Native T1 mapping to detect extent of acute and chronic myocardial infarction: comparison with late gadolinium enhancement technique View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-24

AUTHORS

Amardeep Ghosh Dastidar, Iwan Harries, Giulia Pontecorboli, Vito D. Bruno, Estefania De Garate, Charlie Moret, Anna Baritussio, Thomas W. Johnson, Elisa McAlindon, Chiara Bucciarelli-Ducci

ABSTRACT

Investigate whether native-T1 mapping can assess the transmural extent of myocardial infarction (TEI) thereby differentiating viable from non-viable myocardium without the use of gadolinium-contrast in both acute and chronic myocardial infarction (aMI and cMI). Sixty patients (30 cMI > 1 year and 30 aMI day 2 STEMI) and 20 healthy-controls underwent 1.5 T CMR to assess left ventricular function (cine), native-T1 mapping (MOLLI sequence 5(3)3, motion-corrected) and the presence and TEI from late gadolinium enhancement (LGE) images. Segments with TEI > 75% was considered non-viable. Gold-standard LGE-TEI was compared with corresponding segmental native-T1. Segmental native-T1 correlated significantly with TEI (R = 0.74, p < 0.001 in cMI and R = 0.57, p < 0.001 in aMI). Native-T1 differentiated segments with no LGE (1031 ± 31 ms), LGE positive but viable (1103 ± 57 ms) and LGE positive but non-viable (1206 ± 118 ms) in cMI (p < 0.01). It also differentiated segments with no LGE (1054 ± 65 m), LGE positive but viable (1135 ± 73 ms) and LGE positive but non-viable (1168 ± 71 ms) in aMI (p < 0.01). ROC analysis demonstrated excellent accuracy of native-T1 mapping compared to LGE-TEI (AUC − 0.88, p < 0.001 in cMI, vs AUC − 0.83, p < 0.001 in aMI). Native-T1 performed better in cMI than aMI (p < 0.01). In cMI a segmental T1 threshold of 1085 ms differentiated viable from non-viable segments with a sensitivity 88% and specificity of 88% whereas a T1 of 1110 ms differentiated viable from nonviable with 79% sensitivity and 79% specificity in aMI. Native-T1 mapping correlates significantly with TEI thereby differentiating between normal, viable, and non-viable myocardium with distinctive T1 profiles in aMI and cMI. Native T1-mapping to detect MI performed better in cMI compared to aMI due to absence of myocardial oedema. Native-T1 mapping holds promise for viability assessment without the need for gadolinium-contrast agent. More... »

PAGES

517-527

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10554-018-1467-1

DOI

http://dx.doi.org/10.1007/s10554-018-1467-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107826084

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30357547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Contrast Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Image Interpretation, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging, Cine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Observer Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organometallic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Function, Left", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
            "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dastidar", 
        "givenName": "Amardeep Ghosh", 
        "id": "sg:person.01305761173.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305761173.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
            "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harries", 
        "givenName": "Iwan", 
        "id": "sg:person.01276052260.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276052260.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pontecorboli", 
        "givenName": "Giulia", 
        "id": "sg:person.01217436063.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217436063.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
            "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruno", 
        "givenName": "Vito D.", 
        "id": "sg:person.0616623042.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616623042.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
            "NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK", 
            "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Garate", 
        "givenName": "Estefania", 
        "id": "sg:person.0652067361.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652067361.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moret", 
        "givenName": "Charlie", 
        "id": "sg:person.013740273513.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013740273513.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baritussio", 
        "givenName": "Anna", 
        "id": "sg:person.01260070631.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260070631.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Thomas W.", 
        "id": "sg:person.01031744776.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031744776.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
            "NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McAlindon", 
        "givenName": "Elisa", 
        "id": "sg:person.01355556070.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355556070.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
          "id": "http://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK", 
            "NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK", 
            "Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bucciarelli-Ducci", 
        "givenName": "Chiara", 
        "id": "sg:person.01261634137.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261634137.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1532-429x-14-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003515519", 
          "https://doi.org/10.1186/1532-429x-14-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-015-0173-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008140653", 
          "https://doi.org/10.1186/s12968-015-0173-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-15353-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092483387", 
          "https://doi.org/10.1038/s41598-017-15353-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-014-0099-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052425641", 
          "https://doi.org/10.1186/s12968-014-0099-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1532-429x-16-36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030817605", 
          "https://doi.org/10.1186/1532-429x-16-36"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-10-24", 
    "datePublishedReg": "2018-10-24", 
    "description": "Investigate whether native-T1 mapping can assess the transmural extent of myocardial infarction (TEI) thereby differentiating viable from non-viable myocardium without the use of gadolinium-contrast in both acute and chronic myocardial infarction (aMI and cMI). Sixty patients (30 cMI\u2009>\u20091 year and 30 aMI day 2 STEMI) and 20 healthy-controls underwent 1.5 T CMR to assess left ventricular function (cine), native-T1 mapping (MOLLI sequence 5(3)3, motion-corrected) and the presence and TEI from late gadolinium enhancement (LGE) images. Segments with TEI\u2009>\u200975% was considered non-viable. Gold-standard LGE-TEI was compared with corresponding segmental native-T1. Segmental native-T1 correlated significantly with TEI (R\u2009=\u20090.74, p\u2009<\u20090.001 in cMI and R\u2009=\u20090.57, p\u2009<\u20090.001 in aMI). Native-T1 differentiated segments with no LGE (1031\u2009\u00b1\u200931 ms), LGE positive but viable (1103\u2009\u00b1\u200957 ms) and LGE positive but non-viable (1206\u2009\u00b1\u2009118 ms) in cMI (p\u2009<\u20090.01). It also differentiated segments with no LGE (1054\u2009\u00b1\u200965 m), LGE positive but viable (1135\u2009\u00b1\u200973 ms) and LGE positive but non-viable (1168\u2009\u00b1\u200971 ms) in aMI (p\u2009<\u20090.01). ROC analysis demonstrated excellent accuracy of native-T1 mapping compared to LGE-TEI (AUC \u2212\u20090.88, p\u2009<\u20090.001 in cMI, vs AUC \u2212\u20090.83, p\u2009<\u20090.001 in aMI). Native-T1 performed better in cMI than aMI (p\u2009<\u20090.01). In cMI a segmental T1 threshold of 1085 ms differentiated viable from non-viable segments with a sensitivity 88% and specificity of 88% whereas a T1 of 1110 ms differentiated viable from nonviable with 79% sensitivity and 79% specificity in aMI. Native-T1 mapping correlates significantly with TEI thereby differentiating between normal, viable, and non-viable myocardium with distinctive T1 profiles in aMI and cMI. Native T1-mapping to detect MI performed better in cMI compared to aMI due to absence of myocardial oedema. Native-T1 mapping holds promise for viability assessment without the need for gadolinium-contrast agent.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10554-018-1467-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1025429", 
        "issn": [
          "1569-5794", 
          "1573-0743"
        ], 
        "name": "The International Journal of Cardiovascular Imaging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "non-viable myocardium", 
      "chronic myocardial infarction", 
      "myocardial infarction", 
      "non-viable segments", 
      "gadolinium-contrast agent", 
      "late gadolinium enhancement (LGE) technique", 
      "native T1 mapping", 
      "ventricular function", 
      "late gadolinium enhancement (LGE) images", 
      "transmural extent", 
      "Native T1-mapping", 
      "sensitivity 88", 
      "myocardial edema", 
      "infarction", 
      "LGE", 
      "ROC analysis", 
      "T1 mapping", 
      "myocardium", 
      "T1 threshold", 
      "AMI", 
      "viability assessment", 
      "CMI", 
      "T1 profiles", 
      "enhancement images", 
      "edema", 
      "patients", 
      "specificity", 
      "T1-mapping", 
      "CMR", 
      "segments", 
      "MI", 
      "agents", 
      "T1", 
      "extent", 
      "assessment", 
      "ms", 
      "absence", 
      "sensitivity", 
      "presence", 
      "TEI", 
      "use", 
      "threshold", 
      "profile", 
      "need", 
      "promise", 
      "function", 
      "MS", 
      "comparison", 
      "analysis", 
      "excellent accuracy", 
      "mapping", 
      "technique", 
      "images", 
      "accuracy", 
      "enhancement techniques", 
      "native-T1 mapping", 
      "gadolinium enhancement (LGE) images", 
      "Gold-standard LGE-TEI", 
      "LGE-TEI", 
      "Native-T1", 
      "segmental T1 threshold", 
      "distinctive T1 profiles", 
      "gadolinium enhancement technique"
    ], 
    "name": "Native T1 mapping to detect extent of acute and chronic myocardial infarction: comparison with late gadolinium enhancement technique", 
    "pagination": "517-527", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107826084"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10554-018-1467-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30357547"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10554-018-1467-1", 
      "https://app.dimensions.ai/details/publication/pub.1107826084"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_785.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10554-018-1467-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10554-018-1467-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10554-018-1467-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10554-018-1467-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10554-018-1467-1'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      22 PREDICATES      114 URIs      101 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10554-018-1467-1 schema:about N019e362773a343b9a7481f2eef89ef05
2 N04592f25d75b4b5e81880f7f66f725b9
3 N07b79843d6af41fd9733cbaf29660ca7
4 N0917e0ed468f46229d134b8a7e249d12
5 N2c5812e7110f48b8b23a577775a4b162
6 N44bb6094d6f94236b14c100225e3556c
7 N4e6712d5819249d998487a58feb436f8
8 N5a79e5e1675a4e79a5d1a48498183aba
9 N605149c8c79a41a8a8d34b903b00440d
10 N7297192bfd5e465889191d61f235b045
11 N7a14d1160e5a4afc8075e99bcead340a
12 Na92ed65fe5d4477eab0c0b5b5fcd5a0b
13 Nba53c8f130f146e093408b7ad4af7169
14 Nbdcdb2eb65d742429c4310e7121bc06e
15 Ncd49a5be6f844d64abd23da43b55e4cf
16 Ne831fea4c41e46a8b15623b9894a9e3a
17 Nee5727fe3a4e4b71a419d207c254f6bf
18 Nf5e450cf1d154c9097216f26ca710240
19 Nf5eb639daaa249d89540666da883e6b7
20 Nf6e94b19a06b475eb81f6f49fcf8e5ff
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author Neb4c053972c04c35b037ef0791508538
24 schema:citation sg:pub.10.1038/s41598-017-15353-1
25 sg:pub.10.1186/1532-429x-14-15
26 sg:pub.10.1186/1532-429x-16-36
27 sg:pub.10.1186/s12968-014-0099-4
28 sg:pub.10.1186/s12968-015-0173-6
29 schema:datePublished 2018-10-24
30 schema:datePublishedReg 2018-10-24
31 schema:description Investigate whether native-T1 mapping can assess the transmural extent of myocardial infarction (TEI) thereby differentiating viable from non-viable myocardium without the use of gadolinium-contrast in both acute and chronic myocardial infarction (aMI and cMI). Sixty patients (30 cMI > 1 year and 30 aMI day 2 STEMI) and 20 healthy-controls underwent 1.5 T CMR to assess left ventricular function (cine), native-T1 mapping (MOLLI sequence 5(3)3, motion-corrected) and the presence and TEI from late gadolinium enhancement (LGE) images. Segments with TEI > 75% was considered non-viable. Gold-standard LGE-TEI was compared with corresponding segmental native-T1. Segmental native-T1 correlated significantly with TEI (R = 0.74, p < 0.001 in cMI and R = 0.57, p < 0.001 in aMI). Native-T1 differentiated segments with no LGE (1031 ± 31 ms), LGE positive but viable (1103 ± 57 ms) and LGE positive but non-viable (1206 ± 118 ms) in cMI (p < 0.01). It also differentiated segments with no LGE (1054 ± 65 m), LGE positive but viable (1135 ± 73 ms) and LGE positive but non-viable (1168 ± 71 ms) in aMI (p < 0.01). ROC analysis demonstrated excellent accuracy of native-T1 mapping compared to LGE-TEI (AUC − 0.88, p < 0.001 in cMI, vs AUC − 0.83, p < 0.001 in aMI). Native-T1 performed better in cMI than aMI (p < 0.01). In cMI a segmental T1 threshold of 1085 ms differentiated viable from non-viable segments with a sensitivity 88% and specificity of 88% whereas a T1 of 1110 ms differentiated viable from nonviable with 79% sensitivity and 79% specificity in aMI. Native-T1 mapping correlates significantly with TEI thereby differentiating between normal, viable, and non-viable myocardium with distinctive T1 profiles in aMI and cMI. Native T1-mapping to detect MI performed better in cMI compared to aMI due to absence of myocardial oedema. Native-T1 mapping holds promise for viability assessment without the need for gadolinium-contrast agent.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf Nbd753b86517541b2b2103ac166be6e76
36 Nf9c6b08b64ed489c9f3b3cb24b6fcdf2
37 sg:journal.1025429
38 schema:keywords AMI
39 CMI
40 CMR
41 Gold-standard LGE-TEI
42 LGE
43 LGE-TEI
44 MI
45 MS
46 Native T1-mapping
47 Native-T1
48 ROC analysis
49 T1
50 T1 mapping
51 T1 profiles
52 T1 threshold
53 T1-mapping
54 TEI
55 absence
56 accuracy
57 agents
58 analysis
59 assessment
60 chronic myocardial infarction
61 comparison
62 distinctive T1 profiles
63 edema
64 enhancement images
65 enhancement techniques
66 excellent accuracy
67 extent
68 function
69 gadolinium enhancement (LGE) images
70 gadolinium enhancement technique
71 gadolinium-contrast agent
72 images
73 infarction
74 late gadolinium enhancement (LGE) images
75 late gadolinium enhancement (LGE) technique
76 mapping
77 ms
78 myocardial edema
79 myocardial infarction
80 myocardium
81 native T1 mapping
82 native-T1 mapping
83 need
84 non-viable myocardium
85 non-viable segments
86 patients
87 presence
88 profile
89 promise
90 segmental T1 threshold
91 segments
92 sensitivity
93 sensitivity 88
94 specificity
95 technique
96 threshold
97 transmural extent
98 use
99 ventricular function
100 viability assessment
101 schema:name Native T1 mapping to detect extent of acute and chronic myocardial infarction: comparison with late gadolinium enhancement technique
102 schema:pagination 517-527
103 schema:productId N79d1363bcd4d44e998855505a649b3c3
104 Na169141707e5464388c34a4c0e089315
105 Nabc5fcd2ef1c42089aa0b7052baa913d
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107826084
107 https://doi.org/10.1007/s10554-018-1467-1
108 schema:sdDatePublished 2022-01-01T18:48
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N39f251629c064879bb0e3db44206b91c
111 schema:url https://doi.org/10.1007/s10554-018-1467-1
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N019e362773a343b9a7481f2eef89ef05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Contrast Media
117 rdf:type schema:DefinedTerm
118 N04592f25d75b4b5e81880f7f66f725b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N07b79843d6af41fd9733cbaf29660ca7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Myocardium
123 rdf:type schema:DefinedTerm
124 N0917e0ed468f46229d134b8a7e249d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Myocardial Infarction
126 rdf:type schema:DefinedTerm
127 N0a16eefeaf504cd8b09f7d355e54255b rdf:first sg:person.01217436063.82
128 rdf:rest N24b13af843944603b53d093798e53f26
129 N0d61675080594846ad190d428c4baf6d rdf:first sg:person.01261634137.50
130 rdf:rest rdf:nil
131 N1cd6e4089b9d44d2aec6fc9137eb8c40 rdf:first sg:person.013740273513.25
132 rdf:rest Nce4606c4265f4e1790d5abb37b48cf3a
133 N24b13af843944603b53d093798e53f26 rdf:first sg:person.0616623042.98
134 rdf:rest Na2275ce6436347d5b88ab42e7dbe89ee
135 N2c5812e7110f48b8b23a577775a4b162 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Predictive Value of Tests
137 rdf:type schema:DefinedTerm
138 N39f251629c064879bb0e3db44206b91c schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N44bb6094d6f94236b14c100225e3556c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Middle Aged
142 rdf:type schema:DefinedTerm
143 N482fa8dd526045a3a09acbf1192f1b78 rdf:first sg:person.01031744776.66
144 rdf:rest Nc98f428863e5466aa55c2de758f507d9
145 N4e6712d5819249d998487a58feb436f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Tissue Survival
147 rdf:type schema:DefinedTerm
148 N5a79e5e1675a4e79a5d1a48498183aba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Chronic Disease
150 rdf:type schema:DefinedTerm
151 N5c0a21b9286c4ca891af3423e1174ca9 rdf:first sg:person.01276052260.23
152 rdf:rest N0a16eefeaf504cd8b09f7d355e54255b
153 N605149c8c79a41a8a8d34b903b00440d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Reproducibility of Results
155 rdf:type schema:DefinedTerm
156 N7297192bfd5e465889191d61f235b045 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Organometallic Compounds
158 rdf:type schema:DefinedTerm
159 N79d1363bcd4d44e998855505a649b3c3 schema:name dimensions_id
160 schema:value pub.1107826084
161 rdf:type schema:PropertyValue
162 N7a14d1160e5a4afc8075e99bcead340a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Ventricular Function, Left
164 rdf:type schema:DefinedTerm
165 Na169141707e5464388c34a4c0e089315 schema:name pubmed_id
166 schema:value 30357547
167 rdf:type schema:PropertyValue
168 Na2275ce6436347d5b88ab42e7dbe89ee rdf:first sg:person.0652067361.44
169 rdf:rest N1cd6e4089b9d44d2aec6fc9137eb8c40
170 Na92ed65fe5d4477eab0c0b5b5fcd5a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Male
172 rdf:type schema:DefinedTerm
173 Nabc5fcd2ef1c42089aa0b7052baa913d schema:name doi
174 schema:value 10.1007/s10554-018-1467-1
175 rdf:type schema:PropertyValue
176 Nba53c8f130f146e093408b7ad4af7169 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Observer Variation
178 rdf:type schema:DefinedTerm
179 Nbd753b86517541b2b2103ac166be6e76 schema:issueNumber 3
180 rdf:type schema:PublicationIssue
181 Nbdcdb2eb65d742429c4310e7121bc06e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Humans
183 rdf:type schema:DefinedTerm
184 Nc98f428863e5466aa55c2de758f507d9 rdf:first sg:person.01355556070.94
185 rdf:rest N0d61675080594846ad190d428c4baf6d
186 Ncd49a5be6f844d64abd23da43b55e4cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Magnetic Resonance Imaging, Cine
188 rdf:type schema:DefinedTerm
189 Nce4606c4265f4e1790d5abb37b48cf3a rdf:first sg:person.01260070631.46
190 rdf:rest N482fa8dd526045a3a09acbf1192f1b78
191 Ne831fea4c41e46a8b15623b9894a9e3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Image Interpretation, Computer-Assisted
193 rdf:type schema:DefinedTerm
194 Neb4c053972c04c35b037ef0791508538 rdf:first sg:person.01305761173.69
195 rdf:rest N5c0a21b9286c4ca891af3423e1174ca9
196 Nee5727fe3a4e4b71a419d207c254f6bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Acute Disease
198 rdf:type schema:DefinedTerm
199 Nf5e450cf1d154c9097216f26ca710240 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Case-Control Studies
201 rdf:type schema:DefinedTerm
202 Nf5eb639daaa249d89540666da883e6b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Adult
204 rdf:type schema:DefinedTerm
205 Nf6e94b19a06b475eb81f6f49fcf8e5ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Aged
207 rdf:type schema:DefinedTerm
208 Nf9c6b08b64ed489c9f3b3cb24b6fcdf2 schema:volumeNumber 35
209 rdf:type schema:PublicationVolume
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
214 schema:name Neurosciences
215 rdf:type schema:DefinedTerm
216 sg:journal.1025429 schema:issn 1569-5794
217 1573-0743
218 schema:name The International Journal of Cardiovascular Imaging
219 schema:publisher Springer Nature
220 rdf:type schema:Periodical
221 sg:person.01031744776.66 schema:affiliation grid-institutes:grid.410421.2
222 schema:familyName Johnson
223 schema:givenName Thomas W.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031744776.66
225 rdf:type schema:Person
226 sg:person.01217436063.82 schema:affiliation grid-institutes:grid.410421.2
227 schema:familyName Pontecorboli
228 schema:givenName Giulia
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217436063.82
230 rdf:type schema:Person
231 sg:person.01260070631.46 schema:affiliation grid-institutes:grid.410421.2
232 schema:familyName Baritussio
233 schema:givenName Anna
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260070631.46
235 rdf:type schema:Person
236 sg:person.01261634137.50 schema:affiliation grid-institutes:grid.5337.2
237 schema:familyName Bucciarelli-Ducci
238 schema:givenName Chiara
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261634137.50
240 rdf:type schema:Person
241 sg:person.01276052260.23 schema:affiliation grid-institutes:grid.5337.2
242 schema:familyName Harries
243 schema:givenName Iwan
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276052260.23
245 rdf:type schema:Person
246 sg:person.01305761173.69 schema:affiliation grid-institutes:grid.5337.2
247 schema:familyName Dastidar
248 schema:givenName Amardeep Ghosh
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305761173.69
250 rdf:type schema:Person
251 sg:person.01355556070.94 schema:affiliation grid-institutes:grid.410421.2
252 schema:familyName McAlindon
253 schema:givenName Elisa
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355556070.94
255 rdf:type schema:Person
256 sg:person.013740273513.25 schema:affiliation grid-institutes:grid.410421.2
257 schema:familyName Moret
258 schema:givenName Charlie
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013740273513.25
260 rdf:type schema:Person
261 sg:person.0616623042.98 schema:affiliation grid-institutes:grid.5337.2
262 schema:familyName Bruno
263 schema:givenName Vito D.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616623042.98
265 rdf:type schema:Person
266 sg:person.0652067361.44 schema:affiliation grid-institutes:grid.5337.2
267 schema:familyName De Garate
268 schema:givenName Estefania
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652067361.44
270 rdf:type schema:Person
271 sg:pub.10.1038/s41598-017-15353-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092483387
272 https://doi.org/10.1038/s41598-017-15353-1
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1532-429x-14-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003515519
275 https://doi.org/10.1186/1532-429x-14-15
276 rdf:type schema:CreativeWork
277 sg:pub.10.1186/1532-429x-16-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030817605
278 https://doi.org/10.1186/1532-429x-16-36
279 rdf:type schema:CreativeWork
280 sg:pub.10.1186/s12968-014-0099-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052425641
281 https://doi.org/10.1186/s12968-014-0099-4
282 rdf:type schema:CreativeWork
283 sg:pub.10.1186/s12968-015-0173-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008140653
284 https://doi.org/10.1186/s12968-015-0173-6
285 rdf:type schema:CreativeWork
286 grid-institutes:grid.410421.2 schema:alternateName Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK
287 NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK
288 schema:name Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK
289 NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK
290 rdf:type schema:Organization
291 grid-institutes:grid.5337.2 schema:alternateName Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
292 schema:name Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, BS2 8HW, Bristol, UK
293 NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK
294 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...