s10555-009-9186-7
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N004f1c8e3603420f98a274d138d9fb6f schema:volumeNumber 28
    108 rdf:type schema:PublicationVolume
    109 N26c0f9ccfa494803bd42ec74572aae53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Adolescent
    111 rdf:type schema:DefinedTerm
    112 N3b68fdc80b7d441cbd2972d85ffd8ef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Osteosarcoma
    114 rdf:type schema:DefinedTerm
    115 N4072abe1dc1f4d429d462a9965f32bc3 schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 N4f76ab6d14c44996b8d2ac9a77bbbc7e rdf:first sg:person.0776147135.60
    118 rdf:rest rdf:nil
    119 N616dc3d8f00f496b8791c813fac45cfe schema:name dimensions_id
    120 schema:value pub.1010722520
    121 rdf:type schema:PropertyValue
    122 N634ced91393a4518b80fb533ef72479f schema:name pubmed_id
    123 schema:value 19214708
    124 rdf:type schema:PropertyValue
    125 N7a599d538232472da0a12dcd96ac58cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Neoplasm Staging
    127 rdf:type schema:DefinedTerm
    128 N803c4fe7e3b54c54843fb4d156b9de84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Radiotherapy
    130 rdf:type schema:DefinedTerm
    131 N81a87ec2f7c9462aa96487f3d558d322 schema:issueNumber 1-2
    132 rdf:type schema:PublicationIssue
    133 N9265f8a969034524b10704b62878c959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Antineoplastic Combined Chemotherapy Protocols
    135 rdf:type schema:DefinedTerm
    136 N9e625af476094cb098b0de2bcc2b6d5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Medical Oncology
    138 rdf:type schema:DefinedTerm
    139 Nc17bfcba7d204a2e8dacd177be676fbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Adult
    141 rdf:type schema:DefinedTerm
    142 Nc638ac5422674c68933ae1e63a9ad2e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Bone and Bones
    144 rdf:type schema:DefinedTerm
    145 Nc6eb8565b6ef45318e25ee4558d0d5ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Young Adult
    147 rdf:type schema:DefinedTerm
    148 Ncb0f9adb4bea4352b2d730d155592582 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Child
    150 rdf:type schema:DefinedTerm
    151 Ncbfcfc741eeb4e7b8a497f69361f0d04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Combined Modality Therapy
    153 rdf:type schema:DefinedTerm
    154 Ne173cefaebbd4a18928b382f534bf79c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Models, Biological
    156 rdf:type schema:DefinedTerm
    157 Ne8576b423acd4192ab2587062f60438c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Antineoplastic Agents
    159 rdf:type schema:DefinedTerm
    160 Neaf0344944b94625850d61b9740fb9f1 rdf:first sg:person.010622362137.43
    161 rdf:rest N4f76ab6d14c44996b8d2ac9a77bbbc7e
    162 Nec733dd0c9084dddbe006929abe471bd schema:name doi
    163 schema:value 10.1007/s10555-009-9186-7
    164 rdf:type schema:PropertyValue
    165 Nf0f7529d15a24b279e849a2448dfe220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Humans
    167 rdf:type schema:DefinedTerm
    168 Nf5718cbad4fb4e56b9bbb69475b7afe5 rdf:first sg:person.01241037500.46
    169 rdf:rest Nfd6dd958d9434464ac3e5954003ccf18
    170 Nf99e7d528b074875a02eea1b133d6e86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Bone Neoplasms
    172 rdf:type schema:DefinedTerm
    173 Nfd6dd958d9434464ac3e5954003ccf18 rdf:first sg:person.01151257616.88
    174 rdf:rest Neaf0344944b94625850d61b9740fb9f1
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Oncology and Carcinogenesis
    180 rdf:type schema:DefinedTerm
    181 sg:journal.1096239 schema:issn 0167-7659
    182 1573-7233
    183 schema:name Cancer and Metastasis Reviews
    184 schema:publisher Springer Nature
    185 rdf:type schema:Periodical
    186 sg:person.010622362137.43 schema:affiliation grid-institutes:grid.1055.1
    187 schema:familyName Choong
    188 schema:givenName Peter F. M.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010622362137.43
    190 rdf:type schema:Person
    191 sg:person.01151257616.88 schema:affiliation grid-institutes:grid.413105.2
    192 schema:familyName Dass
    193 schema:givenName Crispin R.
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151257616.88
    195 rdf:type schema:Person
    196 sg:person.01241037500.46 schema:affiliation grid-institutes:grid.1008.9
    197 schema:familyName Ta
    198 schema:givenName Hang T.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241037500.46
    200 rdf:type schema:Person
    201 sg:person.0776147135.60 schema:affiliation grid-institutes:grid.1008.9
    202 schema:familyName Dunstan
    203 schema:givenName Dave E.
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776147135.60
    205 rdf:type schema:Person
    206 sg:pub.10.1007/978-1-4615-3518-8_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033394010
    207 https://doi.org/10.1007/978-1-4615-3518-8_5
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/978-1-4757-3656-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032089040
    210 https://doi.org/10.1007/978-1-4757-3656-4
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/978-3-642-81685-7_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051473855
    213 https://doi.org/10.1007/978-3-642-81685-7_17
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/bf00625042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027901111
    216 https://doi.org/10.1007/bf00625042
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/bf01213553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039009422
    219 https://doi.org/10.1007/bf01213553
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00109-007-0221-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042163119
    222 https://doi.org/10.1007/s00109-007-0221-2
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00432-007-0330-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044293767
    225 https://doi.org/10.1007/s00432-007-0330-x
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00595-003-2651-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1014313319
    228 https://doi.org/10.1007/s00595-003-2651-y
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s10549-007-9540-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684678
    231 https://doi.org/10.1007/s10549-007-9540-9
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s10555-006-9031-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039592876
    234 https://doi.org/10.1007/s10555-006-9031-1
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s10585-006-9004-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024569548
    237 https://doi.org/10.1007/s10585-006-9004-3
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s10585-006-9046-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004001482
    240 https://doi.org/10.1007/s10585-006-9046-6
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nm0402-349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004091227
    243 https://doi.org/10.1038/nm0402-349
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nm982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048361695
    246 https://doi.org/10.1038/nm982
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nri1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013076847
    249 https://doi.org/10.1038/nri1901
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/sj.bjc.6603548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019463625
    252 https://doi.org/10.1038/sj.bjc.6603548
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/sj.bjc.6603678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028419592
    255 https://doi.org/10.1038/sj.bjc.6603678
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/sj.cgt.7700343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032794013
    258 https://doi.org/10.1038/sj.cgt.7700343
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/sj.cgt.7700938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019691444
    261 https://doi.org/10.1038/sj.cgt.7700938
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/sj.cgt.7701044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008252706
    264 https://doi.org/10.1038/sj.cgt.7701044
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/sj.onc.1202179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013496985
    267 https://doi.org/10.1038/sj.onc.1202179
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1111/j.1745-7254.2007.00662.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039947503
    270 https://doi.org/10.1111/j.1745-7254.2007.00662.x
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1186/1750-1172-2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011926705
    273 https://doi.org/10.1186/1750-1172-2-6
    274 rdf:type schema:CreativeWork
    275 grid-institutes:grid.1008.9 schema:alternateName Department of Chemical and Biomolecular Engineering, University of Melbourne, 3010, Melbourne, VIC, Australia
    276 schema:name Department of Chemical and Biomolecular Engineering, University of Melbourne, 3010, Melbourne, VIC, Australia
    277 rdf:type schema:Organization
    278 grid-institutes:grid.1055.1 schema:alternateName Sarcoma Service, Peter MacCallum Cancer Centre, 3002, Melbourne, VIC, Australia
    279 schema:name Departments of Orthopaedics and Surgery, St Vincent’s Hospital Melbourne, 3065, Melbourne, VIC, Australia
    280 Sarcoma Service, Peter MacCallum Cancer Centre, 3002, Melbourne, VIC, Australia
    281 rdf:type schema:Organization
    282 grid-institutes:grid.413105.2 schema:alternateName Departments of Orthopaedics and Surgery, St Vincent’s Hospital Melbourne, 3065, Melbourne, VIC, Australia
    283 schema:name Departments of Orthopaedics and Surgery, St Vincent’s Hospital Melbourne, 3065, Melbourne, VIC, Australia
    284 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...