Targeting hypoxia cell signaling for cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Giovanni Melillo

ABSTRACT

Hypoxia, a decrease in oxygen levels, is a hallmark of solid tumors. Hypoxic cells are more resistant to killing by ionizing radiation and chemotherapy, are more invasive and metastatic, resistant to apoptosis, and genetically unstable. Over the last two decades, the discovery of Hypoxia Inducible Factors, a family of transcription factors crucially involved in the response of mammalian cells to oxygen deprivation, has led to the identification of a molecular target associated with hypoxia suitable for the development of cancer therapeutics. These features of solid tumors may offer a unique opportunity for selective therapeutic approaches. A number of strategies targeting hypoxia and/or Hypoxia Inducible Factors (HIF) have been developed over the last several years and will be described. The exponentially growing interest in therapeutic strategies targeting hypoxia/HIF will undoubtedly generate more active compounds for preclinical and clinical development. A rational development plan aimed to validate target inhibition in preclinical models and early clinical trials is essential for a rapid translation of these agents to the treatment of human cancers. More... »

PAGES

341-352

References to SciGraph publications

  • 2004-06. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways in NATURE MEDICINE
  • 2003-12. Targeting HIF-1 for cancer therapy in NATURE REVIEWS CANCER
  • 1993-06. SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours in BRITISH JOURNAL OF CANCER
  • 2001-04. Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy in GENE THERAPY
  • 2000-12. Suppression of tumor growth through disruption of hypoxia-inducible transcription in NATURE MEDICINE
  • 2006-01. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer in NATURE MEDICINE
  • 2006-04. Lysyl oxidase is essential for hypoxia-induced metastasis in NATURE
  • 2005-06. The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression in ONCOGENE
  • 2006-10. Topoisomerase I inhibitors: camptothecins and beyond in NATURE REVIEWS CANCER
  • 2002-01. Hypoxia — a key regulatory factor in tumour growth in NATURE REVIEWS CANCER
  • 2004-06. Exploiting tumour hypoxia in cancer treatment in NATURE REVIEWS CANCER
  • 2002-02. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis in GENE THERAPY
  • 1997-05. Targeting gene expression to hypoxic tumor cells in NATURE MEDICINE
  • 2003-10. HIF-1 as a target for drug development in NATURE REVIEWS DRUG DISCOVERY
  • 1997-08. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment in GENE THERAPY
  • 2001-04. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10555-007-9059-x

    DOI

    http://dx.doi.org/10.1007/s10555-007-9059-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038171243

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17415529


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